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Molecular genetics and metabolism, ISSN 1096-7192, 6/2017, Volume 121, Issue 2, pp. 150 - 156
Glycosylasparaginase (GA) is an amidase that cleaves Asn-linked glycoproteins in lysosomes. Deficiency of this enzyme causes accumulation of glycoasparagines... 
Glycosylasparaginase | catalytic mechanism | Aspartylglycosaminuria | β-AHA
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 255 - 259
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2004, Volume 45, Issue 51, pp. 9427 - 9429
Database analysis on H ⋯ H interactions of the type CH ⋯ H C and N–H ⋯ H–N in organic crystals substantiate the occurrence of dihydrogen bonds in the absence... 
Weak dihydrogen bond | Occurrence of dihydrogen bonds | Proton ⋯ proton interaction | N–H ⋯ H–N interaction | N-H ⋯ H-N interaction | proton interaction | occurrence of dihydrogen bonds | HYDROGEN-BOND | CHEMISTRY, ORGANIC | weak dihydrogen bond | N-H center dot center dot center dot H-N interaction | proton
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8202 - 8211
BET proteins are key epigenetic regulators that regulate transcription through binding to acetylated lysine (AcLys) residues of histones and transcription... 
PROTEIN-DEGRADATION | CHEMISTRY, MEDICINAL | BRD4
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 17, pp. 2503 - 2510
Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic... 
3-Phosphoglycerate dehydrogenase | PHGDH | PHGDH inhibitor | Inhibitor | Serine synthesis | Cancer metabolism | CHEMISTRY, MEDICINAL | ACID | BIOSYNTHESIS | CHEMISTRY, ORGANIC | IDENTIFICATION | DERIVATIVES | Enzymes | Medical colleges | Serine | Therapeutics | Cancer cells | Physiological aspects | Amides | Cancer | Homeopathy | Materia medica and therapeutics
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, p. 398
Journal Article
Science Translational Medicine, ISSN 1946-6234, 03/2018, Volume 10, Issue 431, p. eaam8460
Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the WNT pathway, remains a therapeutic target of interest in many diseases. While dual GSK3α/β... 
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 04/2002, Volume 12, Issue 7, pp. 1113 - 1115
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2002, Volume 43, Issue 25, pp. 4523 - 4525
A simple synthesis of hexaquinane diones 2 and 22 involving bench-top chemicals is reported. These two hexaquinanes are advanced C-20 precursors to... 
CHEMISTRY, ORGANIC | ROUTE
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2002, Volume 12, Issue 7, pp. 1113 - 1115
First synthesis of a macrocylic cyclophane-based unusual α-amino acid derivative 11 by coupling of ethyl isocyanoacetate with... 
Journal Article
Current Science, ISSN 0011-3891, 01/2001, Volume 80, Issue 1, pp. 26 - 34
Cyclooxygenase, an enzyme involved in the conversion Of C-20 acids to prostaglandins, exists in two isoforms. A third isoform has been recently encountered.... 
SELECTIVE-INHIBITION | SYNTHASE | SITE | ACID | MECHANISM | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | COX-2 INHIBITORS | ASPIRIN
Journal Article
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