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Clinical Cancer Research, ISSN 1078-0432, 03/2011, Volume 17, Issue 5, pp. 989 - 1000
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e67583 - e67583
Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK... 
SELECTIVE INHIBITOR | MELANOMA | PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE | RESISTANCE | B-RAF | MUTATIONS | SQUAMOUS-CELL CARCINOMAS | SORAFENIB | DISCOVERY | Melanoma - metabolism | Humans | Oximes - administration & dosage | Imidazoles - administration & dosage | Melanoma - pathology | Enzyme Activation - drug effects | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Pyridones - administration & dosage | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Female | Mice | Pyrimidinones - administration & dosage | Mutation | Drug Evaluation, Preclinical | Proto-Oncogene Proteins B-raf - metabolism | Mitogen-Activated Protein Kinases - metabolism | Squamous cell carcinoma | Gene mutations | Cell death | Colorectal cancer | Thyroid diseases | Skin | Mitogens | Protein kinases | Ovarian cancer | Cell proliferation | Animal models | Phosphorylation | Ovarian carcinoma | Colorectal carcinoma | Oncology | Biology | Activation | Kinases | Thyroid carcinoma | Skin cancer | Proteins | Signal transduction | Cell growth | Xenografts | Cell cycle | Skin diseases | Inhibition | Lesions | Pharmaceutical sciences | Cholangiocarcinoma | Thyroid | MEK inhibitors | Cloning | Oral administration | Melanoma | Extracellular signal-regulated kinase | Rats | MAP kinase | Chromatography | Signaling | Chemistry | Thyroid cancer | Inhibitors | Protein kinase | Ligands | Portfolio management | Papillary thyroid carcinoma | Tumors | Cancer | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 09/2009, Volume 69, Issue 17, pp. 6969 - 6977
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2013, Volume 4, Issue 3, pp. 358 - 362
Hyperactive signaling of the MAP kinase pathway resulting from the constitutively active B-Raf(v600E) mutated enzyme has been observed in a number of human... 
MAP kinase | melanoma | GSK2118436 | B-Raf | dabrafenib | TRIAL | CHEMISTRY, MEDICINAL | BRAF | MUTATIONS
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2011, Volume 2, Issue 4, pp. 320 - 324
Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) represents a promising strategy for the discovery of a new... 
JTP-74057 | GSK1120212 | MEK inhibitor | antiproliferative | CHEMISTRY, MEDICINAL | PROTEIN-KINASE KINASE | CANCER
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2017, Volume 16, Issue 6, pp. 1010 - 1020
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links to... 
BREAST-CANCER | GROWTH-FACTOR RECEPTOR | GENE FUSIONS | ACTIVATION | PROTEIN | AMPLIFICATION | SOLID TUMORS | ONCOLOGY | BRIVANIB ALANINATE | SIGNALING PATHWAY | GASTRIC-CANCER | Phosphorylation | Humans | Male | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Lysosomes - metabolism | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Pyrazoles - pharmacokinetics | Disease Models, Animal | Pyrazoles - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Quinoxalines - pharmacokinetics | Quinoxalines - administration & dosage | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Drug Discovery | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cell culture | Fibroblast growth factor | Kinases | Metastases | Anticancer properties | Angiogenesis | Embryogenesis | Alterations | Xenografts | Protein-tyrosine kinase | Controlled release | Tyrosine | Wound healing | Extracellular signal-regulated kinase | Pharmacology | Tumor cell lines | Biological activity | Embryonic growth stage | Signaling | Inhibitors | Antitumor activity | Sustained release | Tumors | Cancer | Fibroblast growth factor receptors | Index Medicus
Journal Article
Journal Article
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