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1. Full Text Spatial and temporal patterns of ERK signaling during mouse embryogenesis
by Laura Beth Corson and Yojiro Yamanaka and Ka-Man Venus Lai and Janet Rossant
Development, ISSN 0950-1991, 10/2003, Volume 130, Issue 19, pp. 4527 - 4537
Embryo | Mouse | MAPK | FGF signaling | ERK | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | MAP Kinase Signaling System - physiology | Phosphorylation | Embryonic Development | Embryonic and Fetal Development | Gestational Age | Pregnancy | Embryo, Mammalian - physiology | Embryonic Structures - anatomy & histology | Animals | Embryonic Structures - physiology | Receptors, Fibroblast Growth Factor - metabolism | Female | Mice | Enzyme Activation | Mitogen-Activated Protein Kinase 3 | Morphogenesis - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
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2. Full Text C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice
by Atanasio, Amanda and Decman, Vilma and White, Derek and Ramos, Meg and Ikiz, Burcin and Lee, Hoi-Ching and Siao, Chia-Jen and Brydges, Susannah and Larosa, Elizabeth and Bai, Yu and Fury, Wen and Burfeind, Patricia and Zamfirova, Ralica and Warshaw, Gregg and Orengo, Jamie and Oyejide, Adelekan and Fralish, Michael and Auerbach, Wojtek and Poueymirou, William and Freudenberg, Jan and Gong, Guochun and Zambrowicz, Brian and Valenzuela, David and Yancopoulos, George and Murphy, Andrew and Thurston, Gavin and Lai, Ka-Man Venus
Scientific reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, pp. 23204 - 23204
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Autoimmunity | Guanine Nucleotide Exchange Factors - genetics | Lymphocyte Activation | Autoantibodies - blood | Mice, Inbred C57BL | Transcriptome | Male | Glomerulonephritis, Membranoproliferative - blood | Mice, 129 Strain | Autoantibodies - biosynthesis | Mice, Knockout | Glomerulonephritis, Membranoproliferative - genetics | Lymphoid Tissue - pathology | Glomerulonephritis, Membranoproliferative - immunology | Animals | Sequence Analysis, RNA | Guanine Nucleotide Exchange Factors - metabolism | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Female | C9orf72 Protein | Macrophages - immunology | Cytokines - blood | Plasma Cells - immunology | Cell activation | Autoantibodies | Systemic lupus erythematosus | Rodents | Plasma cells | Homeostasis | Dementia disorders | Amyotrophic lateral sclerosis | Lymphocytes T | Frontotemporal dementia | Haploinsufficiency | Index Medicus
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3. Full Text The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
by Lai, Ka-Man Venus and Pawson, Tony
Genes & development, ISSN 0890-9369, 05/2000, Volume 14, Issue 9, pp. 1132 - 1145
Cardiovascular system | Embryogenesis | Gene targeting | MAP kinase activation | Phosphotyrosine adaptor | ShcA | Molecular genetics | Protein tyrosine kinase | Extracellular matrix | Cellular signal transduction | Genetic aspects | Research | Cytochemistry | ShcA protein | Index Medicus
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4. Full Text Diverse phenotypes and specific transcription patterns in twenty mouse lines with ablated lincRNAs
by Lai, Ka-Man Venus and Gong, Guochun and Atanasio, Amanda and Rojas, José and Quispe, Joseph and Posca, Julita and White, Derek and Huang, Mei and Fedorova, Daria and Grant, Craig and Miloscio, Lawrence and Droguett, Gustavo and Poueymirou, William T and Auerbach, Wojtek and Yancopoulos, George D and Frendewey, David and Rinn, John and Valenzuela, David M
PloS one, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0125522 - e0125522
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Mammals - genetics | Mice, Inbred C57BL | Embryonic Development - genetics | Genes, Reporter - genetics | Male | RNA, Long Noncoding - genetics | Transcriptome - genetics | Mice, Knockout | Phenotype | Animals | Membrane Transport Proteins - genetics | Alleles | Female | Mice | Transcription, Genetic - genetics | Proteins | Embryonic development | Genetic aspects | Genetic transcription | Transcription | Abnormalities | Organs | Muscles | Homeostasis | Lethality | Tissues | Embryos | Defects | Embryonic growth stage | Embryogenesis | Lungs | Coding | Aging | Adults | Index Medicus
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5. Full Text Generation of fertile and fecund F0 XY female mice from XY ES cells
by Kuno, Junko and Kuno, Junko and Poueymirou, William T and Poueymirou, William T and Gong, Guochun and Gong, Guochun and Siao, Chia-Jen and Siao, Chia-Jen and Clarke, Georgia and Clarke, Georgia and Esau, Lakeisha and Esau, Lakeisha and Kojak, Nada and Kojak, Nada and Posca, Julita and Posca, Julita and Atanasio, Amanda and Atanasio, Amanda and Strein, John and Strein, John and Yancopoulos, George D and Yancopoulos, George D and Lai, Ka-Man Venus and Lai, Ka-Man Venus and DeChiara, Thomas M and DeChiara, Thomas M and Frendewey, David and Frendewey, David and Auerbach, Wojtek and Auerbach, Wojtek and Valenzuela, David M and Valenzuela, David M
Transgenic research, ISSN 0962-8819, 2/2015, Volume 24, Issue 1, pp. 19 - 29
Transgenics | Sex reversal | Knockout mice | Biomedicine | Fertility | Molecular Medicine | Plant Sciences | XY female | Plant Genetics & Genomics | Animal Genetics and Genomics | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Biochemical Research Methods | Science & Technology | Gene Targeting | Fertility - genetics | Animals | Embryonic Stem Cells - cytology | Sex Determination Processes | Microinjections | Gonadal Dysgenesis, 46,XY - genetics | Female | Male | Mice | Mutation | Disorders of Sex Development - genetics | Sodium bicarbonate | Carbonates | Index Medicus
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6. Full Text Cleft palate, moderate lung developmental retardation and early postnatal lethality in mice deficient in the Kir7.1 inwardly rectifying K+ channel
by Villanueva, Sandra and Burgos, Johanna and López-Cayuqueo, Karen I and Lai, Ka-Man Venus and Valenzuela, David M and Cid, L. Pablo and Sepúlveda, Francisco V
PloS one, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0139284 - e0139284
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Animals, Newborn | Epithelium - pathology | Lung - pathology | Body Weight | Epithelium - metabolism | Mice, Inbred C57BL | Cleft Palate - embryology | Lung - abnormalities | Embryonic Development | Animals | Potassium Channels, Inwardly Rectifying - deficiency | Mice, Mutant Strains | Cleft Palate - pathology | Survival Analysis | Lung - embryology | Lung - growth & development | Potassium Channels, Inwardly Rectifying - metabolism | Potassium channels (inwardly-rectifying) | Epithelial cells | Genes | Retina | Lethality | Potassium channels | Epithelium | Respiratory system | Ablation | Cleft lip/palate | Genotype & phenotype | Lungs | Plant tissues | Rodents | Retinal degeneration | Photoreceptors | Degeneration | Mutation | Laboratory animals | Index Medicus
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7. Full Text A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides
by van der Geer, Peter and Wiley, Sandra and Ka-Man Lai, Venus and Olivier, Jean Paul and Gish, Gerald D and Stephens, Robert and Kaplan, David and Shoelson, Steven and Pawson, Tony
Current biology, ISSN 0960-9822, 04/1995, Volume 5, Issue 4, pp. 404 - 412
Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Humans | Phosphotyrosine | Molecular Sequence Data | Receptors, Nerve Growth Factor - metabolism | Adaptor Proteins, Vesicular Transport | Recombinant Fusion Proteins - metabolism | Tyrosine - analogs & derivatives | Glutathione Transferase - genetics | Conserved Sequence | Shc Signaling Adaptor Proteins | Amino Acid Sequence | ErbB Receptors - metabolism | Glutathione Transferase - metabolism | Sequence Homology, Amino Acid | Adaptor Proteins, Signal Transducing | Tyrosine - metabolism | Animals | Proteins - metabolism | Src Homology 2 Domain-Containing, Transforming Protein 1 | Phosphopeptides - metabolism | Mice | Genes, src | 3T3 Cells | Cell Line, Transformed | Index Medicus
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8. Full Text Accelerated Mammary Tumor Development in Mutant Polyomavirus Middle T Transgenic Mice Expressing Elevated Levels of Either the Shc or Grb2 Adapter Protein
by Michael J. Rauh and Valerie Blackmore and Eran R. Andrechek and Christopher G. Tortorice and Roger Daly and Venus Ka-Man Lai and Tony Pawson and Robert D. Cardiff and Peter M. Siegel and William J. Muller
Molecular and Cellular Biology, ISSN 0270-7306, 12/1999, Volume 19, Issue 12, pp. 8169 - 8179
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proteins - physiology | Rabbits | Gene Expression | Protein Biosynthesis | Antigens, Polyomavirus Transforming - genetics | Humans | Mice, Transgenic | Adaptor Proteins, Vesicular Transport | Morphogenesis | Proteins - genetics | Adaptor Proteins, Signal Transducing | Animals | Src Homology 2 Domain-Containing, Transforming Protein 1 | GRB2 Adaptor Protein | Mammary Neoplasms, Experimental - pathology | Mammary Tumor Virus, Mouse | Female | Mice | Antigens, Polyomavirus Transforming - physiology | Genetic Vectors | Shc Signaling Adaptor Proteins | polyomavirus | antigen T (middle) | Shc protein | Grb2 protein | Index Medicus | Cell Growth and Development
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9. Full Text The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
by Lai, KMV and Pawson, T
Genes & development, ISSN 0890-9369, 05/2000, Volume 14, Issue 9, pp. 1132 - 1145
Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Neovascularization, Physiologic - genetics | Heart - embryology | Phosphotyrosine | Receptor Protein-Tyrosine Kinases - metabolism | Embryonic and Fetal Development | Restriction Mapping | Mice, Knockout | Blood Vessels - embryology | Proteins - genetics | Homozygote | Adaptor Proteins, Signal Transducing | Animals | Proteins - metabolism | Src Homology 2 Domain-Containing, Transforming Protein 1 | Mice | Cardiovascular System - embryology | Mitogen-Activated Protein Kinases - metabolism | Shc Signaling Adaptor Proteins | phosphotyrosine adaptor | cardiovascular system | embryogenesis | ShcA | MAP kinase activation | gene targeting | Research Paper
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10. Full Text The Shc Adaptor Protein Is Critical for VEGF Induction by Met/HGF and ErbB2 Receptors and for Early Onset of Tumor Angiogenesis
by Caroline Saucier and Hanane Khoury and Ka-Man Venus Lai and Pascal Peschard and David Dankort and Monica A. Naujokas and Jocelyn Holash and George D. Yancopoulos and William J. Muller and Tony Pawson and Morag Park and George F. Vande Woude
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2/2004, Volume 101, Issue 8, pp. 2345 - 2350
Tumor cell line | Proteins | Angiogenesis | Biological Sciences | Receptors | Cell growth | B lymphocytes | Cell lines | Fibroblasts | Human growth | Tumors | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Recombinant Proteins - metabolism | Fibroblasts - physiology | Humans | Adaptor Proteins, Vesicular Transport - genetics | Receptor, ErbB-2 - metabolism | Neoplasms - blood supply | Receptor Protein-Tyrosine Kinases - metabolism | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Adaptor Proteins, Signal Transducing | Blotting, Northern | Animals | Src Homology 2 Domain-Containing, Transforming Protein 1 | Mice, Nude | Cloning, Molecular | Female | Mice | Neoplasms - pathology | Shc Signaling Adaptor Proteins | Research | Cellular biology | Index Medicus
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11. Full Text Opposite effects of the p52(shc)/p46(shc) and p66(shc) splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
by Migliaccio, Enrica and Mele, Simonetta and Salcini, Anna E and Pelicci, Giuliana and Lai, Ka-Man Venus and Superti-Furga, Giulio and Pawson, Tony and Di Fiore, Pier Paolo and Lanfrancone, Luisa and Pelicci, Pier Giuseppe
The EMBO journal, ISSN 0261-4189, 02/1997, Volume 16, Issue 4, pp. 706 - 716
p66(shc) | Phosphorylation | fos | SH2 proteins | p46(shc) | p52(shc) | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology
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