2009, ISBN 9780786434794, ix, 202
Book
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across...
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | Immunology | Infectious Diseases | Immunology and Allergy | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76607
Studies of chronic lymphocytic leukemia (CLL) have yielded substantial progress, however a lack of immortalized cell lines representative of the primary...
SITU HYBRIDIZATION | TRANSFORMATION | HIGH-RISK | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | GENOMIC ABERRATIONS | SHORT SURVIVAL | CLONAL EVOLUTION | CHROMOSOMAL-ABNORMALITIES | EPSTEIN-BARR-VIRUS | B-CLL CELLS | Phenotype | Animals | Herpesvirus 4, Human - physiology | Humans | Cell Line, Tumor | Mice | Cell Culture Techniques | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Cell Transformation, Viral | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Cell Movement | Chronic lymphocytic leukemia | DNA microarrays | Oncology, Experimental | Analysis | Genes | Bone marrow | Development and progression | Transplantation | B cells | Research | Gene expression | Cancer | Lymphocyte receptors | Biotechnology | Transformation | Animal models | Trisomy | Pathogenesis | Leukemia | Kinases | Immunology | Peripheral blood | Genetics | Chromosomes | Spleen | Chronic lymphatic leukemia | Internal medicine | Hematology | Medical treatment | Lymphatic leukemia | Virology | Medicine | CD5 antigen | Pathology | Lymphocytes B | Cell lines | In vivo methods and tests | Mutation | Health risk assessment | Chemokines | Cell migration | Apoptosis
SITU HYBRIDIZATION | TRANSFORMATION | HIGH-RISK | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | GENOMIC ABERRATIONS | SHORT SURVIVAL | CLONAL EVOLUTION | CHROMOSOMAL-ABNORMALITIES | EPSTEIN-BARR-VIRUS | B-CLL CELLS | Phenotype | Animals | Herpesvirus 4, Human - physiology | Humans | Cell Line, Tumor | Mice | Cell Culture Techniques | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Cell Transformation, Viral | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Cell Movement | Chronic lymphocytic leukemia | DNA microarrays | Oncology, Experimental | Analysis | Genes | Bone marrow | Development and progression | Transplantation | B cells | Research | Gene expression | Cancer | Lymphocyte receptors | Biotechnology | Transformation | Animal models | Trisomy | Pathogenesis | Leukemia | Kinases | Immunology | Peripheral blood | Genetics | Chromosomes | Spleen | Chronic lymphatic leukemia | Internal medicine | Hematology | Medical treatment | Lymphatic leukemia | Virology | Medicine | CD5 antigen | Pathology | Lymphocytes B | Cell lines | In vivo methods and tests | Mutation | Health risk assessment | Chemokines | Cell migration | Apoptosis
Journal Article
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 239 - 254.e6
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a...
somatic mutations | DNA damage repair | protein structure analysis | mutational signatures | somatic copy-number alterations | DNA damage footprints | The Cancer Genome Atlas PanCanAtlas project | epigenetic silencing | integrative statistical analysis | Biochemistry, Genetics and Molecular Biology(all) | POLYMERASE-EPSILON | HUMAN COLON | INACTIVATION | REPLICATION FORK STABILITY | PROMOTER HYPERMETHYLATION | STRUCTURAL BASIS | MICROSATELLITE INSTABILITY | MUTANT-CELLS | MUTATIONS | PREDICTS RESPONSE | CELL BIOLOGY
somatic mutations | DNA damage repair | protein structure analysis | mutational signatures | somatic copy-number alterations | DNA damage footprints | The Cancer Genome Atlas PanCanAtlas project | epigenetic silencing | integrative statistical analysis | Biochemistry, Genetics and Molecular Biology(all) | POLYMERASE-EPSILON | HUMAN COLON | INACTIVATION | REPLICATION FORK STABILITY | PROMOTER HYPERMETHYLATION | STRUCTURAL BASIS | MICROSATELLITE INSTABILITY | MUTANT-CELLS | MUTATIONS | PREDICTS RESPONSE | CELL BIOLOGY
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7486, pp. 97 - 101
Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others(1), with the...
TRANSPORTER | INSULIN-RESISTANCE | KCNQ1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | LINKS | POPULATIONS | MELLITUS | ASSOCIATION | ANCESTRY | GENOME | Diabetes Mellitus, Type 2 - genetics | Humans | Asian Continental Ancestry Group - genetics | Male | RNA, Messenger - metabolism | Haplotypes - genetics | Female | Lipid Metabolism - genetics | African Continental Ancestry Group - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Endoplasmic Reticulum - genetics | Liver - metabolism | RNA, Messenger - genetics | Neanderthals - genetics | Triglycerides - metabolism | Animals | Alleles | Indians, North American - genetics | Polymorphism, Single Nucleotide - genetics | Mexico | Liver - cytology | HeLa Cells | Monocarboxylic Acid Transporters - genetics | Cohort Studies | Haplotypes | Genealogy | Genomes | Gene expression | Studies | Confidence intervals | Body mass index | Ratios | Metabolites | Population | Diabetes | Age | Methods
TRANSPORTER | INSULIN-RESISTANCE | KCNQ1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | LINKS | POPULATIONS | MELLITUS | ASSOCIATION | ANCESTRY | GENOME | Diabetes Mellitus, Type 2 - genetics | Humans | Asian Continental Ancestry Group - genetics | Male | RNA, Messenger - metabolism | Haplotypes - genetics | Female | Lipid Metabolism - genetics | African Continental Ancestry Group - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Endoplasmic Reticulum - genetics | Liver - metabolism | RNA, Messenger - genetics | Neanderthals - genetics | Triglycerides - metabolism | Animals | Alleles | Indians, North American - genetics | Polymorphism, Single Nucleotide - genetics | Mexico | Liver - cytology | HeLa Cells | Monocarboxylic Acid Transporters - genetics | Cohort Studies | Haplotypes | Genealogy | Genomes | Gene expression | Studies | Confidence intervals | Body mass index | Ratios | Metabolites | Population | Diabetes | Age | Methods
Journal Article