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1. Full Text Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
by Lavin, Martin F
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 10/2008, Volume 9, Issue 10, pp. 759 - 769
First described over 80 years ago, ataxia-telangiectasia (A-T) was defined as a clinical entity 50 years ago. Although not encountered by most clinicians, it... 
MRE11-RAD50-NBS1 COMPLEX | NIJMEGEN BREAKAGE SYNDROME | DNA-DAMAGE RESPONSE | V(D)J RECOMBINATION | DOUBLE-STRAND BREAKS | ACTIVATES ATM | ATM-DEPENDENT PHOSPHORYLATION | MRN COMPLEX | IONIZING-RADIATION | S-PHASE CHECKPOINT | CELL BIOLOGY | Metabolic Syndrome - etiology | Neoplasms - etiology | Humans | Neoplasms - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Ataxia Telangiectasia - complications | Ataxia Telangiectasia - physiopathology | DNA-Binding Proteins - physiology | Genetic Predisposition to Disease | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Insulin Resistance | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Tumor Suppressor Proteins - physiology | Animals | Models, Biological | DNA Repair | Ataxia Telangiectasia - genetics | Mice | Protein Processing, Post-Translational | DNA Damage | Mutation | Nerve Degeneration | Cell Cycle Proteins - physiology | Ataxia telangiectasia | Genetic aspects | Cellular signal transduction | Research | DNA damage | Risk factors
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2. Full Text A phylogeny of legumes (Leguminosae) based on analysis of the plastid matK gene resolves many well-supported subclades within the family
by Wojciechowski, Martin F and Lavin, Matt and Sanderson, Michael J
American Journal of Botany, ISSN 0002-9122, 11/2004, Volume 91, Issue 11, pp. 1846 - 1862
Phylogenetic analysis of 330 plastid matK gene sequences, representing 235 genera from 37 of 39 tribes, and four outgroup taxa from eurosids I supports many... 
Legumes | Taxa | Alkaloids | Monophyly | Systematics | Botanical gardens | Parsimony | Phylogenetics | Phylogeny | Plastids | Genera | matK | phylogeny | papilionoid legumes | caesalpinioid legumes | Leguminosae | mimosoid legumes | Mimosoid legumes | Caesalpinioid legumes | Papilionoid legumes | Genetic research | Beans | Mimosaceae | Phylogeny (Botany)
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3. Full Text SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress
by Ho, Uda and Luff, John and James, Alexander and Lee, Cheok Soon and Quek, Hazel and Lai, Hui‐Chi and Apte, Simon and Lim, Yi Chieh and Lavin, Martin F and Roberts, Tara L
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2019, Volume 23, Issue 12, pp. 8151 - 8160
Suppressor of morphogenesis in genitalia 1 (SMG1) and ataxia telangiectasia mutated (ATM) are members of the PI3‐kinase like–kinase (PIKK) family of proteins.... 
cancer | inflammation | DNA damage | oxidative stress | lymphoma | Flow cytometry | Oxidative stress | Animal models | Lung cancer | Kinases | Experiments | Morphogenesis | Cell cycle | Ataxia | Research centers | Deoxyribonucleic acid--DNA | Genotypes | Medical research | Genitalia | Cytokines | Health risks | Histology | Breast cancer | Inflammation | Embryos | Heterozygosity | Animals | Alleles | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Software | Lymphomas | Cancer | Tumors | Original
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4. Full Text Generating SM(a)RTer Compounds for Translation Termination Suppression in A-T and Other Genetic Disorders
by Lavin, Martin F
Molecular Therapy, ISSN 1525-0016, 09/2013, Volume 21, Issue 9, pp. 1650 - 1652
Reading of the genetic code through nonsense mutations to restore protein function is a concept that dates back 50 years, with the discovery that streptomycin... 
MEDICINE, RESEARCH & EXPERIMENTAL | CODONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | STRESS | ATAXIA-TELANGIECTASIA | CANCER | Triazoles - pharmacology | Acetanilides - pharmacology | Codon, Terminator - drug effects | Humans | Ataxia Telangiectasia - drug therapy | Codon, Nonsense | Thiourea - pharmacology | Ataxia Telangiectasia Mutated Proteins - genetics | Benzodioxoles - pharmacology | Thiourea - analogs & derivatives
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5. Full Text ATM Activation and DNA Damage Response
by Lavin, Martin F and Kozlov, Sergei
Cell Cycle, ISSN 1538-4101, 04/2007, Volume 6, Issue 8, pp. 931 - 942
Well before the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) was described it was evident from the clinical, molecular and... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Cell cycle checkpoints | ATM activation | Autophosphorylation | Chromatin | Mre11 complex | DNA damage | TELOMERIC PROTEIN PIN2/TRF1 | DEPENDENT PHOSPHORYLATION | DOUBLE-STRAND BREAKS | HISTONE H2AX | chromatin | S-PHASE CHECKPOINT | CELL BIOLOGY | autophosphorylation | CELL-CYCLE PHASE | IN-VIVO | TELANGIECTASIA-MUTATED ATM | cell cycle checkpoints | IONIZING-RADIATION | ATAXIA-TELANGIECTASIA | Protein Kinases - metabolism | DNA-Binding Proteins - physiology | Phosphorylation | Tumor Suppressor Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Protein Processing, Post-Translational - physiology | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Animals | DNA Damage - physiology | Models, Biological | Cell Cycle - physiology | Protein-Serine-Threonine Kinases - metabolism
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6. Full Text The appropriateness of the mouse model for ataxia-telangiectasia: Neurological defects but no neurodegeneration
by Lavin, Martin F
DNA Repair, ISSN 1568-7864, 08/2013, Volume 12, Issue 8, pp. 612 - 619
Patients with ataxia-telangiectasia (A-T) are characterised by genome instability, cancer predisposition and a progressive neurodegeneration. A number of model... 
Ataxia-telangiectasia | Atm | Mouse models | Neurodegeneration | PURKINJE-CELLS | ACTIVATION | DNA-DAMAGE | NEURAL-NETWORKS | GENETICS & HEREDITY | ACETYL CYSTEINE | MITOCHONDRIAL DYSFUNCTION | TOXICOLOGY | INCREASED OXIDATIVE STRESS | ATM-DEFICIENT MICE | GENE-PRODUCT | CELLULAR-RESPONSE | Genomic Instability | Neurons - pathology | Brain - cytology | Genetic Predisposition to Disease | Neurodegenerative Diseases - pathology | Ataxia Telangiectasia Mutated Proteins - metabolism | Neurodegenerative Diseases - genetics | Neurons - cytology | Brain - metabolism | Phenotype | Animals | Ataxia Telangiectasia - pathology | Brain - pathology | Ataxia Telangiectasia - genetics | Mice | Neurons - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Disease Models, Animal | Ataxia telangiectasia | Ataxia | Nervous system diseases | Automated teller machines | Analysis
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7. Full Text The complexity of p53 stabilization and activation
by Lavin, Martin F and Gueven, N
Cell Death and Differentiation, ISSN 1350-9047, 06/2006, Volume 13, Issue 6, pp. 941 - 950
A number of proteins are activated by stress stimuli but none so spectacularly or with the degree of complexity as the tumour suppressor p53 (human p53 gene or... 
Cellular stress | Post-translational modifications | Other factors | Cell cycle control | p53 | TRANSCRIPTIONAL ACTIVITY | DAMAGE-INDUCED PHOSPHORYLATION | UBIQUITIN-PROTEIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ATM-DEPENDENT PHOSPHORYLATION | cell cycle control | cellular stress | other factors | CELL BIOLOGY | P53-MEDIATED G ARREST | IN-VIVO | TUMOR-SUPPRESSOR | POLY(ADP-RIBOSE) POLYMERASE-1 | post-translational modifications | IONIZING-RADIATION | Protein Kinases - metabolism | Mutagens - toxicity | Phosphorylation | Apoptosis - drug effects | Apoptosis - radiation effects | Cell Cycle - radiation effects | Humans | Tumor Suppressor Protein p53 - metabolism | Ubiquitin - metabolism | Protein Processing, Post-Translational - radiation effects | DNA - radiation effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Protein Processing, Post-Translational - drug effects | Acetylation | DNA Damage | Cell Cycle - drug effects | Proto-Oncogene Proteins c-mdm2 - metabolism | DNA - drug effects
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8. Full Text ATM Activation by Oxidative Stress
by Zhi Guo and Sergei Kozlov and Martin F. Lavin and Maria D. Person and Tanya T. Paull
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6003, pp. 517 - 521
The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex... 
Oxidative stress | Phosphorylation | Lymphocytes | DNA | DNA damage | REPORTS | Disulfides | Ataxia telangiectasia | Oxidation | Dimers | Genetic mutation | CELLS | PROTEIN | ANTIOXIDANTS | PHOSPHORYLATION | MANGANESE | TELANGIECTASIA GENE-PRODUCT | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | PURIFICATION | DEFICIENT MICE | ATAXIA-TELANGIECTASIA | Disulfides - metabolism | Tumor Suppressor Proteins - metabolism | Oxidative Stress | Humans | Hydrogen Peroxide | Cell Cycle Proteins - metabolism | DNA Repair Enzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Animals | DNA Repair | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Ataxia Telangiectasia - genetics | Cysteine - metabolism | Enzyme Activation | Mutation | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Ataxia Telangiectasia - enzymology | Influence | Genetic aspects | Research | Properties | Protein kinases | Cellular biology | Kinases | Stresses | Cysteine | Pathways | Deoxyribonucleic acid | Cascades | Activation | Automated teller machines
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9. Full Text Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study
by Yaxley, John W, FRACS and Coughlin, Geoffrey D, FRACS and Chambers, Suzanne K, Prof and Occhipinti, Stefano, PhD and Samaratunga, Hema, FRCPA and Zajdlewicz, Leah, MOrgPsych and Dunglison, Nigel, FRACS and Carter, Rob, Prof and Williams, Scott, MBBS and Payton, Diane J, FRCPA and Perry-Keene, Joanna, FRCPA and Lavin, Martin F, Prof and Gardiner, Robert A, Prof
Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10049, pp. 1057 - 1066
Summary Background The absence of trial data comparing robot-assisted laparoscopic prostatectomy and open radical retropubic prostatectomy is a crucial... 
Internal Medicine | LYMPH-NODE DISSECTION | TRIAL | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | POSITIVE SURGICAL MARGINS | COMPLICATIONS | QUALITY-OF-LIFE | SCALE | INDEX | CANCER | ERECTILE DYSFUNCTION | Postoperative Complications - etiology | Prostatectomy - methods | Robotic Surgical Procedures | Prostatic Neoplasms - surgery | Comorbidity | Humans | Middle Aged | Self Report | Male | Treatment Outcome | Laparoscopy | Prostatic Neoplasms - physiopathology | Prostatectomy - adverse effects | Penile Erection | Quality of Life | Adult | Aged | Urination | Queensland | Robotic surgery | Clinical trials | Laparoscopic surgery | Prostate cancer | Robots | Analysis | Studies | Surgical outcomes | Surgery | Patients | Prostate | Robotics | Quality of life
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10. Full Text Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats
by Zhang, Enguo and Yang, Ye and Chen, Shangya and Peng, Cheng and Lavin, Martin F and Yeo, Abrey J and Li, Chao and Liu, Xiaoshan and Guan, Yingjun and Du, Xinjing and Du, Zhongjun and Shao, Hua
Stem Cell Research and Therapy, ISSN 1757-6512, 11/2018, Volume 9, Issue 1, pp. 311 - 14
Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous... 
Animal model | Bone marrow mesenchymal stem/stromal cells (BMSCs) | Transplantation | Cell therapy | Pulmonary fibrosis | Silicosis | Cyclin D1 - metabolism | Lung - pathology | Phosphorylation | Cell Proliferation | Bone Marrow Cells - cytology | Hydroxyproline - metabolism | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | Pulmonary Fibrosis - pathology | Glycogen Synthase Kinase 3 beta - metabolism | Rats, Sprague-Dawley | beta Catenin - metabolism | Animals | Pulmonary Fibrosis - diagnostic imaging | Silicon Dioxide | Mesenchymal Stem Cells - cytology | Epithelial-Mesenchymal Transition | Pulmonary Fibrosis - chemically induced | Pulmonary Fibrosis - metabolism | Mesenchymal Stem Cell Transplantation | Suspensions | Wnt Signaling Pathway
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