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Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6306, pp. 1399 - 1405
Journal Article
02/2012, ISBN 3527326065, 662
This book was written for graduate and medical students, as well as clinicians and postdoctoral researchers. It describes the theory of alternative pre-mRNA... 
Messenger RNA | RNA splicing
eBook
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 318 - 323
Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron... 
2ND STEP | I SPLICEOSOME | U4/U6.U5 TRI-SNRNP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | CATALYTIC CORE | PRE-MESSENGER-RNA | PRP8 | INSIGHTS | Spliceosomes - chemistry | Humans | Cell Cycle Proteins - ultrastructure | RNA Splicing Factors - chemistry | RNA, Messenger - metabolism | RNA Splicing Factors - metabolism | Cell Cycle Proteins - chemistry | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | Base Sequence | Protein Domains | Ribonucleoproteins, Small Nuclear - chemistry | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Biocatalysis | Introns - genetics | Movement | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Exons - genetics | Spliceosomes - ultrastructure | RNA Stability | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Adenosine - metabolism | Saccharomyces cerevisiae - enzymology | RNA, Messenger - chemistry | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Ribonuclease H - metabolism | Genetic research | Genetic engineering | Research | Methods | RNA splicing | Proteins | Yeast | Catalysis | Molecular structure | Microscopy | Ribonucleic acid--RNA
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 12/2009, Volume 16, Issue 12, pp. 1237 - 1243
The spliceosome is a ribonucleoprotein machine that removes introns from pre-mRNA in a two-step reaction. To investigate the catalytic steps of splicing, we... 
2ND REACTION | PRP2 | ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | PRE-MESSENGER-RNA | CELL BIOLOGY | BIOPHYSICS | DEPENDENT ATPASE | INTERACTS | SLU7 | CATALYTIC STEPS | Adenosine Triphosphatases - isolation & purification | RNA Helicases - metabolism | DEAD-box RNA Helicases - isolation & purification | RNA Splicing Factors | Adenosine Triphosphatases - metabolism | Ribonucleoprotein, U5 Small Nuclear - metabolism | Ribonucleoprotein, U2 Small Nuclear - isolation & purification | Spliceosomes - ultrastructure | RNA, Fungal - metabolism | Saccharomyces cerevisiae - metabolism | Spliceosomes - metabolism | Ribonucleoprotein, U2 Small Nuclear - metabolism | Image Processing, Computer-Assisted | Microscopy, Electron - methods | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - isolation & purification | RNA, Fungal - isolation & purification | DEAD-box RNA Helicases - metabolism | RNA Helicases - isolation & purification | Ribonucleoprotein, U5 Small Nuclear - isolation & purification | Ribonucleoproteins, Small Nuclear - isolation & purification | Ribonucleoproteins, Small Nuclear - metabolism | Ribonucleoproteins | Physiological aspects | Genetic aspects | Research | Structure | Brewer's yeast | Health aspects | RNA splicing | Proteins | Catalysis | Mutation | Molecular structure | Molecular biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 43, pp. 17418 - 17423
Journal Article