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activated phosphoinositide 3-kinase δ syndrome, pik3cd gene, bronchiectasis, hematopoietic stem cell transplantation, immunodeficiency, p110δ-activating mutation causing senescent t cells, lymphadenopathy, and immunodeficiency, phosphoinositide 3-kinase inhibitor, phosphoinositide 3-kinase δ (1) 1
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by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | CT | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 131, Issue 6, pp. 1594 - 1603.e9
Background Primary immunodeficiencies are a rare group of inborn diseases characterized by a broad clinical and genetic heterogeneity. Substantial advances in... 
Allergy and Immunology | thymus | T-cell immunodeficiency | mucosal-associated invariant T cell | severe combined immune deficiency | EBV-associated B-cell lymphoproliferation | invariant natural killer T cell | Primary immunodeficiency | HOMEOSTASIS | WISKOTT-ALDRICH-SYNDROME | THYMIC EGRESS | SYNDROME PROTEIN | IMMUNOLOGY | MATURATION | T-LYMPHOCYTE | ALLERGY | KINASE ITK | INKT CELL | GENERATION | MUTATIONS | Immunologic Deficiency Syndromes - pathology | Humans | Infant | Male | Exome | Base Sequence | B-Lymphocytes - virology | Female | Immunologic Deficiency Syndromes - immunology | Child | Gene Order | Microfilament Proteins - genetics | B-Lymphocytes - metabolism | Siblings | Amino Acid Sequence | Microfilament Proteins - chemistry | Gene Expression | Microfilament Proteins - deficiency | Protein Structure, Secondary | Lymphoproliferative Disorders - virology | Herpesvirus 4, Human - immunology | Models, Molecular | Lymphoproliferative Disorders - genetics | Lymphoproliferative Disorders - pathology | Sequence Alignment | Pedigree | Immunologic Deficiency Syndromes - genetics | Consanguinity | Mutation | T cells | Genomics | Risk factors | Immunodeficiency | Antigens | Genealogy | Genes | Families & family life | Kinases | Patients | Streptococcus infections | Proteins | Chemotherapy | Parents & parenting | Lymphocytes | Tetanus | Genetic testing | Potassium | Age | Deoxyribonucleic acid--DNA
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 5, pp. 1131 - 1141.e9
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 130, Issue 5, pp. 1144 - 1152.e11
Background Signals emanating from the antigen T-cell receptor (TCR) are required for T-cell development and function. The T lymphocyte–specific protein... 
Allergy and Immunology | LCK, SRC tyrosine kinase | recurrent infections | CD4 | T-cell receptor signaling | autoinflammation | immunodeficiency | genetic defect | lymphopenia | ACTIVATION | COMPLEX | SRC tyrosine kinase | PROTEIN-TYROSINE KINASES | P56(LCK) | IMMUNOLOGY | MICE LACKING | SIGNAL-TRANSDUCTION | ALLERGY | LCK | MUTATION | DOCK8 DEFICIENCY | FYN | ANTIGEN RECEPTOR | Genetic Predisposition to Disease | T-Lymphocytopenia, Idiopathic CD4-Positive - diagnosis | Receptors, Antigen, T-Cell - metabolism | Genes, Recessive - genetics | Humans | Cells, Cultured | Child, Preschool | T-Lymphocytopenia, Idiopathic CD4-Positive - genetics | Mutation, Missense - genetics | Polymorphism, Genetic | CD4-Positive T-Lymphocytes - immunology | DNA Mutational Analysis | Pedigree | Immunologic Deficiency Syndromes - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - chemistry | Female | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Calcium Signaling - genetics | France | Immunologic Deficiency Syndromes - diagnosis | Tyrosine | Antigens | T cells | Genes | Immunodeficiency | T cell receptors | Infections | Kinases | Viral infections | Immune system | Autoimmunity | Calcium mobilization | Phosphorylation | CD8 antigen | Recurrent infection | Inflammation | Lymphocytes T | Risk factors | CD4 antigen | Calcium signalling | T-cell receptor | Missense mutation | Lymphopenia | Lck protein | Respiratory tract diseases | Differentiation | Protein-tyrosine kinase | Age | uniparental disomy | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 816 - 819.e4
Journal Article
by Aad, G and Abajyan, T and Abbott, B and Abdallah, J and Abdel Khalek, S and Abdinov, O and Aben, R and Abi, B and Abolins, M and AbouZeid, O.S and Abramowicz, H and Abreu, H and Abulaiti, Y and Acharya, B.S and Adamczyk, L and Adams, D.L and Addy, T.N and Adelman, J and Adomeit, S and Adye, T and Aefsky, S and Aguilar-Saavedra, J.A and Agustoni, M and Ahlen, S.P and Ahmad, A and Ahsan, M and Aielli, G and Åkesson, T.P.A and Akimoto, G and Akimov, A.V and Alam, M.A and Albert, J and Albrand, S and Alconada Verzini, M.J and Aleksa, M and Aleksandrov, I.N and Alessandria, F and Alexa, C and Alexander, G and Alexandre, G and Alexopoulos, T and Alhroob, M and Aliev, M and Alimonti, G and Alio, L and Alison, J and Allbrooke, B.M.M and Allison, L.J and Allport, P.P and Allwood-Spiers, S.E and Almond, J and Aloisio, A and Alon, R and Alonso, A and Alonso, F and Altheimer, A and Alvarez Gonzalez, B and Alviggi, M.G and Amako, K and Amaral Coutinho, Y and Amelung, C and Ammosov, V.V and Amor Dos Santos, S.P and Amorim, A and Amoroso, S and Amram, N and Anastopoulos, C and Ancu, L.S and Andari, N and Andeen, T and Anders, C.F and Anders, G and Anderson, K.J and Andreazza, A and Andrei, V and Anduaga, X.S and Angelidakis, S and Anger, P and Angerami, A and Anghinolfi, F and Anisenkov, A.V and Anjos, N and Annovi, A and Antonaki, A and Antonelli, M and Antonov, A and Antos, J and Anulli, F and Aoki, M and Aperio Bella, L and Apolle, R and Arabidze, G and Aracena, I and Arai, Y and Arce, A.T.H and Arfaoui, S and Arguin, J-F and Argyropoulos, S and Arik, M and Arik, E and ... and ATLAS Collaboration and Partikel- och astropartikelfysik and Skolan för teknikvetenskap (SCI) and KTH and Fysik
Physics Letters B, ISSN 0370-2693, 10/2013, Volume 726, Issue 1-3, pp. 120 - 144
Studies of the spin and parity quantum numbers of the Higgs boson are presented, based on proton–proton collision data collected by the ATLAS experiment at the... 
Spin | Parity | Higgs boson | BROKEN SYMMETRIES | MASSES | LHC | ASTRONOMY & ASTROPHYSICS | PHYSICS, NUCLEAR | GAUGE | PHYSICS, PARTICLES & FIELDS | Physics - High Energy Physics - Experiment | Physics | High Energy Physics - Experiment | Fysik | Physical Sciences | Naturvetenskap | Natural Sciences
Journal Article
Journal of High Energy Physics (Online), ISSN 1029-8479, 08/2018, Volume 2018, Issue 11
JHEP 11 (2018) 085 A search for charged Higgs bosons heavier than the top quark and decaying via $H^\pm \rightarrow tb$ is presented. The data analysed... 
Physics - High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Higgs physics | Beyond Standard Model | Hadron-Hadron scattering (experiments)
Journal Article
Journal Article
Journal Article
by Aad, G and Abbott, B and Abdallah, J and Abdelalim, A.A and Abdesselam, A and Abdinov, O and Abi, B and Abolins, M and Abramowicz, H and Abreu, H and Acerbi, E and Acharya, B.S and Adams, D.L and Addy, T.N and Adelman, J and Aderholz, M and Adomeit, S and Adragna, P and Adye, T and Aefsky, S and Aguilar-Saavedra, J.A and Aharrouche, M and Ahlen, S.P and Ahles, F and Ahmad, A and Ahsan, M and Aielli, G and Akdogan, T and Åkesson, T.P.A and Akimoto, G and Akimov, A.V and Akiyama, A and Alam, M.S and Alam, M.A and Albert, J and Albrand, S and Aleksa, M and Aleksandrov, I.N and Alessandria, F and Alexa, C and Alexander, G and Alexandre, G and Alexopoulos, T and Alhroob, M and Aliev, M and Alimonti, G and Alison, J and Aliyev, M and Allport, P.P and Allwood-Spiers, S.E and Almond, J and Aloisio, A and Alon, R and Alonso, A and Alviggi, M.G and Amako, K and Amaral, P and Amelung, C and Ammosov, V.V and Amorim, A and Amorós, G and Amram, N and Anastopoulos, C and Ancu, L.S and Andari, N and Andeen, T and Anders, G and Anders, C.F and Anderson, K.J and Andreazza, A and Andrei, V and Andrieux, M.-L and Anduaga, X.S and Angerami, A and Anghinolfi, F and Anjos, N and Annovi, A and Antonaki, A and Antonelli, M and Antonov, A and Antos, J and Anulli, F and Aoun, S and Aperio Bella, L and Apolle, R and Arabidze, G and Aracena, I and Arai, Y and Arce, A.T.H and Archambault, J.P and Arfaoui, S and Arguin, J.-F and Arik, M and Arik, E and Armbruster, A.J and Arnaez, O and Arnault, C and Artamonov, A and Artoni, G and Arutinov, D and ... and ATLAS Collaboration and Partikel- och astropartikelfysik and Skolan för teknikvetenskap (SCI) and KTH and Fysik
Physics Letters B, ISSN 0370-2693, 11/2011, Volume 705, Issue 5, pp. 452 - 470
A search for the Standard Model Higgs boson in the two photon decay channel is reported, using of proton–proton collision data at a centre-of-mass energy of 7... 
PHYSICS, NUCLEAR | PARTON DISTRIBUTIONS | ASTRONOMY & ASTROPHYSICS | PHYSICS, PARTICLES & FIELDS | Analysis | Standards | Detectors | Searching | Decay | Higgs bosons | Mathematical models | Photons | Channels | Physics - High Energy Physics - Experiment | Physics | High Energy Physics - Experiment | Fysik | Physical Sciences | Naturvetenskap | Natural Sciences
Journal Article