Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (42) 42
humans (37) 37
electricity (29) 29
genetics & heredity (28) 28
article (27) 27
electric communication technique (27) 27
telephonic communication (27) 27
genomes (19) 19
blasting (18) 18
cold rooms (18) 18
combined heating and refrigeration systems (18) 18
cooling or freezing apparatus not covered by any othersubclass (18) 18
heat pump systems (18) 18
heating (18) 18
ice-boxes (18) 18
lighting (18) 18
liquefaction solidification of gases (18) 18
manufacture or storage of ice (18) 18
mechanical engineering (18) 18
producing, working or handling ice (18) 18
refrigeration or cooling (18) 18
refrigerators (18) 18
weapons (18) 18
genome-wide association (17) 17
mathematical & computational biology (17) 17
computer simulation (16) 16
casings or constructional details of electric apparatus (15) 15
electric techniques not otherwise provided for (15) 15
manufacture of assemblages of electrical components (15) 15
printed circuits (15) 15
rare variants (14) 14
statistics & probability (14) 14
studies (14) 14
physics (13) 13
research (13) 13
calculating (12) 12
computing (12) 12
counting (12) 12
electric digital data processing (12) 12
genetic association studies - methods (12) 12
genetics (12) 12
genomics (12) 12
models, genetic (12) 12
polymorphism, single nucleotide (12) 12
female (11) 11
genetic variation (11) 11
male (11) 11
phenotype (10) 10
case-control studies (9) 9
genome-wide association study (9) 9
basic electric elements (8) 8
genetic predisposition to disease (8) 8
genotype & phenotype (8) 8
performing operations (8) 8
transporting (8) 8
biology (7) 7
data processing (7) 7
education (7) 7
genes (7) 7
genetic aspects (7) 7
methods (7) 7
population (7) 7
regression analysis (7) 7
software (7) 7
traits (7) 7
advertising (6) 6
after-treatment of the shaped products, e.g. repairing (6) 6
analysis (6) 6
atherosclerosis (6) 6
common diseases (6) 6
cryptography (6) 6
data interpretation, statistical (6) 6
disease (6) 6
display (6) 6
gene expression (6) 6
gene sequencing (6) 6
genotype (6) 6
gwas (6) 6
indexing scheme associated with subclass b29c, relating to particulararticles (6) 6
indexing scheme associated with subclasses b29b, b29c or b29d, relating to moulding materials (6) 6
phenotypes (6) 6
quantitative trait loci (6) 6
risk (6) 6
seals (6) 6
sequence analysis, dna - methods (6) 6
shaping of material in a plastic state, not otherwise providedfor (6) 6
shaping or joining of plastics (6) 6
working of plastics (6) 6
working of substances in a plastic state, in general (6) 6
association (5) 5
devices or arrangements, the optical operation of which ismodified by changing the optical properties of the medium of thedevices or arrangements for the control of the intensity,colour, phase, polarisation or direction of light, e.g.switching, gating, modulating or demodulating (5) 5
frequency-changing (5) 5
genetic association studies (5) 5
genetic research (5) 5
genetic-variants (5) 5
meta-analysis (5) 5
mixed models (5) 5
multidisciplinary sciences (5) 5
non-linear optics (5) 5
optical analogue/digital converters (5) 5
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
by Wu, Michael C and Lee, Seunggeun and Cai, Tianxi and Li, Yun and Boehnke, Michael and Lin, Xihong
The American Journal of Human Genetics, ISSN 0002-9297, 07/2011, Volume 89, Issue 1, pp. 82 - 93
Sequencing studies are increasingly being conducted to identify rare variants associated with complex traits. The limited power of classical single-marker... 
REGRESSION | MIXED MODELS | COMMON DISEASES | GENETICS & HEREDITY | SNPS | GENETIC PATHWAY | TRAITS | GENOME-WIDE ASSOCIATION | STRATEGIES | Genetic Variation | Sequence Analysis - methods | Computer Simulation | Gene Frequency | Humans | Databases, Genetic | Genetic Association Studies - methods | Models, Genetic | Software | Genetic Loci | Usage | Research | Regression analysis | Nucleotide sequencing | Genetic variation | Genomes | Triglycerides | Simulation | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Optimal tests for rare variant effects in sequencing association studies
by Lee, Seunggeun and Wu, Michael C and Lin, Xihong
Biostatistics, ISSN 1465-4644, 09/2012, Volume 13, Issue 4, pp. 762 - 775
With development of massively parallel sequencing technologies, there is a substantial need for developing powerful rare variant association tests. Common... 
Kernel association test | Score test | Burden tests | Correlated effects | Rare variants | HDL | ALLELES | MIXED MODELS | DISEASE | MATHEMATICAL & COMPUTATIONAL BIOLOGY | STATISTICS & PROBABILITY | Genetic Variation | Data Interpretation, Statistical | Sample Size | Computer Simulation | Humans | Genetic Association Studies - methods | Sequence Analysis, DNA - methods | Genotype & phenotype | Biostatistics | Cardiovascular disease | Genomes | Medical technology | Genetic testing | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants
by Ionita-Laza, Iuliana and Lee, Seunggeun and Makarov, Vlad and Buxbaum, Joseph D and Lin, Xihong
The American Journal of Human Genetics, ISSN 0002-9297, 06/2013, Volume 92, Issue 6, pp. 841 - 853
Recent developments in sequencing technologies have made it possible to uncover both rare and common genetic variants. Genome-wide association studies (GWASs)... 
DISEASE ASSOCIATION | SET | GENETICS & HEREDITY | FRAMEWORK | SNPS | RISK | GENETIC-VARIANTS | PROPORTION | GENOME | Crohn Disease - genetics | Data Interpretation, Statistical | Genetic Predisposition to Disease | Genetic Testing | Gene Frequency | Humans | Genetic Association Studies - methods | Logistic Models | Nod2 Signaling Adaptor Protein - genetics | Risk | Algorithms | Child Development Disorders, Pervasive - genetics | Computer Simulation | Low Density Lipoprotein Receptor-Related Protein-2 - genetics | Models, Genetic | Software | Autism | Genomes | Biological variation | Risk assessment | Crohns disease | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies
by Lee, Seunggeun and Teslovich, Tanya M and Boehnke, Michael and Lin, Xihong
The American Journal of Human Genetics, ISSN 0002-9297, 07/2013, Volume 93, Issue 1, pp. 42 - 53
We propose a general statistical framework for meta-analysis of gene- or region-based multimarker rare variant association tests in sequencing association... 
TESTS | DISEASES | ROBUST | GENETICS & HEREDITY | LOCI | COMPLEX TRAITS | MAP | GENOME-WIDE ASSOCIATION | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Meta-Analysis as Topic | Reproducibility of Results | Humans | Genetic Diseases, Inborn - genetics | Genetic Association Studies - methods | Logistic Models | Genetics, Population - methods | Computer Simulation | Lipids - blood | Polymorphism, Single Nucleotide | Genetic Diseases, Inborn - diagnosis | Research | Nucleotide sequencing | Genetic variation | Meta-analysis | DNA sequencing | Genetic markers | Genetic disorders | Biological variation | Simulation | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies
by Lee, Seunggeun and Emond, Mary J and Bamshad, Michael J and Barnes, Kathleen C and Rieder, Mark J and Nickerson, Deborah A and Christiani, David C and Wurfel, Mark M and Lin, Xihong and ESP Lung Project Team and NHLBI GO Exome Sequencing Project and NHLBI GO Exome Sequencing Project—ESP Lung Project Team
The American Journal of Human Genetics, ISSN 0002-9297, 08/2012, Volume 91, Issue 2, pp. 224 - 237
We propose in this paper a unified approach for testing the association between rare variants and phenotypes in sequencing association studies. This approach... 
CHAIN-KINASE GENE | COMMON DISEASES | GENETICS & HEREDITY | FRAMEWORK | ACUTE LUNG INJURY | RISK | STRATEGIES | Genetic Variation | Rare Diseases - genetics | Data Interpretation, Statistical | Exome - genetics | Computer Simulation | Humans | Genetic Association Studies - methods | Models, Genetic | Sequence Analysis, DNA - methods | Case-Control Studies | Acute respiratory distress syndrome | Genetic variation | Analysis | Exome sequencing | Resampling (Statistics) | Genetic aspects | Diagnosis | Research | Methods | Genotype & phenotype | Genomes | Genetic testing | Sample size | Causality | Correlation analysis | Index Medicus | Heart | Kernels | Data processing | Lung | Blood
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text A novel random effect model for GWAS meta‐analysis and its application to trans‐ethnic meta‐analysis
by Shi, Jingchunzi and Lee, Seunggeun
Biometrics, ISSN 0006-341X, 09/2016, Volume 72, Issue 3, pp. 945 - 954
Meta-analysis of trans-ethnic genome-wide association studies (GWAS) has proven to be a practical and profitable approach for identifying loci that contribute... 
Effect‐size heterogeneity | GWAS | Trans‐ethnic meta‐analysis | Random effect model | Meta‐analysis | Kernel regression | Effect-size heterogeneity | Trans-ethnic meta-analysis | Meta-analysis | MIXED MODELS | SEQUENCING ASSOCIATION | BIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | STATISTICS & PROBABILITY | GENOME-WIDE ASSOCIATION | Meta-Analysis as Topic | Ethnic Groups - genetics | Computer Simulation | Diabetes Mellitus, Type 2 - genetics | Humans | Polymorphism, Single Nucleotide | Genome-Wide Association Study - statistics & numerical data | Models, Statistical | Genetic Heterogeneity | Type 2 diabetes | Models | Single nucleotide polymorphisms | Genomics | Genomes | Genealogy | Random variables | Populations | Computer simulation | Diabetes mellitus | Single-nucleotide polymorphism | Genetic distance | Genetic diversity | Regression analysis | Ethnic factors | Consortia | Heterogeneity | Computing time | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies
by Barnett, Ian J and Lee, Seunggeun and Lin, Xihong
Genetic Epidemiology, ISSN 0741-0395, 02/2013, Volume 37, Issue 2, pp. 142 - 151
In the increasing number of sequencing studies aimed at identifying rare variants associated with complex traits, the power of the test can be improved by... 
selective sampling | extreme phenotype sampling | rare genetic variants | complex trait associations | Extreme phenotype sampling | Rare genetic variants | Complex trait associations | Selective sampling | TESTS | QUANTITATIVE-TRAIT LOCI | SIB PAIRS | EXTREMELY DISCORDANT | STRATEGIES | LINKAGE DISEQUILIBRIUM | COMMON DISEASES | GENETICS & HEREDITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | MISSING HERITABILITY | SCORE TEST | GENOME-WIDE ASSOCIATION | Genetic Variation | Angiopoietin-like 4 Protein | Phenotype | Angiopoietin-like Proteins | Genetic Association Studies | Humans | Models, Genetic | Triglycerides - genetics | Angiopoietins - genetics | Sequence Analysis, DNA - methods | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Improving power for rare‐variant tests by integrating external controls
by Lee, Seunggeun and Kim, Sehee and Fuchsberger, Christian
Genetic Epidemiology, ISSN 0741-0395, 11/2017, Volume 41, Issue 7, pp. 610 - 619
Due to the drop in sequencing cost, the number of sequenced genomes is increasing rapidly. To improve power of rare‐variant tests, these sequenced samples... 
Rare‐variant test | external controls | next‐generation sequencing | next-generation sequencing | Rare-variant test | KERNEL MACHINE REGRESSION | GENETICS & HEREDITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | PHENOTYPE ASSOCIATION | TRAITS | LINEAR-MODELS | GENE LEVEL | EQUIVALENCE | Type 2 diabetes | Macular degeneration | Analysis | Genomics | Statistical analysis | Pipelines | Diabetes mellitus | Data processing | Genomes | Degeneration | Statistical methods | Impact tests | Statistical tests | Age | Gene sequencing | Index Medicus | Rare variant test | External controls | Next generation sequencing
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Family-based association tests for sequence data, and comparisons with population-based association tests
by Ionita-Laza, Iuliana and Lee, Seunggeun and Makarov, Vladimir and Buxbaum, Joseph D and Lin, Xihong
European Journal of Human Genetics, ISSN 1018-4813, 10/2013, Volume 21, Issue 10, pp. 1158 - 1162
Recent advances in high-throughput sequencing technologies make it increasingly more efficient to sequence large cohorts for many complex traits. We discuss... 
burden and variance-component tests | sequence data | family-and population-based association tests | COMMON VARIANTS | family- and population-based association tests | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISORDERS | PATTERNS | DESIGNS | RARE VARIANTS | UNIFIED APPROACH | GENETICS & HEREDITY | FRAMEWORK | MUTATIONS | DISEASE VARIANTS | GENOME-WIDE ASSOCIATION | Exome | Child Development Disorders, Pervasive - genetics | Pedigree | Humans | Sensitivity and Specificity | Genetic Association Studies - methods | Software | Population - genetics | Sequence Analysis, DNA - methods | Hypothesis testing | Disease | Data processing | Principal components analysis | Genomes | Generalized linear models | Computer programs | Studies | Autism | Hypotheses | Population | Genetics | Random variables | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Multi‐SKAT: General framework to test for rare‐variant association with multiple phenotypes
by Dutta, Diptavo and Scott, Laura and Boehnke, Michael and Lee, Seunggeun
Genetic Epidemiology, ISSN 0741-0395, 02/2019, Volume 43, Issue 1, pp. 4 - 23
In genetic association analysis, a joint test of multiple distinct phenotypes can increase power to identify sets of trait‐associated variants within genes or... 
rare variants | Copula | METSIM study | related individuals | multiple phenotypes | phenotype kernel | pleiotropy | SKAT | gene‐based test | gene-based test | BRANCHED-CHAIN | GENETIC-VARIANTS | AMINO-ACIDS | INSULIN-RESISTANCE | GENETICS & HEREDITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | COMMON | TRAITS | Genetic Variation | Exome - genetics | Phenotype | Algorithms | Genetic Association Studies | Time Factors | Computer Simulation | Humans | Models, Genetic | Association analysis | Amino acids | Phenotypes | Regression analysis | Metabolic disorders | Genetic analysis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text CONVERGENCE AND PREDICTION OF PRINCIPAL COMPONENT SCORES IN HIGH-DIMENSIONAL SETTINGS
by Seunggeun Lee and Fei Zou and Fred A. Wright
The Annals of Statistics, ISSN 0090-5364, 12/2010, Volume 38, Issue 6, pp. 3605 - 3629
A number of settings arise in which it is of interest to predict Principal Component (PC) scores for new observations using data from an initial sample. In... 
Datasets | Estimate reliability | Eigenvalues | Principal components analysis | Eigenvectors | Matrices | Covariance matrices | Estimators | Simulation training | Consistent estimators | PC regression | PC scores | Random matrix | PCA | random matrix | SURVIVAL | CONSISTENCY | MODELS | LARGEST EIGENVALUE | GEOMETRIC REPRESENTATION | WHOLE-GENOME ASSOCIATION | STATISTICS & PROBABILITY | SAMPLE COVARIANCE MATRICES | Studies | Eigen values | Convergence | 15A18 | 62H25 | PC Scores | Random Matrix | PC Regression
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Multi-SKAT: General framework to test for rare-variant association with multiple phenotypes
: DUTTA et al
by Dutta, Diptavo and Scott, Laura and Boehnke, Michael and Lee, Seunggeun
Genetic Epidemiology, ISSN 0741-0395, 02/2019, Volume 43, Issue 1, pp. 4 - 23
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Asymptotic properties of principal component analysis and shrinkage-bias adjustment under the generalized spiked population model
by Dey, Rounak and Lee, Seunggeun
Journal of Multivariate Analysis, ISSN 0047-259X, 09/2019, Volume 173, pp. 145 - 164
With the development of high-throughput technologies, principal component analysis (PCA) in the high-dimensional regime is of great interest. Most of the... 
High-dimensional data | PC scores | Random matrix | Consistent estimation | SAMPLE EIGENVALUES | EIGENVECTORS | SCORES | LIMITING SPECTRAL DISTRIBUTION | CONVERGENCE | STATISTICS & PROBABILITY | COVARIANCE MATRICES
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Test for interactions between a genetic marker set and environment in generalized linear models
by Lin, Xihong and Lin, Xinyi and Lee, Seunggeun and Christiani, David C
Biostatistics, ISSN 1465-4644, 09/2013, Volume 14, Issue 4, pp. 667 - 681
We consider in this paper testing for interactions between a genetic marker set and an environmental variable. A common practice in studying gene-environment... 
Gene-environment interactions | Asymptotic bias analysis | Genome-wide association studies | Single-nucleotide polymorphism | Variance component test | Score statistic | REGRESSION | MIXED MODELS | VARIANTS | STATISTICS & PROBABILITY | SMOKING | LOCI | LUNG-CANCER | MATHEMATICAL & COMPUTATIONAL BIOLOGY | 15Q25 | ASSOCIATION | Lung Neoplasms - genetics | Genetic Predisposition to Disease | Computer Simulation | Genetic Markers - genetics | Humans | Female | Linear Models | Male | Smoking - genetics | Models, Genetic | Polymorphism, Single Nucleotide | Gene-Environment Interaction | Biostatistics | Genetics | Simulation | Lung cancer | Polymorphism | Index Medicus | Gene–environment interactions
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights