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Cellular Immunology, ISSN 0008-8749, 06/2019, Volume 340, p. 103878
Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential... 
Innate and adaptive immune responses | Ubiquitination | Immune-related disorders | T cell tolerance | Cbl-b | PROTEIN | C-CBL | RING-TYPE | IMMUNOLOGY | CUTTING EDGE | CELL BIOLOGY | UBA DOMAINS | NEGATIVE REGULATION | BINDING-SITE | T-CELL DEVELOPMENT | K33-LINKED POLYUBIQUITINATION | ACTIVATION THRESHOLD
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 723 - 723
Abstract Janus Kinase 2 (JAK2) is the central tyrosine kinase in the signaling pathway of an array of hematopoietic receptors including thrombopoietin receptor... 
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 11/2017, Volume 4, Issue 6, p. e1378156
Myelosuppression is one of the most severe and limiting side effects of chemotherapy. Our recent work outlines a strategy to prevent chemotherapy-induced... 
quizartinib | hematopoietic progenitors | acute myeloid leukemia | FLT3 | myelosuppression | chemotherapy
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 508 - 512
Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy(1). New therapeutic approaches to block... 
ACTIVATION | MOUSE NK CELLS | WARFARIN | AXL | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | TYROSINE KINASES | IDENTIFICATION | CELLULAR TARGETS | Mammary Neoplasms, Experimental - immunology | Proto-Oncogene Proteins c-cbl - metabolism | Melanoma, Experimental - drug therapy | Male | Mammary Neoplasms, Experimental - genetics | Warfarin - pharmacology | Warfarin - therapeutic use | Ubiquitination | Melanoma, Experimental - immunology | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - immunology | Neoplasm Metastasis - prevention & control | c-Mer Tyrosine Kinase | Mammary Neoplasms, Experimental - pathology | Killer Cells, Natural - immunology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-cbl - deficiency | Mammary Neoplasms, Experimental - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | Melanoma, Experimental - pathology | Anticoagulants - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Animals | Melanoma, Experimental - genetics | Adaptor Proteins, Signal Transducing - deficiency | Anticoagulants - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Cell receptors | Killer cells | Ligases | Physiological aspects | Development and progression | Genetic aspects | Metastasis | Research | Proteins | Lungs | Rodents | Melanoma | Cytotoxicity | Ligands | Kinases | Immune system | Tumors | Cancer
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 04/2001, Volume 2, Issue 4, pp. 294 - 307
Journal Article
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 4041 - 4041
Abstract Introduction Chemotherapy-inducedmyelosuppressionis a major complication for cancer patients causing high rates of morbidity and mortality.... 
Journal Article
Nature, ISSN 0028-0836, 03/2002, Volume 416, Issue 6877, pp. 183 - 187
Journal Article
Genes and Development, ISSN 0890-9369, 12/1998, Volume 12, Issue 23, pp. 3663 - 3674
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2012, Volume 14, Issue 1, pp. 51 - 60
  Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK pathway is severely perturbed. Depletion of FAK, detachment of... 
Autophagy (Cytology) | Gene targeting | Cancer cells | Genetic aspects | Cellular signal transduction | Research | Properties | Protein kinases
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2014, Volume 13, Issue 12, pp. 1875 - 1884
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 2/2015, Volume 194, Issue 4, pp. 1639 - 1645
CD28 costimulation is essential for the development of Thymic-derived CD4 + CD25 + Foxp3 + regulatory T cells ("tTregs"). E3 ubiquitin ligase Cbl-b has been... 
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2005, Volume 391, Issue 2, pp. 153 - 166
The activation of signalling pathways by ligand engagement with transmembrane receptors is responsible for determining many aspects of cellular function and... 
T-cell receptor | Ubiquitin | Receptor tyrosine kinase | E3 ligase | Cbl | Thymocyte | BIOCHEMISTRY & MOLECULAR BIOLOGY | thymocyte | receptor tyrosine kinase | ubiquitin | Protein Structure, Tertiary | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins c-cbl - metabolism | Animals | Signal Transduction |