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Current Opinion in Immunology, ISSN 0952-7915, 2012, Volume 24, Issue 4, pp. 482 - 487
Highlights ► Regulatory T cells (Treg) accumulate with age in mice and humans. ► The pro-apoptotic molecule Bim is progressively downregulated in Treg with... 
Allergy and Immunology | EFFECTOR | INTERLEUKIN-2 | REACTIVATION | INFECTION | IL-2 | AGED MICE | IMMUNOLOGY | NAIVE | BINDING CYTOKINES | EXPRESSION | IMMUNOSENESCENCE | Animals | Aging - physiology | Homeostasis - physiology | Humans | T-Lymphocytes, Regulatory - immunology | T cells
Journal Article
Journal Article
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 9/2015, Volume 195, Issue 6, pp. 2624 - 2632
Impaired functionality of dendritic cells (DCs) significantly contributes to decreased adaptive immune responses in aged hosts. The expression of MHC-peptide... 
phagocytosis | metabolism | dendritic cells | aging | T cell priming | antigen presentation
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 1/2017, Volume 65, Issue 1, pp. 174 - 188
Biliary atresia is a fibroinflammatory obstruction of the extrahepatic biliary tree in neonates. While intrahepatic bile duct proliferation is universal at... 
interleukin 17A | CCL2 | bile duct paucity | inflammatory monocyte-derived macrophages | CCR2
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2/2016, Volume 63, Issue 2, pp. 512 - 523
Deficiency for mdr2, a canalicular phospholipid floppase, leads to excretion of low phospholipid “toxic” bile causing progressive cholestasis. We hypothesize... 
liver fibrosis | cholestasis | bile acid signaling | primary sclerosing cholangitis | SC-435
Journal Article
Pediatric Research, ISSN 0031-3998, 07/2017, Volume 82, Issue 1, pp. 122 - 132
BACKGROUND: Heterozygous mutations in the gene ABCB4, encoding the phospholipid floppase MDR3 (Mdr2 in mice), are associated with various chronic liver... 
PATHOGENESIS | EPITHELIAL INJURY | LYSOPHOSPHATIDYLCHOLINE | MOUSE | GENE-EXPRESSION | PEDIATRICS | MICE | LIVER-DISEASE | PHOSPHATIDYLCHOLINE | EXPERIMENTAL BILIARY ATRESIA | T-CELLS | Homeostasis | Genotype & phenotype | Lipids | Liver diseases | Gene expression | Bile
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2011, Volume 186, Issue 1, pp. 156 - 163
We have previously shown that regulatory T cells (Treg) accumulate dramatically in aged animals and negatively impact the ability to control persistent... 
Journal Article