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Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 1, pp. 75 - 87
Summary Background Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1... 
Hematology, Oncology and Palliative Medicine | POLY(ADP-RIBOSE) POLYMERASE | OLAPARIB | ONCOLOGY | HOMOLOGOUS RECOMBINATION DEFICIENCY | MUTANT-CELLS | DNA-REPAIR | CANCER | HETEROZYGOSITY | TUMORS | BREAST | GENOMIC LOSS | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Ovarian Neoplasms - pathology | Salvage Therapy | Neoplasm Recurrence, Local - drug therapy | Germ-Line Mutation - genetics | Neoplasm Recurrence, Local - pathology | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Poly(ADP-ribose) Polymerases - chemistry | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Fallopian Tube Neoplasms - drug therapy | Peritoneal Neoplasms - pathology | Neoplasms, Glandular and Epithelial - pathology | Fallopian Tube Neoplasms - pathology | Survival Rate | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | BRCA1 Protein - genetics | International Agencies | Peritoneal Neoplasms - genetics | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Indoles - therapeutic use | Neoplasm Recurrence, Local - genetics | Aged | Neoplasm Staging | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Sugars | Monosaccharides | Ovarian cancer | Analysis | Carcinoma | Cancer
Journal Article
by Coleman, Robert L and Coleman, R L and Oza, Amit M and Oza, A M and Lorusso, D and Lorusso, Domenica and Aghajanian, C and Aghajanian, Carol and Oaknin, A and Oaknin, Ana and Dean, A and Dean, Andrew and Colombo, N and Colombo, Nicoletta and Weberpals, Johanne I and Weberpals, J I and Clamp, Andrew and Clamp, A and Scambia, Giovanni and Scambia, G and Leary, A and Leary, Alexandra and Holloway, Robert W and Holloway, R W and Gancedo, M Amenedo and Gancedo, Margarita Amenedo and Fong, Peter C and Fong, P C and Goh, Jeffrey C and Goh, J C and O'Malley, David M and O'Malley, D M and Armstrong, Deborah K and Armstrong, D K and Garcia-Donas, Jesus and Garcia-Donas, J and Swisher, E M and Swisher, Elizabeth M and Floquet, A and Floquet, Anne and Konecny, Gottfried E and Konecny, G E and McNeish, I A and McNeish, Iain A and Scott, C L and Scott, Clare L and Cameron, Terri and Maloney, Lara and Isaacson, Jeff and Goble, Sandra and Grace, Caroline and Harding, Thomas C and Raponi, Mitch and Sun, James and Lin, Kevin K and Giordano, Heidi and Ledermann, J A and Ledermann, Jonathan A and Buck, M and Friedlander, M L and Harnett, P and Kichenadasse, G and Denys, H and Dirix, L and Vergote, I and Elit, L and Ghatage, P and Plante, M and Provencher, D and Welch, S and Gladieff, L and Joly, F and Lortholary, A and Lotz, J and Medioni, J and Tredan, O and You, B and El-Balat, A and Hänle, C and Krabisch, P and Neunhöffer, T and Pölcher, M and Wimberger, P and Amit, A and Kovel, S and Leviov, M and Safra, T and Shapira-Frommer, R and Stemmer, S and Bologna, A and Pignata, S and Sabbatini, R F and Tamberi, S and Zamagni, C and O'Donnell, A and Herraez, A Casado and Guerra, E M and Palacio, I and Romero, I and Sanchez, A and ... and ARIEL3 Investigators and ARIEL3 investigators
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10106, pp. 1949 - 1961
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a mutation or high percentage of... 
MEDICINE, GENERAL & INTERNAL | MULTICENTER | SOLID TUMORS | BEVACIZUMAB | OPEN-LABEL | CANCER | HETEROZYGOSITY | EPITHELIAL OVARIAN | CHEMOTHERAPY | Double-Blind Method | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Ovarian Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | Survival Rate | Treatment Outcome | Ovarian Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Indoles - administration & dosage | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Maintenance Chemotherapy - methods | Internationality | Ovarian Neoplasms - therapy | Female | Aged | Molecular Targeted Therapy - methods | Clinical trials | Care and treatment | Carcinoma | Drug therapy | Ovarian cancer | Cancer | Analysis | Chemotherapy | Ovarian carcinoma | Platinum | Biomarkers | Mutation | Cancer therapies | Tumors | Homologous recombination | Central nervous system | Poly(ADP-ribose) | Homology | Genomes | Fallopian tube | ADP | Anticancer properties | Metastases | Homologous recombination repair | Randomization | Pain | Motivation | Ribose | Hemoglobin | Alanine | Anemia | Poly(ADP-ribose) polymerase | Breast cancer | Patients | Survival | Heterozygosity | Abdomen | Polymerase | Inhibitors | Point mutation | Loss of heterozygosity | Antitumor activity | Aspartate aminotransferase | Peritoneum
Journal Article
by Khazaei, Mohamad and Baig, Sara and Merchant, Jainetri and Chan, Priscilla and Fehlings, Michael and Fehlings, Michael and Fehlings, Michael and Giudice, J. Sebastian and Forman, Jason and Panzer, Matthew B and Dalton, Jay and Mauria, Rohit and Chapple, Kristina and Cook, Alan and Turner, Jay and McCrea, Michael A and Nelson, Lindsay D and Tummala, Shanti and Meaney, David and Hawryluk, Gregory and Nielson, Jessica and Huie, J. Russell and Zimmermann, Lara and Saigal, Rajiv and Ding, Quan and Ferguson, Adam and Manley, Geoffrey and Lee, Stephanie and Gajavelli, Shyam and Gajavelli, Shyam and Gajavelli, Shyam and Spurlock, Markus and Spurlock, Markus and Rivera, Karla and Rivera, Karla and Rivera, Karla and Androni, Cody and de Rivero Vaccari, Juan Pablo and de Rivero Vaccari, Juan Pablo and Keane, Robert and Bulock, Ross and Dietrich, Dalton and Meeker, Kole and Bullock, Kristin and Banks, William and Cook, David and Main, Bevan and Villapol, Sonia and Barton, David and Sloley, Stephanie and Stefos, Kathryn and Burns, Mark and Swanson, Randel and Johnson, Victoria and Parker, Andrew and Elliott, Mark and Weber, Maura and Acharya, Nimish and Cognetti, John and Cullen, Kacy and Verma, Ragini and Smith, Douglas and Pat, Betty and Pat, Betty and McAllister, Sean and Floyd, Candace and Floyd, Candace and Harris, Neil G and Reynolds, Joshua and Turtle, Joel and Leal, Gizelle and Huang, Yung-Jen and Strain, Misty and Grau, James and Greco, Tiffany and Giza, Christopher and Prins, Mayumi and Folkerts, Michael and Russo, Robin and Koch, Paul and Koch, Paul and Adam, Christopher and Weber, Maura and Johnson, Victoria and Johnson, Victoria and Wolf, John and Wolf, John and Cai, Yan and Perigo, Shauna and Bhaduri, Srija and Rosenbaum, Philip and Harris, Neil G and Giza, Christopher C and Kumar, Raj and Kumar, Raj and Ranganathan, Prerna and Ranganathan, Prerna and Ranganathan, Prerna and Oh, Byung-Mo and Wagner, Amy and ...
Journal of Neurotrauma, ISSN 0897-7151, 07/2017, Volume 34, Issue 13, pp. A-1 - A-163
Journal Article
by Medici, Marco and Porcu, Eleonora and Pistis, Giorgio and Teumer, Alexander and Brown, Stephen and Jensen, Richard and Rawal, R and Roef, Greet and Plantinga, Theo S and Vermeulen, Sita and Lahti, Jari and Simmonds, Mark and Husemoen, Lise Lotte and Freathy, Rachel and Shields, Beverley and Pietzner, Diana and Nagy, Rebecca and Broer, Linda and Chaker, Layal and Korevaar, Tim and Plia, Maria Grazia and Sala, Cinzia and Völker, Uwe and Richards, Brent and Sweep, Fred and Gieger, Christian and Corre, Tanguy and Kajantie, Eero and Thuesen, Leif and Taes, Youri and Visser, Wil Edward and Hattersley, Anew and Kratzsch, Jürgen and Hamilton, Amy and Li, Wei and Homuth, Georg and Lobina, Monia and Mariotti, Stefano and Soranzo, Nicole and Cocca, Massimiliano and Nauck, Matthias and Spielhagen, Christin and Ross, Alec and Arnold, Alice and Bunt, Martijn and Liyanarachchi, Sandya and Heier, Margit and Grabe, Hans Jörgen and Masciullo, Corrado and Galesloot, Tessel and Lim, Ee Mun and Reischl, Gunilla and Leedman, Peter and Lai, Sana and Delitala, Alessano and Bremner, Alexana and Philips, David I and Beilby, John and Mulas, Antonella and Vocale, Matteo and Abecasis, Gonçalo and Forsen, Tom and James, Alan and Widen, Elisabeth and Hui, Jennie and Prokisch, Holger and Rietzschel, Ernst and Palotie, Aarno and Feddema, Wouter and Fletcher, Stephen and Schramm, Katharina and Rotter, Jerome and Kluttig, Alexander and Radke, Dörte and Traglia, Michela and Surdulescu, Gabriela and He, Hao and Franklyn, Jayne and Tiller, Daniel and Vaidya, Bijay and Meyer, Thorsten and Jorgensen, Torben and Hagen, Knut and O'Leary, Peter and Wichmann, Eric and Hermus, Ad and Psaty, Bruce and Ittermann, Till and Hofman, Albert and Bosi, Emanuele and Schlessinger, David and Wallaschofski, Henri and Pirastu, Nicola and Aulchenko, Yurii and de la Chapelle, Albert and Netea-Maier, Romana and Gough, Julie and Meyer zu Schwabedissen, Henriette and Frayling, Timothy and Kaufman, Jean-Marc and ...
PL o S Genetics (Online), ISSN 1553-7390, 02/2014, Volume 10, Issue 2, p. e1004123
Journal Article
Journal Article