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1. Legami di Luigi Settembrini con la calabria e la Basilicata
by Laviola, Giovanni
1981, 1. ed. --, 77
Settembrini, Luigi, 1813-1876 | Statesmen | Biography
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2. Full Text Cardiovascular disease and glycemic control in type 2 diabetes: now that the dust is settling from large clinical trials
by Giorgino, Francesco and Leonardini, Anna and Laviola, Luigi
Annals of the New York Academy of Sciences, ISSN 0077-8923, 04/2013, Volume 1281, Issue 1, pp. 36 - 50
The relationship between glucose control and cardiovascular outcomes in type 2 diabetes has been a matter of controversy over the years. Although... 
blood pressure | lipids | type 2 diabetes | VADT | macrovascular disease | HbA | glucagon‐like peptide‐1 | hypoglycemia | ACCORD | ADVANCE | Type 2 diabetes | Glucagon-like peptide-1 | Lipids | Blood pressure | Macrovascular disease | Hypoglycemia | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | SEVERE HYPOGLYCEMIA | MULTIDISCIPLINARY SCIENCES | glucagon-like peptide-1 | POSITION STATEMENT | NONDIABETIC PATIENTS | ALL-CAUSE MORTALITY | HbA(1c) | INSULIN-RESISTANCE | ACUTE MYOCARDIAL-INFARCTION | MULTIFACTORIAL INTERVENTION | BLOOD-PRESSURE CONTROL | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Risk Factors | Diabetes Mellitus, Type 2 - epidemiology | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - blood | Animals | Clinical Trials as Topic - trends | Glycemic Index - physiology | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Clinical Trials as Topic - methods | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Glycemic Index - drug effects | Cardiovascular disease | Diabetes | Original | HbA1c
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3. The IGF-I signaling pathway
by Laviola, Luigi and Natalicchio, Annalisa and Giorgino, Francesco
Current Pharmaceutical Design, ISSN 1381-6128, 03/2007, Volume 13, Issue 7, pp. 663 - 669
The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell... 
PI 3-kinase | IGF-I receptor | Akt | Insulin receptor | ERK | 3T3-L1 ADIPOCYTES | MYOBLAST DIFFERENTIATION | PHOSPHATIDYLINOSITOL 3-KINASE | CYTOPLASMIC DOMAINS | TRANSDUCTION PATHWAYS | GLYCOGEN-SYNTHASE KINASE-3-BETA | SH2 DOMAIN | PHARMACOLOGY & PHARMACY | insulin receptor | INSULIN-RECEPTOR SUBSTRATE-1 | PROTEIN-TYROSINE-PHOSPHATASE | GROWTH-FACTOR-I | Brain - metabolism | Receptor, IGF Type 1 - metabolism | Insulin-Secreting Cells - metabolism | Animals | Signal Transduction | Humans | Myocardium - metabolism | Muscle, Skeletal - metabolism | Insulin-Like Growth Factor I - metabolism
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4. Full Text Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases
by Incalza, Maria Angela and D'Oria, Rossella and Natalicchio, Annalisa and Perrini, Sebastio and Laviola, Luigi and Giorgino, Francesco
Vascular Pharmacology, ISSN 1537-1891, 2017, Volume 100, pp. 1 - 19
Abstract Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as important second messengers within the cells; however, an... 
Cardiovascular | ER stress | Hyperglycemia | Inflammation | Lipotoxicity | Endothelium | INTERCELLULAR-ADHESION MOLECULE-1 | NITRIC-OXIDE SYNTHASE | LOW-DENSITY-LIPOPROTEIN | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | TUMOR-NECROSIS-FACTOR | OSCILLATORY SHEAR-STRESS | PHARMACOLOGY & PHARMACY | IDIOPATHIC PULMONARY-FIBROSIS | NF-KAPPA-B | EXTRACELLULAR-SUPEROXIDE DISMUTASE | TYPE-2 DIABETES-MELLITUS | Oxidative stress | Cardiovascular disease | Damage prevention | Risk factors | Second messengers | Antioxidants | Atherosclerosis | Aging | Heart diseases | Hypertension | Oxygen | Phenotypes | MiRNA | Health risks | Blood vessels | Bioavailability | Risk analysis | Molecular chains | Endothelial cells | Intermediates | Diseases | Nitric oxide | Arteriosclerosis | Cardiovascular diseases | Metabolic disorders
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5. Full Text The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis
by Sebastio Perrini and Luigi Laviola and Marcos C Carreira and Angelo Cignarelli and Annalisa Natalicchio and Francesco Giorgino
Journal of Endocrinology, ISSN 0022-0795, 06/2010, Volume 205, Issue 3, pp. 201 - 210
The widespread increase in life expectancy is accompanied by an increased prevalence of features of physical frailty. Signs and symptoms may include sarcopenia... 
IGF-I | MINERAL DENSITY | MESSENGER-RNA EXPRESSION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | BODY-MASS INDEX | CELL-PROLIFERATION | HORMONE REPLACEMENT THERAPY | INSULIN-RECEPTOR SUBSTRATE-1 | AGING MEN | GROWTH-FACTOR-I | Bone and Bones - physiopathology | Sarcopenia - physiopathology | Animals | Growth Hormone - physiology | Insulin-Like Growth Factor I - physiology | Humans | Muscle, Skeletal - physiopathology | Signal Transduction - physiology | Osteoporosis - physiopathology | Disease Models, Animal
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6. Full Text Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
by Vaccaro, Olga and Masulli, Maria and Nicolucci, Antonio and Bonora, Enzo and Del Prato, Stefano and Maggioni, Aldo Pietro and Maggioni, Aldo P and Rivellese, Angela A and Rivellese, Angela Albarosa and Squatrito, Sebastiano and Giorda, Carlo B and Sesti, Giorgio and Mocarelli, Paolo and Lucisano, Giuseppe and Sacco, Michele and Signorini, Stefano and Cappellini, Fabrizio and Perriello, Gabriele and Babini, Massimiliano and Babini, Anna Carla and Lapolla, Annunziata and Gregori, Giovanna and Giordano, Carla and Corsi, Simona and Corsi, Laura and Corsi, Anna and Buzzetti, Raffaella and Clemente, Gennaro and Di Cianni, Graziano and Iannarelli, Rossella and Cordera, Renzo and La Macchia, Olga and Zamboni, Chiara and Scaranna, Cristiana and Boemi, Massimo and Iovine, Ciro and Lauro, Davide and Leotta, Sergio and Dall'Aglio, Elisabetta and Cannarsa, Emanuela and Tonutti, Laura and Pugliese, Giuseppe and Bossi, Antonio C and Bossi, Antonio Carlo and Anichini, Roberto and Dotta, Francesco and Di Benedetto, Antonino and Citro, Giuseppe and Antenucci, Daniela and Ricci, Lucia and Giorgino, Francesco and Santini, Costanza and Gnasso, Agostino and De Cosmo, Salvatore and Zavaroni, Donatella and Vedovato, Monica and Consoli, Agostino and Calabrese, Maria and di Bartolo, Paolo and Fornengo, Paolo and Riccardi, Gabriele and D'Angelo, Federica and D'Angelo, Paola and Giansanti, Roberto and Tanase, Laura and Lanari, Luigi and Testa, Ivano and Pancani, Francesca and Ranchelli, Anna and Vagheggi, Paolo and Scatona, Alessia and Fontana, Lucia and Laviola, Luigi and Tarantino, Lucia and Ippolito, Claudia and Ippolito, Giulio and Gigantelli, Vittoria and Manicone, Mariangela and Conte, Eleonora and Trevisan, Roberto and Rota, Giuseppe and Rota, Rossella and Dodesini, Alessandro R and Reggiani, Giulio Marchesini and Montesi, Luca and Mazzella, Natalia and Forlani, Gabriele and Caselli, Chiara and Di Luzio, Raffaella and Mazzotti, Arianna and Aiello, Antimo and Barrea, Angelina and Musto, Antonio and D'Amico, Fiorentina and Sinagra, Tiziana and Longhitano, Sara and Trowpea, Vanessa and Sparti, Maria and Italia, Salvatore and Lisi, Enrico and ... and Thizolidinediones Sulfonylureas Ca and Italian Diabetes Society and Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) study group
The Lancet Diabetes & Endocrinology, ISSN 2213-8587, 11/2017, Volume 5, Issue 11, pp. 887 - 897
The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We... 
MORTALITY | INSULIN | GLYCEMIC CONTROL | IMPACT | METAANALYSIS | GLUCOSE-LOWERING DRUGS | ENDOCRINOLOGY & METABOLISM | FOLLOW-UP | RISK | GLIMEPIRIDE | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Metformin - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Pioglitazone | Sulfonylurea Compounds - therapeutic use | Male | Treatment Outcome | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Thiazolidinediones - therapeutic use | Cardiovascular Diseases - epidemiology | Female | Aged | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications
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7. Full Text 2266-PUB: Effects of Combined Exercise Protocols on Glucose Variability in Patients with Autoimmune Diabetes on CSII Therapy
by CIGNARELLI, ANGELO and LISCO, GIUSEPPE and GIOIA, LUDOVICO DI and NATALICCHIO, ANNALISA and PERRINI, SEBASTIO and LAVIOLA, LUIGI and GIORGINO, FRANCESCO
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 2266
Physical exercise may profoundly affect glucose variability (GV) in insulinopenic diabetes leading to both hypo- and hyperglycemia and feeling of discomfort... 
Hyperglycemia | Exercise | Statistical analysis | Diabetes mellitus | Diabetes | Glucose | Autoimmune diseases | Insulin
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8. Full Text 1762-P: Insulin Receptor Isoforms in Human Adipose Tissue and Adipose Stem Cells
by GENCHI, VALENTINA ANNAMARIA and CIGNARELLI, ANGELO and PERRINI, SEBASTIO and PORRO, STEFANIA and CACCIOPPOLI, CRISTINA and NATALICCHIO, ANNALISA and LAVIOLA, LUIGI and GIORGINO, FRANCESCO
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1762
Insulin regulates the development and metabolism of adipose tissue (AT) by activating its tyrosine kinase receptor in this tissue. The insulin receptor (IR)... 
Tyrosine | Phosphorylation | Adipose tissue | AKT protein | Adipocytes | Gene expression | Insulin | Developmental stages | Isoforms | Stem cells | Protein-tyrosine kinase receptors | Lipogenesis | Protein-tyrosine kinase | Adipogenesis
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9. Full Text 1763-P: The Secretome from Visceral Adipose Stem Cells of Obese Subjects Induces Apoptosis and Insulin Resistance in Cardiac Progenitor Cells
by PORRO, STEFANIA and PERRINI, SEBASTIO and CACCIOPPOLI, CRISTINA and DORIA, ROSSELLA and GENCHI, VALENTINA ANNAMARIA and CIGNARELLI, ANGELO and NATALICCHIO, ANNALISA and LAVIOLA, LUIGI and GIORGINO, FRANCESCO
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1763
Increased abdominal visceral adipose tissue (VAT) is associated with cardiovascular risk in metabolically unhealthy subjects. The viability of cardiac... 
Heart | Obesity | Auricle | Phosphorylation | Adipose tissue | Secretion | Caspase | AKT protein | Immunoblotting | Secretome | Adipocytes | Glucose | Caspase-3 | Insulin | Progenitor cells | Biopsy | Stem cells | Insulin resistance | Cardiovascular diseases | Enzyme-linked immunosorbent assay | Apoptosis
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10. Full Text GLP‐1 receptor agonist added to insulin versus basal‐plus or basal‐bolus insulin therapy in type 2 diabetes: A systematic review and meta‐analysis
by Castellana, Marco and Cignarelli, Angelo and Brescia, Francesco and Laviola, Luigi and Giorgino, Francesco
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 01/2019, Volume 35, Issue 1, pp. e3082 - n/a
Background Current guidelines recommend that antihyperglycaemic treatment in patients with type 2 diabetes not achieving the HbA(1c) target on basal insulin... 
type 2 diabetes mellitus | meta‐analysis | glucagon‐like peptide‐1 receptor agonist | insulin | systematic review | HbA | meta-analysis | glucagon-like peptide-1 receptor agonist | COMBINATION THERAPY | GLARGINE U100 | OPEN-LABEL | ALBIGLUTIDE | DEGLUDEC | LIXISENATIDE | HbA(1c) | LIRAGLUTIDE | ENDOCRINOLOGY & METABOLISM | HYPOGLYCEMIA | OUTCOMES | PRANDIAL INSULIN | Glucagon | Prospero protein | Diabetes mellitus | Body weight | Clinical trials | Systematic review | Body weight loss | Diabetes | Hypoglycemia | Diabetes mellitus (non-insulin dependent) | Insulin | Patients
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11. Full Text Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy
by Rossi, Luigi and Nicoletti, Maria Celeste and Carmosino, Monica and Mastrofrancesco, Lisa and Di Franco, Antonella and Indrio, Francesca and Lella, Rossella and Laviola, Luigi and Giorgino, Francesco and Svelto, Maria and Gesualdo, Loreto and Procino, Giuseppe
Journal of Diabetes Research, ISSN 2314-6745, 2017, Volume 2017, pp. 4360357 - 13
Diabetic nephropathy (DN) is a microangiopathic complication of diabetes mellitus (DM) affecting one-third of diabetic patients. The large variability in the... 
MEDICINE, RESEARCH & EXPERIMENTAL | CHANNEL | INCREASE | DISEASE | ENDOCRINOLOGY & METABOLISM | VASOPRESSIN | EXOSOMES | MELLITUS | AQP2 | EXPRESSION | WATER-BALANCE DISORDERS | RENAL-INSUFFICIENCY | Diabetic Nephropathies - urine | Aquaporin 2 - urine | Biomarkers - urine | Humans | Middle Aged | Male | Aquaporin 5 - urine | Diabetes Mellitus, Type 2 - urine | Diabetic Nephropathies - diagnosis | Albuminuria - diagnosis | Female | Aged | Albuminuria - urine
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12. Full Text The myokine irisin is released in response to saturated fatty acids and promotes pancreatic β-cell survival and insulin secretion
by Natalicchio, Annalisa and Marrano, Nicola and Biondi, Giuseppina and Spagnuolo, Rosaria and Labarbuta, Rossella and Porreca, Immacolata and Cignarelli, Angelo and Bugliani, Marco and Marchetti, Piero and Perrini, Sebastio and Laviola, Luigi and Giorgino, Francesco
Diabetes, ISSN 0012-1797, 11/2017, Volume 66, Issue 11, pp. 2849 - 2856
This study explored the role of irisin as a new pancreatic beta-cell secretagogue and survival factor and its potential role in the communication between... 
PROLIFERATION | GLUCOSE | KINASE | TISSUE | ENDOCRINOLOGY & METABOLISM | Insulin-Secreting Cells - physiology | Islets of Langerhans - drug effects | Fibronectins - pharmacology | Palmitates - toxicity | Apoptosis - drug effects | Humans | Mice, Inbred C57BL | Gene Expression Regulation - physiology | Rats | Male | Glucose | Muscle Fibers, Skeletal - drug effects | Random Allocation | Recombinant Proteins - pharmacology | Fibronectins - metabolism | Insulin - metabolism | Animals | Islets of Langerhans - cytology | Cell Proliferation - drug effects | Fibronectins - genetics | Mice | Insulin Secretion | Cell Survival - physiology | Fatty Acids - pharmacology | Protein kinase A | Cell proliferation | Medical research | Cell culture | Myotubes | Cell survival | Secretion | AKT protein | Biosynthesis | Cell interactions | Palmitic acid | Fatty acids | Insulin | Skeletal muscle | High fat diet | Serum levels | Beta cells | Survival factor | Pancreas | Apoptosis
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13. Attività fisica per la persona con diabete
by Laviola, Luigi and Bonomo, Matteo
Giornale Italiano di Diabetologia e Metabolismo, ISSN 1593-6104, 06/2016, Volume 36, Issue 2, pp. 55 - 56
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14. Full Text 412-P: Oleate Prevents Palmitate-Induced Apoptosis and Autophagy in Human Cardiac Progenitor Cells by Inhibiting p38 MAPK and c-Jun Phosphorylation
by DORIA, ROSSELLA and SCHIPANI, ROSSELLA and CACCIOPPOLI, CRISTINA and INCALZA, MARIA ANGELA and LEONARDINI, ANNA and NATALICCHIO, ANNALISA and PERRINI, SEBASTIO and CIGNARELLI, ANGELO and LAVIOLA, LUIGI and GIORGINO, FRANCESCO
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 412
Elevated circulating levels of saturated fatty acids (SFA; e.g., palmitate) are associated with increased cardiovascular risk in diabetes. In contrast,... 
Heart | Cadaverine | Auricle | Phosphorylation | Transcription factors | Diabetes mellitus | c-Jun protein | Homeostasis | Caspase | MAP kinase | Immunoblotting | Palmitic acid | Caspase-3 | Fatty acids | Autophagy | Progenitor cells | Stem cells | Supplementation | Diabetes | Cardiovascular diseases | Phagocytosis | Enzyme-linked immunosorbent assay | Apoptosis
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15. Full Text Monitoraggio in continuo del glucosio: il ruolo della tecnologia nella gestione del diabete mellito
by Laviola, Luigi and Lisco, Giuseppe and Giorgino, Francesco
L'Endocrinologo, ISSN 1590-170X, 8/2019, Volume 20, Issue 4, pp. 216 - 219
L’utilizzo della tecnologia nella gestione del diabete mellito è incalzante, con particolare riferimento al monitoraggio glicemico. I sistemi di monitoraggio... 
iCGM | Medicine & Public Health | Monitoraggio continuo del glucosio | Metabolic Diseases | CGM | Internal Medicine | Medicine/Public Health, general | Endocrinology | Diabete mellito
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