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1. Full Text Assessing Fluid Responsiveness in Clinical Practice
by Lefrant, Jean Yves and Muller, Laurent
Anesthesia and Analgesia, ISSN 0003-2999, 05/2016, Volume 122, Issue 5, pp. 1256 - 1257
Life Sciences | Human health and pathology
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2. Full Text Assessing Fluid Responsiveness in Clinical Practice: So Many Tools Available, So Many Questions to Answer
by Lefrant, Jean Yves and Muller, Laurent
Anesthesia & Analgesia, ISSN 0003-2999, 05/2016, Volume 122, Issue 5, pp. 1256 - 1257
Evidence-Based Medicine | Humans | Index Medicus | Abridged Index Medicus
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3. Full Text What’s new in pharmacokinetics of antimicrobials in AKI and RRT?
by Roberts, Jason A and Lefrant, Jean-Yves and Lipman, Jeffrey
Intensive Care Medicine, ISSN 0342-4642, 06/2017, Volume 43, Issue 6, pp. 904 - 906
Dosing | Antibiotic | Pharmacodynamics | Dialysis | Antibiotic resistance | Life Sciences | Human health and pathology
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4. Full Text In reply
by Daurat, Gerald and Muller, Laurent and Daurat, Aurelien and Lefrant, Jean‐Yves
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, pp. 3147 - 3148
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5. Full Text In reply
by Gerald Daurat and Laurent Muller and Aurelien Daurat and Jean-Yves Lefrant
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, p. 3147
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6. Full Text In reply
: LETTERS TO THE EDITOR
by Daurat, Gerald and Muller, Laurent and Daurat, Aurelien and Lefrant, Jean-Yves
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, pp. 3147 - 3148
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7. Full Text In reply
by Daurat, Gerald and Muller, Laurent and Daurat, Aurelien and Lefrant, Jean-Yves
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, p. 3147
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8. Full Text In reply
by Daurat, Gerald and Muller, Laurent and Daurat, Aurelien and Lefrant, Jean-Yves
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, pp. 3147 - 3148
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9. Full Text In reply
by Daurat, Gerald and Muller, Laurent and Daurat, Aurelien and Lefrant, Jean-Yves
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, pp. 3147 - 3148
Life Sciences | Human health and pathology | Hematology
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10. Full Text Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction 6among high-risk patients undergoing major surgery: A randomized clinical trial
by Futier, Emmanuel and Lefrant, Jean-Yves and Guinot, Pierre-Gregoire and Godet, Thomas and Lorne, Emmanuel and Cuvillon, Philippe and Bertran, Sebastien and Leone, Marc and Pastene, Bruno and Piriou, Vincent and Molliex, Serge and Albanese, Jacques and Julia, Jean-Michel and Tavernier, Benoit and Imhoff, Etienne and Bazin, Jean-Etienne and Constantin, Jean-Michel and Pereira, Bruno and Jaber, Samir
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 10/2017, Volume 318, Issue 14, pp. 1346 - 1357
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11. Full Text A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery
by Futier, Emmanuel and Constantin, Jean-Michel and Paugam-Burtz, Catherine and Pascal, Julien and Eurin, Mathilde and Neuschwander, Arthur and Marret, Emmanuel and Beaussier, Marc and Gutton, Christophe and Lefrant, Jean-Yves and Allaouchiche, Bernard and Verzilli, Daniel and Leone, Marc and De Jong, Audrey and Bazin, Jean-Etienne and Pereira, Bruno and Jaber, Samir and IMPROVE Study Grp and IMPROVE Study Group
The New England Journal of Medicine, ISSN 0028-4793, 08/2013, Volume 369, Issue 5, pp. 428 - 437
Low-tidal-volume ventilation with positive end-expiratory pressure is the standard of care in acute respiratory distress syndrome. In this trial, the use of... 
POSTOPERATIVE PULMONARY COMPLICATIONS | MEDICINE, GENERAL & INTERNAL | MULTIFACTORIAL RISK INDEX | INFLAMMATORY RESPONSES | MECHANICAL VENTILATION | LUNG INJURY | ORGAN DYSFUNCTION | PROTECTIVE-VENTILATION | GENERAL-ANESTHESIA | RESPIRATORY-DISTRESS-SYNDROME | RECRUITMENT MANEUVERS | Double-Blind Method | Humans | Middle Aged | Postoperative Complications - prevention & control | Respiratory Insufficiency - etiology | Male | Postoperative Complications - therapy | Positive-Pressure Respiration - methods | Respiratory Insufficiency - therapy | Tidal Volume | Abdomen - surgery | Operative Time | Digestive System Surgical Procedures | Respiratory Insufficiency - prevention & control | Intention to Treat Analysis | Female | Abdominal surgery | Patient outcomes | Artificial respiration | Methods | Statistical analysis | Motivation | Risk groups | Lung | Surgery | Mortality | Clinical trials | Ventilation | Intubation | Teaching hospitals | Index Medicus | Abridged Index Medicus
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12. Full Text Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
by Papazian, Laurent and Forel, Jean-Marie and Gacouin, Arnaud and Penot-Ragon, Christine and Perrin, Gilles and Loundou, Anderson and Jaber, Samir and Arnal, Jean-Michel and Perez, Didier and Seghboyan, Jean-Marie and Constantin, Jean-Michel and Courant, Pierre and Lefrant, Jean-Yves and Guérin, Claude and Prat, Gwenaël and Morange, Sophie and Roch, Antoine and ACURASYS Study Investigators
The New England Journal of Medicine, ISSN 0028-4793, 09/2010, Volume 363, Issue 12, pp. 1107 - 1116
The investigators induced muscle paralysis in patients with the acute respiratory distress syndrome (ARDS) by administering a neuromuscular blocking agent,... 
MECHANICAL VENTILATION | MEDICINE, GENERAL & INTERNAL | ACUTE LUNG INJURY | WEAKNESS | OUTCOMES | BLOCKING-AGENTS | Neuromuscular Blocking Agents - adverse effects | Atracurium - analogs & derivatives | Double-Blind Method | Pneumothorax - epidemiology | Humans | Middle Aged | Neuromuscular Blocking Agents - therapeutic use | Proportional Hazards Models | Survival Rate | Treatment Outcome | Combined Modality Therapy | Respiratory Distress Syndrome, Adult - mortality | Respiratory Distress Syndrome, Adult - drug therapy | Respiration, Artificial | Atracurium - adverse effects | Multiple Organ Failure | Atracurium - therapeutic use | Infusions, Intravenous | Ventilator Weaning - methods | Respiratory Distress Syndrome, Adult - therapy | Acute respiratory distress syndrome | Neuromuscular blocking agents | Usage | Patient outcomes | Drug therapy | Health aspects | Artificial respiration | Anesthesia | Ventilation | Statistical analysis | Respiratory distress syndrome | Mortality | Index Medicus | Abridged Index Medicus
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13. Full Text Respiratory variations of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure: Need for a cautious use
by Muller, Laurent and Bobbia, Xavier and Toumi, Mehdi and Louart, Guillaume and Molinari, Nicolas and Ragonnet, Benoit and Quintard, Hervé and Leone, Marc and Zoric, Lana and Lefrant, Jean Y and AzuRea Grp and AzuRea group and the AzuRea group
Critical Care, ISSN 1364-8535, 10/2012, Volume 16, Issue 5, pp. R188 - R188
Introduction: To investigate whether respiratory variation of inferior vena cava diameter (cIVC) predict fluid responsiveness in spontaneously breathing... 
CENTRAL VENOUS-PRESSURE | FILLING PRESSURES | CHALLENGE | VOLUME STATUS | ULTRASOUND | VENTILATED SEPTIC PATIENTS | WEDGE PRESSURE | CRITICALLY-ILL PATIENTS | INTENSIVE-CARE UNIT | DOPPLER-ECHOCARDIOGRAPHY | CRITICAL CARE MEDICINE | Predictive Value of Tests | Acute Disease | Humans | Middle Aged | Shock - physiopathology | Stroke Volume - physiology | Male | Fluid Therapy - methods | Female | Shock - therapy | Aged | Vena Cava, Inferior - physiology | Blood Flow Velocity - physiology | Respiratory Mechanics - physiology | Medicine, Experimental | Medical research | Wave propagation | Index Medicus | Research
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14. Full Text Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial
by Futier, Emmanuel and Lefrant, Jean-Yves and Guinot, Pierre-Gregoire and Godet, Thomas and Lorne, Emmanuel and Cuvillon, Philippe and Bertran, Sebastien and Leone, Marc and Pastene, Bruno and Piriou, Vincent and Molliex, Serge and Albanese, Jacques and Julia, Jean-Michel and Tavernier, Benoit and Imhoff, Etienne and Bazin, Jean-Etienne and Constantin, Jean-Michel and Pereira, Bruno and Jaber, Samir and INPRESS Study Grp and INPRESS Study Group and for the INPRESS Study Group
JAMA, ISSN 0098-7484, 10/2017, Volume 318, Issue 14, pp. 1346 - 1357
IMPORTANCE: Perioperative hypotension is associated with an increase in postoperative morbidity and mortality, but the appropriate management strategy remains... 
COGNITIVE DYSFUNCTION | ACUTE KIDNEY INJURY | INFLAMMATORY RESPONSE SYNDROME | INTERNATIONAL CONSENSUS CONFERENCE | MEDICINE, GENERAL & INTERNAL | GOAL-DIRECTED THERAPY | GENERAL-SURGERY | NONCARDIAC SURGERY | ACUTE-RENAL-FAILURE | MYOCARDIAL INJURY | INTRAOPERATIVE HYPOTENSION | Length of Stay | Vasoconstrictor Agents - administration & dosage | Kidney Diseases - prevention & control | Surgical Procedures, Operative | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Postoperative Complications - prevention & control | Epinephrine - administration & dosage | Norepinephrine - administration & dosage | Male | Abdomen - surgery | Hypotension - drug therapy | Postoperative Care | Intention to Treat Analysis | Systemic Inflammatory Response Syndrome - prevention & control | Female | Aged | Postoperative Complications - drug therapy | Blood Pressure Determination | Respiratory Tract Diseases - prevention & control | Precision Medicine | Measurement | Clinical trials | Usage | Blood pressure | Research | Postoperative care | Surgical outcomes | Medical services | Risk | Inflammatory response | Blood | Randomization | Motivation | Surgery | Anesthesia | Kidneys | Risk groups | Complications | Mortality | Health risks | Inflammation | Management | Patients | Morbidity | Hypotension | Strategy | Sepsis | Norepinephrine | Risk management | Mercury | Kidney transplantation | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | Caring for the Critically Ill Patient | Online First | Original Investigation
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15. Full Text The measurement of pain in intensive care unit: Comparison of 5 self-report intensity scales
by Chanques, Gérald and Viel, Eric and Constantin, Jean-Michel and Jung, Boris and Lattre, Sylvie de and Carr, Julie and Cissé, Moussa and Lefrant, Jean-Yves and Jaber, Samir
Pain, ISSN 0304-3959, 12/2010, Volume 151, Issue 3, pp. 711 - 721
Unlike wards, where chronic and acute pain are regularly managed, comparisons of the most commonly used self-report pain tools have not been reported for the... 
Delirium | Critical care | Analgesia | Intensive care units | Pain | Pain measurement | MULTICENTER | OBSERVATION TOOL | VALIDATION | NEUROSCIENCES | ADULT | CLINICAL NEUROLOGY | MECHANICALLY VENTILATED PATIENTS | AGITATION-SEDATION SCALE | ICU PATIENTS | ANESTHESIOLOGY | CRITICALLY-ILL PATIENTS | POSTOPERATIVE PAIN | Severity of Illness Index | Intensive Care Units | Pain Measurement - methods | Reproducibility of Results | Humans | Sensitivity and Specificity | Female | Male | Psychometrics | Care and treatment | Analgesics | Comparative analysis | Index Medicus
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16. Full Text Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
by Mercat, Alain and Richard, Jean-Christophe M and Vielle, Bruno and Jaber, Samir and Osman, David and Diehl, Jean-Luc and Lefrant, Jean-Yves and Prat, Gwenaël and Richecoeur, Jack and Nieszkowska, Ania and Gervais, Claude and Baudot, Jérôme and Bouadma, Lila and Brochard, Laurent and Expiratory Pressure (Express) Study Group, for the and Expiratory Pressure Express Study and Expiratory Pressure (Express) Study Group
JAMA, ISSN 0098-7484, 02/2008, Volume 299, Issue 6, pp. 646 - 655
CONTEXT The need for lung protection is universally accepted, but the optimal level of positive end-expiratory pressure (PEEP) in patients with acute lung... 
MORTALITY | MEDICINE, GENERAL & INTERNAL | TIDAL VOLUME | STRATEGY | MANEUVERS | AIRWAY PRESSURES | DERECRUITMENT | MECHANICAL VENTILATION | PROTECTIVE-VENTILATION | ALVEOLAR RECRUITMENT | PULMONARY-EDEMA | Respiratory Distress Syndrome, Adult - physiopathology | Hospital Mortality | Humans | Middle Aged | Survival Analysis | Female | Male | Aged | Tidal Volume | Positive-Pressure Respiration | Ventilator Weaning | Respiratory Distress Syndrome, Adult - therapy | Ventilators | Care and treatment | Usage | Diagnosis | Respiratory distress syndrome | Clinical trials | Airway management | Adults | Respiratory diseases | Clinical outcomes | Index Medicus | Abridged Index Medicus
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17. Full Text An intervention to decrease complications related to endotracheal intubation in the intensive care unit: a prospective, multiple-center study
by Jaber, Samir and Jung, Boris and Corne, Philippe and Sebbane, Mustapha and Muller, Laurent and Chanques, Gerald and Verzilli, Daniel and Jonquet, Olivier and Eledjam, Jean-Jacques and Lefrant, Jean-Yves
Intensive Care Medicine, ISSN 0342-4642, 2/2010, Volume 36, Issue 2, pp. 248 - 255
To determined whether the implementation of an intubation management protocol leads to the reduction of intubation-related complications in the intensive care... 
Pediatrics | Emergency Medicine | Complications | Intensive / Critical Care Medicine | Pain Medicine | Airway management | Pneumology/Respiratory System | Medicine & Public Health | Non-invasive ventilation | Practice guidelines | Anesthesiology | Intubation | Mechanical ventilation | RAPID-SEQUENCE INTUBATION | RISK-FACTORS | PREOXYGENATION | EMERGENCY TRACHEAL INTUBATION | SEPTIC SHOCK | POSITIVE-PRESSURE VENTILATION | CRITICALLY-ILL PATIENTS | CLINICAL-PRACTICE | NONINVASIVE VENTILATION | CRITICAL CARE MEDICINE | Prospective Studies | Humans | Middle Aged | Postoperative Complications - prevention & control | Respiration, Artificial - statistics & numerical data | Female | Intensive Care Units - statistics & numerical data | Male | Intubation, Intratracheal - statistics & numerical data | Postoperative Complications - epidemiology | Positive-Pressure Respiration | Practice Guidelines as Topic | Practice guidelines (Medicine) | Complications and side effects | Research | Trachea | Artificial respiration | Index Medicus
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18. Full Text DALI: Defining antibiotic levels in intensive care unit patients: Are current ß-lactam antibiotic doses sufficient for critically ill patients?
by Roberts, Jason A and Paul, Sanjoy K and Akova, Murat and Bassetti, Matteo and De Waele, Jan J and Dimopoulos, George and Kaukonen, Kirsi-Maija and Koulenti, Despoina and Martin, Claude and Montravers, Philippe and Rello, Jordi and Rhodes, Andrew and Starr, Therese and Wallis, Steven C and Lipman, Jeffrey and Margarit Ribas, Antonio and De Crop, Luc and Spapen, Herbert and Wauters, Joost and Dugernier, Thierry and Jorens, Philippe and Dapper, Ilse and De Backer, Daniel and Taccone, Fabio S and Ruano, Laura and Afonso, Elsa and Alvarez-Lerma, Francisco and Gracia-Arnillas, Maria Pilar and Fernández, Francisco and Feijoo, Neus and Bardolet, Neus and Rovira, Assumpta and Garro, Pau and Colon, Diana and Castillo, Carlos and Fernado, Juan and Lopez, Maria Jesus and Fernandez, Jose Luis and Arribas, Ana Maria and Teja, Jose Luis and Ots, Elsa and Carlos Montejo, Juan and Catalan, Mercedes and Prieto, Isidro and Gonzalo, Gloria and Galvan, Beatriz and Blasco, Miguel Angel and Meyer, Estibaliz and Del Nogal, Frutos and Vidaur, Loreto and Sebastian, Rosa and Garde, Pila Marco and Martin Velasco, Maria Del Mar and Zaragoza Crespo, Rafael and Esperatti, Mariano and Torres, Antoni and Baldesi, Olivier and Dupont, Herve and Mahjoub, Yazine and Lasocki, Sigismond and Constantin, Jean Michel and Payen, Jean François and Albanese, Jacques and Malledant, Yannick and Pottecher, Julien and Lefrant, Jean-Yves and Jaber, Samir and Joannes-Boyau, Olivier and Orban, Christophe and Ostermann, Marlies and McKenzie, Cathrine and Berry, William and Smith, John and Lei, Katie and Rubulotta, Francesca and Gordon, Anthony and Brett, Stephen and Stotz, Martin and Templeton, Maie and Ebm, Claudia and Moran, Carl and Pettilä, Ville and Xristodoulou, Aglaia and Theodorou, Vassiliki and Kouliatsis, Georgios and Sertaridou, Eleni and Anthopoulos, Georgios and Choutas, George and Rantis, Thanos and Karatzas, Stylianos and Balla, Margarita and Papanikolaou, Metaxia and Myrianthefs, Pavlos and Gavala, Alexandra and Fildisis, Georgios and Koutsoukou, Antonia and Kyriakopoulou, Magdalini and Petrochilou, Kalomoira and Kompoti, Maria and Michalia, Martha and ...
Clinical Infectious Diseases, ISSN 1058-4838, 04/2014, Volume 58, Issue 8, pp. 1072 - 1083
pharmacokinetics | extended infusion | adverse events | pharmacodynamics | continuous infusion
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19. Full Text SP241HETEROGENEITY OF SEVERE AKI FOR ETIOLOGY CARE AND PROGNOSIS
by Cedric, Aglae and Laurent, Muller and Sylvain, Cariou and Pascal, Reboul and Sophie, Renaud and Claire, Roger and Samir, Barbar and Remi, Trusson and Davidpaul, Debrauwere and Ziyad, Messikh and Jean, Yves Lefrant and Moranne, Olivier
Nephrology Dialysis Transplantation, ISSN 0931-0509, 06/2019, Volume 34, Issue Supplement_1
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20. Full Text Interest of Urinary [TIMP-2] × [IGFBP-7] for Predicting the Occurrence of Acute Kidney Injury after Cardiac Surgery: A Gray Zone Approach
by Finge, Toufic and Bertran, Sébastien and Roger, Claire and Candela, Damien and Pereira, Bruno and Scott, Christopher and Muller, Laurent and Louart, Benjamin and Lefrant, Jean-Yves
Anesthesia and Analgesia, ISSN 0003-2999, 09/2017, Volume 125, Issue 3, pp. 762 - 769
This study assessed the ability of 3-hour postoperative urinary tissue inhibitor of metalloproteinases-2 × insulin-like growth factor binding protein-7... 
Acute Kidney Injury - urine | Predictive Value of Tests | Biomarkers - urine | Humans | Middle Aged | Male | Cardiac Surgical Procedures - adverse effects | Postoperative Complications - epidemiology | Cardiac Surgical Procedures - trends | Postoperative Complications - diagnosis | Tissue Inhibitor of Metalloproteinase-2 - urine | Time Factors | Acute Kidney Injury - diagnosis | Aged, 80 and over | Female | Aged | Acute Kidney Injury - epidemiology | Postoperative Complications - urine | Insulin-Like Growth Factor Binding Proteins - urine | Index Medicus | Abridged Index Medicus
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