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Angewandte Chemie International Edition, ISSN 1433-7851, 09/2016, Volume 55, Issue 39, pp. 11824 - 11828
We describe herein formal syntheses of the indole alkaloids cis‐trikentrin A and herbindole B from a common meso‐hydroquinone intermediate prepared by a... 
indole alkaloids | natural products | desymmetrization | C−H activation | indolization | (+/-)-CIS-TRIKENTRIN-A | C(SP)-H BONDS | (+/-)-HERBINDOLE | AMIDATION | NATURAL HERBINDOLES | ABSOLUTE STRUCTURES | CHEMISTRY, MULTIDISCIPLINARY | (+/-)-TRANS-TRIKENTRIN-A | AMINATION | C-H activation | ARYL CHLORIDES | Palladium | Methods
Journal Article
Current Immunology Reviews, ISSN 1573-3955, 08/2016, Volume 12, Issue 2, pp. 83 - 97
Journal Article
Journal Article
Angewandte Chemie, ISSN 1433-7851, 09/2016, Volume 55, Issue 39, p. 11824
  We describe herein formal syntheses of the indole alkaloids cis-trikentrinA and herbindoleB from a common meso-hydroquinone intermediate prepared by a... 
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2016, Volume 55, Issue 39, pp. 11824 - 11828
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2013, Volume 56, Issue 13, pp. 5261 - 5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We... 
HAMMETT SUBSTITUENT CONSTANTS | POTENT | SEMAGACESTAT | DESIGN | CHEMISTRY, MEDICINAL | BMS-708163 | ALZHEIMERS-DISEASE | ORAL BIOAVAILABILITY | BICYCLIC SULFONAMIDE-PYRAZOLES | MECHANISMS | BINDING | Transcription Factor HES-1 | Gene Expression - drug effects | Models, Chemical | Area Under Curve | Heterocyclic Compounds, 3-Ring - pharmacology | Pyrazoles - chemical synthesis | Receptors, Notch - metabolism | Humans | Microsomes, Liver - metabolism | Male | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | RNA, Messenger - metabolism | Quinolines - pharmacology | Dose-Response Relationship, Drug | Quinolines - pharmacokinetics | Receptors, Notch - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Time Factors | Microsomes, Liver - drug effects | Amyloid beta-Peptides - metabolism | Drug Design | Amyloid beta-Peptides - cerebrospinal fluid | Molecular Structure | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Basic Helix-Loop-Helix Transcription Factors - genetics | Sulfonamides - chemistry | Drug Stability | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Rats | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Homeodomain Proteins - genetics | Quinolines - chemical synthesis | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Heterocyclic Compounds, 3-Ring - chemistry | Dogs | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 2014, Volume 140, pp. e198 - e198
Journal Article
Addictive Behaviors, ISSN 0306-4603, 08/2015, Volume 47, p. 33
  Hepatitis C virus (HCV) is primarily spread through risky injection practices, including sharing needles, cookers, cottons, rinse water, and the practice of... 
Hepatitis | Injections | Gender differences | Epidemiology | Drug use
Journal Article
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2016, Volume 215, Issue 1, pp. 103.e1 - 103.e14
Journal Article