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1. Full Text A phase Ib open-label multicenter study of AZD4547 in patients with advanced squamous cell lung cancers
by Paik, Paul K and Shen, Ronglai and Berger, Michael F and Ferry, David and Soria, Jean-Charles and Mathewson, Alastair and Rooney, Claire and Smith, Neil R and Cullberg, Marie and Kilgour, Elaine and Landers, Donal and Frewer, Paul and Brooks, Nigel and Andre, Fabrice
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 18, pp. 5366 - 5373
Purpose: Squamous cell lung cancers (SQCLC) account for 25% of all NSCLCs, yet the prognosis of these patients is poor and treatment options are limited.... 
ACTIVATION | ONCOLOGY | THERAPEUTIC TARGET | FGFR1 | Immunohistochemistry | Pharmacodynamics | Lung cancer | Pharmacology | Gene expression | Patients | Gene sequencing | Anticancer properties | Amplification | Gene amplification | Experimental design | Safety engineering | Medical prognosis | Cell lines | Chromosome 8 | Xenografts | Antitumor activity | Pharmacokinetics | Fibroblast growth factor receptor 1 | Tumors | Cancer | Fibroblast growth factor receptors
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2. Full Text BISCAY, a phase Ib, biomarker-directed multidrug umbrella study in patients with metastatic bladder cancer
by Powles, Thomas and Kilgour, Elaine and Mather, Richard and Galer, Anne and Arkenau, Hendrik-Tobias and Farnsworth, Andrew and Wilde, Jonathan and Ratnayake, Jayantha and Landers, Donal
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. TPS4577 - TPS4577
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3. Full Text Correlation of circulating tumor DNA (ctDNA), tissue-based genomic profiling and clinical efficacy in the biomarker directed Ph1b trial in metastatic bladder cancer (BISCAY)
by Carroll, Danielle and McEwen, Rob and Kozarewa, Iwanka and Harrington, Elizabeth and L'Hernault, Anne and Ratnayake, Jayantha and Mather, Richard and Hodgson, Darren and Barrett, J Carl and Cosaert, Jan G. C. E and Brachet, Pierre Emmanuel and Grivas, Petros and Chowdhury, Simon and Powles, Thomas and Landers, Donal
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 4553 - 4553
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4. Full Text Complexity of FGFR signalling in metastatic urothelial cancer
by Rodriguez-Vida, Alejo and Saggese, Matilde and Hughes, Simon and Rudman, Sarah and Chowdhury, Simon and Smith, Neil R and Lawrence, Peter and Rooney, Claire and Dougherty, Brian and Landers, Donal and Kilgour, Elaine and Arkenau, Hendrik-Tobias
Journal of Hematology and Oncology, ISSN 1756-8722, 10/2015, Volume 8, Issue 1, p. 119
Background: Urothelial cancers (UC) are the fourth most common tumours worldwide after prostate (or breast), lung and colorectal cancer. Despite recent... 
AZD4547 | Urothelial cancer | Biomarker | FGFR | BLADDER-CANCER | GUIDELINES | AMPLIFICATION | ONCOLOGY | PREDICT | SENSITIVE FGFR2 | PROTEIN EXPRESSION | MUTATIONS | HEMATOLOGY | CARCINOMA | Immunohistochemistry | Receptor, Epidermal Growth Factor - genetics | Pyrazoles - therapeutic use | Humans | Middle Aged | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Kidney Pelvis - metabolism | Male | Antineoplastic Agents - therapeutic use | Ureteral Neoplasms - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Ureteral Neoplasms - drug therapy | Neoplasm Metastasis | Receptor, Epidermal Growth Factor - metabolism | Benzamides - therapeutic use | Urinary Bladder Neoplasms - genetics | Gene Expression Regulation, Neoplastic - drug effects | Urinary Bladder Neoplasms - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Ureteral Neoplasms - genetics | Kidney Pelvis - pathology | In Situ Hybridization, Fluorescence | Piperazines - therapeutic use | Signal Transduction - genetics | Urinary Bladder Neoplasms - drug therapy | Signal Transduction - drug effects | Medical research | Care and treatment | Chemotherapy | Analysis | Colorectal cancer | Medicine, Experimental | Development and progression | Fibroblast growth factors | Metastasis | Cancer
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5. Full Text Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study
by Saka, Hideo and Kitagawa, Chiyoe and Kogure, Yoshihito and Takahashi, Yasuo and Fujikawa, Koshi and Sagawa, Tamotsu and Iwasa, Satoru and Takahashi, Naoki and Fukao, Taro and Tchinou, Catherine and Landers, Dónal and Yamada, Yasuhide
Investigational New Drugs, ISSN 0167-6997, 8/2017, Volume 35, Issue 4, pp. 451 - 462
Background AZD4547 is a potent, oral, highly selective fibroblast growth factor receptor (FGFR) inhibitor in clinical development for treating tumours with a... 
AZD4547 | Phase I | Medicine & Public Health | Oncology | Safety | Pharmacology/Toxicology | Pharmacokinetics | FGFR | Japanese | PLACEBO | PAZOPANIB | EFFICACY | CELL LUNG-CANCER | TRIAL | INTERFERON-ALPHA | AMPLIFICATION | ONCOLOGY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | MUTATIONS | SOFT-TISSUE SARCOMA | Neoplasms - metabolism | Pyrazoles - therapeutic use | Benzamides - pharmacokinetics | Humans | Middle Aged | Half-Life | Male | Antineoplastic Agents - therapeutic use | Benzamides - therapeutic use | Neoplasms - blood | Antineoplastic Agents - adverse effects | Pyrazoles - blood | Adult | Female | Antineoplastic Agents - pharmacokinetics | Piperazines - pharmacokinetics | Piperazines - blood | Pyrazoles - pharmacokinetics | Benzamides - adverse effects | Pyrazoles - adverse effects | Benzamides - blood | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Treatment Outcome | Piperazines - therapeutic use | Piperazines - adverse effects | Neoplasms - drug therapy | Asian Continental Ancestry Group | Antineoplastic Agents - blood | Aged | Care and treatment | Physiological aspects | Dosage and administration | Research | Health aspects | Antineoplastic antibiotics | Tumors | Fibroblast growth factor receptors | Fibroblast growth factor | Toxicity | Fluorescence | Dosage | Quality | Fluorescence in situ hybridization | Fibroblasts | Growth factors | Neutropenia | Dosing | Diarrhea | Radioactive half-life | Nausea | Pharmacology | Patients | Steady state | Studies | Stomatitis | Inhibitors | Aberration | Mutation | Index Medicus | Phase I Studies
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6. Full Text A Phase 1b Open Label Multicentre Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
by Paik, Paul K and Shen, Ronglai and Berger, Michael F and Ferry, David and Soria, Jean-Charles and Mathewson, Alastair and Rooney, Claire and Smith, Neil R and Cullberg, Marie and Kilgour, Elaine and Landers, Donal and Frewer, Paul and Brooks, Nigel and Andre, Fabrice
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 9/2017, Volume 23, Issue 18, pp. 5366 - 5373
AZD4547 | squamous lung cancer | FGFR1
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7. Full Text RADICAL trial: A phase Ib/IIa study to assess the safety and efficacy of AZD4547 in combination with either anastrozole or letrozole in ER positive breast cancer patients progressing on these aromatase inhibitors (AIs)
by Seckl, Michael and Badman, Philip David and Liu, Xinxue and MacPherson, Iain R and Zubairi, Ishtiaq Husain and Baird, Richard D and Garcia-Corbacho, Javier and Cresti, Nicola and Plummer, Elizabeth R and Armstrong, Anne Caroline and Allerton, Rozenn and Landers, Donal and Nicholas, Hanna and McLellan, Lyndall and Lim, Adrian K and Coombes, Charles
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 1059 - 1059
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8. Full Text A phase 1 expansion cohort of the fibroblast growth factor receptor (FGFR) inhibitor AZD4547 in patients (pts) with advanced gastric (GC) and gastroesophageal (GOJ) cancer
by Arkenau, Hendrik-Tobias and Saggese, Matilde and Hollebecque, Antoine and Mathewson, Alastair and Lemech, Charlotte Rose and Landers, Donal and Frewer, Paul and Kilgour, Elaine and Brooks, Nigel
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15_suppl, pp. 2620 - 2620
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9. Full Text A randomized, open-label phase II study of AZD4547 (AZD) versus Paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with Fibroblast Growth Factor Receptor 2 (FGFR2) polysomy or gene amplification (amp): SHINE study
by Bang, Yung-Jue and Van Cutsem, Eric and Mansoor, Wasat and Petty, Russell D and Chao, Yee and Cunningham, David and Ferry, David and Landers, Donal and Stockman, Paul and Smith, Neil R and Geh, Catherine and Kilgour, Elaine
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. 4014 - 4014
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10. Full Text Erratum to: Development and Evaluation of a New Technological Way of Engaging Patients and Enhancing Understanding of Drug Tolerability in Early Clinical Development: PROACT
by Hughes, Andrew and Landers, Donal and Arkenau, Hendrik-Tobias and Shah, Saj and Stephens, Richard and Mahal, Amrik and Simmons, Matthew and Lemech, Charlotte and Royle, Jennifer
Advances in therapy, ISSN 0741-238X, 09/2016, Volume 33, Issue 9, pp. 1677 - 1678
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12325-016-0390-x 
Erratum
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11. Full Text A phase 1b open-label multicenter study of AZD4547 in patients with advanced squamous cell lung cancers: Preliminary antitumor activity and pharmacodynamic data
by Paik, Paul K and Shen, Ronglai and Ferry, David and Soria, Jean-Charles and Mathewson, Alastair and Kilgour, Elaine and Landers, Donal and Frewer, Paul and Brooks, Nigel and Andre, Fabrice
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15_suppl, pp. 8035 - 8035
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12. Full Text FIESTA: A phase Ib and pharmacokinetic trial of AZD4547 in combination with gemcitabine and cisplatin
by Jones, Robert Hugh and Anthoney, David Alan and Jones, Robert J and Crabb, Simon J and Hussain, Syed A and Birtle, Alison J and Spiliopoulou, Pavlina and Robinson, Timothy and Knowles, Margaret and McLellan, Lyndall and Jones, Hazel and Boylan, Zoe and Landers, Donal and Atuah, Kwame and Sherratt, Debbie and Brown, Sarah R and Flanagan, Louise and Loadman, Paul and Twelves, Chris and Chester, John David
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. 4521 - 4521
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13. Full Text Erratum to: Development and Evaluation of a New Technological Way of Engaging Patients and Enhancing Understanding of Drug Tolerability in Early Clinical Development: PROACT (Adv Ther, (2016), 33, (1012-1024), 10.1007/s12325-016-0335-4)
by Hughes, Andrew and Landers, Donal and Arkenau, Hendrik-Tobias and Shah, Saj and Stephens, Richard and Mahal, Amrik and Simmons, Matthew and Lemech, Charlotte and Royle, Jennifer
Advances in Therapy, ISSN 0741-238X, 09/2016, Volume 33, Issue 9, pp. 1677 - 1678
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14. Full Text Development and Evaluation of a New Technological Way of Engaging Patients and Enhancing Understanding of Drug Tolerability in Early Clinical Development: PROACT
by Hughes, Andrew and Landers, Donal and Arkenau, Hendrik-Tobias and Shah, Saj and Stephens, Richard and Mahal, Amrik and Simmons, Matthew and Lemech, Charlotte and Royle, Jennifer
Advances in Therapy, ISSN 0741-238X, 6/2016, Volume 33, Issue 6, pp. 1012 - 1024
During early clinical testing of a new medication, it is critical to understand and characterise patient tolerability. However, in early clinical studies, it... 
Phase I | Medicine & Public Health | Rheumatology | Internal Medicine | Oncology | PROACT | Tolerability | Patient feedback | Safety | Cardiology | Pharmacology/Toxicology | Endocrinology | MEDICINE, RESEARCH & EXPERIMENTAL | TRIALS | PHARMACOLOGY & PHARMACY | Therapies, Investigational - methods | Humans | Drug Tolerance | United Kingdom | Confidentiality - standards | Pilot Projects | Therapies, Investigational - adverse effects | Patient Safety - standards | Quality Improvement | Patient Participation - methods | Investigational New Drug Application - organization & administration | Investigational New Drug Application - methods | Disclosure - standards | Patient Reported Outcome Measures | Original Research
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15. Full Text Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study
by Rothwell, DG and Ayub, M and Cook, N and Thistlethwaite, F and Carter, L and Dean, E and Smith, N and Villa, S and Dransfield, J and Clipson, A and White, D and Nessa, K and Ferdous, S and Howell, M and Gupta, A and Kilerci, B and Mohan, S and Frese, K and Gulati, S and Miller, C and Jordan, A and Eaton, H and Hickson, N and O'Brien, C and Graham, D and Kelly, C and Aruketty, S and Metcalf, R and Chiramel, J and Tinsley, N and Vickers, AJ and Kurup, R and Frost, H and Stevenson, J and Southam, S and Landers, D and Wallace, A and Marais, R and Hughes, AM and Brady, G and Dive, C and Krebs, MG
NATURE MEDICINE, ISSN 1078-8956, 05/2019, Volume 25, Issue 5, pp. 738 - 738
Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCERS | EFFICACY | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRECISION MEDICINE | TUMORS | CELL BIOLOGY | Circulating Tumor DNA - genetics | Humans | Sequence Analysis, DNA | DNA Copy Number Variations | Patient Selection | Biomarkers, Tumor - blood | Neoplasms - therapy | Neoplasms - blood | Neoplasms - genetics | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Circulating Tumor DNA - blood | Mutation | Clinical Trials, Phase I as Topic | Molecular targeted therapy | Cancer patients | Care and treatment | Clinical trials | Genetic aspects | Identification and classification | Health aspects | Methods | Tumors | Medical research | Profiling | Copy number | Patients | Blood | Gene sequencing | Next-generation sequencing | Gene frequency | Blood circulation | Deoxyribonucleic acid--DNA | DNA sequencing
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16. Full Text Abstract LB-146: A phase II randomized placebo-controlled study of AZD8931, an inhibitor of EGFR, HER2, and HER3 signaling, plus paclitaxel (P) vs P alone in patients (pts) with low HER2-expressing advanced breast cancer (BC) (THYME)
by Baselga, José and Hegg, Roberto and Losada, Maria Vidal and Vidaurre, Tatiana and Lluch, Ana and Petrakova, Katerina and Mann, Helen and Ghiorghiu, Serban and Stuart, Mary and Landers, Dónal and Thress, Kenneth and Klinowska, Teresa and Cortes, Javier
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. LB-146 - LB-146
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17. Full Text Exploring men's preferred strategies for learning about testicular disorders inclusive of testicular cancer: A qualitative descriptive study
by Saab, Mohamad M and Landers, Margaret and Hegarty, Josephine
European Journal of Oncology Nursing, ISSN 1462-3889, 2016, Volume 26, pp. 27 - 35
Abstract Purpose Men's awareness of testicular disorders is lacking and their intention to seek help for testicular symptoms is sub-optimal. Studies conducted... 
Hematology, Oncology and Palliative Medicine | Qualitative research | Learning | Men's health | Testicular cancer | Awareness | Testicular diseases | PROSTATE | YOUNG MEN | INFORMATION | NURSING | KNOWLEDGE | HEALTH-PROMOTION | PREVENTION | COMMUNITY | ONCOLOGY | BELIEFS | YOUTH | DEAF | Testicular Neoplasms - diagnosis | Humans | Middle Aged | Heterosexuality - psychology | Male | Sexual and Gender Minorities - psychology | Health Knowledge, Attitudes, Practice | Neoplasms, Germ Cell and Embryonal - diagnosis | Neoplasms, Germ Cell and Embryonal - psychology | Young Adult | Ireland | Adolescent | Sexual and Gender Minorities - education | Testicular Neoplasms - psychology | Adult | Qualitative Research | Patient Education as Topic | Research | Analysis | Learning strategies | Oncology, Experimental | Cancer
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18. Full Text Teaching literature of war from multiple perspectives within the North Carolina standard course of study
by Landers, Michael Henry
01/2016, ISBN 9781339851914
This thesis offers a rationale for a set of teaching strategies and lesson plans for teaching the literature and film of war to North Carolina high school... 
Literature | Education | Secondary education
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19. Full Text An extranet architecture for inter-operability among healthcare systems
by Landers, D and Buckley, M and Roantree, M
Health Informatics Journal, ISSN 1460-4582, 12/2000, Volume 6, Issue 4, pp. 228 - 235
Most federations of healthcare systems have operated in an in-house environment where local area networks coupled with layers of interoperability were used to... 
federated database systems | models | OASIS | Trusted Third Party | extranet
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20. Full Text Attorney Reed honored for environmental work
: SPOKANE Edition
by Rich Landers Outdoors editor
Spokesman Review, ISSN 1064-7317, 10/2000
Daniel Beard, National Audubon Society vice president, is scheduled to be in Coeur d'Alene Saturday to present [Scott Reed] with the association's Presidents... 
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