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BLOOD, ISSN 0006-4971, 09/2014, Volume 124, Issue 10, pp. 1626 - 1636
The aim of this study was to assess the efficiency of p53 reactivation and induction of massive apoptosis (PRIMA-1(Met)) in inducing myeloma cell death, using... 
WILD-TYPE P53 | MULTIPLE-MYELOMA | BUTHIONINE SULFOXIMINE BSO | IN-VIVO | MUTANT P53 | SELF-RENEWAL | INDUCTION | HEMATOLOGY | PHASE-I | CANCER | CHEMOTHERAPY
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 03/2017, Volume 102, Issue 3, pp. E112 - E114
Journal Article
Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 761 - 764
INHIBITION | ONCOLOGY | MCL-1 | DEATH | LEUKEMIA | HEMATOLOGY | ABT-199 | ADDICTION | Recurrence | Antineoplastic Agents - chemical synthesis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Male | Plasma Cells - pathology | Plasma Cells - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Peptides - chemical synthesis | bcl-X Protein - antagonists & inhibitors | Aged, 80 and over | Biological Assay | Female | Plasma Cells - metabolism | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cytochromes c - secretion | Multiple Myeloma - diagnosis | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Multiple Myeloma - metabolism | Organ Specificity | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Peptides - pharmacology | Sulfonamides - chemical synthesis | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Multiple Myeloma - pathology | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Aniline Compounds - chemical synthesis | Multiple Myeloma - genetics | Drug metabolism | Development and progression | Genetic aspects | Tumor proteins | Health aspects | Multiple myeloma | Index Medicus | Life Sciences | Cancer | BCL-2 | BH3 profiling | BH3 mimetics | Multiple Myeloma | Apoptosis
Journal Article
Leukemia, ISSN 0887-6924, 04/2019
The microenvironment strongly influences mantle cell lymphoma (MCL) survival, proliferation, and chemoresistance. However, little is known regarding the... 
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 05/2017, Volume 91, Issue 5, pp. 533 - 544
The β2 adrenergic receptor (β2AR) increases intracellular Ca2+ in a variety of cell types. By combining pharmacological and genetic manipulations, we reveal a... 
Index Medicus
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 05/2017, Volume 91, Issue 5, pp. 533 - 533
The beta(2) adrenergic receptor (beta(2)AR) increases intracellular Ca2+ in a variety of cell types. By combining pharmacological and genetic manipulations, we... 
EXTRACELLULAR ATP | GROWTH-FACTOR RECEPTOR | CYCLIC-AMP | SMOOTH-MUSCLE | ACTIVATED PROTEIN-KINASE | BETA-ADRENERGIC-RECEPTORS | ADENYLYL-CYCLASE | ADENOSINE PATHWAY | PHOSPHOLIPASE-C | PHARMACOLOGY & PHARMACY | P2Y RECEPTOR
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 12/2017, Volume 8
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling... 
DOPAMINE D2 RECEPTOR | SIGNALING PATHWAYS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED-RECEPTORS | HYDROGEN-BOND NETWORK | BETA-ARRESTIN | ADRENERGIC-RECEPTOR | BETA-ADRENERGIC RECEPTOR | NECK-CANCER | ACTIVATION PATHWAYS
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2009, Volume 331, Issue 1, pp. 297 - 307
Journal Article
Blood, ISSN 0006-4971, 10/2018
BH3-mimetics are promising drugs for hematologic malignancies that trigger cell death by promoting the release of pro-apoptotic BCL2 family members from... 
Life Sciences | Cancer
Journal Article
Leukemia, ISSN 0887-6924, 2019
The microenvironment strongly influences mantle cell lymphoma (MCL) survival, proliferation and chemoresistance. However, little is known regarding the... 
Life Sciences | Cancer
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10036, pp. 2402 - 2411
Summary Background Short intensive chemotherapy is the standard of care for adult patients with Burkitt's leukaemia or lymphoma. Findings from single-arm... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | CODOX-M/IVAC | CLEAVED-CELL LYMPHOMA | ACUTE-LYMPHOBLASTIC-LEUKEMIA | MULTIAGENT CHEMOTHERAPY | ADOLESCENTS | PLUS RITUXIMAB | NON-HODGKIN-LYMPHOMA | SURVIVAL RATE | PEDIATRIC-ONCOLOGY-SOCIETY | CHILDREN | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Injections, Intravenous | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Patient Selection | Burkitt Lymphoma - pathology | Hydrocortisone - administration & dosage | Vincristine - administration & dosage | Adult | Female | France | Odds Ratio | Burkitt Lymphoma - drug therapy | Doxorubicin - administration & dosage | Prednisone - administration & dosage | Drug Administration Schedule | Biomarkers, Tumor - analysis | Proportional Hazards Models | Treatment Outcome | Burkitt Lymphoma - diagnosis | Burkitt Lymphoma - chemistry | Cytarabine - administration & dosage | Rituximab - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Methotrexate - administration & dosage | Aged | Bone Marrow Neoplasms - drug therapy | Neoplasm Staging | Central Nervous System Neoplasms - drug therapy | Methylprednisolone - administration & dosage | Chemotherapy | Leukemia | Lymphomas | Adults | Epidemiology | Biometry | Cancer | Survival analysis | Biomedical research | Dehydrogenases | Medical prognosis | Clinical trials | Index Medicus | Abridged Index Medicus | Life Sciences
Journal Article
Hematological Oncology, ISSN 0278-0232, 06/2019, Volume 37, Issue S2, pp. 342 - 343
Journal Article
Leukemia, ISSN 0887-6924, 12/2014, Volume 28, Issue 12, pp. 2367 - 2375
Journal Article
SCIENCE SIGNALING, ISSN 1945-0877, 12/2018, Volume 11, Issue 559
Frizzleds (FZDs) are a group of seven transmembrane-spanning (7TM) receptors that belong to class F of the G protein-coupled receptor (GPCR) superfamily. FZDs... 
CELLS | ACTIVATION | COMPLEX | WNT/BETA-CATENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | DRIVEN | FRIZZLED-5 | CRYO-EM STRUCTURE | FAMILY | FEATURES | CELL BIOLOGY
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2017, Volume 377, Issue 13, pp. 1250 - 1260
The use of rituximab every 2 months for 3 years after immunochemotherapy and autologous stem-cell transplantation prolonged progression-free and overall... 
TRIAL | SURVIVAL | MAINTENANCE | MEDICINE, GENERAL & INTERNAL | IMMUNOCHEMOTHERAPY | NORDIC MCL2 | FOLLOW-UP | HIGH-DOSE CYTARABINE | PHASE-3 | INTERGROUP | MCL YOUNGER | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Dexamethasone - administration & dosage | Humans | Middle Aged | Immunologic Factors - administration & dosage | Proportional Hazards Models | Hematopoietic Stem Cell Transplantation | Lymphoma, Mantle-Cell - drug therapy | Male | Transplantation, Autologous | Combined Modality Therapy | Cytarabine - administration & dosage | Cisplatin - administration & dosage | Lymphoma, Mantle-Cell - mortality | Rituximab - administration & dosage | Lymphoma, Mantle-Cell - therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Adult | Female | Aged | Maintenance Chemotherapy | Care and treatment | Usage | Patient outcomes | Mantle cell lymphoma | Stem cells | Outcome and process assessment (Health Care) | Reports | Transplantation | Observations | Medical research | Autografts | Dexamethasone | Cell survival | Hypersensitivity | Stem cell transplantation | Rituximab | Lymphoma | Cancer therapies | Survival | Studies | Chemotherapy | Cytarabine | Platinum | Lymphomas | Index Medicus | Abridged Index Medicus | Life Sciences | Hematology | Human health and pathology
Journal Article
Caravelle, ISSN 1147-6753, 04/2019, Issue 111, pp. 41 - 58
Journal Article
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