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Journal of Experimental Medicine, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3147 - 3149
Journal Article
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3147 - 3149
The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOLOGY | Inflammasomes | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Inhibitors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 534 - 535
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7660, p. 606
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 3, pp. 379 - 391
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 223 - 224
The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules... 
CRYOPYRIN/NALP3 | ACTIVATION | IMMUNOLOGY | Animals | Humans | Mitosis - immunology | Female | Male | Protein-Serine-Threonine Kinases - immunology | Carrier Proteins - immunology | Macrophages - immunology | Cell receptors | Genetic aspects | Health aspects | Phosphotransferases | Cellular control mechanisms
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 69 - 73
Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation.... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | ACTIVATION | 6Q23 | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MICE | INHIBITOR | NF-KAPPA-B | ASSOCIATION | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Index Medicus | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7411, pp. 389 - 393
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7660, pp. 606 - 608
Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and... 
Proteins | Immunology | Intestine | Diarrhea | Viruses | Infants | Infections | Viral infections | Apoptosis
Journal Article
Current Biology, ISSN 0960-9822, 07/2016, Volume 26, Issue 13, pp. R568 - R572
Injury and physical trauma may inflict accidental cell death, but we have come to realize during the past four decades that cells may also actively engage cell... 
INFLAMMASOME ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASES | CELL-DEATH | CELL BIOLOGY | Pyroptosis - physiology | Inflammasomes - physiology | Inflammation - pathology | Humans | Embryonic development | Cell death | Index Medicus
Journal Article