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1. Full Text Crohn's disease management after intestinal resection: a randomised trial
by De Cruz, Peter, PhD and Kamm, Michael A, Prof and Hamilton, Amy L, BSc and Ritchie, Kathryn J, RN and Krejany, Efrosinia O, MSc and Gorelik, Alexandra, MSc and Liew, Danny, Prof and Prideaux, Lani, PhD and Lawrance, Ian C, Prof and Andrews, Jane M, Prof and Bampton, Peter A, MD and Gibson, Peter R, Prof and Sparrow, Miles, MBBS and Leong, Rupert W, Prof and Florin, Timothy H, Prof and Gearry, Richard B, PhD and Radford-Smith, Graham, PhD and Macrae, Finlay A, Prof and Debinski, Henry, MD and Selby, Warwick, MD and Kronborg, Ian, MBBS and Johnston, Michael J, MBBS and Woods, Rodney, MBBS and Elliott, P Ross, MD and Bell, Sally J, MD and Brown, Steven J, PhD and Connell, William R, MD and Desmond, Paul V, MBBS
Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9976, pp. 1406 - 1417
Summary Background Most patients with Crohn's disease need an intestinal resection, but a majority will subsequently experience disease recurrence and require... 
Internal Medicine | ILEAL RESECTION | SURGERY | ILEOCOLIC RESECTION | MEDICINE, GENERAL & INTERNAL | THERAPY | ADALIMUMAB | POSTOPERATIVE RECURRENCE | POPULATION-BASED COHORT | PREVENTION | AZATHIOPRINE | INFLIXIMAB | Recurrence | Azathioprine - therapeutic use | Humans | Middle Aged | Crohn Disease - surgery | Male | Treatment Outcome | Crohn Disease - therapy | Antibodies, Monoclonal, Humanized - administration & dosage | Crohn Disease - pathology | Mercaptopurine - therapeutic use | Metronidazole - therapeutic use | Colonoscopy | Adult | Female | Adalimumab | Prevention | Hospitals | Australia | Gastrointestinal diseases | Surgery | Studies | Gastrointestinal surgery | Disease management | Drug therapy | Crohns disease | Index Medicus | Abridged Index Medicus
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2. Full Text Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
by Jostins, Luke and Ripke, Stephan and Weersma, Rinse K and Duerr, Richard H and McGovern, Dermot P and Hui, Ken Y and Lee, James C and Schumm, L. Philip and Sharma, Yashoda and Anderson, Carl A and Essers, Jonah and Mitrovic, Mitja and Ning, Kaida and Cleynen, Isabelle and Theatre, Emilie and Spain, Sarah L and Raychaudhuri, Soumya and Goyette, Philippe and Wei, Zhi and Abraham, Clara and Achkar, Jean-Paul and Ahmad, Tariq and Amininejad, Leila and Ananthakrishnan, Ashwin N and Andersen, Vibeke and Anews, Jane M and Baidoo, Leonard and Balschun, Tobias and Bampton, Peter A and Bitton, Alain and Boucher, Gabrielle and Brand, Stephan and Büning, Carsten and Cohain, Ariella and Cichon, Sven and D'Amato, Mauro and de Jong, Dirk and Devaney, Kathy L and Dubinsky, Marla and Edwards, Cathryn and Ellinghaus, David and Ferguson, Lynnette R and Franchimont, Denis and Fransen, Karin and Gearry, Richard and Georges, Michel and Gieger, Christian and Glas, Jürgen and Haritunians, Talin and Hart, Ailsa and Hawkey, Chris and Hedl, Matija and Hu, Xinli and Karlsen, Tom H and Kupcinskas, Limas and Kugathasan, Subra and Latiano, Anna and Laukens, Debby and Lawrance, Ian C and Lees, Charlie W and Louis, Edouard and Mahy, Gillian and Mansfield, John and Morgan, Angharad R and Mowat, Craig and Newman, William and Palmieri, Orazio and Ponsioen, Cyriel Y and Potocnik, Uros and Prescott, Natalie J and Regueiro, Miguel and Rotter, Jerome I and Russell, Richard K and Sanderson, Jeremy D and Sans, Miquel and Satsangi, Jack and Schreiber, Stefan and Simms, Lisa A and Sventoraityte, Jurgita and Targan, Stephan R and Taylor, Kent D and Tremelling, Mark and Verspaget, Hein W and de Vos, Martine and Wijmenga, Cisca and Wilson, David C and Winkelmann, Juliane and Xavier, Ramnik J and Zeissig, Sebastian and Zhang, Bin and Zhang, Clarence K and Zhao, Hongyu and Silverberg, Mark S and Annese, Vito and Hakonarson, Hakon and Brant, Steven R and Radford-Smith, Graham and Mathew, Christopher G and Rioux, John D and Schadt, Eric E and ... and Int IBD Genetics Consortium IIBDGC and International IBD Genetics Consortium (IIBDGC) and The International IBD Genetics Consortium (IIBDGC) and Region Örebro län and Örebro universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 2012, Volume 491, Issue 7422, pp. 119 - 124
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with... 
HYPER-IGE SYNDROME | RISK LOCI | NETWORK | NUMBER | METAANALYSIS | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MUTATIONS | EXPRESSION | Crohn Disease - genetics | Humans | Inflammatory Bowel Diseases - immunology | Colitis, Ulcerative - genetics | Mycobacterium tuberculosis - immunology | Inflammatory Bowel Diseases - physiopathology | Colitis, Ulcerative - immunology | Host-Pathogen Interactions - immunology | Mycobacterium tuberculosis - pathogenicity | Haplotypes - genetics | Mycobacterium - pathogenicity | Mycobacterium Infections - genetics | Inflammatory Bowel Diseases - genetics | Crohn Disease - microbiology | Mycobacterium Infections - microbiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Reproducibility of Results | Mycobacterium - immunology | Crohn Disease - immunology | Genome, Human - genetics | Phenotype | Colitis, Ulcerative - microbiology | Host-Pathogen Interactions - genetics | Polymorphism, Single Nucleotide - genetics | Inflammatory Bowel Diseases - microbiology | Crohn Disease - physiopathology | Colitis, Ulcerative - physiopathology | Inflammatory bowel disease | Candidates | Tuberculosis | Architecture | Genetics | Genomes | Diabetes | Gene expression | Health risk assessment | Immune system | Index Medicus | Rheumatology and Autoimmunity | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
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3. Full Text Maintenance Therapy with Certolizumab Pegol for Crohn's Disease
by Schreiber, Stefan and Khaliq-Kareemi, Mani and Lawrance, Ian C and Thomsen, Ole Østergaard and Hanauer, Stephen B and McColm, Juliet and Bloomfield, Ralph and Sandborn, William J and PRECISE 2 Study Investigators
The New England Journal of Medicine, ISSN 0028-4793, 07/2007, Volume 357, Issue 3, pp. 239 - 250
Patients who had a response to open-label induction treatment with certolizumab pegol were randomly assigned to receive maintenance treatment with certolizumab... 
RHEUMATOID-ARTHRITIS | TRIAL | MEDICINE, GENERAL & INTERNAL | TUMOR-NECROSIS-FACTOR | ADALIMUMAB | PEGYLATED FAB FRAGMENT | CDP870 | INFLIXIMAB | ETANERCEPT | ANTI-TNF AGENTS | FACTOR-ALPHA | Certolizumab Pegol | Follow-Up Studies | Humans | Immunoglobulin Fab Fragments - adverse effects | Immunosuppressive Agents - therapeutic use | Middle Aged | Antibodies | Polyethylene Glycols - adverse effects | Male | Immunoglobulin Fab Fragments - therapeutic use | Polyethylene Glycols - therapeutic use | Antibodies, Monoclonal, Humanized | Injections, Subcutaneous | Anti-Inflammatory Agents - therapeutic use | Adult | Female | C-Reactive Protein - analysis | Drug Therapy, Combination | Double-Blind Method | Antibodies, Antinuclear | Crohn Disease - classification | Treatment Outcome | Crohn Disease - immunology | Remission Induction | Crohn Disease - drug therapy | Adolescent | Aged | Immunoglobulin Fab Fragments - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Drug therapy | Crohn's disease | Clinical trials | Pharmaceutical industry | Bowel disease | Apoptosis | Index Medicus | Abridged Index Medicus
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4. Full Text Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
by Cleynen, Isabelle, PhD and Boucher, Gabrielle, MSc and Jostins, Luke, PhD and Schumm, L Philip, MA and Zeissig, Sebastian, PhD and Ahmad, Tariq, PhD and Andersen, Vibeke, Prof and Andrews, Jane M, Prof and Annese, Vito, MD and Brand, Stephan, Prof and Brant, Steven R, MD and Cho, Judy H, Prof and Daly, Mark J, Prof and Dubinsky, Marla, MD and Duerr, Richard H, Prof and Ferguson, Lynnette R, Prof and Franke, Andre, Prof and Gearry, Richard B, Prof and Goyette, Philippe, PhD and Hakonarson, Hakon, Prof and Halfvarson, Jonas, MD and Hov, Johannes R, PhD and Huang, Hailang, PhD and Kennedy, Nicholas A, PhD and Kupcinskas, Limas, Prof and Lawrance, Ian C, Prof and Lee, James C, PhD and Satsangi, Jack, Prof and Schreiber, Stephan, Prof and Théâtre, Emilie, PhD and van der Meulen-de Jong, Andrea E, MD and Weersma, Rinse K, Prof and Wilson, David C, Prof and Parkes, Miles, PhD and Vermeire, Severine, Prof and Rioux, John D, Prof and Mansfield, John, MD and Silverberg, Mark S, PhD and Radford-Smith, Graham, PhD and McGovern, Dermot P B, Prof and Barrett, Jeffrey C, Dr and Lees, Charlie W, Dr and Int Inflammatory Bowel Dis Genet and Örebro universitet and Institutionen för medicinska vetenskaper
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10014, pp. 156 - 167
Summary Background Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been... 
Internal Medicine | POPULATION | MEDICINE, GENERAL & INTERNAL | INFLAMMATORY-BOWEL-DISEASE | SUSCEPTIBILITY | FOLLOW-UP | CLASSIFICATION | RISK | INDUCTION | CLINICAL-COURSE | MAINTENANCE THERAPY | PRIMARY SCLEROSING CHOLANGITIS | Medicine, Experimental | Genetic research | Medical research | Genetic aspects | Colitis | Inflammatory bowel disease | Genotype & phenotype | Genetics | Colon | Family medical history | Crohns disease | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterology and Hepatology | Gastroenterologi
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5. Full Text Secreted Protein Acidic and Rich in Cysteine (SPARC) Exacerbates Colonic Inflammatory Symptoms in Dextran Sodium Sulphate-Induced Murine Colitis
by Ng, Yoke-Leng and Klopcic, Borut and Lloyd, Frances and Forrest, Cynthia and Greene, Wayne and Lawrance, Ian C
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77575 - e77575
Background: Secreted Protein Acidic and Rich in Cysteine (SPARC) is expressed during tissue repair and regulates cellular proliferation, migration and cytokine... 
INTESTINAL INFLAMMATION | IMMUNE-RESPONSE | NULL MICE EXHIBIT | CELL-MATRIX | MATRICELLULAR PROTEIN | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | MEDIATED COLITIS | EXPRESSION | MOUSE MODELS | BOWEL-DISEASE | Inflammation - pathology | T-Lymphocytes, Regulatory - metabolism | Intestinal Mucosa - metabolism | Cytokines - metabolism | Colon - pathology | Colitis - genetics | Mice, Inbred C57BL | Colon - drug effects | Dextran Sulfate - adverse effects | Lymph Nodes - metabolism | Osteonectin - metabolism | Colitis - pathology | Colon - metabolism | Mice, Knockout | Inflammation - metabolism | Animals | Osteonectin - genetics | Spleen - metabolism | Colitis - chemically induced | Colitis - metabolism | Inflammation - genetics | Female | Mice | Cytokines - genetics | Dextran | Cysteine | Thiols | Tumor necrosis factor | Bone morphogenetic proteins | Inflammation | Colitis | T cells | Transforming growth factors | Enzyme-linked immunosorbent assay | Cystine | Drinking water | Mucosa | Recruitment | Proteins | Restoration | Foxp3 protein | Growth factors | Spleen | Antigens | Wound healing | Cytokines | Diarrhea | Interleukin 12 | Glycoproteins | Leukocytes (neutrophilic) | Interleukin 13 | Gene expression | Inflammatory bowel disease | Sodium | Interleukin 10 | Cell migration | Monocyte chemoattractant protein 1 | Lymph | Flow cytometry | Lymphocytes T | Sodium sulfates | Sulfates | Macrophages | Lymph nodes | Interleukin 6 | Ethics | Interleukin 4 | Interleukin 5 | Endoscopes | Lymphocytes | Intestine | Rodents | Gastroenterology | Interleukin 1 | Tumor necrosis factor-TNF | Colon | Endoscopy | CD11b antigen | Pharmacology | Medicine | Drainage | Cytometry | Immunofluorescence | Chemokines | Index Medicus
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6. Full Text A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies
by Bodea, Corneliu A and Neale, Benjamin M and Ripke, Stephan and Barclay, Murray and Peyrin-Biroulet, Laurent and Chamaillard, Mathias and Colombel, Jean-Frederick and Cottone, Mario and Croft, Anthony and D’Incà, Renata and Halfvarson, Jonas and Hanigan, Katherine and Henderson, Paul and Hugot, Jean-Pierre and Karban, Amir and Kennedy, Nicholas A and Khan, Mohammed Azam and Lémann, Marc and Levine, Arie and Massey, Dunecan and Massey, Dunecan C.O and Milla, Monica and Montgomery, Grant W and Ng, Sok Meng and Ng, Sok Meng Evelyn and Oikonomou, Ioannis and Peeters, Harald and Proctor, Deborah D and Rahier, Jean-Francois and Roberts, Rebecca and Roberts, Rebecca L and Rutgeerts, Paul and Seibold, Frank and Stronati, Laura and Taylor, Kirstin M and Törkvist, Leif and Ublick, Kullak and Van Limbergen, Johan and Van Gossum, André and Van Gossum, Andre and Vatn, Morten H and Zhang, Clarence and Zhang, Hu and Zhang, Wei and Andrews, Jane M and Bampton, Peter A and Florin, Timothy H and Gearry, Richard and Krishnaprasad, Krupa and Lawrance, Ian C and Mahy, Gillian and Radford-Smith, Graham and Simms, Lisa A and Amininijad, Leila and Cleynen, Isabelle and Dewit, Olivier and Franchimont, Denis and Georges, Michel and Laukens, Debby and Theatre, Emilie and Vermeire, Severine and Aumais, Guy and Baidoo, Leonard and Barrie, Arthur M and Beck, Karen and Bernard, Edmond-Jean and Binion, David G and Bitton, Alain and Brant, Steve R and Cho, Judy H and Cohen, Albert and Croitoru, Kenneth and Daly, Mark J and Datta, Lisa W and Deslandres, Colette and Duerr, Richard H and Dutridge, Debra and Ferguson, John and Fultz, Joann and Goyette, Philippe and Greenberg, Gordon R and Haritunians, Talin and Jobin, Gilles and Katz, Seymour and Lahaie, Raymond G and McGovern, Dermot P and Nelson, Linda and Ning, Kaida and Paré, Pierre and Regueiro, Miguel D and Rioux, John D and Ruggiero, Elizabeth and Schumm, L. Philip and Schwartz, Marc and Scott, Carol E and Scott, Richard and Scott, Regan and Sharma, Yashoda and Silverberg, Mark S and Spears, Denise and ... and International IBD Genetics Consortium
The American Journal of Human Genetics, ISSN 0002-9297, 05/2016, Volume 98, Issue 5, pp. 857 - 868
One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative... 
Genetics, Population | Genetic Predisposition to Disease | Disease - genetics | Gene Frequency | Humans | Bayes Theorem | Heredity - genetics | Polymorphism, Single Nucleotide - genetics | Genotype | Software | Case-Control Studies | Genetic Linkage | Genetic research | Usage | Methods | Gaussian processes | Genetics | Disease | Genes | Risk factors | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterology and Hepatology | Gastroenterologi
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