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1. Full Text Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeutics
by Linehan, W. Marston
Genome Research, ISSN 1088-9051, 11/2012, Volume 22, Issue 11, pp. 2089 - 2100
Kidney cancer is not a single disease; it is made up of a number of different types of cancer, including clear cell, type 1 papillary, type 2 papillary,... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPEL-LINDAU-DISEASE | HEREDITARY LEIOMYOMATOSIS | FUMARATE-HYDRATASE | RENAL-CELL CARCINOMA | CHROMOSOME-TRANSLOCATION | TUBEROUS SCLEROSIS COMPLEX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | HOGG-DUBE-SYNDROME | GERMLINE MUTATIONS | TUMOR-SUPPRESSOR PROTEIN | PARENCHYMAL SPARING SURGERY | Carcinoma - drug therapy | Genetic Predisposition to Disease | Kidney Neoplasms - genetics | Genes, Neoplasm | Genomics | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents | Carcinoma - genetics | Mutation | Kidney Neoplasms - drug therapy | Care and treatment | Gene mutations | Kidney cancer | Genetic aspects | Research | Genetic transcription | Risk factors
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2. Full Text Comprehensivemolecular characterization of clear cell renal cell carcinoma
by Creighton, Chad J and Morgan, Margaret and Gunaratne, Preethi H and Wheeler, David A and Gibbs, Richard A and Robertson, Gordon and Chu, Andy and Beroukhim, Rameen and Cibulskis, Kristian and Signoretti, Sabina and Vandin, Fabio and Wu, Hsin-Ta and Raphael, Benjamin J and Verhaak, Roel G.W and Tamboli, Pheroze and Torres-Garcia, Wandaliz and Akbani, Rehan and Weinstein, John N and Reuter, Victor and Hsieh, James J and Brannon, A. Rose and Hakimi, A. Ari and Jacobsen, Anders and Ciriello, Giovanni and Reva, Boris and Ricketts, Christopher J and Linehan, W. Marston and Stuart, Joshua M and Rathmell, W. Kimryn and Hui, Shen and Laird, Peter W and Muzny, Donna and Davis, Caleb and Liu, Xi and Chang, Kyle and Kakkar, Nipun and Treviño, Lisa R and Benton, Susan and Reid, Jeffrey G and Morton, Donna and Doddapaneni, Harsha and Yi, Han and Lewis, Lora and Huyen, Dinh and Kovar, Christie and Zhu, Yiming and Santibanez, Jireh and Min, Wang and Hale, Walker and Kalra, Divya and Getz, Gad and Lawrence, Michael S and Sougnez, Carrie and Carter, Scott L and Sivachenko, Andrey and Lee, Lichtenstein and Stewart, Chip and Voet, Doug and Fisher, Sheila and Gabriel, Stacey B and Lander, Eric and Schumacher, Steve E and Tabak, Barbara and Saksena, Gordon and Onofrio, Robert C and Cherniack, Andrew D and Gentry, Jeff and Ardlie, Kristin and Meyerson, Matthew and Chun, Hye-Jung E and Mungall, Andrew J and Sipahimalani, Payal and Stoll, Dominik and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S.N and Carlsen, Rebecca and Carter, Candace and Chuah, Eric and Coope, Robin J.N and Dhalla, Noreen and Gorski, Sharon and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lebovitz, Chandra and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Pleasance, Erin and Plettner, Patrick and Schein, Jacqueline E and Shafiei, Arash and Slobodan, Jared R and Tam, Angela and Thiessen, Nina and Varhol, Richard J and Wye, Natasja and ... and Canc Genome Atlas Res Network and Anal Working Grp
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7456, pp. 43 - 49
Genetic changes underlying clear cell renal cell carcinoma(ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the... 
GENETIC-BASIS | METHYLATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | ARM | KIDNEY CANCER | Proteins | DNA methylation | Mutation | Kinases | Chromosomes | Genes
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3. Full Text Molecular pathways: Fumarate Hydratase-deficient kidney cancer - Targeting the warburg effect in cancer
by Linehan, W. Marston and Rouault, Tracey A
Clinical Cancer Research, ISSN 1078-0432, 07/2013, Volume 19, Issue 13, pp. 3345 - 3352
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a hereditary cancer syndrome in which affected individuals are at risk for development of... 
MET PROTOONCOGENE | INHIBITION | HIF | ONCOLOGY | HEREDITARY LEIOMYOMATOSIS | HLRCC SYNDROME | MUTATIONS | UTERINE LEIOMYOMAS | TUMORS | RENAL-CELL CARCINOMA | Uterine Neoplasms - genetics | AMP-Activated Protein Kinases - metabolism | Uterine Neoplasms - metabolism | Skin Neoplasms - drug therapy | Humans | Translational Medical Research | Leiomyomatosis - metabolism | Antineoplastic Agents - therapeutic use | Fumarate Hydratase - deficiency | Fumarate Hydratase - genetics | Molecular Targeted Therapy | Neoplastic Syndromes, Hereditary | Skin Neoplasms - metabolism | Fumarate Hydratase - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Signal Transduction - drug effects | Leiomyomatosis - drug therapy | Skin Neoplasms - genetics | Uterine Neoplasms - drug therapy | Antineoplastic Agents - pharmacology | Leiomyomatosis - genetics
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4. Full Text Comparison of MR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer
by Siddiqui, M. Minhaj and Rais-Bahrami, Soroush and Turkbey, Baris and George, Arvin K and Rothwax, Jason and Shakir, Nabeel and Okoro, Chinonyerem and Raskolnikov, Dima and Parnes, Howard L and Linehan, W. Marston and Merino, Maria J and Simon, Richard M and Choyke, Peter L and Wood, Bradford J and Pinto, Peter A
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 01/2015, Volume 313, Issue 4, pp. 390 - 397
IMPORTANCE Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect prostate cancer. The implications of targeted biopsy... 
LOCALIZATION | MEDICINE, GENERAL & INTERNAL | TARGETED BIOPSY | SCORE | RESONANCE | MRI | ACTIVE SURVEILLANCE | RISK | RADICAL PROSTATECTOMY | RECURRENCE | OUTCOMES | Biopsy - methods | Ultrasonography, Interventional - methods | Prospective Studies | Humans | Image-Guided Biopsy - methods | Middle Aged | Magnetic Resonance Imaging - methods | Male | Risk | Prostatic Neoplasms - diagnosis | Prostate-Specific Antigen - blood | Prostate - pathology | Prostatic Neoplasms - blood | Aged | Usage | Biopsy | Men | Diagnosis | Prostate cancer | Health aspects | Risk factors | Ultrasonic imaging | Medical diagnosis
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5. Full Text The metabolic basis of kidney cancer
by Linehan, W. Marston and Ricketts, Christopher J
Seminars in Cancer Biology, ISSN 1044-579X, 2012, Volume 23, Issue 1, pp. 46 - 55
Abstract Kidney cancer is not a single disease; it is made up of a number of different types of cancer that occur in the kidney. Each of these different types... 
Hematology, Oncology and Palliative Medicine | Renal cell carcinoma (RCC) | Cancer metabolism | Cancer metabolism targeted therapy | Hereditary kidney cancer | Warburg effect | TYROSINE KINASE DOMAIN | HIPPEL-LINDAU-DISEASE | HEREDITARY LEIOMYOMATOSIS | FUMARATE-HYDRATASE | RENAL-CELL CARCINOMA | CHROMOSOME-TRANSLOCATION | TUBEROUS SCLEROSIS COMPLEX | ONCOLOGY | HOGG-DUBE-SYNDROME | TUMOR-SUPPRESSOR PROTEIN | PARENCHYMAL SPARING SURGERY | Proto-Oncogene Proteins - metabolism | Carcinoma, Renal Cell - metabolism | Kidney Neoplasms - genetics | Tumor Suppressor Proteins - metabolism | Tuberous Sclerosis - metabolism | Humans | Carcinoma, Renal Cell - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Kidney Neoplasms - metabolism | Mutation | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Citric Acid Cycle | Care and treatment | Genes | Kidney cancer | Cancer | Renal Cell Carcinoma (RCC) | Hereditary Kidney Cancer | Warburg Effect | Cancer Metabolism | Cancer Metabolism Targeted Therapy
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6. Full Text The genetic basis of kidney cancer: a metabolic disease
by Linehan, W. Marston and Srinivasan, Ramaprasad and Schmidt, Laura S
Nature Reviews Urology, ISSN 1759-4812, 05/2010, Volume 7, Issue 5, pp. 277 - 285
Kidney cancer is not a single disease but comprises a number of different types of cancer that occur in the kidney, each caused by a different gene with a... 
VONHIPPEL-LINDAU DISEASE | FUMARATE-HYDRATASE GENE | SMALL-MOLECULE INHIBITORS | HOGG-DUBE-SYNDROME | TUMOR-SUPPRESSOR GENE | UROLOGY & NEPHROLOGY | HEREDITARY LEIOMYOMATOSIS | IRON-REGULATORY PROTEINS | RENAL-CELL CARCINOMA | HYPOXIA-INDUCIBLE FACTOR-1 | ENDOTHELIAL GROWTH-FACTOR | Kidney Neoplasms - genetics | Humans | Carcinoma, Renal Cell - genetics | Proto-Oncogene Proteins - genetics | Fumarate Hydratase - genetics | Proto-Oncogene Proteins c-met - genetics | Receptors, Growth Factor - genetics | Citric Acid Cycle - genetics | Succinate Dehydrogenase - genetics | Tumor Suppressor Proteins - genetics | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mutation | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Care and treatment | Transcription factors | Gene mutations | Kidney cancer | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Health aspects
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7. Full Text Reductive carboxylation supports growth in tumour cells with defective mitochondria
by Mullen, Andrew R and Wheaton, William W and Jin, Eunsook S and Chen, Pei-Hsuan and Sullivan, Lucas B and Cheng, Tzuling and Yang, Youfeng and Linehan, W. Marston and Chandel, Navdeep S and Deberardinis, Ralph J
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 385 - 388
Mitochondrial metabolism provides precursors to build macromolecules in growing cancer cells(1,2). In normally functioning tumour cell mitochondria, oxidative... 
GENE | MULTIDISCIPLINARY SCIENCES | LIVER | LINE | ROS | PARAGANGLIOMA | FLUX | MUTATIONS | CANCER | DEHYDROGENASE | GLUTAMINE-METABOLISM | Neoplasms - metabolism | Electron Transport | Electron Transport Complex III - metabolism | Kidney Neoplasms - genetics | Humans | Carcinoma, Renal Cell - genetics | Glutamine - metabolism | Kidney Neoplasms - metabolism | Electron Transport Complex I - metabolism | Cell Hypoxia | Fumarate Hydratase - metabolism | NADP - metabolism | Carcinoma, Renal Cell - pathology | Mitochondria - metabolism | Fumarate Hydratase - genetics | Mitochondria - pathology | Acetyl Coenzyme A - metabolism | Carcinoma, Renal Cell - metabolism | Animals | Cell Line, Tumor | Glucose - metabolism | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Citric Acid - metabolism | Mice | Neoplasms - pathology | Control | Cytochrome b | Cancer cells | Physiological aspects | Carboxylation | Genetic aspects | Mitochondrial DNA | Research | Lipids | Mutation | Metabolites | Cancer
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8. Full Text Sarcomatoid Renal Cell Carcinoma: A Comprehensive Review of the Biology and Current Treatment Strategies
by Shuch, Brian and Bratslavsky, Gennady and Linehan, W. Marston and Srinivasan, Ramaprasad
The Oncologist, ISSN 1083-7159, 01/2012, Volume 17, Issue 1, pp. 46 - 54
Learning Objectives After completing this course, the reader will be able to: Describe histologic features associated with sarcomatoid renal cell carcinoma.... 
Renal cell carcinoma | Sarcomatoid | Kidney cancer | LYMPH-NODE DISSECTION | TARGETED THERAPY | CYTOREDUCTIVE NEPHRECTOMY | IMMUNOHISTOCHEMICAL EXPRESSION | TUMOR-SUPPRESSOR GENE | HEREDITARY LEIOMYOMATOSIS | SYSTEMIC THERAPY | CANCER | RADICAL NEPHRECTOMY | ONCOLOGY | MUTATIONS | Carcinoma, Renal Cell - therapy | Kidney Neoplasms - pathology | Carcinoma, Renal Cell - pathology | Humans | Kidney Neoplasms - therapy | Renal, Bladder, and Testicular | Genitourinary Cancer
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9. Genetic predisposition to kidney cancer
by Schmidt, Laura S and Linehan, W. Marston
Seminars in Oncology, ISSN 0093-7754, 10/2016, Volume 43, Issue 5, pp. 566 - 574
Kidney cancer is not a single disease but is made up of a number of different types of cancer classified by histology that are disparate in presentation,... 
Hereditary leiomyomatosis and renal cell carcinoma | Von Hippel-Lindau | Inherited renal cancer syndromes | Birt-Hogg-Dubé syndrome | Hereditary papillary renal carcinoma | Kidney neoplasms | TYROSINE KINASE DOMAIN | MITF GERMLINE MUTATION | HEREDITARY LEIOMYOMATOSIS | FUMARATE-HYDRATASE | HYPOXIA-INDUCIBLE FACTORS | MET PROTOONCOGENE | ONCOLOGY | Birt-Hogg-Dube syndrome | HOGG-DUBE-SYNDROME | TUMOR-SUPPRESSOR PROTEIN | HIF-ALPHA | RENAL-CELL CANCER | Genetic Predisposition to Disease | Kidney Neoplasms - genetics | Succinate Dehydrogenase - genetics | Humans | Kidney Neoplasms - etiology | Tumor Suppressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mutation | Kidney Neoplasms - therapy | Proto-Oncogene Proteins c-met - genetics | Tuberous Sclerosis - genetics
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10. Full Text FLCN: The causative gene for Birt-Hogg-Dubé syndrome
by Schmidt, Laura S and Linehan, W. Marston
Gene, ISSN 0378-1119, 01/2018, Volume 640, pp. 28 - 42
Germline mutations in the novel tumor suppressor gene are responsible for the autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that... 
FLCN | PGC1α | Birt-Hogg-Dubé syndrome | Kidney tumor | Folliculin | DENN domain | mTOR | AMPK | FNIP1 | FNIP2 | SPONTANEOUS PNEUMOTHORAX | TUMOR-SUPPRESSOR GENE | INTRAGENIC DELETIONS | AMINO-ACID PERMEASE | BHD GENE | RENAL-CELL CARCINOMA | PRIMARY CILIUM | PGC1 alpha | COLORECTAL-CANCER | GENETICS & HEREDITY | Birt-Hogg-Dube syndrome | EMBRYONIC LETHALITY | NIHON RAT MODEL | Birt-Hogg-Dube Syndrome - etiology | Proto-Oncogene Proteins - genetics | Mutation | Signal Transduction | Humans | Tumor Suppressor Proteins - genetics | Genes | Estrogen | Tuberous sclerosis | Heat shock proteins | Development and progression | Genetic transcription | Embryonic stem cells | Proteins | Caenorhabditis elegans | Gene mutations | Glutathione transferase | Genetic research | GABA | Lymphomas | G proteins | Protein kinases | Growth factors | Adenosine triphosphatase | folliculin
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11. Full Text The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome
by Merino, Maria J and Torres-Cabala, Carlos and Pinto, Peter and Marston Linehan, William
American Journal of Surgical Pathology, ISSN 0147-5185, 10/2007, Volume 31, Issue 10, pp. 1578 - 1585
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant familial syndrome characterized by the development of cutaneous and uterine... 
Fumarate hydratase | Skin and uterine leiomyomata | Renal cancer | Hereditary renal syndrome | SURGERY | SPONTANEOUS PNEUMOTHORAX | COLLECTING DUCT CARCINOMA | uterine leiomyomata | NEOPLASMS | renal cancer | CLASSIFICATION | PATHOLOGY | CANCER | SOMATIC MUTATIONS | GENE | fumarate hydratase | hereditary renal syndrome | skin and | HOGG-DUBE-SYNDROME | CUTANEOUS LEIOMYOMATOSIS | UTERINE LEIOMYOMAS | Genetic Predisposition to Disease | Kidney Neoplasms - genetics | Carcinoma, Renal Cell - pathology | Humans | Middle Aged | Carcinoma, Renal Cell - genetics | Male | Fumarate Hydratase - genetics | Loss of Heterozygosity | Syndrome | Cell Nucleus - pathology | Kidney Neoplasms - enzymology | Adolescent | Leiomyomatosis - pathology | Biomarkers, Tumor - metabolism | Germ-Line Mutation | Adult | Carcinoma, Renal Cell - enzymology | Female | Kidney Neoplasms - pathology | Aged | DNA, Neoplasm - analysis | Leiomyomatosis - enzymology | Leiomyomatosis - genetics
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