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1. Full Text Brucella abortus S19 and RB51 vaccine immunogenicity test: Evaluation of three mice (BALB/c, Swiss and CD-1® ) and two challenge strains (544 and 2308)
by Miranda, Karina Leite and Dorneles, Elaine Maria Seles and Pauletti, Rebeca Barbosa and Poester, Fernando Padilla and Lage, Andrey Pereira
Vaccine, ISSN 0264-410X, 2014, Volume 33, Issue 4, pp. 507 - 511
Abstract The aim of the present study was to evaluate the use of different mouse strains (BALB/c, Swiss and CD-1® ) and different challenge strains ( Brucella... 
Allergy and Immunology | Brucellosis | Mice | RB51 | S19 | Immunogenicity | Potency test | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | RESIDUAL VIRULENCE | INDUCTION | IMMUNOLOGY | MELITENSIS REV-1 | DELETION | IMMUNIZATION | PROTECTIVE IMMUNITY | MOUSE MODEL | INFECTION | GENERAL CONTROL METHOD | Animals | Vaccine Potency | Brucella abortus - immunology | Female | Bacterial Load | Brucella Vaccine - administration & dosage | Brucellosis - prevention & control | Spleen - microbiology | Brucella Vaccine - immunology | Disease Models, Animal | Analysis | Vaccination | Vaccines
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2. Full Text Non-toxigenic strain of Clostridioides difficile Z31 reduces the occurrence of C. difficile infection (CDI) in one-day-old piglets on a commercial pig farm
by Oliveira Júnior, C.A and Silva, R.O.S and Lage, A.P and Coura, F.M and Ramos, C.P and Alfieri, A.A and Guedes, R.M.C and Lobato, F.C.F
Veterinary Microbiology, ISSN 0378-1135, 04/2019, Volume 231, pp. 1 - 6
Neonatal porcine diarrhea (NPD) is a current problem on pig farms and is caused by several enteropathogens. Among them, stands out due to its importance in... 
Probiotic | Neonatal porcine diarrhea | Escherichia coli | Clostridium perfringens | Clostridium difficile | PERFRINGENS TYPE-A | DIARRHEA | ENTEROPATHOGENS | PREVENTION | MICROBIOLOGY | COLONIZATION | PREVALENCE | DISEASE | SURVEILLANCE | VETERINARY SCIENCES | PCR | EPIDEMIOLOGY | Animals, Newborn | Enterotoxigenic Escherichia coli - isolation & purification | Diarrhea - prevention & control | Diarrhea - veterinary | Swine Diseases - prevention & control | Clostridium Infections - prevention & control | Clostridium difficile - pathogenicity | Clostridium perfringens - isolation & purification | Feces - microbiology | Bacterial Shedding | Clostridium Infections - microbiology | Diarrhea - microbiology | Animals | Clostridium difficile - physiology | Farms | Swine | Swine Diseases - microbiology | Prevention | Pork industry | Analysis | Diarrhea | Livestock farms | Health aspects | Hamsters | Neonates | E coli | Infections | Spores
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3. Full Text Identification and Characterization of Escherichia coli, Salmonella Spp., Clostridium perfringens, and C. difficile Isolates from Reptiles in Brazil
by Ramos, CP and Santana, JA and Coura, FM and Xavier, RGC and Leal, CAG and Oliveira, CA and Heinemann, MB and Lage, AP and Lobato, FCF and Silva, ROS
BIOMED RESEARCH INTERNATIONAL, ISSN 2314-6133, 2019, Volume 2019, pp. 9530732 - 9
Considering the increasing popularity of reptiles as pets and their possible role as reservoirs of pathogenic microorganisms, the aim of this study was to... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PREVALENCE | Reptiles | Salmonella | Laboratories | Virulence | Trimethoprim | Phylogeny | Snakes | Sulfamethoxazole | Microorganisms | E coli | Lizards | Phylogenetics | Bacteria | Cephalothin | Strains (organisms) | Serotyping | Public health | Multidrug resistance | Chloramphenicol | Chloromycetin | Zoonoses | Studies | Pets | Animals | Animal health | Ribotyping | Serotypes | Captivity | Multilocus sequence typing | Ciprofloxacin
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4. Full Text The nonsense mutation MSH2 c.2152C>T shows a founder effect in Portuguese Lynch syndrome families
by Pinheiro, Manuela and Francisco, Inês and Pinto, Carla and Peixoto, Ana and Veiga, Isabel and Filipe, Bruno and Santos, Catarina and Maia, Sofia and Silva, João and Pinto, Pedro and Santos, Rui and Claro, Isabel and Lage, Pedro and Lopes, Paula and Ferreira, Sara and Rosa, Isadora and Fonseca, Ricardo and Rodrigues, Paula and Henrique, Rui and Chaves, Paula and Pereira, António Dias and Brandão, Catarina and Albuquerque, Cristina and Teixeira, Manuel R
Genes, Chromosomes and Cancer, ISSN 1045-2257, 09/2019, Volume 58, Issue 9, pp. 657 - 664
The mutational spectrum of the MMR genes is highly heterogeneous, but specific mutations are observed at high frequencies in well‐defined populations or ethnic... 
MSH2 | founder mutation | Lynch syndrome | CRITERIA | NONPOLYPOSIS COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | RISK | MLH1 | IDENTIFICATION | DELETION | ONCOLOGY | MISMATCH REPAIR GENES | GENETICS & HEREDITY | GERMLINE MUTATIONS | ASSOCIATION | Genetic research | Genetic aspects | Single nucleotide polymorphisms | Genetic screening | Haplotypes | Recombination | Microsatellites | Nonsense mutation | MSH2 protein | Single-nucleotide polymorphism | Mutation | Founder effect | Minority & ethnic groups | Ethnic factors
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5. Full Text Natural convection and surface radiation in a heated wall, c-shaped fracture
by Lugarini, Alan and Franco, Admilson T and Junqueira, Silvio L. M and Lage, Jose L
Journal of Heat Transfer, ISSN 0022-1481, 08/2018, Volume 140, Issue 8
The present study considers the coupled natural convection and surface radiation process through an open fracture of a solid wall facing a reservoir containing... 
OPEN CAVITY | SIDE | SQUARE BODY | NUMBER | THERMODYNAMICS | CENTERED CONDUCTING BODY | LAMINAR | THERMAL-RADIATION | COMPUTATION | ENCLOSURE | ENGINEERING, MECHANICAL
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6. Full Text A global reference for human genetic variation
by Altshuler, D.M and Albers, C.A and Abecasis, G.R and et al and Genomes Project Consortium and 1000 Genomes Project Consortium and The 1000 Genomes Project Consortium
Nature, ISSN 0028-0836, 2015, Volume 526, Issue 7571, pp. 68 - 74
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set... 
BAYES FACTORS | INDIVIDUALS | COMPLEMENT FACTOR-H | POPULATION HISTORY | MULTIDISCIPLINARY SCIENCES | MUTATION | DISEASE | SUSCEPTIBILITY | MACULAR DEGENERATION | VARIANT | GENOME-WIDE ASSOCIATION | Rare Diseases - genetics | Genome-Wide Association Study | Datasets as Topic | Demography | Disease Susceptibility | Physical Chromosome Mapping | Humans | Genetics, Population - standards | Genomics - standards | Genotype | INDEL Mutation - genetics | Sequence Analysis, DNA | Genome, Human - genetics | Haplotypes - genetics | Exome - genetics | Reference Standards | Genetics, Medical | Internationality | Polymorphism, Single Nucleotide - genetics | Genetic Variation - genetics | High-Throughput Nucleotide Sequencing | Quantitative Trait Loci - genetics | Genetic research | Nucleotide sequencing | Observations | Genetic variation | Methods | DNA sequencing | Studies | Haplotypes | Genotype & phenotype | Accuracy | Genealogy | Population | Genomes | Genetic diversity | Mitochondrial DNA | Binding sites
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7. Full Text Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase
by Zhou, Jun and Liu, Min and Aneja, Ritu and Chandra, Ramesh and Lage, Hermann and Joshi, Harish C
Cancer Research, ISSN 0008-5472, 01/2006, Volume 66, Issue 1, pp. 445 - 452
A significant impediment to the success of cancer chemotherapy is multidrug resistance (MDR). A typical form of MDR is attributable to the overexpression of... 
PROMOTER ACTIVITY | MDR-1 GENE-EXPRESSION | APOPTOSIS | ACTIVATION | ONCOLOGY | PROTEIN-KINASE | STABILITY | N-TERMINAL KINASE | STRESS-RESPONSE | DOWN-REGULATION | MICROTUBULE-INTERFERING AGENTS | Pancreatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | Down-Regulation | Humans | JNK Mitogen-Activated Protein Kinases - biosynthesis | RNA, Messenger - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Daunorubicin - pharmacology | Stomach Neoplasms - metabolism | Drug Resistance, Neoplasm | JNK Mitogen-Activated Protein Kinases - metabolism | Stomach Neoplasms - drug therapy | RNA, Messenger - metabolism | Adenoviridae - enzymology | Pancreatic Neoplasms - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Adenoviridae - genetics | Cell Line, Tumor | JNK Mitogen-Activated Protein Kinases - genetics | Antibiotics, Antineoplastic - pharmacokinetics | Daunorubicin - pharmacokinetics | Drug Resistance, Multiple - physiology
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8. Full Text High ultraviolet C resistance of marine Planctomycetes
by Viana, Flávia and Lage, Olga Maria and Oliveira, Rui
Antonie van Leeuwenhoek, ISSN 0003-6072, 10/2013, Volume 104, Issue 4, pp. 585 - 595
Planctomycetes are bacteria with particular characteristics such as internal membrane systems encompassing intracellular compartments, proteinaceous cell... 
Life Sciences | Medical Microbiology | UVC resistance | Microbiology | Planctomycetes | Genotoxicity | Plant Sciences | DNA diffusion assay | Comet assay | Soil Science & Conservation | INDUCED DNA-DAMAGE | PHYLOGENETIC DIVERSITY | BACTERIA | PENAEUS-MONODON | MICROBIOLOGY | RHODOPIRELLULA-BALTICA | PIRELLULA SP STRAIN-1 | UV-RADIATION | REPAIR | GIANT TIGER PRAWN | IN-SITU | Bacteria - radiation effects | Seawater - microbiology | Bacteria - chemistry | Bacteria - classification | Phylogeny | RNA, Ribosomal, 16S | Bacteria - genetics | DNA Damage - radiation effects | Ultraviolet Rays - adverse effects | Papain | Bacteria | Hydrogen peroxide | Nuclear radiation | Genomics | Ultraviolet radiation | DNA damage | Bacteriology
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9. Full Text Probing the efficacy of a heterologous Leishmania/L. Viannia braziliensis recombinant enolase as a candidate vaccine to restrict the development of L. infantum in BALB/c mice
by Santos, Thaís T.O and Martins, Vívian T and Lage, Daniela P and Costa, Lourena E and Salles, Beatriz C.S and Carvalho, Ana M.R.S and Dias, Daniel S and Ribeiro, Patrícia A.F and Chávez-Fumagalli, Miguel A and Machado-de-Ávila, Ricardo A and Roatt, Bruno M and de Magalhães-Soares, Danielle F and Menezes-Souza, Daniel and Coelho, Eduardo A.F and Duarte, Mariana C
Acta Tropica, ISSN 0001-706X, 07/2017, Volume 171, pp. 8 - 16
In the present study, the enolase protein was evaluated as a vaccine candidate against visceral leishmaniasis (VL). The DNA sequence was cloned and the... 
Leishmania braziliensis | Leishmania infantum | Vaccine | Immune response | Enolase | DRUG | DONOVANI | PROTECTIVE EFFICACY | TROPICAL MEDICINE | TEGUMENTARY LEISHMANIASIS | IMMUNE-RESPONSES | INFECTION | PROTEINS | VISCERAL LEISHMANIASIS | PROSPECTS | PARASITOLOGY | CHAGASI | Leishmaniasis Vaccines - immunology | Leishmaniasis, Visceral - prevention & control | Enzyme-Linked Immunosorbent Assay | Adjuvants, Immunologic | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Interleukin-12 | Leishmania braziliensis - immunology | Phosphopyruvate Hydratase - metabolism | Interferon-gamma - metabolism | Phosphopyruvate Hydratase - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Gene Expression Regulation, Enzymologic | Animals | Recombinant Proteins - immunology | Leishmania braziliensis - enzymology | Leishmania infantum - immunology | Female | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Interferon-gamma - genetics | Investigations | Vaccines | Analysis | Immunoglobulin G | Vaccination | Leishmaniasis | Nucleotide sequencing | T cells | Recombinant proteins | DNA sequencing
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10. Full Text Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics
by Ekta Khurana and Yao Fu and Vincenza Colonna and Xinmeng Jasmine Mu and Hyun Min Kang and Tuuli Lappalainen and Andrea Sboner and Lucas Lochovsky and Jieming Chen and Arif Harmanci and Jishnu Das and Alexej Abyzov and Suganthi Balasubramanian and Kathryn Beal and Dimple Chakravarty and Daniel Challis and Yuan Chen and Declan Clarke and Laura Clarke and Fiona Cunningham and Uday S. Evani and Paul Flicek and Robert Fragoza and Erik Garrison and Richard Gibbs and Zeynep H. Gümüş and Javier Herrero and Naoki Kitabayashi and Yong Kong and Kasper Lage and Vaja Liluashvili and Steven M. Lipkin and Daniel G. MacArthur and Gabor Marth and Donna Muzny and Tune H. Pers and Graham R. S. Ritchie and Jeffrey A. Rosenfeld and Cristina Sisu and Xiaomu Wei and Michael Wilson and Yali Xue and Fuli Yu and Emmanouil T. Dermitzakis and Haiyuan Yu and Mark A. Rubin and Chris Tyler-Smith and Mark Gerstein and 1000 Genomes Project Consortium
Science, ISSN 0036-8075, 10/2013, Volume 342, Issue 6154, pp. 84 - 84
Interpreting variants, especially noncoding ones, in the increasing number of personal genomes is challenging. We used patterns of polymorphisms in... 
RESEARCH ARTICLE SUMMARY | Genomes | GENETIC-VARIATION | ELEMENTS | TERT PROMOTER MUTATIONS | NETWORK | POSITIVE SELECTION | HUMAN-EVOLUTION | MULTIDISCIPLINARY SCIENCES | NATURAL-SELECTION | PROSTATE-CANCER | COPY NUMBER | DISEASE | Genomics | Humans | Selection, Genetic | Molecular Sequence Annotation - methods | Binding Sites - genetics | RNA, Untranslated - genetics | Genetic Variation | Neoplasms - genetics | Kruppel-Like Transcription Factors - metabolism | Polymorphism, Single Nucleotide | Mutation | Genome, Human | Population - genetics
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