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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 263 - 267
Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly... 
PANITUMUMAB | THERAPY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ACQUIRED-RESISTANCE | SOMATIC MUTATION | IDENTIFICATION | GENE COPY NUMBER | ACTIVATING MUTATIONS | BREAST | INSIGHTS | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors | Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2017, Volume 23, Issue 19, pp. 5923 - 5935
Purpose: Activation of the receptor tyrosine kinase MET is associated with poor clinical outcome in certain cancers. To target MET more effectively, we... 
CELL LUNG-CANCER | DOSE-ESCALATION | AMPLIFICATION | SOLID TUMORS | ONCOLOGY | GASTRIC-CANCER | GROWTH | ACQUIRED-RESISTANCE | TARGETING MET | MUTATIONS | MONOCLONAL-ANTIBODIES | Receptor, Epidermal Growth Factor - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Neoplasms - drug therapy | Proto-Oncogene Proteins c-met - genetics | Epitopes - immunology | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Antibodies, Monoclonal, Humanized - administration & dosage | Proto-Oncogene Proteins c-met - immunology | Neoplasms - genetics | Antibodies, Monoclonal - administration & dosage | Neoplasms - immunology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Gene Amplification - genetics | Mice | Mutation | Antibodies, Monoclonal, Humanized - immunology | Antibody-Dependent Cell Cytotoxicity - drug effects | Neoplasms - pathology | Antibodies, Monoclonal - immunology | Cell culture | Biotechnology | Toxicity | Lung cancer | Immunoglobulin G | Cytotoxicity | Activation | Monkeys | c-Met protein | Toxicology | Safety engineering | Xenografts | Protein-tyrosine kinase receptors | Bioindicators | Inhibition | Protein-tyrosine kinase | Gastric cancer | Tyrosine | Effectiveness | Epidermal growth factor receptors | Pharmacology | Tumor cell lines | Epitopes | Amplification | Experimental design | Cell lines | Biomarkers | Cancer | Tumors | Index Medicus
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2009, Volume 525, pp. 261 - 277
Symplex is an antibody discovery technology that identifies fully human antigen-specific antibody repertoires directly from plasma cells. The technology... 
Immunization | Flow Cytometry | Humans | Antibodies - analysis | Cloning, Molecular | Polymerase Chain Reaction | Antibodies - immunology | Immunoglobulin Fab Fragments - immunology | Molecular Biology - methods | Genetic Vectors - genetics | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2017, Volume 16, Issue 12, pp. 2780 - 2791
Increased MET activity is linked with poor prognosis and outcome in several human cancers currently lacking targeted therapies. Here, we report on the... 
LUNG-CANCER | TRASTUZUMAB | ONCOLOGY | ONARTUZUMAB | KINASE | RESISTANCE | RECEPTOR | MUTATIONS | HER2 | ANTIBODY MIXTURE | EGFR | Biotechnology | Immunoglobulins | Immunoglobulin G | Antibodies | High-throughput screening | Tumor cell lines | Epitopes | Degradation | c-Met protein | Internalization | Cell lines | Tumors | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5626 - 5626
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5629 - 5629
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1723 - 1723
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 4495 - 4495
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2006, Volume 357, Issue 2, pp. 607 - 620
Journal Article
International Journal of Cancer, ISSN 0020-7136, 11/2016, Volume 139, Issue 9, pp. 2095 - 2105
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1219 - 1219
The tyrosine kinase receptor MET is involved in progression of a variety of human cancers and constitutes a promising therapeutic target. Particularly, subsets... 
Journal Article
Journal of Virology, ISSN 0022-538X, 02/2011, Volume 85, Issue 4, pp. 1820 - 1833
Journal Article
Journal Article
Journal Article