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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2008, Volume 105, Issue 36, pp. 13544 - 13549
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth via mTOR complex 1 (mTORC1), whose activation has been... 
Rapamycin | Colon cancer | Adenoma | RAD001 | Mammalian target of rapamycin | Biological Sciences | mammalian target of rapamycin | adenoma | colon cancer | rapamycin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 52, pp. 22299 - 22304
NVP-BEZ235 is a dual PI3K/mTOR inhibitor currently in phase I clinical trials. We profiled this compound against a panel of breast tumor cell lines to identify... 
Cell growth | Lethal dose 50 | Cell death | Cell lines | Medical genetics | Breast cancer | Genetic mutation | Tumors | Apoptosis | Cancer | mTOR | Small molecule | PI3K | Breat cancer | Kinase inhibitor | small molecule | COMPLEX | CASPASE-2 | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | PTEN | PHOSPHATIDYLINOSITOL 3-KINASE/MAMMALIAN TARGET | VIVO ANTITUMOR-ACTIVITY | PI3K INHIBITOR | kinase inhibitor | breat cancer | MEK | GROWTH | RAPAMYCIN INHIBITOR | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Apoptosis - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Breast Neoplasms - metabolism | Genes, erbB-2 - drug effects | Female | PTEN Phosphohydrolase - genetics | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Breast Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Gene Amplification | Signal Transduction - drug effects | Breast Neoplasms - pathology | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | TOR Serine-Threonine Kinases | Apoptosis - physiology | Mutation | Drug Resistance, Neoplasm - physiology | Biological Sciences
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 16, pp. 2630 - 2637
Purpose Cross-talk between the estrogen receptor (ER) and the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathways is a mechanism... 
INHIBITOR RAD001 EVEROLIMUS | MAMMALIAN TARGET | ADVANCED SOLID TUMORS | ONCOLOGY | TAMOXIFEN | DOUBLE-BLIND | ENDOCRINE THERAPY | AKT | POSTMENOPAUSAL WOMEN | PROGNOSTIC VALUE | MTOR | Cyclin D1 - metabolism | Palpation | Triazoles - administration & dosage | Phosphorylation | Receptors, Estrogen - metabolism | Ribosomal Protein S6 Kinases - metabolism | United States | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Ki-67 Antigen - metabolism | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Nitriles - administration & dosage | Time Factors | Aged, 80 and over | Biomarkers, Tumor - metabolism | Postmenopause | Adult | Female | Neoadjuvant Therapy | Chemotherapy, Adjuvant | Everolimus | Aromatase Inhibitors - administration & dosage | Sirolimus - analogs & derivatives | Double-Blind Method | Europe | Treatment Outcome | Breast Neoplasms - drug therapy | Antibiotics, Antineoplastic - administration & dosage | Gene Expression Regulation, Enzymologic | Phosphatidylinositol 3-Kinases - genetics | Sirolimus - administration & dosage | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biopsy | Breast Neoplasms - pathology | Aged | Cell Proliferation - drug effects | Mutation | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 3789 - 3789
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2004, Volume 10, Issue 6, pp. 594 - 601
Journal Article
by Sullivan, Patrick and Yuan, Maoli and Coleman, John and Destefano, Joanne and Zhang, Xinsheng and Yates, Nicole and Barouch, Dan and Ackerman, Margaret and Decamp, Allan and Alter, Galit and Tomaras, Georgia and Tomaras, Georgia and Montefiori, David and Montefiori, David and Rasmussen, Beth and Morrow, Gavin and Koff, Wayne and Kashuba, Angela and Kashuba, Angela and Mascola, John and Picker, Louis and Kent, Stephen and Selhorst, Philippe and Masson, Lindi and Ngandu, Nobubelo and Rademeyer, Cecilia and Karim, Quarraisha Abdool and Kijak, Gustavo and Barouch, Dan and Rasheed, Ata Ur and Havenar-Daughton, Colin and Pham, Matthew and Kovalenkov, Yevgeniy and Gumber, Sanjeev and Johnson, Matthew and Wrammert, Jens and Villinger, Francois and Haynes, Barton and Haynes, Barton and Fox, Christopher and Reed, Steve and Vasilakos, John and Tomai, Mark and Crotty, Shane and Ahmed, Rafi and Pulendran, Bali and Fukazawa, Yoshinori and Lifson, Jeffrey and Lifson, Jeffrey and Moore, Penny and Chatora, Kumbirai and Skorochod, Elisabeth and Madidi, Ngonidzashe and Gomez, Anabel and Ncube, Getrude and Sundaram, Maaya and Kretschmer, Steve and Pauthner, Matthias and Briney, Bryan and Lee, Jeong Hyun and Saye-Francisco, Karen and Hsueh, Jessica and Ramos, Alejandra and Le, Khoa and Jones, Meaghan and Jardine, Joseph and Bastidas, Raiza and Sarkar, Anita and Liang, Chi-Hui and Wilson, Ian and Ward, Andrew and Zhu, Jiang and Poignard, Pascal and Burton, Dennis and Krebs, Shelly and Law, Wiliam and Gift, Syna and Chenine, Agnes and Rolland, Morgane and Moody, M. Anthony and Jarosinski, Marissa and Georgiev, Ivelin and Chuang, Gwo-Yu and Chuang, Gwo-Yu and Asokan, Mangaiarkarasi and Bailer, Robert T and Cale, Evan M and Louder, Mark and Kwong, Peter D and Polonis, Victoria and Tovanabutra, Sodsai and Robb, Merlin and Mascola, John R and Wibmer, Constantinos Kurt and Wibmer, Constantinos Kurt and Madzorera, Vimbai S and Doria-Rose, Nicole A and Morris, Lynn and Moore, Penny L and Anthony, Colin and ...
AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2016, Volume 32, Issue S1, pp. 1 - 409
Journal Article