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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 8
Abstract Foxp3+ regulatory T cells (Tregs) represent a major fraction of skin resident T cells. Although normally protective, Tregs have been shown to produce... 
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 128 - 132
The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic... 
ANDROGEN RECEPTOR | ACETYLATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | ACETYLTRANSFERASES P300 | EXPRESSION | SMALL-MOLECULE INHIBITOR | Catalytic Domain - drug effects | p300-CBP Transcription Factors - antagonists & inhibitors | Prostatic Neoplasms, Castration-Resistant - enzymology | Histone Acetyltransferases - chemistry | Humans | Receptors, Androgen - metabolism | Crystallography, X-Ray | Male | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Cell Lineage - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Prostatic Neoplasms, Castration-Resistant - pathology | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Biocatalysis - drug effects | Histone Acetyltransferases - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | p300-CBP Transcription Factors - chemistry | Binding, Competitive | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Models, Molecular | Neoplasms - enzymology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Antineoplastic Agents - chemistry | Mice, SCID | Enzyme Inhibitors - therapeutic use | Acetyl Coenzyme A - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Animals | Histone Acetyltransferases - antagonists & inhibitors | Cell Line, Tumor | Hematologic Neoplasms - drug therapy | Protein Conformation | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Care and treatment | Chemical inhibitors | Usage | Transferases | Binding proteins | Health aspects | Tumors | Histone deacetylase | Transcription factors | Molecular structure | Transcription | Peptides | Androgen receptors | Amino acids | Event-related potentials | Selectivity | Catalytic activity | Kinases | Experiments | Crystallography | Proteins | CREB-binding protein | Castration | Xenografts | Coenzyme A | Acetylation | Catalysis | Inhibition | Crystal structure | Hematology | Feasibility studies | Cyclic AMP response element-binding protein | Histone acetyltransferase | Inhibitors | Microscopy | Natural products | Regulatory mechanisms (biology) | Epigenetics | Ligands | Prostate cancer | Prostate | Cancer | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2007, Volume 13, Issue 9, pp. 2728 - 2737
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2017, Volume 13, Issue 3, pp. 317 - 324
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7710, pp. E1 - E1
In the originally published version of this Letter, the authors Arthur F. Kluge, Michael A. Patane and Ce Wang were inadvertently omitted from the author list.... 
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 128 - 132
The dynamic and reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is a major epigenetic... 
CBP | EP300 | prostate cancer | androgen receptor | histone acetyltransferase | H3K27Ac
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2015, Volume 6, Issue 1, pp. 58 - 62
Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity... 
antitumor | Wee1 kinase inhibitors | CHEMISTRY, MEDICINAL | CHECKPOINT KINASE | TYROSINE KINASE | MITOTIC CATASTROPHE | GENE-EXPRESSION | CDK1 | CANCER-THERAPY
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1481 - 1486
In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were... 
Cdk1 | G1 checkpoint | G2/M checkpoint | Wee1 | Cdc2 | CHEMISTRY, MEDICINAL | CHECKPOINT KINASE | CHEMISTRY, ORGANIC | G2 CHECKPOINT
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 10/2009, Volume 7, Issue 10, pp. 1686 - 1692
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2018, Volume 9, Issue 1, pp. 28 - 33
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation,... 
CBP | p300 | histone acetyl transferase | CHEMISTRY, MEDICINAL | PROTEIN | STRUCTURAL BASIS | ACETYLATION | TARGETS | CITRATE SYNTHASE | BINDING | SMALL-MOLECULE INHIBITOR
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 05/2007, Volume 18, Issue 5, pp. 1645 - 1656
Journal Article
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