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Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1791, pp. 179 - 192
The formation of new myelin in persistent multiple sclerosis (MS) lesions is compromised, leading to a reduction in neuron function and subject to degeneration... 
High throughput | Image analysis | Multiple sclerosis | Myelination | Oligodendrocyte | Primary cell-based assay | Differentiation | Drug screening | Myelin basic protein
Journal Article
Current Protocols in Cell Biology, ISSN 1934-2500, 06/2018, Volume 79, Issue 1, p. e49
Multiple sclerosis (MS) is an autoimmune disease that involves an immune-mediated inflammatory response in the central nervous system and optic nerve resulting... 
differentiation | myelin basic protein | multiple sclerosis | high throughput screening assay | oligodendrocyte
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 08/2005, Volume 94, Issue 3, pp. 819 - 827
Minocycline is neuroprotective in animal models of a number of acute CNS injuries and neurodegenerative diseases. While anti‐inflammatory and anti‐apoptotic... 
neurodegenerative diseases | lipid peroxidation assay | deoxyribose degradation assay | radical scavenging assay | tetracyclines | mixed neuronal cultures | Deoxyribose degradation assay | Mixed neuronal cultures | Radical scavenging assay | Neurodegenerative diseases | Tetracyclines | Lipid peroxidation assay | CEREBELLAR GRANULE NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROTOXICITY | NEUROSCIENCES | neuroclegenerative diseases | CELL-DEATH | IN-VITRO | CORTICAL-NEURONS | MOUSE MODEL | DISEASE | SPINAL-CORD-INJURY | CYTOCHROME-C RELEASE | Free Radical Scavengers - pharmacology | L-Lactate Dehydrogenase - metabolism | Embryo, Mammalian | Minocycline - pharmacology | Antipyrine - pharmacology | Minocycline - chemistry | Oxidative Stress - physiology | Cerebral Cortex - cytology | Deoxyribose - metabolism | Dose-Response Relationship, Drug | Drug Interactions | Neuroprotective Agents - pharmacology | Antipyrine - analogs & derivatives | Chromans - pharmacology | Lipid Peroxidation - drug effects | Inhibitory Concentration 50 | Cell Death - drug effects | Neurons - drug effects | Glutamic Acid - pharmacology | Cells, Cultured | Phenethylamines - metabolism | Rats | Antioxidants - pharmacology | Rats, Sprague-Dawley | Sulfonic Acids - metabolism | Animals | Free Radicals - pharmacology | Oxidative Stress - drug effects | Dizocilpine Maleate - pharmacology | Benzothiazoles | Vitamin E - pharmacology | Antioxidants | Oxidation | Antibiotics | Neurons | Stress
Journal Article
Developmental Cell, ISSN 1534-5807, 07/2015, Volume 34, Issue 2, pp. 152 - 167
Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown.... 
F-ACTIN | NERVE-FIBERS | CYTOSKELETON | MEMBRANE | ARP2/3 COMPLEX | N-WASP | DEVELOPMENTAL BIOLOGY | SCHWANN-CELLS | BASIC-PROTEIN | MORPHOMETRIC-ANALYSIS | MYOSIN-II | CELL BIOLOGY | Medical colleges | Muscle proteins | Actin | Cells | Myelin proteins | Neurophysiology
Journal Article
Glia, ISSN 0894-1491, 05/2015, Volume 63, Issue 5, pp. 768 - 779
Inflammatory signals present in demyelinated multiple sclerosis lesions affect the reparative remyelination process conducted by oligodendrocyte progenitor... 
myelin | chemokine | inflammation | oligodendrocyte | interleukin‐17 | ERK | Chemokine | Inflammation | Interleukin-17 | Oligodendrocyte | Myelin | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS LESIONS | RECEPTOR/IL-6 FUSION PROTEIN | NECROSIS-FACTOR-ALPHA | PROLIFERATION | ASTROCYTES | NEUROSCIENCES | HELPER T-CELLS | INTERLEUKIN-6 IL-6 | interleukin-17 | INTERFERON-GAMMA | Freund's Adjuvant - toxicity | Peptide Fragments - toxicity | Green Fluorescent Proteins - genetics | Receptors, Interleukin-17 - genetics | Receptors, Interleukin-17 - deficiency | Myelin-Oligodendrocyte Glycoprotein - toxicity | Flow Cytometry | Oligodendroglia - drug effects | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Cytokines - genetics | Organ Culture Techniques | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Cytokines - metabolism | Cerebellum - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Gene Expression Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Myelin Proteolipid Protein - genetics | Cerebellum - cytology | Stem Cells - drug effects | Oligodendroglia - enzymology | Stem Cells - physiology | Mice | In Vitro Techniques | Interleukins | Biological response modifiers | Cytokines | Medical research | Cell cycle
Journal Article
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 08/2015, Volume 88, Issue 2, pp. 357 - 367
Journal Article
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2004, Volume 153, Issue 1, pp. 108 - 121
FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for sphingosine-1-phosphate (S1P). We show that administration of either... 
Lymphopoenia | Gene expression | Relapsing–remitting EAE | FTY720 | Relapsing-remitting EAE | PROTEOLIPID PROTEIN | LYSOPHOSPHOLIPID RECEPTORS | COLONY-STIMULATING FACTOR | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | SPINAL-CORD | IMMUNOLOGY | NEUROSCIENCES | lymphopoenia | CIRCULATING MATURE LYMPHOCYTES | MULTIPLE-SCLEROSIS | SKIN ALLOGRAFT SURVIVAL | IN-VIVO | POSSESSING UNIQUE MECHANISMS | relapsing-remitting EAE | gene expression | Peptide Fragments | Encephalomyelitis, Autoimmune, Experimental - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Immunosuppressive Agents - therapeutic use | Molecular Sequence Data | Antineoplastic Agents - therapeutic use | Interferon-gamma - metabolism | Receptors, G-Protein-Coupled - agonists | Receptors, Lysophospholipid | Nitric Oxide Synthase - genetics | Nitric Oxide Synthase Type II | Lymphopenia - etiology | Dose-Response Relationship, Drug | RNA, Messenger - biosynthesis | Lymphocytes - physiology | Drug Interactions | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Time Factors | Propylene Glycols - therapeutic use | Reverse Transcriptase Polymerase Chain Reaction - methods | Female | Interferon-gamma - genetics | Immunosuppressive Agents - pharmacology | Mitoxantrone - therapeutic use | Disease Models, Animal | Propylene Glycols - pharmacology | Myelin Proteolipid Protein | Gene Expression Regulation - immunology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Encephalomyelitis, Autoimmune, Experimental - blood | Fingolimod Hydrochloride | Mice, Inbred Strains | Myelin Proteins - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Sphingosine - analogs & derivatives | Animals | Lymphopenia - drug therapy | Lymphocytes - drug effects | Mice | Nitric Oxide Synthase - metabolism | Myelin Proteins - metabolism
Journal Article
Journal Article
Brain Research, ISSN 0006-8993, 2003, Volume 990, Issue 1, pp. 182 - 194
Lysophosphatidic acid (1-acyl-2-lyso-sn-glycero-3-phosphate; LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids which respectively act as... 
Lysophospholipid receptor | Sphingosine kinase | Astrocyte signalling | Lysophosphatidic acid | Sphingosine-1-phosphate | LYSOPHOSPHATIDIC ACID RECEPTOR | sphingosine kinase | PROTEIN-COUPLED RECEPTORS | SPHINGOSINE-1-PHOSPHATE RECEPTORS | RELEASE | lysophospholipid receptor | astrocyte signalling | NEUROSCIENCES | SPHINGOSINE 1-PHOSPHATE | lysophosphatidic acid | CA2 | GENES | sphingosine-1-phosphate | EXPRESSION | Lysophospholipids - metabolism | Arachidonic Acid - metabolism | Phosphorylation | Cerebral Cortex - cytology | Receptors, Lipoprotein - drug effects | Actins - genetics | RNA, Messenger - biosynthesis | Cloning, Molecular | Lysophospholipids - pharmacology | Cerebral Cortex - drug effects | Inositol Phosphates - metabolism | Astrocytes - drug effects | Actins - biosynthesis | Cells, Cultured | Receptors, Lipoprotein - biosynthesis | Rats | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Astrocytes - physiology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Calcium Signaling - drug effects | Cerebral Cortex - physiology | Enzyme Activation - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Receptor Cross-Talk - drug effects
Journal Article