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The Journal of Organic Chemistry, ISSN 0022-3263, 01/2018, Volume 83, Issue 2, pp. 1011 - 1018
An efficient synthetic method for establishing chiral α-thio-α-quaternary stereogenic center was successfully developed. The enantioselective α-alkylation of... 
PRACTICAL ASYMMETRIC-SYNTHESIS | ACIDS | AMINO | CONSTRUCTION | ARYLATION | CHEMISTRY, ORGANIC | SULFENYLATION | Chemical reactions | Usage | Catalysis
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 50, p. 4384
Peroxisome proliferator-activated receptor delta (PPAR[delta]) is considered as a promising biological target for the development of new drugs to treat... 
Medical colleges | Penicillamine
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, p. 3155
Inspired by the well-known PPAR[gamma] partial agonism of angiotensin II type 1 receptor (AT1R) antagonists exemplified by an antihypertensive drug,... 
Type 2 diabetes | Hypertension | Hyperglycemia | Angiotensin | Antihypertensive drugs | Hypoglycemic agents
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, p. 2275
As a potential treatment of type 2 diabetes, a novel PPAR[gamma] non-TZD full agonist, compound 18 (BR102375) was identified from the original lead BR101549 by... 
Type 2 diabetes | Metabolites | Drug therapy | Gene expression | Diabetes therapy
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 50, pp. 4384 - 4386
[Display omitted] •Method for unique dimethyl thiazoline containing intermediate of PPARδ agonists.•TBAHS as catalyst for efficient coupling of 11 with... 
GW501516 | d-Penicillamine | 4-Mercapto-2-methylphenol | PPAR agonists | TBAHS catalyst | D-Penicillamine | BETA/DELTA | DESIGN | PPAR-DELTA | GROWTH | CHEMISTRY, ORGANIC
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 4, p. 631
The new class of PPARgamma non-TZD agonist originally derived from the backbone of anti-hypertensive Fimasartan, BR101549, was identified as a potential lead... 
Type 2 diabetes | Hypertension | Blood sugar | Drug therapy | Diabetes therapy
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, pp. 3155 - 3160
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 24, pp. 10863 - 10884
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2275 - 2282
[Display omitted] As a potential treatment of type 2 diabetes, a novel PPARγ non-TZD full agonist, compound 18 (BR102375) was identified from the original lead... 
Drug discovery | Non-TZD full agonist | Antidiabetics | PPARγ agonist | TELMISARTAN | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | RECEPTOR | PPAR gamma agonist
Journal Article
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