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JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 7, pp. 668 - 680
Abstract Background Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting... 
Cardiovascular | Internal Medicine | β-blocker | nebivolol | inflammation | endothelial dysfunction | pulmonary hypertension | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | beta-blocker | RATS | CROSS-TALK | THERAPY | SMOOTH-MUSCLE HYPERPLASIA | ARTERIAL-HYPERTENSION | ANIMAL-MODELS | BLOCKADE | PROGRESSION | Ethanolamines - pharmacology | Benzopyrans - therapeutic use | Cell Proliferation | Rats, Wistar | Metoprolol - pharmacology | Humans | Monocrotaline | Adrenergic beta-1 Receptor Antagonists - pharmacology | Hypertension, Pulmonary - physiopathology | Endothelium, Vascular - drug effects | Male | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Hypertension, Pulmonary - drug therapy | Cell Culture Techniques | Vascular Remodeling - drug effects | Benzopyrans - pharmacology | Disease Models, Animal | Nebivolol | Endothelium, Vascular - physiopathology | Rats | Metoprolol - therapeutic use | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Animals | Myocytes, Smooth Muscle | Cell Communication - drug effects | Endothelium, Vascular - pathology | Ethanolamines - therapeutic use | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Heart | Sects | Pulmonary hypertension | Endothelium | Studies | Cell growth | Pulmonary arteries | Mortality | Smooth muscle | Veins & arteries | Index Medicus | Abridged Index Medicus | Life Sciences
Journal Article
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 07/2019, Volume 20, Issue 14, p. 3575
Idiopathic pulmonary arterial hypertension (IPAH) is a complex disease associated with vascular remodeling and a proliferative disorder in pulmonary artery... 
proliferation | DNA damage | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | idiopathic pulmonary artery hypertension | CELL-GROWTH | CHEMISTRY, MULTIDISCIPLINARY | pulmonary artery smooth muscle cells | energetic metabolism | REPAIR | INFLAMMATION | ARTERIAL-HYPERTENSION | BIOLOGY | TELOMERE LENGTH | Index Medicus | Life Sciences
Journal Article
Circulation, ISSN 0009-7322, 03/2015, Volume 131, Issue 11, pp. 1006 - 1018
BACKGROUND—The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle... 
Human | Hypertension | Vimentin | Sirolimus | Twist1 protein | Vascular remodeling | Epithelial-mesenchymal transition | Neointima | Animal | Type ii | Models | Bone morphogenetic protein receptors | Cardiovascular diseases | Pulmonary | RAPAMYCIN | MIGRATION | FIBROSIS | models, animal | CARDIAC & CARDIOVASCULAR SYSTEMS | neointima | hypertension, pulmonary | vimentin | cardiovascular diseases | vascular remodeling | DISCOVERY | bone morphogenetic protein receptors, type II | IN-VITRO | sirolimus | TWIST1 protein, human | ARTERIAL-HYPERTENSION | PERIPHERAL VASCULAR DISEASE | epithelial-mesenchymal transition | SMOOTH-MUSCLE-CELLS | KNOCKOUT RATS | TRANSDIFFERENTIATION | Vascular Remodeling | Humans | Gene Expression Profiling | Hypertension, Pulmonary - chemically induced | Actins - genetics | RNA, Messenger - biosynthesis | Vimentin - genetics | Cell Transdifferentiation | Lung - metabolism | Disease Models, Animal | Lung - pathology | Actins - biosynthesis | Bone Morphogenetic Protein Receptors, Type II - genetics | Vimentin - biosynthesis | Cells, Cultured | Rats | Hypertension, Pulmonary - genetics | Hypoxia - complications | Monocrotaline - toxicity | Sirolimus - pharmacology | Animals | Biomarkers | Mutation | Endothelial Cells - pathology | Lung - blood supply | Hypertension, Pulmonary - pathology | Mesoderm - pathology | Bone Morphogenetic Protein Receptors, Type II - biosynthesis | Cell Movement | Index Medicus | Abridged Index Medicus | Life Sciences
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77073 - e77073
Background: Pulmonary hypertension (PH) is a progressive disorder characterized by an increase in pulmonary artery pressure and structural changes in the... 
ARTERIES | INHIBITION | MULTIDISCIPLINARY SCIENCES | ORGAN-CULTURE | MUSCLE-CELL APOPTOSIS | PROLIFERATION | GROWTH-FACTOR | DNA-SYNTHESIS | CARCINOMA | BINDING | Apoptosis - drug effects | Humans | Rats | Male | Monocrotaline - adverse effects | Enzyme Activation - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Hypertension, Pulmonary - chemically induced | Hypertension, Pulmonary - prevention & control | Muscle, Smooth, Vascular - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Suramin - therapeutic use | Cell Proliferation - drug effects | Hypertension, Pulmonary - drug therapy | Phosphorylation - drug effects | In Vitro Techniques | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Suramin - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Muscle, Smooth, Vascular - drug effects | Tyrosine | Respiratory agents | Growth factors | Pulmonary hypertension | Heart | Suramin | Fibroblast growth factor | Phosphorylation | Normalizing | Platelet-derived growth factor | Lung | Monocrotaline | Smooth muscle | Inflammatory response | Receptors | Epidermal growth factor | Rodents | Protein-tyrosine kinase receptors | Inhibition | Protein-tyrosine kinase | Hypertension | Fibroblast growth factor 2 | Platelet-derived growth factor receptors | Epidermal growth factor receptors | Muscles | Extracellular signal-regulated kinase | Inflammation | Injection | Growth factor receptors | Pulmonary artery | Studies | Collagen | Ventricle | Cancer | Hypertrophy | Veins & arteries | Fibroblast growth factor receptors | Index Medicus
Journal Article
The Journal of Heart and Lung Transplantation, ISSN 1053-2498, 06/2019
BACKGROUND - Pulmonary endothelial cells play a key role in the pathogenesis of ChronicThromboembolic Pulmonary Hypertension (CTEPH). Increased synthesis... 
Life Sciences
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 10/2017, Volume 1864, Issue 10, pp. 1631 - 1641
Idiopathic pulmonary arterial hypertension (iPAH) is characterized by obstructive hyperproliferation and apoptosis resistance of distal pulmonary artery smooth... 
Caspase | FoxO3A | MAPkinase | Survivin | Lung | Cell cycle | ACTIVATION | MYOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE-CELL PROLIFERATION | PROTEIN PHOSPHATASE 2A | VASCULAR SMOOTH-MUSCLE | CELL BIOLOGY | CALCIUM-CHANNELS | GENE | ALDOSTERONE | EXPRESSION | CONTRIBUTES | Index Medicus
Journal Article
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 10/2017, Volume 1864, Issue 10, p. 1631
Idiopathic pulmonary arterial hypertension (iPAH) is characterized by obstructive hyperproliferation and apoptosis resistance of distal pulmonary artery smooth... 
Pulmonary hypertension | Phosphatases | Apoptosis
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A18517 - A18517
BackgroundWe identified autosomal recessive bi-allelic mutations in the EIF2AK4 gene (coding for GCN2) as the major genetic cause of pulmonary veno-occlusive... 
Journal Article