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Defective cholesterol clearance limits remyelination in the aged central nervous system
Science (American Association for the Advancement of Science), ISSN 0036-8075, 02/2018, Volume 359, Issue 6376, pp. 684 - 688
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System - metabolism | Lysosome-Associated Membrane Glycoproteins - metabolism | Myelin Sheath - pathology | Crystallization | Phagocytes - metabolism | Cholesterol - metabolism | Demyelinating Diseases - metabolism | Apolipoproteins E - metabolism | Mice, Knockout | Myelin Sheath - metabolism | Central Nervous System - physiology | Animals | Aging - physiology | Apolipoproteins E - genetics | Mice | Remyelination | Aging - metabolism | Physiological aspects | Observations | Cholesterol metabolism | Central nervous system | Drugs | Multiple sclerosis | Immune clearance | Inflammatory response | Stimulation | Nervous system | Phase transitions | Regeneration (physiology) | Immunosuppressive agents | Phagocytes | Restoration | Sheaths | Demyelination | Apolipoprotein E | Atherosclerosis | Aging | Lesions | Damage accumulation | Debris | Immune system | Efflux | Immune response | Myelin | Tissue engineering | Rupture | Detritus | Crystals | Inflammation | Cholesterol | Medicine | Regeneration | Myelination | Injury prevention | Arteriosclerosis | Index Medicus
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2008, Volume 51, Issue 16, pp. 1553 - 1561
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Mice, Inbred C57BL | Risk Factors | Arteriosclerosis - physiopathology | Male | Brain Ischemia - physiopathology | Brain Ischemia - prevention & control | Cardiovascular System - drug effects | Endothelium - physiopathology | Phytosterols - pharmacology | Arteriosclerosis - prevention & control | Phytosterols - administration & dosage | Animals | Phytosterols - blood | Plant Preparations | Female | Aged | Mice | Dietary Supplements | Plasma | Sterols | Ischemia | Diet | Rodents | Atherosclerosis | Brain damage | Cardiovascular disease | Smooth muscle | Cholesterol | Functional foods & nutraceuticals
Journal Article
Journal of lipid research, ISSN 0022-2275, 2014, Volume 55, Issue 3, pp. 583 - 591
Alkyne lipid | Click reaction | Probe | Analog | Oxysterols | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cholesterol Esters - metabolism | Sterols - metabolism | Saccharomyces cerevisiae - genetics | Humans | Cell Tracking - methods | Endoplasmic Reticulum - metabolism | Acyltransferases - metabolism | Cholesterol - chemistry | Saccharomyces cerevisiae - metabolism | Alkynes - metabolism | Cholesterol Oxidase - metabolism | Cell Membrane - metabolism | Molecular Structure | Cholesterol - analogs & derivatives | Rats | Alkynes - chemistry | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Cholesterol - metabolism | Animals | 5-Aminolevulinate Synthetase - genetics | Cell Line, Tumor | Golgi Apparatus - metabolism | Kinetics | Mutation | Microscopy, Fluorescence | Saccharomyces cerevisiae - growth & development | Index Medicus | analog | alkyne lipid | click reaction | oxysterols | Methods | probe
Journal Article
American journal of human genetics, ISSN 0002-9297, 11/2018, Volume 103, Issue 5, pp. 777 - 785
lanosterol synthase | hypothrichosis | hair | alopecia | LSS | whole-exome sequencing | cholesterol biosynthetic pathway | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Alopecia | Gene mutations | Baldness | Physiological aspects | Genetic aspects | Research | Risk factors | Care and treatment | Usage | Exome sequencing | Index Medicus | Report
Journal Article
Nature immunology, ISSN 1529-2908, 02/2014, Volume 15, Issue 2, pp. 152 - 160
Life Sciences & Biomedicine | Immunology | Science & Technology | Humans | Gene Expression Profiling | Systems Biology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lipoproteins, HDL - pharmacology | Atherosclerosis - therapy | Chromatin Immunoprecipitation | Lipoproteins, HDL - therapeutic use | Female | Macrophages - immunology | Activating Transcription Factor 3 - genetics | Mice, Inbred C57BL | Cells, Cultured | Cytokines - secretion | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Cholesterol - metabolism | Activating Transcription Factor 3 - metabolism | Mice, Inbred C3H | Inflammation - therapy | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Macrophages - drug effects | High-Throughput Nucleotide Sequencing | Mice | Macrophage Activation - drug effects | Care and treatment | High density lipoproteins | Atherosclerosis | Physiological aspects | Genetic aspects | Research | Macrophages | Health aspects | Index Medicus
Journal Article
Journal of lipid research, ISSN 0022-2275, 02/2015, Volume 56, Issue 2, pp. 319 - 330
Cholesterol/absorption | Sterols | Transport | Bile | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Intestinal Mucosa - metabolism | Enterocytes - metabolism | Lipoproteins - genetics | Liver - metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 5 | Cholesterol - metabolism | Mutation - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 8 | Mice, Knockout | Animals | Feces - chemistry | ATP-Binding Cassette Transporters - genetics | Lipoproteins - metabolism | Phytosterols - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Biological Transport - physiology | Mice | Index Medicus | cholesterol | s | sterols | transport | absorption | bile
Journal Article
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 05/2017, Volume 169, pp. 1 - 3
Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Congresses as Topic | Inflammation Mediators | Metabolic Diseases - therapy | Animals | Metabolic Diseases - etiology | Humans | Cholesterol - metabolism | Oxysterols - metabolism | Index Medicus
Journal Article
Journal of neurology, ISSN 0340-5354, 02/2020, Volume 267, Issue 2, pp. 572 - 573
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2016, Volume 68, Issue 3, pp. 325 - 326
Journal Article
Heart (British Cardiac Society), ISSN 1355-6037, 08/2019, Volume 105, Issue 16, pp. 1291 - 1292
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cholesterol, LDL | Cardiovascular Diseases | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Humans | Cholesterol | Statins | Atherosclerosis | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 48, pp. 37405 - 37414
Journal Article
Cholesterol, ISSN 2090-1283, 02/2017, Volume 2017, pp. 5046294 - 9
Usage | Dosage and administration | Diagnosis | Biological markers | Cholesterol | Antilipemic agents | Plasma | Sterols | Rodents | Lipids | Feces | Apolipoproteins | Bile | Vegetarianism | Review
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, pp. 1906 - 1906
interleukin-4 | sterol regulatory element binding protein-2 | lipoxygenase | chemokine | type B | arachidonate 15-lipoxygenase | cholesterol | macrophage | Life Sciences & Biomedicine | Immunology | Science & Technology | Cellular signal transduction | Research | Macrophages | Health aspects | Cholesterol | Membrane proteins
Journal Article