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The New England Journal of Medicine, ISSN 0028-4793, 01/2014, Volume 370, Issue 4, pp. 322 - 333
In two phase 3 trials in patients with Alzheimer's disease, bapineuzumab, a humanized anti–amyloid-beta monoclonal antibody, did not improve clinical outcomes.... 
ANTIBODIES | MEDICINE, GENERAL & INTERNAL | EPITOPE | IMAGING ABNORMALITIES | PEPTIDE | MOUSE MODEL | Phosphorylation | Humans | Middle Aged | Male | Positron-Emission Tomography | Treatment Failure | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Female | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Biomarkers - analysis | Alzheimer Disease - drug therapy | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Cognition - drug effects | Neuropsychological Tests | Amyloid beta-Peptides - antagonists & inhibitors | Apolipoproteins E - genetics | Intention to Treat Analysis | Amyloid beta-Peptides - analysis | Brain - pathology | Aged | Biomarkers - cerebrospinal fluid | Edema - chemically induced | Alzheimer Disease - genetics | Monoclonal antibodies | Product development | Research | Drug therapy | Alzheimer's disease | Health aspects | Edema | Nuclear magnetic resonance--NMR | Intravenous administration | Neurodegenerative diseases | Cognitive ability | Clinical trials | Cerebrospinal fluid | Patients | Studies | Tau protein | Apolipoprotein E | Immunotherapy | Alleles | Dementia disorders | Alzheimers disease | Brain | Neurosciences | pathology | Biological Markers | Antibodies | Cognition | tau Proteins | 80 and over | genetics | Amyloid beta-Peptides | Apolipoproteins E | Monoclonal | Neurovetenskaper | drug therapy | chemically induced | Humanized | drug effects | Alzheimer Disease | analysis | antagonists & inhibitors | cerebrospinal fluid | adverse effects | therapeutic use
Journal Article
by Pogue, Janice and Riddle, Matthew C and Chazova, I and Gilbert, R and Gomis, R and Pīrāgs, V and Bogaty, P and Corson, M and Harper, W.L and Cukierman-Yaffee, T and MacRae, S and Alvarez, N and Amuchastegui, M and Bello, F and Caccavo, A and Calveira, M and Camino, A and Cardone, M and Corinaldesi, F and Crespo, C and Fares Taie, A and Fernandez, A and Ferrari, N and Gutierrez, N and Hasbani, E and Hrabar, A and Lobo Marquez, L and Lugo, M and Mainini, S and Manzano, R and Mendez, N and Odetto, I and Polari, P and Ramirez, A and Sanchez, R and Smith Casabella, T and Streitenberger, P and Villamil, A and Amerena, J and Farshid, A and Lefkovits, J and O'Neal, D and Poynten, A and Simpson, R and Teede, H and Tiong, F and Waddell-Smith, K and Blocher, J and Brath, H and Breuss, J and Jankovic, V and Kann, T and Placher-Sorko, G and Sonnenfeld, M and Vetter, B and Wallner, F and Lazareva, I and Delana, J and Feitosa, G and Garcia, V and Kanedlai, N and Mothe, F and Ninno, T and Oliveira, C and Oliveira, O and Roldan, F and Bailey, A and Belanger, A and Carlson, B and Chagnon, P and Chessex, C and Crepeau, J and Dube, F and Gosselin, G and Harper, W and Ho, K and Hramiak, I and Hutchinson, A and Langlois, M and Lavoie, M and Mercier, M and Nawaz, S and O'Keefe, D and Pruneau, G and Raby, K and Richard, C and Steinson, D and VanRossum, N and Warnica, W and Galloso, R and Stockins, B and Chen, Y and Gao, X and Ji, L and Jia, W and Li, Q and Li, Y and Ling, Y and Lu, B and Peng, Y and ... and The ORIGIN Trial Investigators and ORIGIN Trial Investigators and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Centrum för klinisk forskning, Västerås
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 4, pp. 319 - 328
In this study with a 2-by-2 factorial design, patients with cardiovascular risk factors and dysglycemia or type 2 diabetes received insulin glargine or... 
DIABETES-MELLITUS | MEDICINE, GENERAL & INTERNAL | GLYCEMIC CONTROL | THERAPY | GLARGINE | GLUCOSE CONTROL | DISEASE | RISK | PEOPLE | ENDOTHELIAL FUNCTION | BETA-CELL FUNCTION | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Male | Incidence | Glucose Intolerance - drug therapy | Cardiovascular Diseases - epidemiology | Female | Drug Therapy, Combination | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Fasting | Blood Glucose - analysis | Double-Blind Method | Proportional Hazards Models | Hospitalization | Glucose Intolerance - complications | Insulin, Long-Acting - adverse effects | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Intention to Treat Analysis | Triglycerides - blood | Fatty Acids, Omega-3 - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Complications and side effects | Care and treatment | Insulin glargine | Patient outcomes | Causes of | Cardiovascular diseases | Risk factors | Myocardial infarction | Fees & charges | Cerebral infarction | Medical research | Stroke | Heart attacks | Statistical analysis | Diabetes mellitus | Glucose | Hypoglycemia | Fatty acids | Insulin | Glucose tolerance | Insulin resistance | Microvasculature | Diabetes | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Cardiovascular Diseases | Insulin, Long-Acting | Blood Glucose | Triglycerides | Glucose Intolerance | Cholesterol | Life Sciences | Hypoglycemic Agents | Diabetes Mellitus, Type 2 | Fatty Acids, Omega-3 | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
by Bosch, Jackie and Riddle, Matthew C and Rydén, Lars E and Chazova, I and Gilbert, R and Gomis, R and Pīrāgs, V and Bogaty, P and Corson, M and Harper, W.L and Cukierman-Yaffee, T and MacRae, S and Alvarez, N and Amuchastegui, M and Bello, F and Caccavo, A and Calveira, M and Camino, A and Cardone, M and Corinaldesi, F and Crespo, C and Fares Taie, A and Fernandez, A and Ferrari, N and Gutierrez, N and Hasbani, E and Hrabar, A and Lobo Marquez, L and Lugo, M and Mainini, S and Manzano, R and Mendez, N and Odetto, I and Polari, P and Ramirez, A and Sanchez, R and Smith Casabella, T and Streitenberger, P and Villamil, A and Amerena, J and Farshid, A and Lefkovits, J and O'Neal, D and Poynten, A and Simpson, R and Teede, H and Tiong, F and Waddell-Smith, K and Blocher, J and Brath, H and Breuss, J and Jankovic, V and Kann, T and Placher-Sorko, G and Sonnenfeld, M and Vetter, B and Wallner, F and Lazareva, I and Delana, J and Feitosa, G and Garcia, V and Kanedlai, N and Mothe, F and Ninno, T and Oliveira, C and Oliveira, O and Roldan, F and Bailey, A and Belanger, A and Carlson, B and Chagnon, P and Chessex, C and Crepeau, J and Dube, F and Gosselin, G and Harper, W and Ho, K and Hramiak, I and Hutchinson, A and Langlois, M and Lavoie, M and Mercier, M and Nawaz, S and O'Keefe, D and Pruneau, G and Raby, K and Richard, C and Steinson, D and VanRossum, N and Warnica, W and Galloso, R and Stockins, B and Chen, Y and Gao, X and Ji, L and Jia, W and Li, Q and Li, Y and Ling, Y and Lu, B and ... and The ORIGIN Trial Investigators and ORIGIN Trial Investigators and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Centrum för klinisk forskning, Västerås
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 4, pp. 309 - 318
Participants with impaired fasting glucose who were at risk for cardiovascular events were assigned to receive daily n−3 fatty acids or placebo and to receive... 
MEDICINE, GENERAL & INTERNAL | EVENTS | PREVENTION | FISH | RISK | CORONARY-HEART-DISEASE | OMEGA-3-FATTY-ACID INTAKE | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Male | Incidence | Glucose Intolerance - drug therapy | Treatment Failure | Cardiovascular Diseases - mortality | Female | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Double-Blind Method | Proportional Hazards Models | Glucose Intolerance - complications | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Intention to Treat Analysis | Triglycerides - blood | Fatty Acids, Omega-3 - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Prevention | Complications and side effects | Care and treatment | Patient outcomes | Dietary supplements | Causes of | Diabetes | Cardiovascular diseases | Fatty acids | Health aspects | Myocardial infarction | Arrhythmia | Diabetes mellitus | Lipids | Esters | Cardiovascular disease | Insulin | Glucose tolerance | Diet | Death | Supplementation | Diabetes mellitus (non-insulin dependent) | Heart diseases | Cardiovascular Diseases | Insulin, Long-Acting | Triglycerides | Glucose Intolerance | Cholesterol | Life Sciences | Hypoglycemic Agents | Diabetes Mellitus, Type 2 | Fatty Acids, Omega-3 | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
by Daskalopoulou, Stella S., MD, PhD and Rabi, Doreen M., MD, MSc and Zarnke, Kelly B., MD, MSc and Dasgupta, Kaberi, MD, MSc and Nerenberg, Kara, MD, MSc and Cloutier, Lyne, RN, PhD and Gelfer, Mark, MD and Lamarre-Cliche, Maxime, MD and Milot, Alain, MD, MSc and Bolli, Peter, MD and McKay, Donald W., PhD and Tremblay, Guy, MD and McLean, Donna, RN, NP, PhD and Tobe, Sheldon W., MD, MSc(HPTE) and Ruzicka, Marcel, MD, PhD and Burns, Kevin D., MD and Vallée, Michel, MD, PhD and Ramesh Prasad, G.V., MBBS, MSc and Lebel, Marcel, MD and Feldman, Ross D., MD and Selby, Peter, MBBS, MHSc and Pipe, Andrew, CM, MD and Schiffrin, Ernesto L., MD, PhD and McFarlane, Philip A., MD, PhD and Oh, Paul, MD and Hegele, Robert A., MD and Khara, Milan, MBChB and Wilson, Thomas W., MD and Brian Penner, S., MD and Burgess, Ellen, MD and Herman, Robert J., MD and Bacon, Simon L., PhD and Rabkin, Simon W., MD and Gilbert, Richard E., MD, PhD and Campbell, Tavis S., PhD and Grover, Steven, MD, MPA and Honos, George, MD and Lindsay, Patrice, RN, PhD and Hill, Michael D., MD, MSc and Coutts, Shelagh B., MD and Gubitz, Gord, MD and Campbell, Norman R.C., MD and Moe, Gordon W., MD, MSc and Howlett, Jonathan G., MD and Boulanger, Jean-Martin, MD and Prebtani, Ally, MD and Larochelle, Pierre, MD and Leiter, Lawrence A., MD and Jones, Charlotte, MD, PhD and Ogilvie, Richard I., MD and Woo, Vincent, MD and Kaczorowski, Janusz, PhD and Trudeau, Luc, MD and Petrella, Robert J., MD, PhD and Hiremath, Swapnil, MD, MPH and Stone, James A., MD, PhD and Drouin, Denis, MD and Lavoie, Kim L., PhD and Hamet, Pavel, MD, PhD and Fodor, George, MD, PhD and Grégoire, Jean C., MD and Fournier, Anne, MD and Lewanczuk, Richard, MD, PhD and Dresser, George K., MD, PhD and Sharma, Mukul, MD, MSc and Reid, Debra, PhD, RD and Benoit, Geneviève, MD and Feber, Janusz, MD and Harris, Kevin C., MD, MHSc and Poirier, Luc, BPharm, MSc and Padwal, Raj S., MD, MSc and Canadian Hypertension Education Program and Canadian Hypertension Educ Program
Canadian Journal of Cardiology, ISSN 0828-282X, 2015, Volume 31, Issue 5, pp. 549 - 568
Journal Article