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PLoS Pathogens, ISSN 1553-7366, 01/2012, Volume 8, Issue 1, p. e1002498
Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating... 
ACTIVATION | TRANSCRIPTION | MICROBIOLOGY | INTRINSIC IMMUNITY | VIRAL-INFECTION | P53 | INTERFERON-INDUCIBLE PROTEIN | VIROLOGY | ENDOTHELIAL-CELLS | INFLAMMASOME | EXPRESSION | PARASITOLOGY | LATE PROMOTER | DNA, Viral - biosynthesis | Humans | Viral Proteins - immunology | Cercopithecus aethiops | Sp1 Transcription Factor - metabolism | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - metabolism | Sp1 Transcription Factor - immunology | Cytomegalovirus Infections - genetics | Phosphoproteins - metabolism | Viral Proteins - metabolism | DNA-Directed DNA Polymerase - genetics | Embryo, Mammalian - metabolism | Immunity, Innate - physiology | HEK293 Cells | Embryo, Mammalian - virology | Cytomegalovirus Infections - pathology | Nuclear Proteins - genetics | Response Elements - physiology | Cytomegalovirus - physiology | Vero Cells | Fibroblasts - metabolism | Fibroblasts - virology | Embryo, Mammalian - pathology | DNA-Directed DNA Polymerase - immunology | Viral Proteins - genetics | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Fibroblasts - pathology | DNA, Viral - immunology | Animals | Sp1 Transcription Factor - genetics | Embryo, Mammalian - immunology | Fibroblasts - immunology | Mice | DNA-Directed DNA Polymerase - metabolism | DNA, Viral - genetics | Virus Replication - physiology | Transcription factors | Viral genetics | Cytomegaloviruses | DNA | Physiological aspects | Genetic aspects | Research | Proteins | Cytomegalovirus | Microbiology | Cell cycle | Viruses | Gene expression | Experiments | Viral infections
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 05/2018, Volume 9, Issue MAY, p. 1180
Absent in melanoma 2 (AIM2)-like receptors (ALRs) are a newly characterized class of pathogen recognition receptors (PRRs) involved in cytosolic and nuclear... 
IFN-inducible protein 16 | Absent in melanoma 2 (AIM2)-like receptor | Inflammasome | Interferon | Systemic lupus erythematosus | Cell receptors | Physiological aspects | Development and progression | Genetic aspects | Research | systemic lupus erythematosus | interferon | inflammasome | absent in melanoma 2 (AIM2)-like receptor
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-594 - S-594
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63045
IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions. It is also a target for... 
RHEUMATOID-ARTHRITIS | PATHWAYS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | MULTIDISCIPLINARY SCIENCES | SCLEROSIS | AUTOANTIGEN | INDUCIBLE GENE IFI16 | INTERFERONS | RECEPTORS | EXPRESSION | FAMILY | Phosphoproteins - immunology | Nuclear Proteins - blood | Enzyme-Linked Immunosorbent Assay | Human Umbilical Vein Endothelial Cells - metabolism | Down-Regulation | Nuclear Proteins - metabolism | DNA - metabolism | Nuclear Proteins - immunology | Phosphoproteins - metabolism | Autoimmune Diseases - blood | Antibodies, Neutralizing - immunology | Extracellular Space - metabolism | Phosphoproteins - blood | Cell Nucleus - genetics | Human Umbilical Vein Endothelial Cells - pathology | Cell Membrane - metabolism | Kinetics | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Cell Movement | Autoimmunity | Enzymes | Autoantibodies | Cytokines | DNA | Hostages | Autoimmune diseases | Endothelium | Cell culture | Pediatrics | Genes | Antibodies | Viruses | Assaying | Nuclei | Medical schools | Proteins | Immunology | Transfection | Epidermal growth factor | Rodents | Penicillin | Fibroblasts | Inhibition | Public health | Deoxyribonucleic acid--DNA | Recombinant | Lupus | Rheumatology | Inflammation | Interdisciplinary aspects | Patients | Endothelial cells | Medicine | Hypotheses | N-Terminus | Affinity | Immunofluorescence | Viability | Binding sites | Cell migration | Cytoplasm | Apoptosis | Deoxyribonucleic acid
Journal Article
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 08/2015, Volume 17, Issue 1, p. 208
Introduction: There is evidence that interferon is involved in the pathogenesis of primary Sjogren's syndrome (pSS). The interferon-inducible IFI16 protein,... 
SALIVARY-GLAND BIOPSY | ANTI-IFI16 ANTIBODIES | MULTICENTER | AUTOIMMUNITY | INFLAMMATION | RHEUMATOLOGY | GENE IFI16 | ASSOCIATION | EXPRESSION | SIGNATURE | FEATURES | Nuclear Proteins - blood | Phosphoproteins - blood | T-Lymphocytes - metabolism | Sjogren's Syndrome - diagnosis | Humans | Middle Aged | Sjogren's Syndrome - blood | Female | Male | Biomarkers - blood
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76482
Peptide dendrimers are a class of molecules that exhibit a large array of biological effects including antiviral activity. In this report, we analyzed the... 
TOPICAL MICROBICIDES | QUANTITATIVE DETECTION | ENTRY INHIBITORS | VAGINAL TRANSMISSION | ENVELOPE GLYCOPROTEIN GP120 | MULTIDISCIPLINARY SCIENCES | ANTIVIRAL ACTIVITY | ANTIRETROVIRAL THERAPY | HEPARAN-SULFATE PROTEOGLYCANS | HUMAN-IMMUNODEFICIENCY-VIRUS | PREEXPOSURE PROPHYLAXIS | Dendrimers - metabolism | Species Specificity | Vagina - drug effects | Humans | HIV Envelope Protein gp41 - metabolism | Host-Pathogen Interactions - drug effects | HIV Envelope Protein gp120 - metabolism | Leukocytes, Mononuclear - virology | Flow Cytometry | HIV-1 - physiology | Peptides - metabolism | Antiviral Agents - chemistry | Female | Molecular Structure | Dendrimers - pharmacology | Cervix Uteri - drug effects | Amino Acid Sequence | Virus Replication - drug effects | Antiviral Agents - pharmacology | Leukocytes, Mononuclear - drug effects | Cervix Uteri - virology | Peptides - chemistry | HIV-1 - drug effects | Tissue Culture Techniques | HIV Infections - virology | HIV-1 - classification | Peptides - pharmacology | Vagina - virology | Dendrimers - chemistry | Protein Binding | Leukocytes, Mononuclear - cytology | Infection | Antiviral agents | Dendrimers | Peptides | Lysine | Analysis | HIV (Viruses) | Health aspects | Patient compliance | Heparan sulfate | Proteoglycans | Glycoprotein gp41 | Viruses | Leukocytes (mononuclear) | Infections | Biological activity | Molecular chains | Biological effects | Disease transmission | Acquired immune deficiency syndrome--AIDS | Infectivity | Human immunodeficiency virus--HIV | Antiviral activity | Peripheral blood mononuclear cells | Heparan sulfate proteoglycans | Surface plasmon resonance | Inhibition | Sulfate | Viability | Strains (organisms) | Glycoprotein gp120 | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article