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Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 2224 - 2224
Maintenance of the blood cell system throughout the lifetime of an organism at steady state and in response to stress requires longevity and integrity of the... 
Journal Article
Blood, ISSN 0006-4971, 08/2010, Volume 116, Issue 5, pp. 783 - 787
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1431 - 13
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The... 
EXTRACELLULAR HSP27 | POLYCYTHEMIA-VERA | HSP90 INHIBITOR | ACTIVATION | SHOCK-PROTEIN 27 | MULTIDISCIPLINARY SCIENCES | MYELOPROLIFERATIVE NEOPLASMS | SERUM | MESENCHYMAL TRANSITION | TYROSINE-PHOSPHATASE | BONE-MARROW FIBROSIS | Leukocytes - pathology | Whole-Body Irradiation | Humans | STAT5 Transcription Factor - immunology | Primary Myelofibrosis - pathology | Molecular Targeted Therapy | HSP27 Heat-Shock Proteins - genetics | Leukocytes - immunology | STAT5 Transcription Factor - genetics | Thrombopoietin - immunology | Oligonucleotides - pharmacology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | HEK293 Cells | Female | Disease Models, Animal | Primary Myelofibrosis - drug therapy | Janus Kinase 2 - immunology | Transduction, Genetic | Mice, Inbred C57BL | Primary Myelofibrosis - immunology | Bone Marrow Cells - pathology | Janus Kinase 2 - genetics | Mice, Transgenic | HSP27 Heat-Shock Proteins - immunology | Thrombopoietin - genetics | Primary Myelofibrosis - genetics | Animals | K562 Cells | Cell Line, Tumor | Leukocytes - drug effects | Mice | Mutation | Spleen | CD34 antigen | Cell proliferation | Animal models | Myelofibrosis | Therapeutic applications | Lung diseases | Heat shock proteins | Antisense oligonucleotides | Stat5 protein | Disease control | Patients | Neoplasms | Thrombopoietin | Janus kinase 2 | Hsp27 protein | Fibrosis | Weight reduction | Apoptosis | Cancer | Heat shock | Tumors | Life Sciences
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 11/2015, Volume 19, Issue 11, pp. 2564 - 2574
JAK2 inhibition therapy is used to treat patients suffering from myeloproliferative neoplasms (MPN). Conflicting data on this therapy are reported possibly... 
myeloproliferative neoplasms | preclinical murine models | fibrosis | JAK2 inhibitor | Preclinical murine models | Fibrosis | Myeloproliferative neoplasms | MYELOFIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | JAK2(V617F) | POLYCYTHEMIA-VERA | MECHANISM | EFFICACY | RUXOLITINIB | CELL BIOLOGY | HEMATOPOIETIC-CELLS | MURINE MODEL | MUTATIONS | EXPRESSION | Thrombocythemia, Essential - drug therapy | Primary Myelofibrosis - drug therapy | Thrombocythemia, Essential - physiopathology | Splenomegaly - drug therapy | Primary Myelofibrosis - physiopathology | Polycythemia Vera - blood | Pyrrolidines - administration & dosage | Thrombocythemia, Essential - blood | Disease Progression | Primary Myelofibrosis - blood | Protein Kinase Inhibitors - administration & dosage | Animals | Platelet Count | Polycythemia Vera - drug therapy | Mice | Janus Kinase 2 - antagonists & inhibitors | Polycythemia Vera - physiopathology | Sulfonamides - administration & dosage | Transforming growth factors | Health aspects | Stem cells | Tumors | Spleen | Bone marrow | Rodents | Erythropoiesis | Splenomegaly | Therapy | Polycythemia vera | Kinases | Neoplasms | Blockage | Biomedical materials | Blood platelets | Polycythemia | Janus kinase 2 | Osteosclerosis | Inhibition | Phenotypes | Dysplasia | Myelofibrosis | Cytokines | Anemia | Progenitor cells | Mutation | Platelets | Original
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1963 - 1963
Abstract Myelofibrosis (MF) is the most aggressive myeloproliferative neoplasms (MPN) with the highest degree of morbidity and mortality, including progressive... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1133 - 1133
Abstract Background. Monocytes are a heterogeneous population of peripheral blood leukocytes. The expression of CD14 and CD16 distinguishes CD14+/CD16-... 
Journal Article
Blood, ISSN 0006-4971, 09/2014, Volume 124, Issue 13, pp. 2104 - 2115
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 2851 - 2851
Abstract Introduction GS-0387 (momelotinib, formerly CYT387) is a type I JAK1/2 inhibitor. Phase 1/2 trial results in primary myelofibrosis (PMF) or... 
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 21, pp. 616 - 616
Abstract Abstract 616 JAK2V617F is the major mutation involved in classic myeloproliferative neoplasm (MPN). It promotes growth factor independent cell growth... 
Journal Article