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The New England Journal of Medicine, ISSN 0028-4793, 12/2016, Volume 375, Issue 22, pp. 2154 - 2164
Journal Article
by Coleman, Robert L and Coleman, R L and Oza, Amit M and Oza, A M and Lorusso, D and Lorusso, Domenica and Aghajanian, C and Aghajanian, Carol and Oaknin, A and Oaknin, Ana and Dean, A and Dean, Andrew and Colombo, N and Colombo, Nicoletta and Weberpals, Johanne I and Weberpals, J I and Clamp, Andrew and Clamp, A and Scambia, Giovanni and Scambia, G and Leary, A and Leary, Alexandra and Holloway, Robert W and Holloway, R W and Gancedo, M Amenedo and Gancedo, Margarita Amenedo and Fong, Peter C and Fong, P C and Goh, Jeffrey C and Goh, J C and O'Malley, David M and O'Malley, D M and Armstrong, Deborah K and Armstrong, D K and Garcia-Donas, Jesus and Garcia-Donas, J and Swisher, E M and Swisher, Elizabeth M and Floquet, A and Floquet, Anne and Konecny, Gottfried E and Konecny, G E and McNeish, I A and McNeish, Iain A and Scott, C L and Scott, Clare L and Cameron, Terri and Maloney, Lara and Isaacson, Jeff and Goble, Sandra and Grace, Caroline and Harding, Thomas C and Raponi, Mitch and Sun, James and Lin, Kevin K and Giordano, Heidi and Ledermann, J A and Ledermann, Jonathan A and Buck, M and Friedlander, M L and Harnett, P and Kichenadasse, G and Denys, H and Dirix, L and Vergote, I and Elit, L and Ghatage, P and Plante, M and Provencher, D and Welch, S and Gladieff, L and Joly, F and Lortholary, A and Lotz, J and Medioni, J and Tredan, O and You, B and El-Balat, A and Hänle, C and Krabisch, P and Neunhöffer, T and Pölcher, M and Wimberger, P and Amit, A and Kovel, S and Leviov, M and Safra, T and Shapira-Frommer, R and Stemmer, S and Bologna, A and Pignata, S and Sabbatini, R F and Tamberi, S and Zamagni, C and O'Donnell, A and Herraez, A Casado and Guerra, E M and Palacio, I and Romero, I and Sanchez, A and ... and ARIEL3 Investigators and ARIEL3 investigators
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10106, pp. 1949 - 1961
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a mutation or high percentage of... 
MEDICINE, GENERAL & INTERNAL | MULTICENTER | SOLID TUMORS | BEVACIZUMAB | OPEN-LABEL | CANCER | HETEROZYGOSITY | EPITHELIAL OVARIAN | CHEMOTHERAPY | Double-Blind Method | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Ovarian Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | Survival Rate | Treatment Outcome | Ovarian Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Indoles - administration & dosage | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Maintenance Chemotherapy - methods | Internationality | Ovarian Neoplasms - therapy | Female | Aged | Molecular Targeted Therapy - methods | Clinical trials | Care and treatment | Carcinoma | Drug therapy | Ovarian cancer | Cancer | Analysis | Chemotherapy | Ovarian carcinoma | Platinum | Biomarkers | Mutation | Cancer therapies | Tumors | Homologous recombination | Central nervous system | Poly(ADP-ribose) | Homology | Genomes | Fallopian tube | ADP | Anticancer properties | Metastases | Homologous recombination repair | Randomization | Pain | Motivation | Ribose | Hemoglobin | Alanine | Anemia | Poly(ADP-ribose) polymerase | Breast cancer | Patients | Survival | Heterozygosity | Abdomen | Polymerase | Inhibitors | Point mutation | Loss of heterozygosity | Antitumor activity | Aspartate aminotransferase | Peritoneum
Journal Article
Annals of Oncology, ISSN 0923-7534, 04/2016, Volume 27, Issue suppl 1, pp. i40 - i44
Slow progress in improving the outcome of ovarian cancer with chemotherapy over the last decade has stimulated research into molecularly targeted therapy.... 
Olaparib | Maintenance therapy | Homologous recombination deficiency | PARP inhibitors | BRCA mutation | Ovarian cancer | Drug Synergism | Humans | Female | Mutation | Drug Discovery | Ovarian Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use
Journal Article
by Dowsett, M and Forbes, J. F and Bradley, R and Ingle, J and Aihara, T and Bliss, J and Boccardo, F and Coates, A and Coombes, R. C and Cuzick, J and Dubsky, P and Gnant, M and Kaufmann, M and Kilburn, L and Perrone, F and Rea, D and Thurlimann, B and van de Velde, C and Pan, H and Peto, R and Davies, C and Gray, R and Burrett, J and Clarke, M and Duane, F and Evans, V and Gettins, L and Godwin, J and Liu, H and McGale, P and MacKinnon, E and McHugh, T and James, S and Morris, P and Read, S and Taylor, C and Wang, Y and Wang, Z and Bergh, J and Pritchard, K and Albain, K and Anderson, S and Arriagada, R and Barlow, W and Bergsten-Nordstrom, E and Buyse, M and Cameron, D and Coleman, R and Correa, C and Costantino, J and Davidson, N and Di Leo, A and Ewertz, M and Forbes, J and Gelber, R and Geyer, C and Gianni, L and Goldhirsch, A and Hayes, D and Hill, C and Janni, W and Martin, M and Norton, L and Ohashi, Y and Paik, S and Perez, E and Piccart, M and Pierce, L and Raina, V and Ravdin, P and Robertson, J and Rutgers, E and Sparano, J and Swain, S and Viale, G and von Minckwitz, G and Wang, X and Whelan, T and Wilcken, N and Winer, E and Wolmark, N and Wood, W and Abe, O and Abe, R and Enomoto, K and Kikuchi, K and Koyama, H and Masuda, H and Nomura, Y and Sakai, K and Sugimachi, K and Toi, M and Tominaga, T and Uchino, J and Yoshida, M and Haybittle, J. L and Leonard, C. F and Calais, G and Garaud, P and Collett, V and ... and Early Breast Canc Trialists and Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 10001, pp. 1341 - 1352
Journal Article
by Darby, S and McGale, P and Correa, C and Taylor, C and Arriagada, R and Clarke, M and Cutter, D and Davies, C and Ewertz, M and Godwin, J and Gray, R and Pierce, L and Whelan, T and Wang, Y and Peto, R and Albain, K and Anderson, S and Barlow, W and Bergh, J and Bliss, J and Buyse, M and Cameron, D and Carrasco, E and Coates, A and Collins, R and Costantino, J and Cuzick, J and Davidson, N and Davies, K and Delmestri, A and Di Leo, A and Dowsett, M and Elphinstone, P and Evans, V and Gelber, R and Gettins, L and Geyer, C and Goldhirsch, A and Gregory, C and Hayes, D and Hill, C and Ingle, J and Jakesz, R and James, S and Kaufmann, M and Kerr, A and MacKinnon, E and McHugh, T and Norton, L and Ohashi, Y and Paik, S and Pan, H. C and Perez, E and Piccart, M and Pritchard, K and Pruneri, G and Raina, V and Ravdin, P and Robertson, J and Rutgers, E and Shao, Y. F and Swain, S and Valagussa, P and Viale, G and Winer, E and Wood, W and Abe, O and Abe, R and Enomoto, K and Kikuchi, K and Koyama, H and Masuda, H and Nomura, Y and Sakai, K and Sugimachi, K and Toi, M and Tominaga, T and Uchino, J and Yoshida, M and Haybittle, J. L and Leonard, C. F and Calais, G and Geraud, P and Collett, V and Sayer, J and Harvey, V. J and Holdaway, I. M and Kay, R. G and Mason, B. H and Forbes, J. F and Wilcken, N and Bartsch, R and Dubsky, P and Fesl, C and Fohler, H and Gnant, M and Greil, R and Lang, A and Luschin-Ebengreuth, G and Marth, C and ... and Early Breast Canc Trialists Collab and Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Lancet, The, ISSN 0140-6736, 2011, Volume 378, Issue 9804, pp. 1707 - 1716
Journal Article