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1. Full Text Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease
by Krawczyk, Marcin and Zimmermann, Simone and Hess, Georg and Holz, Robert and Dauer, Marc and Raedle, Jochen and Lammert, Frank and Grünhage, Frank
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173506
Latest data suggest that placental growth factor (PLGF), growth differentiation factor-15 (GDF-15) and hepatic growth factor (HGF) are involved in hepatic... 
DIAGNOSIS | VIRUS-INFECTION | CIRRHOSIS | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | GROWTH | RATS | ELASTOGRAPHY | ACCURACY | Liver Diseases - blood | Prospective Studies | Humans | Liver Diseases - pathology | Liver Cirrhosis - pathology | Liver Cirrhosis - blood | Biomarkers - blood | Chronic Disease | Cohort Studies | Liver diseases | Diagnosis | Research | Growth factors | Risk factors | Fibrosis | Liver | Markers | Histology | Regression analysis | Patients | Medicine | Cirrhosis | Hepatitis | Algorithms | Placenta | Hepatology | Rodents | Stiffness | Diagnostic systems | Liver cirrhosis
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2. Full Text The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
by Nischalke, Hans Dieter and Berger, Cordula and Luda, Carolin and Berg, Thomas and Müller, Tobias and Grünhage, Frank and Lammert, Frank and Coenen, Martin and Krämer, Benjamin and Körner, Christian and Vidovic, Natascha and Oldenburg, Johannes and Nattermann, Jacob and Sauerbruch, Tilman and Spengler, Ulrich
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27087
Background: An isoleucine. methionine mutation at position 148 in the PNPLA3 gene (p. I148M, rs738409) has recently been identified as a susceptibility factor... 
FIBROSIS | HEPATOCELLULAR-CARCINOMA | GENE VARIANT | MULTIDISCIPLINARY SCIENCES | DISEASE | I148M | DOMAIN-CONTAINING 3 | TRENDS | SEVERITY | ADIPONUTRIN | CHILDREN | Humans | Middle Aged | Male | Case-Control Studies | Liver Neoplasms - etiology | Young Adult | Carcinoma, Hepatocellular - genetics | Aged, 80 and over | Adult | Female | Hepatitis C - complications | Carcinoma, Hepatocellular - etiology | Liver Cirrhosis - genetics | Liver Cirrhosis, Alcoholic - complications | Genetic Predisposition to Disease | Liver Neoplasms - genetics | Liver Cirrhosis - complications | Membrane Proteins - genetics | Risk Factors | European Continental Ancestry Group | Genotype | Hepatitis C - genetics | Liver Cirrhosis, Alcoholic - genetics | Aged | Lipase - genetics | Type 2 diabetes | Obesity | Genes | Development and progression | Amino acids | Risk factors | Infection | Genetic aspects | Hepatitis C virus | Health aspects | Liver cirrhosis | Cancer | Diabetes therapy | Hepatitis B | Pediatrics | Pathogenesis | Liver | Viruses | Lipids | Hepatocellular carcinoma | Homozygosity | Gene polymorphism | Alcohol use | Proteins | Confidence intervals | Hepatitis | Liver cancer | Genotype & phenotype | Rodents | Hepatology | Gastroenterology | Genotypes | Isoleucine | Liver diseases | Statistical analysis | Hematology | Internal medicine | Diabetes mellitus | Cloning | Health risks | Methionine | Patients | Disease control | Medicine | Cirrhosis | Hospitals | Damage detection | Alcoholic beverages | Hepatitis C | Polymorphism
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3. Kongresspräsident der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten 2017: Arzt, Wissenschaftler und Homo politicus
by Lammert, Frank
Zeitschrift fur Gastroenterologie, ISSN 0044-2771, 08/2017, Volume 55, Issue 8, pp. 739 - 740
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4. Full Text Genetics in Common Liver Diseases: From Pathophysiology to Precise Treatment
by Lammert, Frank
Digestive Diseases, ISSN 0257-2753, 05/2016, Volume 34, Issue 4, pp. 391 - 395
In the past 2 decades, advances in genetics have improved our understanding of liver disease and physiology. Firstly, developments in genomic technologies... 
From Basic Science to the Clinic | Adiponutrin | Gene variant | NOD2 | Genome-wide association study | Polymorphism | Genetic Predisposition to Disease | Genome-Wide Association Study | Liver Diseases - genetics | Genomics | Humans | Risk Factors | Liver Diseases - therapy | Chemical and Drug Induced Liver Injury - genetics | Lipase - metabolism | Overnutrition - complications | Chemical and Drug Induced Liver Injury - therapy | Precision Medicine - trends | Alcoholism - genetics | Membrane Proteins - metabolism | Alcoholism - complications | Liver Diseases - physiopathology | Overnutrition - genetics
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5. Screening is caring: Community-based non-invasive diagnosis and treatment strategies for hepatitis C to reduce liver disease burden
by Isabel Graupera and Frank Lammert
Journal of Hepatology, ISSN 0168-8278, 09/2018, Volume 69, Issue 3, p. 562
Liver diseases | Hepatitis C
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6. Full Text Identification of combined genetic determinants of liver stiffness within the SREBP1c-PNPLA3 pathway
by Krawczyk, Marcin and Grünhage, Frank and Lammert, Frank
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2013, Volume 14, Issue 10, pp. 21153 - 21166
The common PNPLA3 (adiponutrin) variant, p.I148M, was identified as a genetic determinant of liver fibrosis. Since the expression of PNPLA3 is induced by... 
Hepatic fibrosis | Adiponutrin | Gene variant | Sterol regulatory binding protein 1c | sterol regulatory binding protein 1c | CHRONIC HEPATITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | POLYMORPHISM | CHEMISTRY, MULTIDISCIPLINARY | PNPLA3 I148M RS738409 | adiponutrin | HEPATOCELLULAR-CARCINOMA | COMMON VARIANT | INSULIN-RESISTANCE | FATTY LIVER | hepatic fibrosis | GALLSTONE RISK | gene variant | Liver - pathology | Membrane Proteins - genetics | Humans | Middle Aged | Genotype | Male | Signal Transduction - genetics | Young Adult | Sterol Regulatory Element Binding Protein 1 - genetics | Adolescent | Aged, 80 and over | Liver Cirrhosis - pathology | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Liver Cirrhosis - genetics | Lipase - genetics
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7. Full Text Sa1176 Effect of Different Sedation Methods on the Critical Flicker Frequency in a Tertiary Centre Endoscopy Unit
by Grünhage, Frank and Lammert, Frank
Gastroenterology, ISSN 0016-5085, 2013, Volume 144, Issue 5, pp. S-221 - S-221
Gastroenterology and Hepatology
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8. Full Text Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers
by Krawczyk, Marcin and Bantel, Heike and Rau, Monika and Schattenberg, Jörn M and Grünhage, Frank and Pathil, Anita and Demir, Münevver and Kluwe, Johannes and Boettler, Tobias and Weber, Susanne N and Geier, Andreas and Lammert, Frank and NAFLD Clinical Study Grp NAFLD CSG and NAFLD Clinical Study Group (NAFLD CSG)
Journal of Human Genetics, ISSN 1434-5161, 05/2018, Volume 63, Issue 5, pp. 621 - 626
Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrome. Variants PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7... 
CONFERS SUSCEPTIBILITY | INDIVIDUALS | BIOMARKERS | GENETICS & HEREDITY | PNPLA3 | BODY-MASS INDEX | STEATOHEPATITIS | VARIANT | ASSOCIATION | CELL-DEATH | TM6SF2 | Liver diseases
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9. Full Text Correction: Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease
by Krawczyk, Marcin and Zimmermann, Simone and Hess, Georg and Holz, Robert and Dauer, Marc and Raedle, Jochen and Lammert, Frank and Grünhage, Frank
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 6, p. e0179205
[This corrects the article DOI: 10.1371/journal.pone.0173506.]. 
Stiffness | Liver diseases | Patients | Liver | Fibrosis | Markers
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10. Full Text A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population
by Müllenbach, Roman and Weber, Susanne N and Krawczyk, Marcin and Zimmer, Vincent and Sarrazin, Christoph and Lammert, Frank and Grünhage, Frank
BMC Gastroenterology, ISSN 1471-230X, 06/2012, Volume 12, Issue 1, pp. 63 - 63
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the... 
FIBROSIS | POLYMORPHISMS | URSODEOXYCHOLIC ACID | ANTIVIRAL THERAPY | FEEDBACK-REGULATION | DISEASE | SUSCEPTIBILITY | RISK | ELASTOGRAPHY | GASTROENTEROLOGY & HEPATOLOGY | PROGRESSION | Genetic Predisposition to Disease | Genetic Association Studies | Gene Frequency | Humans | Middle Aged | Elasticity | Male | Disease Progression | Germany - epidemiology | Genetic Variation | Young Adult | Liver Cirrhosis - virology | ATP-Binding Cassette Transporters - genetics | ATP Binding Cassette Subfamily B Member 11 | Aged, 80 and over | Adult | Female | Aged | Hepatitis C, Chronic - genetics | Liver Cirrhosis - genetics | Medical research | Care and treatment | Liver | Genes | Amino acids | Disease susceptibility | Biological response modifiers | Exports | Virus diseases | Infection | Medicine, Experimental | Genetic research | Interferon | Hepatitis C virus | Hepatitis C | Health aspects | Liver cirrhosis | Bile | Hepatitis | Infections | Rodents
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11. Full Text Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease
by Krawczyk, Marcin and Grünhage, Frank and Zimmer, Vincent and Lammert, Frank
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 2, pp. 299 - 306
Background & Aims Recent genome-wide association studies have identified the variant p.I148M of the adiponutrin gene PNPLA3 as a risk factor for developing... 
Gastroenterology and Hepatology | Hepatic fibrosis | Personalized medicine | Fibrogenesis | Susceptibility gene | DIAGNOSIS | POPULATION | CHRONIC HEPATITIS-C | BIOPSY | STIFFNESS MEASUREMENT | TRANSIENT ELASTOGRAPHY | CIRRHOSIS | I148M | GASTROENTEROLOGY & HEPATOLOGY | PROGRESSION | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Liver Diseases - genetics | Cross-Sectional Studies | Membrane Proteins - genetics | Humans | Middle Aged | Risk Factors | Liver Diseases - pathology | Male | DNA Primers - genetics | Young Adult | Base Sequence | Adolescent | Aged, 80 and over | Liver Cirrhosis - pathology | Adult | Female | Aged | Polymorphism, Single Nucleotide | Chronic Disease | Liver Cirrhosis - genetics | Elasticity Imaging Techniques | Lipase - genetics | Medical research | Genomics | Fibrosis | Alcoholics | Medicine, Experimental | Genetic research | Disease susceptibility | Hepatitis C | Hepatitis C virus | Risk factors
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12. Full Text Serum 25-hydroxyvitamin D levels and mortality risk in patients with liver cirrhosis: A protocol for a systematic review and meta-analysis of observational studies
by Völker, Désirée and Grünhage, Frank and Wagenpfeil, Stefan and Lammert, Frank and Stokes, Caroline S
Systematic Reviews, ISSN 2046-4053, 03/2019, Volume 8, Issue 1, pp. 73 - 6
Liver cirrhosis represents a substantial global burden in terms of morbidity and mortality. Observational studies have reported an increased risk of death with... 
Death | Calcidiol | Survival | Deficiency | Liver disease | Studies | Bacterial infections | Vitamin D | Mortality | Systematic review | Vitamin deficiency | Health risk assessment | Liver cirrhosis
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13. Full Text Common genetic variation in vitamin D metabolism is associated with liver stiffness
by Grünhage, Frank and Hochrath, Katrin and Krawczyk, Marcin and Höblinger, Aksana and Obermayer‐Pietsch, Barbara and Geisel, Jürgen and Trauner, Michael and Sauerbruch, Tilman and Lammert, Frank
Hepatology, ISSN 0270-9139, 11/2012, Volume 56, Issue 5, pp. 1883 - 1891
Recently, genome‐wide studies identified genetic variants that affect serum 25‐hydroxyvitamin D levels in healthy populations (rs12785878, near... 
SEVERE FIBROSIS | SUNLIGHT EXPOSURE | PRIMARY BILIARY-CIRRHOSIS | CHRONIC HEPATITIS-C | D SUPPLEMENTATION | DISEASE | D DEFICIENCY | PARATHYROID-HORMONE | GASTROENTEROLOGY & HEPATOLOGY | GENOME-WIDE ASSOCIATION | NONINVASIVE ASSESSMENT | Multivariate Analysis | Humans | Middle Aged | Elasticity | Male | Young Adult | Cytochrome P450 Family 2 | Vitamin D - genetics | Statistics, Nonparametric | Aged, 80 and over | Adult | Female | Oxidoreductases Acting on CH-CH Group Donors - genetics | Liver Cirrhosis - genetics | Genetic Predisposition to Disease - genetics | Linear Models | Liver Cirrhosis - blood | Vitamin D - blood | Homozygote | Vitamin D-Binding Protein - genetics | Cholestanetriol 26-Monooxygenase - genetics | Adolescent | Alleles | Liver Cirrhosis - pathology | Heterozygote | Vitamin D - analogs & derivatives | Aged | Polymorphism, Single Nucleotide | Elasticity Imaging Techniques | Vitamin deficiency | Histology | Vitamin D | Metabolism | Hepatology
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14. Full Text Cancer risk in chronic hepatitis B: Do genome‐wide association studies hit the mark?
by Casper, Markus and Grünhage, Frank and Lammert, Frank and Kowdley, Kris and McCaughan, Geoffrey and Trautwein, Christian
Hepatology, ISSN 0270-9139, 04/2011, Volume 53, Issue 4, pp. 1390 - 1392
To identify susceptibility variants for hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC), we conducted a genome‐wide association study by... 
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15. Full Text Serum Antibodies against CD28- A New Potential Marker of Dismal Prognosis in Melanoma Patients
by Körner, Rebecca and Preuss, Klaus-Dieter and Fadle, Natalie and Madjidi, Darius and Neumann, Frank and Bergeler, Lennart and Gräber, Stefan and Müller, Cornelia S. L and Grünhage, Frank and Pfreundschuh, Michael and Lammert, Frank and Vogt, Thomas and Pföhler, Claudia
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e58087
Background: Autoantibodies against CD28 have been found in patients with autoimmune and atopic diseases. These antibodies may act as superagonists and activate... 
INTERFERON | MEMORY | AUTOIMMUNITY | EXPRESSION | MULTIDISCIPLINARY SCIENCES | T-CELL-ACTIVATION | Melanoma - blood | Prognosis | Antibodies, Antinuclear - immunology | Autoantibodies - blood | Humans | Middle Aged | Hepatitis - blood | Male | Interferons - therapeutic use | Skin Neoplasms - blood | Hepatitis - drug therapy | Thyroglobulin - immunology | Young Adult | HEK293 Cells | Aged, 80 and over | Adult | Female | Recombinant Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Skin Neoplasms - immunology | Jurkat Cells | Antibodies, Neoplasm - blood | CD28 Antigens - immunology | Disease Progression | Biomarkers, Tumor - blood | Disease-Free Survival | CD28 Antigens - blood | Melanoma - immunology | Hepatitis - immunology | Aged | Autoimmunity | Medical research | Psoriasis | Melanoma | Antibodies | B cells | T cells | Blood donors | Viral antibodies | Medicine, Experimental | Enzyme-linked immunosorbent assay | Hepatitis B | Viruses | Stimulation | Lymphocytes T | Metastasis | CD28 antigen | Atopy | Skin cancer | Hepatitis | Lymphocytes | Plasmacytoma | Hepatitis B virus | Antigens | Immunoglobulins | Autoantibodies | Internal medicine | Blood & organ donations | Dermatology | Immunoregulation | T cell receptors | Survival | Patients | Allergies | Asthma | Medicine | Immunosuppression | Hospitals | Medical prognosis | Interferon | Gene therapy
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16. Full Text TACE plus sorafenib for the treatment of hepatocellular carcinoma: results of the multicenter, phase II SOCRATES trial
by Erhardt, Andreas and Kolligs, Frank and Dollinger, Matthias and Schott, Eckart and Wege, Hennig and Bitzer, Michael and Gog, Christiane and Lammert, Frank and Schuchmann, Markus and Walter, Clemens and Blondin, Dirk and Ohmann, Christian and Häussinger, Dieter
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 11/2014, Volume 74, Issue 5, pp. 947 - 954
The present multicenter phase II trial investigated the combination of TACE and sorafenib for the treatment of HCC.Eligibility criteria included histologically... 
Carcinoma | Treatment | Medicine & Public Health | Liver | Sorafenib | Oncology | Cancer Research | Pharmacology/Toxicology | THERAPY | ONCOLOGY | PHARMACOLOGY & PHARMACY | CONCURRENT TRANSARTERIAL CHEMOEMBOLIZATION | Niacinamide - analogs & derivatives | Ascites - etiology | Humans | Middle Aged | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Fatigue - etiology | Male | Treatment Outcome | Combined Modality Therapy | Liver Neoplasms - therapy | Ethiodized Oil - adverse effects | Niacinamide - administration & dosage | Chemoembolization, Therapeutic - methods | Ethiodized Oil - administration & dosage | Phenylurea Compounds - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Chemoembolization, Therapeutic - adverse effects | Hepatic Encephalopathy - etiology | Aged | Carcinoma, Hepatocellular - therapy | Doxorubicin - adverse effects | Doxorubicin - administration & dosage | Anthracyclines | Ablation (Surgery) | Clinical trials | Product development | Drug therapy | Cancer
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