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index medicus (7) 7
life sciences (7) 7
photoperiod (7) 7
animals (6) 6
choroid plexus (5) 5
female (5) 5
humans (5) 5
immunology (5) 5
sheep (5) 5
tolerance (5) 5
choroid plexus - metabolism (4) 4
other (4) 4
polychlorinated biphenyls (4) 4
[ sdv.ot ] life sciences [q-bio]/other [q-bio.ot] (3) 3
cerebrospinal-fluid (3) 3
dendritic cells - drug effects (3) 3
dendritic cells - immunology (3) 3
ewe (3) 3
ewes (3) 3
expression (3) 3
in-vitro (3) 3
maturation (3) 3
proteins (3) 3
toxicology (3) 3
transplantation (3) 3
[ sdv ] life sciences [q-bio] (2) 2
activation (2) 2
autre (2) 2
blood cerebrospinal fluid barrier (2) 2
blood-cerebrospinal fluid-barrier (2) 2
blotting, western (2) 2
brain (2) 2
brain - metabolism (2) 2
cd4 t-cells (2) 2
cd4-positive t-lymphocytes - immunology (2) 2
cell biology (2) 2
choroid plexus - cytology (2) 2
choroid plexus - drug effects (2) 2
claudin-1 (2) 2
cytokines - biosynthesis (2) 2
dendritic cells (2) 2
dose-response relationship, drug (2) 2
environmental sciences (2) 2
estradiol (2) 2
gonadotropin (2) 2
human dendritic cells (2) 2
il-2 (2) 2
il-2rα (2) 2
immature (2) 2
in-vivo (2) 2
induction (2) 2
jour court (2) 2
jour long (2) 2
melatonin (2) 2
mycophenolic acid - pharmacology (2) 2
neurosciences (2) 2
ovin (2) 2
permeability (2) 2
photopériode (2) 2
plexus choroide (2) 2
polychlorinated biphenyls - toxicity (2) 2
polychlorinated-biphenyls (2) 2
receptor (2) 2
receptors, vascular endothelial growth factor - metabolism (2) 2
reverse transcriptase polymerase chain reaction (2) 2
rna (2) 2
rna, messenger - metabolism (2) 2
récepteur (2) 2
tight junction (2) 2
tight junctions (2) 2
tight junctions - metabolism (2) 2
time factors (2) 2
transplantation tolerance (2) 2
vascular endothelial growth factor (2) 2
vascular endothelial growth factor a - metabolism (2) 2
vegf (2) 2
1-alpha,25-dihydroxyvitamin d-3 (1) 1
2-week treatment (1) 1
[ sdv.mhep ] life sciences [q-bio]/human health and pathology (1) 1
[sdv.ot]life sciences [q-bio]/other [q-bio.ot] (1) 1
agonists (1) 1
allergy (1) 1
allergy and immunology (1) 1
amino-acid (1) 1
angiogenic factors (1) 1
antagonists (1) 1
anterior-pituitary (1) 1
antibody specificity - immunology (1) 1
antigen (1) 1
antigen-presenting cells (1) 1
apoptosis (1) 1
apoptosis - drug effects (1) 1
aroclor 1254 (1) 1
bacteria (1) 1
bcl-2 protein family (1) 1
bifidobacterium - immunology (1) 1
bifidobacterium breve (1) 1
biomedicine (1) 1
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blood-brain barrier - metabolism (1) 1
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1. Full Text Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway
by Hoarau, Cyrille and Lagaraine, Christine and Martin, Laurence and Velge-Roussel, Florence and Lebranchu, Yvon
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2006, Volume 117, Issue 3, pp. 696 - 702
Commensal gut bacteria are essential for the development and maintenance of the gut's immune system. Some bacteria strains, such as and species, have been... 
maturation | dendritic cells | cell survival | Bcl-2 protein family | Toll-like receptor 2 | Bifidobacterium breve | allergy | IL-12 | tolerance | IL-10 | Allergy | Cell survival | Dendritic cells | Maturation | Tolerance | PROBIOTIC BACTERIA | C-FOS | PROTEIN-KINASE | CD4(+) T-CELLS | INDUCTION | IMMUNOLOGY | CUTTING EDGE | IN-VITRO | TOLL-LIKE RECEPTORS | PLACEBO-CONTROLLED TRIAL | LACTOBACILLUS-RHAMNOSUS | Bifidobacterium - immunology | Cell Line | Immunity, Cellular - immunology | Signal Transduction - immunology | Cell Proliferation | Dendritic Cells - immunology | Humans | Toll-Like Receptor 2 - immunology | Cell Survival - immunology | Interleukin-10 - immunology | Gastrointestinal diseases | Proteins | Flow cytometry | Probiotics | Lymphocytes | Bacteria | Ligands | Regulation | Immune system | Apoptosis | Life Sciences | Human health and pathology
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2. Full Text Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods
by Szczepkowska, Aleksandra and Wąsowska, Barbara and Gilun, Przemysław D and Lagaraine, Christine and Robert, Vincent and Dufourny, Laurence and Thiéry, Jean-Claude and Skipor, Janina
Cell and Tissue Research, ISSN 0302-766X, 10/2012, Volume 350, Issue 1, pp. 157 - 166
Vascular endothelial growth factor (VEGF-A) plays an important role in maintaining cerebrospinal fluid (CSF) homeostasis and the function of the choroid... 
Human Genetics | Choroid plexus | Biomedicine | VEGF receptors | VEGF | Proteomics | Sheep | Molecular Medicine | Photoperiod | FACTOR VEGF | CELLS | PHYSIOLOGY | MELATONIN | NEUROPILIN-1 | CEREBROSPINAL-FLUID | HEPARIN | ANGIOGENIC FACTORS | CELL BIOLOGY | ESTRADIOL | NEUROGENESIS | Immunohistochemistry | Protein Multimerization | RNA, Messenger - genetics | Choroid Plexus - metabolism | Gene Expression Regulation | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sheep, Domestic - metabolism | Vascular Endothelial Growth Factor A - genetics | Blotting, Western | Choroid Plexus - cytology | Animals | Protein Isoforms - metabolism | Receptors, Vascular Endothelial Growth Factor - metabolism | Antibody Specificity - immunology | Time Factors | Female | Receptors, Vascular Endothelial Growth Factor - genetics | Protein Isoforms - genetics | RNA | Vascular endothelial growth factor | Estrogen | Brain | Life Sciences | Other | Regular
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3. Full Text Effects of immunosuppressive drugs on dendritic cells and tolerance induction
by Lagaraine, Christine and Lebranchu, Yvon
Transplantation, ISSN 0041-1337, 05/2003, Volume 75, Issue 9, pp. 37S - 42S
Dendritic cells, the most effective antigen-presenting cells for priming naive T cells and initiating immune responses, are also able to induce tolerance. This... 
SURGERY | GLUCOCORTICOIDS | CD4(+) T-CELLS | KAPPA-B | IMMUNOLOGY | MATURATION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | LANGERHANS CELLS | TRANSPLANTATION | IN-VITRO | INHIBITION | ANTIGEN-PRESENTING CELLS | DIFFERENTIATION | Dendritic Cells - drug effects | Transplantation Tolerance | Animals | Transplantation Conditioning - methods | Immunosuppressive Agents - pharmacology | Humans
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4. Full Text Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cells
by Christine Lagaraine and Roxane Lemoine and Christophe Baron and Hubert Nivet and Florence Velge-Roussel and Yvon Lebranchu
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2008, Volume 84, Issue 4, pp. 1057 - 1064
Depending on their degree of maturation, costimulatory molecule expression, and cytokine secretion, dendritic cells (DC) can induce immunity or tolerance. DC... 
T lymphocytes | suppression | tolerance | Tolerance | Suppression | RAPAMYCIN | ACTIVATION | STIMULATION | IMMUNOLOGY | CELL BIOLOGY | SEMI-MATURE | TRANSPLANTATION TOLERANCE | IN-VIVO | IMMUNOLOGICAL SELF-TOLERANCE | IMMATURE | EX-VIVO | HEMATOLOGY | ANTIGEN | Interleukin-2 Receptor alpha Subunit - deficiency | Coculture Techniques | Dendritic Cells - immunology | Humans | Immunophenotyping | DNA Primers | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes - drug effects | Mycophenolic Acid - pharmacology | Interleukin-2 - pharmacology | Dendritic Cells - drug effects | T-Lymphocytes - immunology | Transplantation Tolerance - immunology | CD4-Positive T-Lymphocytes - drug effects | Cytokines - biosynthesis | Interleukin-2 Receptor alpha Subunit - immunology
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5. Full Text Design, synthesis and biological evaluation of fluorescent ligands for MT1 and/or MT2 melatonin receptors
by Viault, G and Poupart, S and Mourlevat, S and Lagaraine, C and Devavry, S and Lefoulon, F and Bozon, V and Dufourny, L and Delagrange, P and Guillaumet, G and Suzenet, F
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 67, pp. 62508 - 62521
Fluorescent melatoninergic ligands have been designed by associating the 4-azamelatonin ligands with different fluorophores. The ligands show good affinities... 
BODIPY | SUBTYPES | MT1/MT2 | RETINA | ANTAGONISTS | DIMERS | PHARMACOLOGICAL EVALUATION | DERIVATIVES | AGONISTS | CHEMISTRY, MULTIDISCIPLINARY | Life Sciences | Other
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6. Full Text PCB153 (2,2′,4,4′,5,5′-hexachlorobiphenyl) differentially affects the VEGF/VEGFR system depending on photoperiod in the ovine choroid plexus
by Szczepkowska, Aleksandra and Lagaraine, Christine and Robert, Vincent and Młynarczuk, Jarosław and Dufourny, Laurence and Thiéry, Jean-Claude and Skipor, Janina
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 02/2016, Volume 124, pp. 303 - 308
-substituted polychlorinated biphenyls (PCBs) preferentially accumulate in the brain and cerebrospinal fluid (CSF) compared with other PCBs. We previously... 
Choroid plexus | Polychlorinated biphenyls | Ewes | Photoperiod | Vascular endothelial growth factor | PERMEABILITY | VEGF | 2-WEEK TREATMENT | MAINTENANCE | ENVIRONMENTAL SCIENCES | PATHWAY | TOXICOLOGY | RECEPTOR-2 | EXPRESSION | GONADOTROPIN | ENDOTHELIAL GROWTH-FACTOR | Choroid Plexus - metabolism | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Estradiol | Brain - metabolism | Choroid Plexus - drug effects | Dose-Response Relationship, Drug | Animals | Receptors, Vascular Endothelial Growth Factor - metabolism | Polychlorinated Biphenyls - toxicity | Female | Sheep | RNA | Endothelium | Index Medicus | Life Sciences | Other
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7. Full Text Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods
by Szczepkowska, Aleksandra and Lagaraine, Christine and Robert, Vincent and Dufourny, Laurence and Thiéry, Jean-Claude and Skipor, Janina
Neurotoxicology and Teratology, ISSN 0892-0362, 05/2013, Volume 37, pp. 63 - 67
Ortho-substituted polychlorinated biphenyls (PCBs) preferentially accumulate in the brain and cerebrospinal fluid (CSF) compared to other PCBs. We previously... 
Choroid plexus | Polychlorinated biphenyls | Ewes | Photoperiod | Tight junctions | Blood-cerebrospinal fluid-barrier | Tight Junctions - metabolism | Tight Junction Proteins - genetics | Gene Expression - drug effects | Choroid Plexus - metabolism | Polychlorinated Biphenyls - blood | Blotting, Western | Environmental Pollutants - blood | Tight Junction Proteins - biosynthesis | Choroid Plexus - drug effects | Dose-Response Relationship, Drug | Tissue Distribution | Animals | Polychlorinated Biphenyls - toxicity | Time Factors | Female | Sheep | Environmental Pollutants - toxicity | Seasons | Tight Junctions - drug effects | Proteins
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8. Full Text Tight junction proteins vary in the choroid plexus of ewes according to photoperiod
by Lagaraine, Christine and Skipor, Janina and Szczepkowska, Aleksandra and Dufourny, Laurence and Thiery, Jean-Claude
Brain Research, ISSN 0006-8993, 2011, Volume 1393, pp. 44 - 51
Abstract Sheep from temperate latitudes exhibit seasonal variations in many physiological functions such as reproduction, food intake, body weight, and pelage... 
Neurology | Blood–cerebrospinal fluid barrier | Tight junction | Photoperiod | Reproductive status | Blood-cerebrospinal fluid barrier | CEREBROSPINAL-FLUID SYSTEM | SHEEP | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | TRANSEPITHELIAL TRANSPORT | P-GLYCOPROTEIN | AMINO-ACID | HORMONE | MELATONIN RECEPTORS | RESISTANCE | CENTRAL-NERVOUS-SYSTEM | Tight Junctions - metabolism | Cadherins - metabolism | Choroid Plexus - metabolism | Reproduction - physiology | Phosphoproteins - metabolism | Cell Adhesion Molecules - metabolism | Claudin-1 | Blood-Brain Barrier - metabolism | Occludin | Choroid Plexus - cytology | Animals | Zonula Occludens-1 Protein | Cerebrospinal Fluid - metabolism | Female | Sheep | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Zonula Occludens-2 Protein | Physiological aspects | Permeability | Progesterone | Leptin | Body weight | Life Sciences
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9. Full Text Effect of a two-week treatment with a low dose of 2,2'4,4' 5,5'-hexacholorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods
by Szczepkowska, Aleksandra and LAGARAINE, Christine and Robert, Vincent and Dufourny, Laurence and Thiéry, Jean-Claude and Skipor, Janina
Neurotoxicology and Teratology, ISSN 0892-0362, 2013, Volume 37, pp. 63 - 67
Ortho-substituted polychlorinated biphenyls (PCBs) preferentially accumulate in the brain and cerebrospinal fluid (CSF) compared to other PCBs. We previously... 
Life Sciences | Other
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10. Full Text Effect of a two-week treatment with a low dose of 2,2′4,4′,5,5′-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods
by Szczepkowska, Aleksandra and Lagaraine, Christine and Robert, Vincent and Dufourny, Laurence and Thiéry, Jean-Claude and Skipor, Janina
Neurotoxicology and Teratology, ISSN 0892-0362, 2013, Volume 37, pp. 63 - 67
Abstract Ortho-substituted polychlorinated biphenyls (PCBs) preferentially accumulate in the brain and cerebrospinal fluid (CSF) compared to other PCBs. We... 
Medical Education | Emergency | Choroid plexus | Polychlorinated biphenyls | Ewes | Photoperiod | Tight junctions | Blood–cerebrospinal fluid-barrier | SYSTEM | RECEPTOR | NEUROSCIENCES | CLAUDIN-1 | Blood-cerebrospinal fluid-barrier | TOXICOLOGY | BRAIN | POLYCHLORINATED-BIPHENYLS | BLOOD
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11. Full Text Photoperiod modulates access of 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB153) to the brain and its effect on gonadotropin and thyroid hormones in adult ewes
by Skipor, Janina and MŁynarczuk, JarosŁaw and Szczepkowska, Aleksandra and Lagaraine, Christine and Grochowalski, Adam and Guillaume, Daniel and Dufourny, Laurence and Thiéry, Jean-Claude
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 04/2012, Volume 78, pp. 336 - 343
The effects of photoperiod on the cerebrospinal fluid (CSF) concentration of six -substituted polychlorinated biphenyls (PCBs: PCB28, PCB52, PCB101, PCB138,... 
Polychlorinated biphenyls | Luteinizing hormone | Ewe | Photoperiod | Thyroid hormones | Cerebrospinal fluid | ANTERIOR-PITUITARY | THYROXINE TRANSPORT | INACTIVATING ENZYME GENES | AROCLOR 1254 | CEREBROSPINAL-FLUID | ESTROGEN-RECEPTOR | LUTEINIZING-HORMONE | ENVIRONMENTAL SCIENCES | CHOROID-PLEXUS | TOXICOLOGY | EXPOSURE | POLYCHLORINATED-BIPHENYLS | Estradiol - blood | Gonadotropins - blood | Luteinizing Hormone - blood | Gonadotropins - cerebrospinal fluid | Polychlorinated Biphenyls - metabolism | Brain - metabolism | Animals | Gonadotropins - metabolism | Thyroid Hormones - blood | Thyroid Hormones - metabolism | Thyroxine - metabolism | Female | Sheep | Luteinizing Hormone - cerebrospinal fluid | Estradiol - pharmacology | Thyroid Hormones - cerebrospinal fluid | Pituitary hormones | Thyroxine | Glycoproteins | Hormones | Gonadotropin | Life Sciences
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12. Full Text OR.52. IL2/IL2R Pathway in Dendritic Cells Modulates Both Their Cytokine Synthesis Profiles and Their Capacity to Activate Allogeneic CD4 T Cells
by Kaouther, Mnasria and Lagaraine, Christine and Manaa, Jamel and Lebranchu, Yvon and Ridha, Oueslati
Clinical Immunology, ISSN 1521-6616, 2009, Volume 131, pp. S23 - S23
Allergy and Immunology
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13. Full Text Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways
by Lagaraine, Christine and Hoarau, Cyrille and Chabot, Valérie and Velge-Roussel, Florence and Lebranchu, Yvon
International Immunology, ISSN 0953-8178, 04/2005, Volume 17, Issue 4, pp. 351 - 363
Immature dendritic cells (DCs) can induce T-cell hyporesponsiveness, thus interfering with the process of DC maturation in a pro-inflammatory context, may... 
Tolerance | Transplantation | Cell therapy | Immunosuppressive agent | ACTIVATION | TOLERANCE INDUCTION | immunosuppressive agent | TRANSPLANT RECIPIENTS | IMMUNOLOGY | MATURATION | IN-VITRO | cell therapy | transplantation | IMMATURE | EXPRESSION | tolerance | T-CELLS | MHC CLASS-II | MOFETIL | Cell Movement - drug effects | Lymphocyte Activation - immunology | IMP Dehydrogenase - antagonists & inhibitors | Apoptosis - drug effects | Dendritic Cells - enzymology | Lymphocyte Activation - drug effects | Dendritic Cells - immunology | Humans | Mycophenolic Acid - pharmacology | Dendritic Cells - drug effects | Cell Proliferation - drug effects
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14. Full Text Anti CD.sub.25 treatment of human dendritic cells modulates both their cytokine synthesis profiles and their capacity to activate allogeneic CD4 T cells: A potential tolerogenic effect
by Mnasria, Kaouther and Lagaraine, Christine and Manaa, Jamel and Lebranchu, Yvon and Oueslati, Ridha
International Immunopharmacology, ISSN 1567-5769, 03/2008, Volume 8, Issue 3, p. 414
Recently, attention has been focused on the role for dendritic cells (DCs) in the promotion of peripheral tolerance. It is currently believed that the... 
Cytokines | Dendritic cells | DNA polymerases | T cells | Gene expression
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15. Full Text Anti CD 25 treatment of human dendritic cells modulates both their cytokine synthesis profiles and their capacity to activate allogeneic CD4 T cells: A potential tolerogenic effect
by Mnasria, Kaouther and Lagaraine, Christine and Manaa, Jamel and Lebranchu, Yvon and Oueslati, Ridha
International Immunopharmacology, ISSN 1567-5769, 2008, Volume 8, Issue 3, pp. 414 - 422
Recently, attention has been focused on the role for dendritic cells (DCs) in the promotion of peripheral tolerance. It is currently believed that the... 
IL-2Rα | Human dendritic cells | Tolerance | IL-2
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16. Full Text Anti CD25 treatment of human dendritic cells modulates both their cytokine synthesis profiles and their capacity to activate allogeneic CD4 T cells: A potential tolerogenic effect
by Mnasria, Kaouther and Lagaraine, Christine and Manaa, Jamel and Lebranchu, Yvon and Oueslati, Ridha
International Immunopharmacology, ISSN 1567-5769, 03/2008, Volume 8, Issue 3, pp. 414 - 422
Recently, attention has been focused on the role for dendritic cells (DCs) in the promotion of peripheral tolerance. It is currently believed that the... 
Tolerance | IL-2Rα | IL-2 | Human dendritic cells | PATHWAYS | IL-2R alpha | INNATE | RECEPTOR | INDUCTION | IMMUNOLOGY | TRANSPLANTATION | CHAIN | IL-2 PRODUCTION | human dendritic cells | IMMUNE-RESPONSES | IN-VIVO | PHARMACOLOGY & PHARMACY | EXPRESSION | tolerance | Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors | Lymphocyte Activation | Humans | Cells, Cultured | Dendritic Cells - physiology | Immune Tolerance | CD4-Positive T-Lymphocytes - immunology | Interleukin-2 - genetics | Endocytosis | Interleukin-2 Receptor alpha Subunit - genetics | Interleukin-2 - biosynthesis | Cytokines - biosynthesis | Interferon-gamma - biosynthesis | Interleukin-12 - biosynthesis
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17. Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways
by Lagaraine, Christine and Hoarau, Cyrille and Chabot, Valerie and Velge-Roussel, Florence and Lebranchu, Yvon
International Immunology, ISSN 0953-8178, 04/2005, Volume 17, Issue 4, pp. 351 - 363
Immature dendritic cells (DCs) can induce T-cell hyporesponsiveness, thus interfering with the process of DC maturation in a pro-inflammatory context, may... 
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18. Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways
by Christine Lagaraine and Cyrille Hoarau and Valérie Chabot and Florence Velge-Roussel and Yvon Lebranchu
International Immunology, ISSN 0953-8178, 04/2005, Volume 17, Issue 4, p. 351
  Immature dendritic cells (DCs) can induce T-cell hyporesponsiveness, thus interfering with the process of DC maturation in a pro-inflammatory context, may... 
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