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1. MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance
by Lage, Hermann
Current drug targets, ISSN 1389-4501, 07/2006, Volume 7, Issue 7, pp. 813 - 821
RNAi | MDR | siRNA | Gene therapy | shRNA | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Drug Resistance, Neoplasm - genetics | Neoplasms - therapy | Animals | Drug Resistance, Multiple - genetics | Neoplasms - genetics | RNA Interference | Humans | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Genetic Therapy - methods
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2. Full Text ABC-transporters: implications on drug resistance from microorganisms to human cancers
by Lage, Hermann
International journal of antimicrobial agents, ISSN 0924-8579, 2003, Volume 22, Issue 3, pp. 188 - 199
Xenobiotics transport | Efflux pumps | Membrane protein | Permease | Multidrug resistance | Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Neoplasms - metabolism | Bacteria - metabolism | Fungi - drug effects | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Models, Molecular | Drug Resistance, Neoplasm | Eukaryota - metabolism | Fungi - metabolism | Neoplasms - drug therapy | Drug Resistance, Microbial | ATP-Binding Cassette Transporters - chemistry | Animals | Communicable Diseases - drug therapy | ATP-Binding Cassette Transporters - metabolism | Eukaryota - drug effects | Index Medicus
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3. Full Text Bacteria-mediated delivery of RNAi effector molecules against viral HPV16-E7 eradicates oral squamous carcinoma cells (OSCC) via apoptosis
by Ahmed, Omar Bauomy and Lage, Hermann
Cancer gene therapy, ISSN 0929-1903, 2018, Volume 26, Issue 5-6, pp. 166 - 173
Life Sciences & Biomedicine | Oncology | Genetics & Heredity | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Polymerase chain reaction | Usage | Messenger RNA | Genetic aspects | Research | Diagnosis | Mouth cancer | Gene silencing | Flow cytometry | hlyA gene | Cell death | RNA-mediated interference | Caspase | Bacteria | E7 protein | Bacterial vesicles | Caspase-3 | Western blotting | Apoptosis | Index Medicus
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4. Therapeutic potential of RNA interference in drug-resistant cancers
by Lage, Hermann
Future oncology (London, England), ISSN 1479-6694, 2009, Volume 5, Issue 2, pp. 169 - 185
RNAi | ShRNA | RNA interference | Gene therapy | SiRNA | Cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Drug Resistance, Neoplasm - genetics | Animals | Drug Resistance, Multiple - genetics | Neoplasms - genetics | Humans | RNA Interference - physiology | Neoplasms - drug therapy
Journal Article
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5. Full Text The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey
by Bocchetta, Martina and Galluzzi, Samantha and Kehoe, Patrick Gavin and Aguera, Eduardo and Bernabei, Roberto and Bullock, Roger and Ceccaldi, Mathieu and Dartigues, Jean-François and de Mendonça, Alexandre and Didic, Mira and Eriksdotter, Maria and Félician, Olivier and Frölich, Lutz and Gertz, Hermann-Josef and Hallikainen, Merja and Hasselbalch, Steen G and Hausner, Lucrezia and Heuser, Isabell and Jessen, Frank and Jones, Roy W and Kurz, Alexander and Lawlor, Brian and Lleo, Alberto and Martinez-Lage, Pablo and Mecocci, Patrizia and Mehrabian, Shima and Monsch, Andreas and Nobili, Flavio and Nordberg, Agneta and Rikkert, Marcel Olde and Orgogozo, Jean-Marc and Pasquier, Florence and Peters, Oliver and Salmon, Eric and Sánchez-Castellano, Carmen and Santana, Isabel and Sarazin, Marie and Traykov, Latchezar and Tsolaki, Magda and Visser, Pieter Jelle and Wallin, Åsa K and Wilcock, Gordon and Wilkinson, David and Wolf, Henrike and Yener, Görsev and Zekry, Dina and Frisoni, Giovanni B
Alzheimer's & dementia, ISSN 1552-5260, 2015, Volume 11, Issue 2, pp. 195 - 206.e1
Neurology | Biomarkers | Diagnosis | Mild cognitive impairment | Alzheimer's disease | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain - diagnostic imaging | Alzheimer Disease - complications | Peptide Fragments - cerebrospinal fluid | Europe | Positron-Emission Tomography | Practice Patterns, Physicians | tau Proteins - cerebrospinal fluid | Cognitive Dysfunction - cerebrospinal fluid | Cognitive Dysfunction - pathology | Alzheimer Disease - cerebrospinal fluid | Cognitive Dysfunction - etiology | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Atrophy | Magnetic Resonance Imaging | Amyloid beta-Peptides - cerebrospinal fluid | Brain - pathology | Fluorodeoxyglucose F18 | Surveys and Questionnaires | Cognitive Dysfunction - diagnosis | Biomarkers - cerebrospinal fluid | Internet | Radiopharmaceuticals | Biological markers | Usage | Index Medicus | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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6. Potential applications of RNA interference technology in the treatment of cancer
by Lage, Hermann
Future oncology (London, England), ISSN 1479-6694, 2005, Volume 1, Issue 1, pp. 103 - 113
RNA interference | Gene therapy | Short hairpin RNA | Short interfering RNA | Cancer | Fusion Proteins, bcr-abl - genetics | Neoplasms - therapy | Animals | RNA Interference | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | RNA, Small Interfering - therapeutic use | Humans | Fusion Proteins, bcr-abl - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | BCR protein | RNA-mediated interference | Abl protein | Fusion protein | P-Glycoprotein | Protein-tyrosine kinase
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7. Full Text Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line
by Mahdizadeh, Shadi and Mahdizadeh, Shadi and Karimi, Gholamreza and Karimi, Gholamreza and Behravan, Javad and Behravan, Javad and Arabzadeh, Sepideh and Arabzadeh, Sepideh and Lage, Hermann and Lage, Hermann and Kalalinia, Fatemeh and Kalalinia, Fatemeh
Daru, ISSN 1560-8115, 06/2016, Volume 24, Issue 1, pp. 17 - 17
MRP1 | A2780/RCIS | MRP2 | A2780 | Multidrug resistance | Crocin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Drug Resistance, Multiple - drug effects | Humans | RNA, Messenger - metabolism | Carotenoids - pharmacology | Ovarian Neoplasms - genetics | Cell Line, Tumor | Female | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Cellular proteins | Genetic aspects | Carotenoids | Drug resistance | Gene expression | Health aspects | Index Medicus
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8. Full Text Complete In Vivo Reversal of the Multidrug Resistance Phenotype by Jet-injection of Anti-MDR1 Short Hairpin RNA-encoding Plasmid DNA
by Stein, Ulrike and Walther, Wolfgang and Stege, Alexandra and Kaszubiak, Alexander and Fichtner, Iduna and Lage, Hermann
Molecular therapy, ISSN 1525-0016, 01/2008, Volume 16, Issue 1, pp. 178 - 186
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Drug Resistance, Multiple - genetics | DNA, Neoplasm - administration & dosage | RNA, Neoplasm - administration & dosage | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Mammary Neoplasms, Experimental - metabolism | Injections, Jet | Mammary Neoplasms, Experimental - genetics | Mammary Neoplasms, Experimental - therapy | RNA, Messenger - biosynthesis | Drug Resistance, Neoplasm - genetics | Phenotype | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Injections, Intralesional | Mice, Nude | RNA, Messenger - antagonists & inhibitors | RNA, Neoplasm - genetics | ATP Binding Cassette Transporter, Sub-Family B | Mice | DNA, Neoplasm - genetics | HeLa Cells | Plasmids - administration & dosage | Index Medicus
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9. Full Text Gene Therapeutic Approaches to Overcome ABCB1-Mediated Drug Resistance
by Lage, Hermann
01/2017, Recent Results in Cancer Research, ISBN 3319429329, Volume 209
RNA interference | CRISPR/Cas9 | Gene therapy | Multidrug resistance | Cancer | Neoplasms - metabolism | Gene Transfer Techniques | Drug Resistance, Multiple - genetics | CRISPR-Associated Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Drug Resistance, Neoplasm - genetics | Neoplasms - therapy | Animals | Transfection | Neoplasms - genetics | CRISPR-Associated Proteins - metabolism | Gene Deletion | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | ATP Binding Cassette Transporter, Sub-Family B - metabolism | RNAi Therapeutics | Genetic Vectors | Neoplasms - pathology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Genetic Therapy - methods
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10. Full Text Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer
by Reis, Mariana Alves and Matos, Ana M and Duarte, Noelia and Ahmed, Omar Bauomy and Ferreira, Ricardo J and Lage, Hermann and Ferreira, Maria-Jose U
Frontiers in pharmacology, ISSN 1663-9812, 05/2020, Volume 11, pp. 599 - 599
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | multidrug resistance | Euphorbia | apoptosis | macrocyclic diterpenes | lathyrane | collateral sensitivity
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