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1. Full Text Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery
by Reinert, Thomas and Schøler, Lone V and Thomsen, Rune and Tobiasen, Heidi and Vang, Søren and Nordentoft, Iver and Lamy, Philippe and Kannerup, Anne-Sofie and Mortensen, Frank V and Stribolt, Katrine and Hamilton-Dutoit, Stephen and Nielsen, Hans J and Laurberg, Søren and Pallisgaard, Niels and Pedersen, Jakob S and Ørntoft, Torben F and Andersen, Claus L
Gut, ISSN 0017-5749, 04/2016, Volume 65, Issue 4, pp. 625 - 634
ObjectiveTo develop an affordable and robust pipeline for selection of patient-specific somatic structural variants (SSVs) being informative about radicality... 
COLON-CANCER | SURVIVAL | PLASMA | BRAF MUTATIONS | QUANTIFICATION | CURATIVE RESECTION | KRAS | GASTROENTEROLOGY & HEPATOLOGY | CELL-FREE DNA | Colorectal Neoplasms - surgery | Colorectal Neoplasms - genetics | Humans | Middle Aged | Neoplasm Recurrence, Local | Male | Sequence Analysis, DNA | Biomarkers, Tumor - blood | DNA, Neoplasm - blood | Colorectal Surgery | Sensitivity and Specificity | Polymerase Chain Reaction | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Colorectal Neoplasms - pathology | Neoplasm Staging | Care and treatment | Usage | DNA | Colorectal cancer | Adjuvant treatment | Diagnosis | Research | Cancer | Intervention | Antigens | Chemotherapy | Surveillance | Pipelines | Surgery | Mutation | Metastasis | Genetic testing | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors
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2. Manglende kompetencer hos nye speciallæger i kirurgi - intet nyt under solen
by Laurberg, Søren
Ugeskrift for Laeger, ISSN 0041-5782, 2018, Volume 180, Issue 4, pp. 310 - 311
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3. Full Text Primary fecal diversion and bowel dysfunction in restorative proctocolectomy for ulcerative colitis: a nationwide cross-sectional study
by Mark-Christensen, Anders and Brandsborg, Søren and Laurberg, Søren
International Journal of Colorectal Disease, ISSN 0179-1958, 2/2018, Volume 33, Issue 2, pp. 223 - 229
The aim of this study was to explore the effects of primary fecal diversion on the risk of pouch dysfunction.Patients operated with an ileal pouch-anal... 
Restorative proctocolectomy | Questionnaire | Medicine & Public Health | Surgery | Hepatology | Gastroenterology | Internal Medicine | Bowel dysfunction | Proctology | Ileal pouch-anal anastomosis | Ulcerative colitis | SEPTIC COMPLICATIONS | SURGERY | RANDOMIZED MULTICENTER TRIAL | RECTUM | SINGLE-CENTER | CANCER | LEAKAGE | LOW ANTERIOR RESECTION | QUALITY-OF-LIFE | GASTROENTEROLOGY & HEPATOLOGY | POUCH-ANAL ANASTOMOSIS | DEFUNCTIONING ILEOSTOMY | Analysis | Inflammatory bowel disease | Intestine | Abscesses | Anastomosis | Feces | Pelvis | Age
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4. Full Text Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis
by Thorsen, Kasper and Schepeler, Troels and Øster, Bodil and Rasmussen, Mads H and Vang, Søren and Wang, Kai and Hansen, Kristian Q and Lamy, Philippe and Pedersen, Jakob S and Eller, Asger and Mansilla, Francisco and Laurila, Kirsti and Wiuf, Carsten and Laurberg, Søren and Dyrskjøt, Lars and Ørntoft, Torben F and Andersen, Claus L
BMC Genomics, ISSN 1471-2164, 10/2011, Volume 12, Issue 1, pp. 505 - 505
Background: Approximately half of all human genes use alternative transcription start sites (TSSs) to control mRNA levels and broaden the transcriptional... 
CELLS | CONSERVATION | MESSENGER-RNA | DATABASE | PROMOTERS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEQUENCE | GENETICS & HEREDITY | COLON | HUMAN GENES | EXPRESSION | PREDICTION | Protein Kinases - metabolism | Promoter Regions, Genetic | Protein Kinases - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Alternative Splicing | Oligonucleotide Array Sequence Analysis | Exons | Colorectal Neoplasms - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | RNA, Messenger - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Carrier Proteins - genetics | Receptors, Steroid | Carrier Proteins - metabolism | Protein Isoforms - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Transcription Initiation Site | Checkpoint Kinase 1 | Colorectal Neoplasms - pathology | Wnt Signaling Pathway | Cohort Studies | Protein Isoforms - genetics | Care and treatment | Exon (Molecular genetics) | Colorectal cancer | Physiological aspects | Genetic aspects | Diagnosis | Research | Genetic transcription | Liver cancer | Brain | Hospitals | Mortality | Genomes | Gene expression | Bioinformatics | Manuscripts | Binding sites
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5. Full Text Clinical implications of monitoring circulating Tumor DNA in patients with colorectal cancer
by Schøler, Lone V and Reinert, Thomas and Ørntoft, Mai-Britt W and Kassentoft, Christine G and Arnadøttir, Sigrid S and Vang, Søren and Nordentoft, Iver and Knudsen, Michael and Lamy, Philippe and Andreasen, Ditte and Mortensen, Frank V and Knudsen, Anders R and Stribolt, Katrine and Sivesgaard, Kim and Mouritzen, Peter and Nielsen, Hans J and Laurberg, Søren and Ørntoft, Torben F and Andersen, Claus L
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 18, pp. 5437 - 5445
Purpose: We investigated whether detection of ctDNA after resection of colorectal cancer identifies the patients with the highest risk of relapse and,... 
INTENSIVE FOLLOW-UP | COLON-CANCER | MORTALITY | METAANALYSIS | ONCOLOGY | RESECTION | STAGE | RECURRENCE | CARCINOEMBRYONIC ANTIGEN | ADJUVANT THERAPY | CARCINOMA | Colorectal Neoplasms - mortality | Recurrence | Prognosis | Prospective Studies | Liquid Biopsy - methods | Colorectal Neoplasms - genetics | Humans | Memory, Episodic | Tomography, X-Ray Computed | Circulating Tumor DNA | Biomarkers, Tumor | Colorectal Neoplasms - diagnosis | Colorectal Neoplasms - therapy | Neoplasm Metastasis | Neoplasm, Residual - diagnosis | Neoplasm Staging | Intervention | Liver | Colorectal carcinoma | Colorectal cancer | Health risks | Minimal residual disease | Patients | Metastases | Lead time | Confidence intervals | Computed tomography | Experimental design | Surgery | Mutation | Deoxyribonucleic acid--DNA | Cancer
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6. Manglende kompetencer hos nye speciallæger i kirurgi – intet nyt under solen
by Laurberg, Søren
Ugeskrift for laeger, 02/2018, Volume 180, Issue 8
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7. Full Text SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism
by Christensen, Lise Lotte and True, Kirsten and Hamilton, Mark P and Nielsen, Morten M and Damas, Nkerorema D and Damgaard, Christian K and Ongen, Halit and Dermitzakis, Emmanouil and Bramsen, Jesper B and Pedersen, Jakob S and Lund, Anders H and Vang, Søren and Stribolt, Katrine and Madsen, Mogens R and Laurberg, Søren and McGuire, Sean E and Ørntoft, Torben F and Andersen, Claus L
Molecular Oncology, ISSN 1574-7891, 10/2016, Volume 10, Issue 8, pp. 1266 - 1282
It is well established that lncRNAs are aberrantly expressed in cancer where they have been shown to act as oncogenes or tumor suppressors. RNA profiling of... 
SNHG16 | Long non-coding RNAs | AGO-CLIP | Wnt pathway | Functional analyses | Colorectal cancer | CELLS | PROTEIN | TRANSCRIPTION | LONG-NONCODING-RNA | IDENTIFICATION | TRANSLATION | ONCOLOGY | POOR-PROGNOSIS | SIRNA | EXPRESSION | BINDING | Cell Proliferation - genetics | Nucleotide Motifs - genetics | Colorectal Neoplasms - genetics | HCT116 Cells | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Apoptosis - genetics | Cytoplasm - metabolism | Up-Regulation - genetics | RNA, Long Noncoding - genetics | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-myc - metabolism | Cell Movement - genetics | Gene Knockdown Techniques | Transcription Factors - metabolism | RNA, Small Nucleolar - metabolism | Wnt Signaling Pathway - genetics | Polyribosomes - metabolism | Lipid Metabolism - genetics | Colorectal Neoplasms - pathology | RNA, Long Noncoding - metabolism | Medical colleges | RNA | Genes | DNA binding proteins | Cells | Crosslinked polymers | MicroRNA | Cell death | Nuclear radiation | Analysis | Physiological aspects | Genetic research | Genetic aspects | Molecular biology | Tumors | Cancer | Ets-2 protein | Deregulation | Transcription factors | Dehydrogenases | Immunoprecipitation | Wnt protein | Mucosa | Colorectal carcinoma | Lipids | Genomes | Myc protein | Neuroblastoma | Kinases | Desaturase | Signal transduction | Cell cycle | Conflicts of interest | Colon | Lipid metabolism | MiRNA | Stearoyl-CoA desaturase | RNA polymerase | Metabolism | Bladder cancer | snoRNA | MicroRNAs | Cell migration | Apoptosis
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8. Full Text Increased Risk of Gallstone Disease Following Colectomy for Ulcerative Colitis
by Mark-Christensen, Anders and Brandsborg, Søren and Laurberg, Søren and Johansen, Niels and Pachler, Jørn Helmut and Thorlacius-Ussing, Ole and Kjær, Mie Dilling and Qvist, Niels and Preisler, Louise and Hillingsø, Jens and Rosenberg, Jacob and Jepsen, Peter
American Journal of Gastroenterology, ISSN 0002-9270, 03/2017, Volume 112, Issue 3, pp. 473 - 478
OBJECTIVES: Biochemical studies suggest that patients who have had a colectomy or restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) are at... 
INFLAMMATORY-BOWEL-DISEASE | CHOLESTEROL CRYSTAL-FORMATION | GALLBLADDER-DISEASE | RESTORATIVE PROCTOCOLECTOMY | LAPAROSCOPIC GASTRIC BYPASS | ABSORPTION | CHOLECYSTECTOMY | GASTROENTEROLOGY & HEPATOLOGY | BILE-ACIDS | POUCH-ANAL ANASTOMOSIS | ILEOSTOMY | Cholecystectomy - statistics & numerical data | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Cholelithiasis - epidemiology | Gallstones - epidemiology | Male | Colectomy | Postoperative Complications - epidemiology | Case-Control Studies | Young Adult | Denmark - epidemiology | Adult | Colitis, Ulcerative - surgery | Female | Proctocolectomy, Restorative
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9. Full Text Significant Individual Variation Between Pathologists in the Evaluation of Colon Cancer Specimens After Complete Mesocolic Excision
by Munkedal, Ditte Louise E and Laurberg, Søren and Hagemann-Madsen, Rikke and Stribolt, Katrine J and Krag, Søren R P and Quirke, Philip and West, Nicholas P
Diseases of the Colon & Rectum, ISSN 0012-3706, 10/2016, Volume 59, Issue 10, pp. 953 - 961
BACKGROUND:After the introduction of complete mesocolic excision, a new pathological evaluation of the resected colon cancer specimen was introduced. This... 
Validation | Colon cancer | Complete mesocolic excision | Pathological evaluation | Surgical quality | SURGERY | SURVIVAL | QUALITY | RESECTION | CENTRAL VASCULAR LIGATION | GASTROENTEROLOGY & HEPATOLOGY | Biopsy - methods | Pathologists - standards | Reproducibility of Results | Colon - pathology | Humans | Mesocolon - pathology | Colectomy - methods | Specimen Handling - methods | Specimen Handling - standards | United Kingdom | Colonic Neoplasms - surgery | Pathology, Clinical - methods | Colonic Neoplasms - pathology | Colectomy - statistics & numerical data | Denmark | Clinical Competence - standards | Observer Variation
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10. Full Text Low Anterior Resection Syndrome Score Development and Validation of a Symptom-Based Scoring System for Bowel Dysfunction After Low Anterior Resection for Rectal Cancer
by Emmertsen, KJ and Laurberg, S
ANNALS OF SURGERY, ISSN 0003-4932, 05/2012, Volume 255, Issue 5, pp. 922 - 928
Objective: The aim of this study was to develop and validate a scoring system for bowel dysfunction after low anterior resection (LAR) for rectal cancer, on... 
COLOANAL ANASTOMOSIS | INSTRUMENT | SURGERY | FECAL INCONTINENCE | INTERSPHINCTERIC RESECTION | MANAGEMENT | POUCH-ANAL-ANASTOMOSIS | LOW RECTAL-CANCER | PATIENT | LIFE | Fecal Incontinence - epidemiology | Rectal Neoplasms - surgery | Humans | Middle Aged | Male | Treatment Outcome | Postoperative Complications - epidemiology | Recovery of Function | Syndrome | Aged, 80 and over | Quality of Life | Adult | Defecation - physiology | Female | Flatulence - epidemiology | ROC Curve | Surveys and Questionnaires | Aged
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11. Full Text Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer
by Bramsen, Jesper Bertram and Rasmussen, Mads Heilskov and Ongen, Halit and Mattesen, Trine Block and Ørntoft, Mai-Britt Worm and Ørntoft, Torben Falck and Árnadóttir, Sigrid Salling and Sandoval, Juan and Laguna, Teresa and Vang, Søren and Øster, Bodil and Lamy, Philippe and Madsen, Mogens Rørbæk and Laurberg, Søren and Esteller, Manel and Dermitzakis, Emmanouil Theophilos and Andersen, Claus Lindbjerg
Cell Reports, ISSN 2211-1247, 05/2017, Volume 19, Issue 6, pp. 1268 - 1280
Colorectal cancer (CRC) is characterized by major inter-tumor diversity that complicates the prediction of disease and treatment outcomes. Recent efforts help... 
molecular subtypes | prognostification | colorectal cancer | archetype | CRC | molecular subtyping | CMS | CRC classification | prognostic biomarker | tumor microenvironment | microbiome | COLON-CANCER | INSTABILITY | DECONVOLUTION | DENDRITIC CELLS | GENE-EXPRESSION | NEUTROPHILS | DISTINCT TUMOR | DIFFERENTIATION | STAGE-II | REVEALS | CELL BIOLOGY | Microbiota | Colorectal Neoplasms - genetics | Humans | Transcriptome | Tumor Microenvironment | Biomarkers, Tumor - genetics | Colorectal Neoplasms - classification | Colorectal Neoplasms - pathology | Biomarkers, Tumor - classification | Case-Control Studies | Prognosis | Cèl·lules canceroses | Colorectal cancer | Cancer cells | Marcadors bioquímics | Pronòstic mèdic | Càncer colorectal | Biochemical markers
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12. Full Text Paradoxical Impact of Ileal Pouch-Anal Anastomosis on Male and Female Fertility in Patients With Ulcerative Colitis
by Pachler, Frederik R and Brandsborg, Søren B and Laurberg, Søren
Diseases of the Colon & Rectum, ISSN 0012-3706, 06/2017, Volume 60, Issue 6, pp. 603 - 607
BACKGROUND:Birth rates in males with ulcerative colitis and ileal pouch-anal anastomosis have not been studied. OBJECTIVE:This study aimed to estimate birth... 
SYSTEM | SURGERY | Ileal pouch-anal anastomosis | PREGNANCY | WOMEN | Restorative proctocolectomy | INFLAMMATORY-BOWEL-DISEASE | Male fertility | Fertility | DYSFUNCTION | Birth rates | GASTROENTEROLOGY & HEPATOLOGY | Ulcerative colitis | Colonic Pouches | Humans | Middle Aged | Male | Young Adult | Adolescent | Denmark - epidemiology | Adult | Colitis, Ulcerative - surgery | Female | Birth Rate | Retrospective Studies | Proctocolectomy, Restorative | Cohort Studies
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13. Full Text Surgery of the Anus, Rectum and Colon, 3rd Edition
by Laurberg, Søren
Diseases of the Colon & Rectum, ISSN 0012-3706, 04/2009, Volume 52, Issue 4, p. 749
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14. Full Text The value of using the faecal immunochemical test in general practice on patients presenting with non-alarm symptoms of colorectal cancer
by Juul, Jakob Søgaard and Hornung, Nete and Andersen, Berit and Laurberg, Søren and Olesen, Frede and Vedsted, Peter
British Journal of Cancer, ISSN 0007-0920, 08/2018, Volume 119, Issue 4, pp. 471 - 479
BACKGROUND: Around 50% of individuals with colorectal cancer (CRC) initially present with non-alarm symptoms. METHODS: We investigated the value of using the... 
MORTALITY | SOCIETY-TASK-FORCE | DIAGNOSIS | POPULATION | REGISTER | PRIMARY-CARE | CONSENSUS UPDATE | ONCOLOGY | OCCULT-BLOOD-TEST | COLONOSCOPY SURVEILLANCE | HEMOGLOBIN CONCENTRATION | Training | Intestine | Colorectal carcinoma | Bowel disease | Colorectal cancer | Alarm systems | Diagnostic systems | Patients | Cancer | Digestive signs and symptoms | Diagnosis
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15. Full Text Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system
by WorsØe, Jonas and Fynne, Lotte and Gregersen, Tine and Schlageter, Vincent and Christensen, Lisbet A and Dahlerup, Jens F and Rijkhoff, Nico J.M and Laurberg, Søren and Krogh, Klaus
BMC Gastroenterology, ISSN 1471-230X, 12/2011, Volume 11, Issue 1, pp. 145 - 145
Background: Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess... 
GASTROINTESTINAL TRANSIT | HALL SENSORS | HEALTHY-SUBJECTS | SCINTIGRAPHY | MEAL | DISORDERS | MANOMETRY | GASTROENTEROLOGY & HEPATOLOGY | NONINVASIVE TOOL | SMALL-BOWEL MOTILITY | CAPSULE ENDOSCOPY | Fasting | Humans | Middle Aged | Male | Peristalsis | Gastric Emptying | Intestine, Small - physiology | Magnets | Gastrointestinal Transit | Magnetometry | Postprandial Period | Statistics, Nonparametric | Capsule Endoscopes | Adult | Female | Measurement | Motility | Research | Gastrointestinal system | Studies | Hepatology | Sensors | Magnetic fields | Small intestine | Experiments | Manuscripts | Methods | Abdomen
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