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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 4045 - 4050
Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells... 
Glaucoma | Axons | Optic nerve | Eyes | Cell death | Neurons | Small interfering RNA | Mice | Physical trauma | Ganglia | Neuroprotection | Drug discovery | MAP3K12 | ELECTROPORATION | INHIBITOR SELECTIVITY | MULTIDISCIPLINARY SCIENCES | AXONAL REGENERATION | INJURY | DEGENERATION | drug discovery | PATHWAY | neuroprotection | IN-VIVO | NEURONS | MOUSE RETINA | GLAUCOMA | Glaucoma - etiology | Up-Regulation | Rats, Wistar | Humans | Cell Survival - genetics | Male | Retinal Ganglion Cells - pathology | Optic Nerve Diseases - pathology | Cell Death - genetics | RNA Interference | Optic Nerve Injuries - pathology | MAP Kinase Kinase Kinases - antagonists & inhibitors | Cell Survival - physiology | Disease Models, Animal | Optic Nerve Injuries - drug therapy | Cell Survival - drug effects | Retinal Ganglion Cells - enzymology | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Down-Regulation | Cells, Cultured | Rats | Glaucoma - drug therapy | Piperazines - pharmacology | Optic Nerve Injuries - enzymology | Animals | Cell Death - physiology | MAP Kinase Kinase Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Optic Nerve Diseases - etiology | Retinal Ganglion Cells - drug effects | Genomics | Physiological aspects | Retina | Genetic aspects | Research | Health aspects | Genetic screening | Methods | Mitogen-activated protein kinases | Signal transduction | Rodents | Kinases | Cells | Apoptosis | Index Medicus | Biological Sciences
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2017, Volume 18, Issue 10, p. 2105
Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of... 
Curcumin | Caspase-3 | Mitochondrial depolarization | Apoptosis | Endoplasmic reticulum stress | Unfolded protein response | CANCER CELLS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | PROLIFERATION | DEATH | ENDOPLASMIC-RETICULUM STRESS | CHEMISTRY, MULTIDISCIPLINARY | endoplasmic reticulum stress | mitochondrial depolarization | unfolded protein response | THERAPY | PATHWAY | curcumin | caspase-3 | Transcription Factor CHOP - genetics | Unfolded Protein Response - drug effects | Curcumin - analogs & derivatives | Heat-Shock Proteins - metabolism | Humans | Curcumin - pharmacology | Activating Transcription Factor 4 - genetics | Hep G2 Cells | Mitochondrial Membranes - metabolism | Mitochondrial Membranes - drug effects | Heat-Shock Proteins - genetics | Activating Transcription Factor 4 - metabolism | Cell Cycle Checkpoints - drug effects | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Transcription Factor CHOP - metabolism | X-Box Binding Protein 1 - genetics | DNA damage | Cytotoxicity | Hepatocellular carcinoma | Drug development | Depolarization | Analogs | Mitochondria | Pancreatic carcinoma | Protein folding | Cell cycle | Membrane potential | Phosphatidylserine | Deoxyribonucleic acid--DNA | GRP78 protein | Non-small cell lung carcinoma | Caspase | Lung carcinoma | Gene expression | Membrane proteins | Pancreatic cancer | Toxins | Endoplasmic reticulum | Index Medicus
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 8, p. 1934
The 8-hydroxyquinoline pharmacophore scaffold has been shown to possess a range of activities as metal chelation, enzyme inhibition, cytotoxicity, and... 
Betti-reaction | Multicomponent reaction | 8-HQ | 8-hydroxyquinoline | Phenotypic screening | Neurodegeneration | Multitarget directed ligand | HIF1A | Mannich-reaction | Cytoprotection | Mitochondrial membrane potential | CLIOQUINOL | cytoprotection | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial membrane potential | neurodegeneration | multitarget directed ligand | NITROXOLINE | CHEMISTRY, MULTIDISCIPLINARY | NEURODEGENERATIVE DISEASES | MONOAMINE-OXIDASE INHIBITION | DRUGS | A-BETA | phenotypic screening | multicomponent reaction | DERIVATIVES | RASAGILINE | CATHEPSIN-B | Cell Line | Cell Survival - drug effects | Oxyquinoline - pharmacology | Humans | Oxyquinoline - chemical synthesis | Structure-Activity Relationship | Membrane Potential, Mitochondrial - drug effects | Gene Expression Regulation - drug effects | Hypoxia - genetics | Cytoprotection - drug effects | Inhibitory Concentration 50 | Aniline Compounds - chemistry | Cell Death - drug effects | Oxidative Stress - drug effects | Oxyquinoline - chemistry | Aldehydes - chemistry | 8-Hydroxyquinoline | Flow cytometry | Oxidative stress | Animal models | Amines | Toxicity | Central nervous system | Fluorescence | Cytotoxicity | Nervous system | Aldehydes | Assaying | Pyrimidines | Mitochondria | Oxazoles | Formic acid | Chelation | Biocompatibility | Membrane potential | Pyridines | Crystallization | Pharmacology | Gene expression | Hydroxyquinoline | Organic chemistry | Column chromatography | Viability | Scaffolds | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0149832 - e0149832
C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of... 
CANCER-CELLS | APOPTOSIS | UNFOLDED PROTEIN RESPONSE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | DOWN-REGULATION | AGENTS | ENDOPLASMIC-RETICULUM STRESS | HUMAN GLIOMA-CELLS | EXPRESSION CHANGES | Neoplasm Transplantation | Curcumin - analogs & derivatives | Cell Proliferation | Receptors, Notch - metabolism | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Rats, Nude | Brain Neoplasms - metabolism | Receptors, Notch - antagonists & inhibitors | Melanoma, Experimental | Inhibitory Concentration 50 | Female | Glioblastoma - metabolism | Transcription, Genetic | Unfolded Protein Response - drug effects | NF-kappa B - antagonists & inhibitors | Signal Transduction | Rats | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Acrylamides - chemistry | Animals | Cell Line, Tumor | Mice | Glioblastoma - drug therapy | Drosophila melanogaster | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Cell proliferation | Protein kinase C | Brain tumors | Brain cancer | Glioblastoma | Cytotoxicity | AKT protein | Kinases | Cancer therapies | Anticancer properties | Proteins | Glioma cells | Transcription activation | Cell cycle | Tumorigenesis | Curcumin | Inhibition | Stress response | Mitoxantrone | NF-κB protein | Drosophila | Gene expression | Signaling | Cell lines | Antitumor activity | Notch protein | Endoplasmic reticulum | Tumors | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e32602 - e32602
Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other... 
PIGMENT GENES | BIOLOGY | REGIONS TDMS | DEVELOPING MOUSE RETINA | CPG ISLANDS | PHOTORECEPTOR DEVELOPMENT | MICRORNA EXPRESSION | MAMMALIAN RETINA | BINDING PROTEIN IRBP | HUMAN RETINOBLASTOMA CELLS | HYPOMETHYLATION | Cell Line | Retina - metabolism | Humans | Retinal Rod Photoreceptor Cells - metabolism | Organ Specificity | Sulfites - metabolism | Sequence Analysis, DNA | DNA Methylation | Animals | Retina - cytology | Retinal Neurons - metabolism | Retinal Cone Photoreceptor Cells - cytology | Retinal Rod Photoreceptor Cells - cytology | Cloning, Molecular | CpG Islands - genetics | Mice | Retinal Cone Photoreceptor Cells - metabolism | Sulfites | Epigenetic inheritance | Rhodopsin | Analysis | Genes | DNA | Genetic research | Genetic transcription | Methylation | Protein binding | Biotechnology | Bisulfite | Transcription factors | Transcription | Gene regulation | Retina | Homology | Genomes | Rods | Tissues | Liver cancer | Embryogenesis | DNA methylation | Mathematical models | Deoxyribonucleic acid--DNA | Nucleotide sequence | Retinal cells | Gametogenesis | MiRNA | Gene expression | Embryonic growth stage | Polymerase chain reaction | Medicine | Studies | Cones | Cell lines | Epigenetics | Photoreceptors | Retinoblastoma | Interphotoreceptor retinoid-binding protein | retinoblastoma cells | Promoters | epigenetics | interphotoreceptor retinoid-binding protein | Lasers | opsins | miRNA | Index Medicus | Deoxyribonucleic acid
Journal Article
BioTechniques, ISSN 0736-6205, 06/2002, Volume 32, Issue 6, pp. 1330 - 1340
Journal Article
Journal Article