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1. Full Text Defective cholesterol clearance limits remyelination in the aged central nervous system
by Cantuti-Castelvetri, Ludovico and Fitzner, Dirk and Bosch-Queralt, Mar and Weil, Marie-Theres and Su, Minhui and Sen, Paromita and Ruhwedel, Torben and Mitkovski, Miso and Trendelenburg, George and Lütjohann, Dieter and Möbius, Wiebke and Simons, Mikael
Science (American Association for the Advancement of Science), ISSN 0036-8075, 02/2018, Volume 359, Issue 6376, pp. 684 - 688
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System - metabolism | Lysosome-Associated Membrane Glycoproteins - metabolism | Myelin Sheath - pathology | Crystallization | Phagocytes - metabolism | Cholesterol - metabolism | Demyelinating Diseases - metabolism | Apolipoproteins E - metabolism | Mice, Knockout | Myelin Sheath - metabolism | Central Nervous System - physiology | Animals | Aging - physiology | Apolipoproteins E - genetics | Mice | Remyelination | Aging - metabolism | Physiological aspects | Observations | Cholesterol metabolism | Central nervous system | Drugs | Multiple sclerosis | Immune clearance | Inflammatory response | Stimulation | Nervous system | Phase transitions | Regeneration (physiology) | Immunosuppressive agents | Phagocytes | Restoration | Sheaths | Demyelination | Apolipoprotein E | Atherosclerosis | Aging | Lesions | Damage accumulation | Debris | Immune system | Efflux | Immune response | Myelin | Tissue engineering | Rupture | Detritus | Crystals | Inflammation | Cholesterol | Medicine | Regeneration | Myelination | Injury prevention | Arteriosclerosis | Index Medicus
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2. Full Text Vascular Effects of Diet Supplementation With Plant Sterols
by Weingärtner, Oliver and Lütjohann, Dieter and Ji, Shengbo and Weisshoff, Nicole and List, Franka and Sudhop, Thomas and von Bergmann, Klaus and Gertz, Karen and König, Jochem and Schäfers, Hans-Joachim and Endres, Matthias and Böhm, Michael and Laufs, Ulrich
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2008, Volume 51, Issue 16, pp. 1553 - 1561
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Mice, Inbred C57BL | Risk Factors | Arteriosclerosis - physiopathology | Male | Brain Ischemia - physiopathology | Brain Ischemia - prevention & control | Cardiovascular System - drug effects | Endothelium - physiopathology | Phytosterols - pharmacology | Arteriosclerosis - prevention & control | Phytosterols - administration & dosage | Animals | Phytosterols - blood | Plant Preparations | Female | Aged | Mice | Dietary Supplements | Plasma | Sterols | Ischemia | Diet | Rodents | Atherosclerosis | Brain damage | Cardiovascular disease | Smooth muscle | Cholesterol | Functional foods & nutraceuticals
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3. Full Text A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization
by Hofmann, Kristina and Thiele, Christoph and Schoẗt, Hans-Frieder and Gaebler, Anne and Schoene, Mario and Kiver, Yuriy and Friedrichs, Silvia and Luẗjohann, Dieter and Kuerschner, Lars
Journal of lipid research, ISSN 0022-2275, 2014, Volume 55, Issue 3, pp. 583 - 591
Alkyne lipid | Click reaction | Probe | Analog | Oxysterols | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cholesterol Esters - metabolism | Sterols - metabolism | Saccharomyces cerevisiae - genetics | Humans | Cell Tracking - methods | Endoplasmic Reticulum - metabolism | Acyltransferases - metabolism | Cholesterol - chemistry | Saccharomyces cerevisiae - metabolism | Alkynes - metabolism | Cholesterol Oxidase - metabolism | Cell Membrane - metabolism | Molecular Structure | Cholesterol - analogs & derivatives | Rats | Alkynes - chemistry | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Cholesterol - metabolism | Animals | 5-Aminolevulinate Synthetase - genetics | Cell Line, Tumor | Golgi Apparatus - metabolism | Kinetics | Mutation | Microscopy, Fluorescence | Saccharomyces cerevisiae - growth & development | Index Medicus | analog | alkyne lipid | click reaction | oxysterols | Methods | probe
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4. Full Text Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex
by Romano, Maria-Teresa and Tafazzoli, Aylar and Mattern, Maximilian and Sivalingam, Sugirthan and Wolf, Sabrina and Rupp, Alexander and Thiele, Holger and Altmüller, Janine and Nürnberg, Peter and Ellwanger, Jürgen and Gambon, Reto and Baumer, Alessandra and Kohlschmidt, Nicolai and Metze, Dieter and Holdenrieder, Stefan and Paus, Ralf and Lütjohann, Dieter and Frank, Jorge and Geyer, Matthias and Bertolini, Marta and Kokordelis, Pavlos and Betz, Regina C
American journal of human genetics, ISSN 0002-9297, 11/2018, Volume 103, Issue 5, pp. 777 - 785
lanosterol synthase | hypothrichosis | hair | alopecia | LSS | whole-exome sequencing | cholesterol biosynthetic pathway | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Alopecia | Gene mutations | Baldness | Physiological aspects | Genetic aspects | Research | Risk factors | Care and treatment | Usage | Exome sequencing | Index Medicus | Report
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5. Full Text High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
by De Nardo, Dominic and Labzin, Larisa I and Kono, Hajime and Seki, Reiko and Schmidt, Susanne V and Beyer, Marc and Xu, Dakang and Zimmer, Sebastian and Lahrmann, Catharina and Schildberg, Frank A and Vogelhuber, Johanna and Kraut, Michael and Ulas, Thomas and Kerksiek, Anja and Krebs, Wolfgang and Bode, Niklas and Grebe, Alena and Fitzgerald, Michael L and Hernandez, Nicholas J and Williams, Bryan R.G and Knolle, Percy and Kneilling, Manfred and Röcken, Martin and Lütjohann, Dieter and Wright, Samuel D and Schultze, Joachim L and Latz, Eicke
Nature immunology, ISSN 1529-2908, 02/2014, Volume 15, Issue 2, pp. 152 - 160
Life Sciences & Biomedicine | Immunology | Science & Technology | Humans | Gene Expression Profiling | Systems Biology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lipoproteins, HDL - pharmacology | Atherosclerosis - therapy | Chromatin Immunoprecipitation | Lipoproteins, HDL - therapeutic use | Female | Macrophages - immunology | Activating Transcription Factor 3 - genetics | Mice, Inbred C57BL | Cells, Cultured | Cytokines - secretion | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Cholesterol - metabolism | Activating Transcription Factor 3 - metabolism | Mice, Inbred C3H | Inflammation - therapy | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Macrophages - drug effects | High-Throughput Nucleotide Sequencing | Mice | Macrophage Activation - drug effects | Care and treatment | High density lipoproteins | Atherosclerosis | Physiological aspects | Genetic aspects | Research | Macrophages | Health aspects | Index Medicus
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6. Full Text Relative roles of ABCG5/ABCG8 in liver and intestine
by Wang, Jin and Mitsche, Matthew A and Lütjohann, Dieter and Cohen, Jonathan C and Xie, Xiao-Song and Hobbs, Helen H
Journal of lipid research, ISSN 0022-2275, 02/2015, Volume 56, Issue 2, pp. 319 - 330
Cholesterol/absorption | Sterols | Transport | Bile | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Intestinal Mucosa - metabolism | Enterocytes - metabolism | Lipoproteins - genetics | Liver - metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 5 | Cholesterol - metabolism | Mutation - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 8 | Mice, Knockout | Animals | Feces - chemistry | ATP-Binding Cassette Transporters - genetics | Lipoproteins - metabolism | Phytosterols - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Biological Transport - physiology | Mice | Index Medicus | cholesterol | s | sterols | transport | absorption | bile
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7. Full Text Oxysterols: Players in different metabolic leagues
by Lütjohann, Dieter and Lizard, Gérard and Iuliano, Luigi
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 05/2017, Volume 169, pp. 1 - 3
Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Congresses as Topic | Inflammation Mediators | Metabolic Diseases - therapy | Animals | Metabolic Diseases - etiology | Humans | Cholesterol - metabolism | Oxysterols - metabolism | Index Medicus
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8. Full Text Levels of 7alpha-hydroxycholesterol and/or 7alpha-hydroxy-4-cholest-3-one are the optimal biochemical markers for the evaluation of treatment of cerebrotendinous xanthomatosis
by Luetjohann, Dieter and Stellaard, Frans and Bjoerkhem, Ingemar
Journal of neurology, ISSN 0340-5354, 02/2020, Volume 267, Issue 2, pp. 572 - 573
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biomarkers | Adult | Cholic Acid | Hydroxycholesterols | Xanthomatosis, Cerebrotendinous | Humans | Xanthomatosis | Biochemical markers | Index Medicus | Medicin och hälsovetenskap
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9. Full Text Personalize and Optimize Lipid-Lowering Therapies
by Weingärtner, Oliver and Lütjohann, Dieter and Elsässer, Albrecht
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2016, Volume 68, Issue 3, pp. 325 - 326
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiovascular disease | Lipids | Acute coronary syndromes | Low density lipoprotein | Statins | Cholesterol
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10. Full Text Need to individualise cholesterol-lowering therapy
by Lütjohann, Dieter and Weingärtner, Oliver
Heart (British Cardiac Society), ISSN 1355-6037, 08/2019, Volume 105, Issue 16, pp. 1291 - 1292
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cholesterol, LDL | Cardiovascular Diseases | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Humans | Cholesterol | Statins | Atherosclerosis | Index Medicus | Abridged Index Medicus
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11. Full Text Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
by Tamboli, Irfan Y and Barth, Esther and Christian, Leonie and Siepmann, Martin and Kumar, Sathish and Singh, Sandesh and Tolksdorf, Karen and Heneka, Michael T and Lütjohann, Dieter and Wunderlich, Patrick and Walter, Jochen
The Journal of biological chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 48, pp. 37405 - 37414
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Insulin-degrading Enzyme | Amyloid Degradation | Drug Action | Amyloid | Statin | Alzheimer Disease | Exocytosis | Cholesterol | Cell Biology | MVB Exosome Pathways | Microglia
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12. Full Text The Interpretation of Cholesterol Balance Derived Synthesis Data and Surrogate Noncholesterol Plasma Markers for Cholesterol Synthesis under Lipid Lowering Therapies
by Stellaard, Frans and Lütjohann, Dieter
Cholesterol, ISSN 2090-1283, 02/2017, Volume 2017, pp. 5046294 - 9
Usage | Dosage and administration | Diagnosis | Biological markers | Cholesterol | Antilipemic agents | Plasma | Sterols | Rodents | Lipids | Feces | Apolipoproteins | Bile | Vegetarianism | Review
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13. Full Text A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages
by Snodgrass, Ryan G and Zezina, Ekaterina and Namgaladze, Dmitry and Gupta, Sahil and Angioni, Carlo and Geisslinger, Gerd and Lütjohann, Dieter and Brüne, Bernhard
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, pp. 1906 - 1906
interleukin-4 | sterol regulatory element binding protein-2 | lipoxygenase | chemokine | type B | arachidonate 15-lipoxygenase | cholesterol | macrophage | Life Sciences & Biomedicine | Immunology | Science & Technology | Cellular signal transduction | Research | Macrophages | Health aspects | Cholesterol | Membrane proteins
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