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Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 06/2018, Volume 121, pp. 149 - 156
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2017, Volume 32, Issue 1, pp. S40 - S41
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2014, Volume 348, Issue 1, pp. 141 - 152
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2009, Volume 37, Issue 4, pp. 865 - 872
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2008, Volume 283, Issue 2, pp. 889 - 898
Journal Article
The Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2010, Volume 335, Issue 2, pp. 480 - 488
After infection with Citrobacter rodentium , murine hepatic cytochrome P450 (P450) mRNAs are selectively regulated. Several serum proinflammatory cytokines are... 
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2017, Volume 32, Issue 1, pp. S39 - S39
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2010, Volume 335, Issue 2, pp. 480 - 488
After infection with Citrobacter rodentium, murine hepatic cytochrome P450 (P450) mRNAs are selectively regulated. Several serum proinflammatory cytokines are... 
CYTOKINES | INFLAMMATORY-BOWEL-DISEASE | RAT HEPATOCYTES | ADULT HUMAN HEPATOCYTES | DOWN-REGULATION | GENE-EXPRESSION | RECEPTOR | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | PRIMARY CULTURES
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 4/2009, Volume 37, Issue 4, pp. 865 - 872
Whereas many cytochrome P450 enzymes are transcriptionally suppressed by inflammatory stimuli, down-regulation of CYP2B protein by the inflammatory cytokine... 
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2008, Volume 44, Issue 6, pp. 1161 - 1168
The purpose of this study was to determine the role of nitric oxide (NO) in the downregulation of human cytochrome P450 (CYP) enzymes and mRNAs by an... 
Protein degradation | Inflammation | CYP2B6 | Cytokines | Nitric oxide | Cytochrome P450 | nitric oxide | CYP2136 | RAT HEPATOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC-ACTIVITIES | cytochrome P450 | INDUCTION | PRIMARY CULTURES | P450-MEDIATED DRUG-METABOLISM | MESSENGER-RNAS | PRIMARY HUMAN HEPATOCYTES | INHIBITION | inflammation | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | cytokines | protein degradation | HUMAN CYP2B6 | Humans | Middle Aged | RNA, Messenger - analysis | Infant | Male | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | Inflammation - metabolism | Cytochrome P-450 CYP2E1 - drug effects | Adult | Female | Cytochrome P-450 CYP3A - drug effects | Oxidoreductases, N-Demethylating - metabolism | Child | Hepatocytes - drug effects | Gene Expression | Down-Regulation | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Enzyme Inhibitors - pharmacology | Aryl Hydrocarbon Hydroxylases - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Aryl Hydrocarbon Hydroxylases - metabolism | Oxidoreductases, N-Demethylating - drug effects | Cytochrome P-450 CYP3A - metabolism | Adolescent | Nitric Oxide - metabolism | Cytochrome P-450 CYP2B6 | Phosphates | RNA | Proteolysis | Cytochrome P-450 | Biological response modifiers | Mitogens | Phenytoin | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2010, Volume 38, Issue 12, pp. 2166 - 2172
Proteasome inhibitors are important tools for studying the roles of the proteasome in cellular processes. In this study, we observed that the proteasome... 
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 3/2008, Volume 44, Issue 6, pp. 1161 - 1168
The purpose of this study was to determine the role of nitric oxide (NO) in the down-regulation of human CYP enzymes and mRNAs by an inflammatory stimulus in... 
nitric oxide | cytokines | CYP2B6 | cytochrome P450 | inflammation | protein degradation
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2012, Volume 445, Issue 3, pp. 377 - 382
CYP2B proteins in rat hepatocytes undergo NO-dependent proteolytic degradation, but the mechanisms and the reasons for the specificity towards only certain... 
Cytochrome P450 | Immunoproteasome | Nitric oxide (NO) | Interleukin-1 (IL-1) | Proteasome | proteasome | immunoproteasome | nitric oxide (NO) | PROTEIN | RAT HEPATOCYTES | PROTEASOMAL DEGRADATION | HUMAN CYTOCHROME-P450 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELAXING FACTOR | DOWN-REGULATION | interleukin-1 (IL-1) | cytochrome P450 | MHC CLASS-I | S-NITROSYLATION | INTERFERON-GAMMA | TRANSCRIPTIONAL REGULATION | NG-Nitroarginine Methyl Ester - pharmacology | Steroid Hydroxylases - metabolism | Rats, Inbred F344 | Rats | Male | Hepatocytes - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Interleukin-1 - pharmacology | Nuclear Proteins | Animals | Cysteine Endopeptidases - metabolism | Metabolic Networks and Pathways | Models, Biological | Nitric Oxide Synthase Type II - antagonists & inhibitors | Cytochrome P-450 CYP2B1 - metabolism | Kinetics | Nitric Oxide Donors - pharmacology | Proteasome Endopeptidase Complex - metabolism | In Vitro Techniques | Nitric Oxide - metabolism | Proteasome Inhibitors | Genes, Tumor Suppressor | Hepatocytes - drug effects | Nitric Oxide Synthase Type II - metabolism | Index Medicus | IFN, interferon | NOx, nitrate and nitrite | NF-κB, nuclear factor κB | NOS2, inducible nitric oxide synthase | PB, phenobarbital | IL-1, interleukin-1β | LMP, large multifunctional peptidase | P450, cytochrome P450 | L-NAME, NG-nitro-L-arginine methyl ester | CT-L, chymotrypsin-like | GAPDH, glyceraldehyde-3-phosphate dehydrogenase
Journal Article
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