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Journal Article
Journal of Neurology, ISSN 0340-5354, 11/2013, Volume 260, Issue 11, pp. 2802 - 2814
Journal Article
Neurology, ISSN 0028-3878, 08/2012, Volume 79, Issue 8, pp. 785 - 792
Journal Article
RSC Drug Discovery Series, ISSN 2041-3203, 2014, Volume 2014-, Issue 38, pp. 202 - 229
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 1998, Volume 39, Issue 40, pp. 7227 - 7230
This communication reveals the synthesis and application of a novel resin bound isonitrile. The resin is an example of a novel safety-catch linker which upon... 
CHEMISTRY, ORGANIC | 4-COMPONENT CONDENSATION | SOLID-PHASE SYNTHESIS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2000, Volume 41, Issue 17, pp. 3029 - 3033
A new solid-phase efficient route to 1,5-benzothiazepine-4-one derivatives is reported. The synthesis exploits the variety of halo- nitrobenzene derivatives... 
solid-phase synthesis | benzothiazepine | combinatorial chemistry | Combinatorial chemistry | Solid-phase synthesis | Benzothiazepine | REAGENT | LIBRARY | CHEMISTRY, ORGANIC | INHIBITORS | IMIDAZOLE | CLEAVAGE | LINKER
Journal Article
2014, RSC drug discovery series, ISBN 9781849738064, Volume 38, 487
Orphan drugs are designated drug substances that are intended to treat rare or 'orphan' diseases. More than 7000 rare diseases are known that collectively... 
Orphan drugs | Biology, life sciences | Pharmacy | Medical | Maedicaments orphelins | Rare diseases | Drug development
eBook
Tetrahedron Letters, ISSN 0040-4039, 2000, Volume 41, Issue 10, pp. 1509 - 1514
This communication reveals a novel application of resin bound α-amino acids coupled with the UDC (Ugi/DeBOC/cyclize) strategy. Reaction with either... 
LIBRARIES | CONVERTIBLE ISOCYANIDE | SOLID-PHASE SYNTHESIS | UGI 4-COMPONENT CONDENSATION | CHEMISTRY | CHEMISTRY, ORGANIC | DIKETOPIPERAZINE | INHIBITORS | IMIDAZOLINE | ANTAGONISTS | DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2000, Volume 41, Issue 12, pp. 1883 - 1887
This communication reveals a novel application of the so-called convertible isonitriles for the solution/solid phase generation of γ-lactam analogues. Use of... 
UGI 4-COMPONENT CONDENSATION | CHEMISTRY, ORGANIC | MULTICOMPONENT REACTIONS | AMIDES
Journal Article
Tetrahedron, ISSN 0040-4020, 08/1999, Volume 55, Issue 33, pp. 10135 - 10154
Original proline or γ-lactam derivatives bearing either an aryl group such as a phenyl or a 3-indolyl in position 3 of the proline moiety or on the 3-methyl... 
POTENT | DESIGN | PEPTIDOMIMETICS | BETA-D-GLUCOSE | BINDING AFFINITIES | CHEMISTRY, ORGANIC | CYCLIC HEXAPEPTIDE ANALOG | SOMATOSTATIN RECEPTOR
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2000, Volume 41, Issue 12, pp. 1889 - 1893
This communication reveals novel applications of the CO /MeOH reagent combination coupled with the UDC (Ugi/DeBOC/Cyclize) strategy. The Ugi five component... 
BOC/CYCLIZATION UDC STRATEGY | CLEAVAGE STEP | LIBRARIES | ARMSTRONGS CONVERTIBLE ISONITRILE | AZIMILIDE | SOLID-PHASE SYNTHESIS | CHEMISTRY, ORGANIC | CONDENSATION | CYCLIZATION | LINKER
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 03/1999, Volume 64, Issue 6, pp. 1823 - 1830
This paper describes a navel supported Weinreb amide resin that facilitates parallel synthesis of aldehydes and ketones on a scale useful for chemical library... 
CHEMISTRY, ORGANIC | TERMINAL PEPTIDE ALDEHYDES | HYDROXAMIC ACIDS | POLYMERIC REAGENTS | Synthesis | Ketones | Amides | Research | Carboxylic acids | Aldehydes | Organic compounds
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 1993, Volume 58, Issue 5, pp. 1280 - 1283
Journal Article
Tetrahedron, ISSN 0040-4020, 1999, Volume 55, Issue 33, pp. 10135 - 10154
Journal Article
Chemistry Letters, ISSN 0366-7022, 9/1998, Volume 27, Issue 9, pp. 943 - 944
Synthesis of novel spirocyclic lactam peptidomimetics of the binding domain of somatostatin from commercially available D, L-methionine is described. 
ANALOGS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2000, Volume 122, Issue 13, pp. 3007 - 3014
Conformational restrictions in the form of [i, i + 4] lactam bridges were sequentially incorporated into the shortest fragment of hPTH with recognized efficacy... 
CONSTRAINED MOLECULAR-DYNAMICS | CIRCULAR-DICHROISM | PROTEIN-RECEPTOR | DISTANCE GEOMETRY | ADENYLYL-CYCLASE | FEMORAL TRABECULAR BONE | STIMULATING ACTIVITIES | (PTH)/PTH-RELATED PEPTIDE RECEPTOR | HUMORAL HYPERCALCEMIA | OVARIECTOMIZED RATS | CHEMISTRY, MULTIDISCIPLINARY | Parathyroid hormone | Research
Journal Article
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