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1. Full Text Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants
by Ionita-Laza, Iuliana and Lee, Seunggeun and Makarov, Vlad and Buxbaum, Joseph D and Lin, Xihong
American journal of human genetics, ISSN 0002-9297, 06/2013, Volume 92, Issue 6, pp. 841 - 853
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Crohn Disease - genetics | Data Interpretation, Statistical | Genetic Predisposition to Disease | Genetic Testing | Gene Frequency | Humans | Genetic Association Studies - methods | Logistic Models | Nod2 Signaling Adaptor Protein - genetics | Risk | Algorithms | Child Development Disorders, Pervasive - genetics | Computer Simulation | Low Density Lipoprotein Receptor-Related Protein-2 - genetics | Models, Genetic | Software | Autism | Genomes | Biological variation | Risk assessment | Crohns disease | Index Medicus
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2. Full Text Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
by Wu, Michael C and Lee, Seunggeun and Cai, Tianxi and Li, Yun and Boehnke, Michael and Lin, Xihong
American journal of human genetics, ISSN 0002-9297, 07/2011, Volume 89, Issue 1, pp. 82 - 93
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects. Genetic counseling | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Genetic Variation | Sequence Analysis - methods | Computer Simulation | Gene Frequency | Humans | Databases, Genetic | Genetic Association Studies - methods | Models, Genetic | Software | Genetic Loci | Usage | Research | Regression analysis | Nucleotide sequencing | Genetic variation | Genomes | Triglycerides | Simulation | Index Medicus
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3. Full Text Optimal tests for rare variant effects in sequencing association studies
by Lee, Seunggeun and Wu, Michael C and Lin, Xihong
Biostatistics (Oxford, England), ISSN 1465-4644, 09/2012, Volume 13, Issue 4, pp. 762 - 775
Kernel association test | Score test | Burden tests | Correlated effects | Rare variants | Statistics & Probability | Physical Sciences | Mathematics | Life Sciences & Biomedicine | Science & Technology | Mathematical & Computational Biology | Genetic Variation | Data Interpretation, Statistical | Sample Size | Computer Simulation | Humans | Genetic Association Studies - methods | Sequence Analysis, DNA - methods | Genotype & phenotype | Biostatistics | Cardiovascular disease | Genomes | Medical technology | Genetic testing | Index Medicus
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4. Full Text Asymptotic properties of principal component analysis and shrinkage-bias adjustment under the generalized spiked population model
by Dey, Rounak and Lee, Seunggeun
Journal of multivariate analysis, ISSN 0047-259X, 09/2019, Volume 173, pp. 145 - 164
High-dimensional data | PC scores | Random matrix | Consistent estimation | Statistics & Probability | Physical Sciences | Mathematics | Science & Technology
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5. Full Text General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies
by Lee, Seunggeun and Teslovich, Tanya M and Boehnke, Michael and Lin, Xihong
American journal of human genetics, ISSN 0002-9297, 07/2013, Volume 93, Issue 1, pp. 42 - 53
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Meta-Analysis as Topic | Reproducibility of Results | Humans | Genetic Diseases, Inborn - genetics | Genetic Association Studies - methods | Logistic Models | Genetics, Population - methods | Computer Simulation | Lipids - blood | Polymorphism, Single Nucleotide | Genetic Diseases, Inborn - diagnosis | Research | Nucleotide sequencing | Genetic variation | Meta-analysis | DNA sequencing | Genetic markers | Genetic disorders | Biological variation | Simulation | Index Medicus
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6. Full Text Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies
by Barnett, Ian J and Lee, Seunggeun and Lin, Xihong
Genetic epidemiology, ISSN 0741-0395, 02/2013, Volume 37, Issue 2, pp. 142 - 151
selective sampling | extreme phenotype sampling | rare genetic variants | complex trait associations | Extreme phenotype sampling | Rare genetic variants | Complex trait associations | Selective sampling | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Mathematical & Computational Biology | Genetic Variation | Angiopoietin-like 4 Protein | Phenotype | Angiopoietin-like Proteins | Genetic Association Studies | Humans | Models, Genetic | Triglycerides - genetics | Angiopoietins - genetics | Sequence Analysis, DNA - methods | Index Medicus
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7. Full Text Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies
by Lee, Seunggeun and Emond, Mary J and Bamshad, Michael J and Barnes, Kathleen C and Rieder, Mark J and Nickerson, Deborah A and Christiani, David C and Wurfel, Mark M and Lin, Xihong and NHLBI GO Exome Sequencing Project—ESP Lung Project Team and ESP Lung Project Team and NHLBI GO Exome Sequencing Project
American journal of human genetics, ISSN 0002-9297, 08/2012, Volume 91, Issue 2, pp. 224 - 237
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Medical genetics | Genetic Variation | Rare Diseases - genetics | Data Interpretation, Statistical | Exome - genetics | Computer Simulation | Humans | Genetic Association Studies - methods | Models, Genetic | Sequence Analysis, DNA - methods | Case-Control Studies | Acute respiratory distress syndrome | Genetic variation | Analysis | Exome sequencing | Resampling (Statistics) | Genetic aspects | Diagnosis | Research | Methods | Genotype & phenotype | Genomes | Genetic testing | Sample size | Causality | Correlation analysis | Index Medicus | Heart | Kernels | Data processing | Lung | Blood
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8. Full Text A novel random effect model for GWAS meta‐analysis and its application to trans‐ethnic meta‐analysis
by Shi, Jingchunzi and Lee, Seunggeun
Biometrics, ISSN 0006-341X, 09/2016, Volume 72, Issue 3, pp. 945 - 954
Effect‐size heterogeneity | GWAS | Trans‐ethnic meta‐analysis | Random effect model | Meta‐analysis | Kernel regression | Effect-size heterogeneity | Trans-ethnic meta-analysis | Meta-analysis | Statistics & Probability | Physical Sciences | Life Sciences & Biomedicine | Biology | Life Sciences & Biomedicine - Other Topics | Mathematics | Science & Technology | Mathematical & Computational Biology | Meta-Analysis as Topic | Ethnic Groups - genetics | Computer Simulation | Diabetes Mellitus, Type 2 - genetics | Humans | Polymorphism, Single Nucleotide | Genome-Wide Association Study - statistics & numerical data | Models, Statistical | Genetic Heterogeneity | Type 2 diabetes | Models | Single nucleotide polymorphisms | Genomics | Genomes | Genealogy | Random variables | Populations | Computer simulation | Diabetes mellitus | Single-nucleotide polymorphism | Genetic distance | Genetic diversity | Regression analysis | Ethnic factors | Consortia | Heterogeneity | Computing time | Index Medicus
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9. Full Text Multi‐SKAT: General framework to test for rare‐variant association with multiple phenotypes
by Dutta, Diptavo and Scott, Laura and Boehnke, Michael and Lee, Seunggeun
Genetic epidemiology, ISSN 0741-0395, 02/2019, Volume 43, Issue 1, pp. 4 - 23
rare variants | Copula | METSIM study | related individuals | multiple phenotypes | phenotype kernel | pleiotropy | SKAT | gene‐based test | gene-based test | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Mathematical & Computational Biology | Genetic Variation | Exome - genetics | Phenotype | Algorithms | Genetic Association Studies | Time Factors | Computer Simulation | Humans | Models, Genetic | Association analysis | Amino acids | Phenotypes | Regression analysis | Metabolic disorders | Genetic analysis | Index Medicus | Gene-based test | Pleiotropy | Related individuals | Phenotype kernel | Multiple phenotypes | Rare-variants
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10. Full Text Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
by Zhou, Wei and Nielsen, Jonas B and Fritsche, Lars G and Dey, Rounak and Gabrielsen, Maiken E and Wolford, Brooke N and LeFaive, Jonathon and VandeHaar, Peter and Gagliano, Sarah A and Gifford, Aliya and Bastarache, Lisa A and Wei, Wei-Qi and Denny, Joshua C and Lin, Maoxuan and Hveem, Kristian and Kang, Hyun Min and Abecasis, Goncalo R and Willer, Cristen J and Lee, Seunggeun
Nature genetics, ISSN 1061-4036, 09/2018, Volume 50, Issue 9, pp. 1335 - 1341
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Phenotype | Computer Simulation | Humans | Linear Models | Logistic Models | Models, Genetic | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Case-Control Studies | Phenotypes | Costs | Parameter estimation | Model testing | Error analysis | Statistical analysis | Data processing | Genomes | Statistical methods | Statistical tests | Optimization | Quantitative genetics | Normal distribution | Computer applications | Electronic health records | Methods | Index Medicus
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11. Full Text A Fast and Accurate Algorithm to Test for Binary Phenotypes and Its Application to PheWAS
by Dey, Rounak and Schmidt, Ellen M and Abecasis, Goncalo R and Lee, Seunggeun
American journal of human genetics, ISSN 0002-9297, 07/2017, Volume 101, Issue 1, pp. 37 - 49
PheWAS | rare variants | GWAS | single-variant test | saddlepoint approximation | unbalanced case-control | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Gene Frequency - genetics | Genome-Wide Association Study | Phenotype | Reproducibility of Results | Algorithms | Numerical Analysis, Computer-Assisted | Time Factors | Computer Simulation | Genomics | Humans | Polymorphism, Single Nucleotide - genetics | Index Medicus
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