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Angewandte Chemie International Edition, ISSN 1433-7851, 02/2018, Volume 57, Issue 9, pp. 2307 - 2313
The treatment of non‐small cell lung cancer (NSCLC) is currently experiencing a revolution. Over the last decade, the knowledge gained about the biochemical... 
targeted therapy | cancer | structural biology | drug resistance | tyrosine kinases | ALK | ACTIVATION | NSCLC | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | POTENT | C-MET | CRIZOTINIB | MUTATIONS | INHIBITOR | CLINICAL ACTIVITY | Tyrosine | Lung cancer, Small cell | Chemotherapy | Drug resistance | Lung cancer, Non-small cell | Cancer | Lung cancer | Non-small cell lung carcinoma | Biomarkers | Quality of life
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2020, Volume 63, Issue 1, pp. 40 - 51
Journal Article
Chemical Communications, ISSN 1359-7345, 03/2012, Volume 48, Issue 26, pp. 3194 - 3196
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 36, pp. 10909 - 10912
Targeting acquired drug resistance represents the major challenge in the treatment of EGFR‐driven non‐small‐cell lung cancer (NSCLC). Herein, we describe the... 
structure-based drug design | cancer | drug resistance | drug discovery | medicinal chemistry | GEFITINIB | T790M | TIME | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | CELL LUNG-CANCER | COVALENT INHIBITORS | MUTATION | ERLOTINIB | AZD9291 | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Pyridines - chemistry | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Receptor, Epidermal Growth Factor - metabolism | Binding Sites | Pyrazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Non-Small-Cell Lung - metabolism | Pyrazoles - metabolism | Point Mutation | Pyridines - metabolism | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Kinetics | Drug Resistance, Neoplasm - drug effects | Protein Kinase Inhibitors - metabolism | Tyrosine | Drug discovery | Drug resistance | Lung cancer, Non-small cell | Evaluation | Epidermal growth factor receptors | Lung cancer | Non-small cell lung carcinoma | Design analysis | Crystallography | Mutants | X-ray crystallography | Design | Covalence | Inhibitors | Protein X | Lungs | Protein-tyrosine kinase receptors | Mutation | Inhibition | Target acquisition | Protein-tyrosine kinase | Cancer
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2016, Volume 7, Issue 1, pp. 2 - 5
In the last five years, the detailed understanding of how to overcome T790M drug resistance in non-small cell lung cancer (NSCLC) has culminated in the... 
GEFITINIB | CHEMISTRY, MEDICINAL | MUTATIONS | EGFR | ERLOTINIB | AZD9291
Journal Article
ChemMedChem, ISSN 1860-7179, 10/2018, Volume 13, Issue 19, pp. 2065 - 2072
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2018, Volume 9, Issue 8, pp. 779 - 782
The first evidence of osimertinib resistance mediated by the epidermal growth factor receptor (EGFR) mutation C797S was reported three years ago. Since then,... 
MUTANT | DESIGN | CHEMISTRY, MEDICINAL | INHIBITORS | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2019, Volume 62, Issue 11, pp. 5541 - 5546
Pyrazolopyrimidines are well-established as covalent inhibitors of protein kinases such as the epidermal growth factor receptor or Bruton's tyrosine kinase,... 
CHEMISTRY, MEDICINAL | DRUG-RESISTANCE | INHIBITORS | EGFR | DISCOVERY | INSIGHTS
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2018, Volume 130, Issue 9, pp. 2329 - 2335
Die Behandlung des nicht-kleinzelligen Lungenkrebs (NSCLC) erfahrt derzeit eine Revolution. Innerhalb der letzten Dekade fuhrten die gewonnenen Erkenntnisse... 
Lung cancer, Non-small cell
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2018, Volume 130, Issue 9, pp. 2329 - 2335
Die Behandlung des nicht‐kleinzelligen Lungenkrebs (NSCLC) erfährt derzeit eine Revolution. Innerhalb der letzten Dekade führten die gewonnenen Erkenntnisse... 
Tyrosinkinasen | Krebs | Strukturbiologie | Wirkstoffresistenz | Zielgerichtete Therapie
Journal Article
ISSN 1359-7345, 2/2012, Volume 48, Issue 26, pp. 3194 - 3196
A new atom-economical process of direct oxidative intermolecular functionalization of aniline derivatives by simple arenes was developed. The products were... 
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2018, Volume 130, Issue 9, pp. 2329 - 2335
Die Behandlung des nicht‐kleinzelligen Lungenkrebs (NSCLC) erfährt derzeit eine Revolution. Innerhalb der letzten Dekade führten die gewonnenen Erkenntnisse... 
Medical innovations | Non-small cell lung carcinoma
Journal Article
Journal of medicinal chemistry, 01/2020, Volume 63, Issue 1, p. 40
The ErbB receptor tyrosine kinase family members EGFR (epidermal growth factor receptor) and Her2 are among the prominent mutated oncogenic drivers of... 
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 08/2018, Volume 29, Issue 8, p. 2671
The influence on the resistance formation of polymers attached to antibiotics has rarely been investigated. In this study, ciprofloxacin (CIP) was conjugated... 
Conjugates | Bacterial infections | Inspection | DNA topoisomerase IV | Genomes | Drug resistance | p-Xylene | Molecular weight | Weight | Gene sequencing | Antibiotics | E coli | Spacer | Xylene | Dependence | Bacteria | Antibacterial activity | Kinetics | Conjugation | Polymers | Ciprofloxacin
Journal Article
Journal Article
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