Chemistry – A European Journal, ISSN 0947-6539, 04/2016, Volume 22, Issue 18, pp. 6314 - 6322
The interactions of the water‐soluble tetraazaperopyrene dye 1 with ct‐DNA, duplex‐[(dAdT)12⋅(dAdT)12], duplex‐[(dGdC)12⋅(dGdC)12] as well as with two...
dyes/pigments | docking studies | G-quadruplexes | DNA | Water | DNA - chemistry | Solubility | Spectrometry, Fluorescence | G-Quadruplexes | Molecular Docking Simulation | Binding Sites | Circular Dichroism | Coloring Agents - chemistry | Fluorescence spectroscopy | Genetic research | Binding | Dyes | Molecular structure | Deoxyribonucleic acid | Titration calorimetry | Docking | Affinity | Binding sites | Full Paper | pigments | Full Papers | dyes
dyes/pigments | docking studies | G-quadruplexes | DNA | Water | DNA - chemistry | Solubility | Spectrometry, Fluorescence | G-Quadruplexes | Molecular Docking Simulation | Binding Sites | Circular Dichroism | Coloring Agents - chemistry | Fluorescence spectroscopy | Genetic research | Binding | Dyes | Molecular structure | Deoxyribonucleic acid | Titration calorimetry | Docking | Affinity | Binding sites | Full Paper | pigments | Full Papers | dyes
Journal Article
European Journal of Immunology, ISSN 0014-2980, 02/2017, Volume 47, Issue 2, pp. 374 - 384
Establishing and maintaining maternal‐fetal tolerance is essential for a successful pregnancy; failure of immunological adaptation to pregnancy leads to severe...
Tolerance | HLA‐G | MDSC | T cells | Reproductive Immunology | HLA-G | DENDRITIC CELLS | IMMUNOLOGY | CANCER | INHIBITION | IMMUNOSUPPRESSION | EXPANSION | ANTIGEN-PRESENTING CELLS | DIFFERENTIATION | SIGNAL TRANSDUCER | BLOOD | TH2 | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Myeloid-Derived Suppressor Cells - immunology | Membrane Glycoproteins - metabolism | Signal Transduction | Humans | Middle Aged | Cells, Cultured | Immune Tolerance | Immunity, Innate | Pregnancy | Young Adult | Maternal-Fetal Relations | Adolescent | Protein Binding | Adult | Female | Receptors, Immunologic - metabolism | STAT3 Transcription Factor - metabolism | HLA-G Antigens - metabolism | Histocompatibility antigens | Pregnant women | Health aspects | HLA histocompatibility antigens | Phosphorylation | Transcription | Pregnancy complications | Stimulation | Leukocytes (mononuclear) | Lymphocytes T | Suppressor cells | Abortion | Accumulation | Receptors | Immunology | Peripheral blood mononuclear cells | Activation analysis | Immune system | Dioxygenase | Myeloid cells | Complications | Immunomodulation | Fetuses | Stat3 protein | T cell receptors | Immunological tolerance | Major histocompatibility complex | Histocompatibility antigen HLA | Histocompatibility
Tolerance | HLA‐G | MDSC | T cells | Reproductive Immunology | HLA-G | DENDRITIC CELLS | IMMUNOLOGY | CANCER | INHIBITION | IMMUNOSUPPRESSION | EXPANSION | ANTIGEN-PRESENTING CELLS | DIFFERENTIATION | SIGNAL TRANSDUCER | BLOOD | TH2 | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Myeloid-Derived Suppressor Cells - immunology | Membrane Glycoproteins - metabolism | Signal Transduction | Humans | Middle Aged | Cells, Cultured | Immune Tolerance | Immunity, Innate | Pregnancy | Young Adult | Maternal-Fetal Relations | Adolescent | Protein Binding | Adult | Female | Receptors, Immunologic - metabolism | STAT3 Transcription Factor - metabolism | HLA-G Antigens - metabolism | Histocompatibility antigens | Pregnant women | Health aspects | HLA histocompatibility antigens | Phosphorylation | Transcription | Pregnancy complications | Stimulation | Leukocytes (mononuclear) | Lymphocytes T | Suppressor cells | Abortion | Accumulation | Receptors | Immunology | Peripheral blood mononuclear cells | Activation analysis | Immune system | Dioxygenase | Myeloid cells | Complications | Immunomodulation | Fetuses | Stat3 protein | T cell receptors | Immunological tolerance | Major histocompatibility complex | Histocompatibility antigen HLA | Histocompatibility
Journal Article
Biological Chemistry, ISSN 1431-6730, 08/2019, Volume 400, Issue 9, pp. 1089 - 1097
Actin dynamics, the coordinated assembly and disassembly of actin filaments (F-actin), are essential for fundamental cellular processes, including cell shaping...
neurodegeneration | redox balance | ADF/cofilin | stroke | mitochondrial dynamics | PROTEIN | MECHANISM | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | FILAMENT TURNOVER | MOUSE MODEL | N-COFILIN | DYNAMICS | Cytochrome | Brain | Energy metabolism | Reactive oxygen species | Calcium | Homeostasis | Calcium metabolism | Rods | Fission | Proteins | Mitochondria | Head injuries | Filaments | Actin | Cofilin | Calcium homeostasis | Neurodegenerative diseases | Neurons | Cell division | Metabolism | Organelles | Neurological diseases | Cytochrome c | Cell death | Morphology | Dynamin | Cytochromes | Dismantling | Brain injury | Cellular stress response
neurodegeneration | redox balance | ADF/cofilin | stroke | mitochondrial dynamics | PROTEIN | MECHANISM | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | FILAMENT TURNOVER | MOUSE MODEL | N-COFILIN | DYNAMICS | Cytochrome | Brain | Energy metabolism | Reactive oxygen species | Calcium | Homeostasis | Calcium metabolism | Rods | Fission | Proteins | Mitochondria | Head injuries | Filaments | Actin | Cofilin | Calcium homeostasis | Neurodegenerative diseases | Neurons | Cell division | Metabolism | Organelles | Neurological diseases | Cytochrome c | Cell death | Morphology | Dynamin | Cytochromes | Dismantling | Brain injury | Cellular stress response
Journal Article
2015, ISBN 1480340804
Music Score
5.
Full Text
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins
MOLECULAR ENDOCRINOLOGY, ISSN 0888-8809, 12/1999, Volume 13, Issue 12, pp. 2025 - 2038
Mel 1a melatonin receptors belong to the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. So far, interest in Mel la...
ALPHA-SUBUNITS | CELLS | ACTIVATION | OVINE PARS TUBERALIS | PHOSPHOLIPASE-C | ENDOCRINOLOGY & METABOLISM | KINASE-C | SUPRACHIASMATIC CIRCADIAN CLOCK | DOPAMINE-RECEPTORS | PHORBOL ESTER | EXPRESSION | Molecular Weight | Calcium - metabolism | Humans | Molecular Sequence Data | Virulence Factors, Bordetella - pharmacology | Pituitary Gland, Anterior - metabolism | Adenylyl Cyclase Inhibitors | Transfection | Receptors, Cytoplasmic and Nuclear - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - physiology | Amino Acid Sequence | Cell Line | Signal Transduction | Cells, Cultured | Solubility | Pertussis Toxin | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Receptors, Melatonin | Animals | Cytosol - metabolism | Pituitary Gland, Anterior - drug effects | Sheep | Adenylate Cyclase Toxin | Melatonin - pharmacology | Receptors, Cell Surface - genetics
ALPHA-SUBUNITS | CELLS | ACTIVATION | OVINE PARS TUBERALIS | PHOSPHOLIPASE-C | ENDOCRINOLOGY & METABOLISM | KINASE-C | SUPRACHIASMATIC CIRCADIAN CLOCK | DOPAMINE-RECEPTORS | PHORBOL ESTER | EXPRESSION | Molecular Weight | Calcium - metabolism | Humans | Molecular Sequence Data | Virulence Factors, Bordetella - pharmacology | Pituitary Gland, Anterior - metabolism | Adenylyl Cyclase Inhibitors | Transfection | Receptors, Cytoplasmic and Nuclear - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - physiology | Amino Acid Sequence | Cell Line | Signal Transduction | Cells, Cultured | Solubility | Pertussis Toxin | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Receptors, Melatonin | Animals | Cytosol - metabolism | Pituitary Gland, Anterior - drug effects | Sheep | Adenylate Cyclase Toxin | Melatonin - pharmacology | Receptors, Cell Surface - genetics
Journal Article
Immunology, ISSN 0019-2805, 11/2016, Volume 149, Issue 3, pp. 343 - 352
Summary Currently, the amount of sequenced and classified MHC class I genes of the common marmoset is limited, in spite of the wide use of this species as an...
major histocompatibility complex | Caja‐G | common marmoset | new world primate | Caja-G | Major histocompatibility complex | New world primate | Common marmoset | POPULATION | BONE-MARROW | ANTIGEN PRESENTATION | POLYMORPHISM | IMMUNOLOGY | HLA-G | PRIMATES | NEW-WORLD MONKEY | MOLECULES | MHC CLASS-I | SUBSTITUTIONS | Gene Duplication | Humans | Histocompatibility Antigens Class I - genetics | Phylogeny | Sequence Analysis, DNA | Gene Conversion | Polymorphism, Genetic | Biological Evolution | Animals | Alleles | HLA-G Antigens - genetics | Callithrix - immunology | Immunity - genetics | Disease Models, Animal | Monkeys | Histocompatibility antigens | HLA histocompatibility antigens | Genes | Immunology | Original
major histocompatibility complex | Caja‐G | common marmoset | new world primate | Caja-G | Major histocompatibility complex | New world primate | Common marmoset | POPULATION | BONE-MARROW | ANTIGEN PRESENTATION | POLYMORPHISM | IMMUNOLOGY | HLA-G | PRIMATES | NEW-WORLD MONKEY | MOLECULES | MHC CLASS-I | SUBSTITUTIONS | Gene Duplication | Humans | Histocompatibility Antigens Class I - genetics | Phylogeny | Sequence Analysis, DNA | Gene Conversion | Polymorphism, Genetic | Biological Evolution | Animals | Alleles | HLA-G Antigens - genetics | Callithrix - immunology | Immunity - genetics | Disease Models, Animal | Monkeys | Histocompatibility antigens | HLA histocompatibility antigens | Genes | Immunology | Original
Journal Article
Circulation Research, ISSN 0009-7330, 02/2012, Volume 110, Issue 3, pp. 471 - 480
RATIONALE:Hydrogen peroxide (H2O2) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles...
CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | MESENTERIC-ARTERIES | vasodilation | hydrogen peroxide | Ca2+-activated K+ channel | BKCA CHANNEL | CA CHANNELS | endothelium-derived hyperpolarizing factor | VASCULAR SMOOTH-MUSCLE | GUANYLATE-CYCLASE | HYPERPOLARIZING FACTOR | FLOW-INDUCED DILATION | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | protein kinase G | HYDROGEN-PEROXIDE | HEMATOLOGY | Arterioles - physiology | Endothelium, Vascular - cytology | Fluoresceins - pharmacology | Humans | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Large-Conductance Calcium-Activated Potassium Channels - physiology | Vasodilation - physiology | Dimerization | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Coronary Vessels - drug effects | Coronary Vessels - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Peptides - pharmacology | Patch-Clamp Techniques | Vasodilation - drug effects
CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | MESENTERIC-ARTERIES | vasodilation | hydrogen peroxide | Ca2+-activated K+ channel | BKCA CHANNEL | CA CHANNELS | endothelium-derived hyperpolarizing factor | VASCULAR SMOOTH-MUSCLE | GUANYLATE-CYCLASE | HYPERPOLARIZING FACTOR | FLOW-INDUCED DILATION | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | protein kinase G | HYDROGEN-PEROXIDE | HEMATOLOGY | Arterioles - physiology | Endothelium, Vascular - cytology | Fluoresceins - pharmacology | Humans | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Large-Conductance Calcium-Activated Potassium Channels - physiology | Vasodilation - physiology | Dimerization | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Coronary Vessels - drug effects | Coronary Vessels - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Peptides - pharmacology | Patch-Clamp Techniques | Vasodilation - drug effects
Journal Article
Astrophysical Journal, ISSN 0004-637X, 03/2016, Volume 819, Issue 2, p. 126
Comets considered to be pristine objects contain key information about the early formation of the solar system. Their volatile components can provide clues...
comets: individual (67P, ChuryumovGerasimenko) | comets: general | SPECTROMETER | ROSETTA | N-2 | ASTRONOMY & ASTROPHYSICS | WATER ICE | ION | 67P/CHURYUMOV-GERASIMENKO | comets: individual (67P, Churyumov-Gerasimenko) | Comets | Origins | Carbon dioxide | Evolution | Formations | Carbon monoxide | Solar system | Density | Earth and Planetary Astrophysics | Sciences of the Universe | Astrophysics
comets: individual (67P, ChuryumovGerasimenko) | comets: general | SPECTROMETER | ROSETTA | N-2 | ASTRONOMY & ASTROPHYSICS | WATER ICE | ION | 67P/CHURYUMOV-GERASIMENKO | comets: individual (67P, Churyumov-Gerasimenko) | Comets | Origins | Carbon dioxide | Evolution | Formations | Carbon monoxide | Solar system | Density | Earth and Planetary Astrophysics | Sciences of the Universe | Astrophysics
Journal Article
9.
Full Text
Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violence
Journal of Clinical Psychiatry, ISSN 0160-6689, 2012, Volume 73, Issue 8, pp. 1069 - 1076
Objective: The primary aim was to relate Toxoplasma gondii seropositivity and serointensity to scores on the self-rated Suicide Assessment Scale (SUAS-S)....
QUINOLINIC ACID | DEPRESSION SCALE | INTERFERON-GAMMA | PSYCHIATRY | PERSONALITY CHANGES | TRAFFIC ACCIDENTS | ATTEMPTERS | RISK | LATENT TOXOPLASMOSIS | ASSESSMENT SCALE | PSYCHOLOGY, CLINICAL | CEREBRAL TOXOPLASMOSIS | Toxoplasma - immunology | Immunoglobulin G - blood | Toxoplasmosis - immunology | Humans | Middle Aged | Male | Suicidal Ideation | Mental Disorders - immunology | Statistics as Topic | Case-Control Studies | Adult | Female | Surveys and Questionnaires | Cross-Sectional Studies | Self-Injurious Behavior - immunology | Self-Injurious Behavior - psychology | Risk Factors | Self-Injurious Behavior - prevention & control | Violence - psychology | Suicide, Attempted - prevention & control | Mental Disorders - psychology | Suicide, Attempted - psychology | Mass Screening | Chronic Disease | Toxoplasmosis - psychology | Clinical Medicine | Psykiatri | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Psychiatry
QUINOLINIC ACID | DEPRESSION SCALE | INTERFERON-GAMMA | PSYCHIATRY | PERSONALITY CHANGES | TRAFFIC ACCIDENTS | ATTEMPTERS | RISK | LATENT TOXOPLASMOSIS | ASSESSMENT SCALE | PSYCHOLOGY, CLINICAL | CEREBRAL TOXOPLASMOSIS | Toxoplasma - immunology | Immunoglobulin G - blood | Toxoplasmosis - immunology | Humans | Middle Aged | Male | Suicidal Ideation | Mental Disorders - immunology | Statistics as Topic | Case-Control Studies | Adult | Female | Surveys and Questionnaires | Cross-Sectional Studies | Self-Injurious Behavior - immunology | Self-Injurious Behavior - psychology | Risk Factors | Self-Injurious Behavior - prevention & control | Violence - psychology | Suicide, Attempted - prevention & control | Mental Disorders - psychology | Suicide, Attempted - psychology | Mass Screening | Chronic Disease | Toxoplasmosis - psychology | Clinical Medicine | Psykiatri | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Psychiatry
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 07/2019, Volume 55, Issue 62, pp. 9116 - 9119
Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the...
Journal Article
11.
Full Text
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins
Molecular Endocrinology, ISSN 0888-8809, 1999, Volume 13, Issue 12, pp. 2025 - 2038
Journal Article
Scientific Reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, p. 6474
G-protein-coupled receptors regulate signal transduction pathways and play diverse and pivotal roles in the physiology of insects, however, the precise...
DROSOPHILA-MELANOGASTER | VECTOR COMPETENCE | MULTIDISCIPLINARY SCIENCES | PYRETHROID RESISTANCE | HOUSE-FLIES | ANOPHELES-GAMBIAE | FUNCTIONAL-CHARACTERIZATION | AEDES-AEGYPTI | DELTAMETHRIN RESISTANCE | NEUROHORMONE GPCRS | WEST-NILE | Insecticides - pharmacology | Gene Expression Regulation | Insecticide Resistance - genetics | Receptors, G-Protein-Coupled - biosynthesis | Signal Transduction - genetics | Gene Knockdown Techniques | Culex - genetics | Animals | Signal Transduction - drug effects | Culex - drug effects | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Receptors, G-Protein-Coupled - genetics | Genome, Insect | Polymerase chain reaction | Signal transduction | Mosquitoes | G protein-coupled receptors | Permethrin | RNA-mediated interference | Genomes | Transduction | Gene expression
DROSOPHILA-MELANOGASTER | VECTOR COMPETENCE | MULTIDISCIPLINARY SCIENCES | PYRETHROID RESISTANCE | HOUSE-FLIES | ANOPHELES-GAMBIAE | FUNCTIONAL-CHARACTERIZATION | AEDES-AEGYPTI | DELTAMETHRIN RESISTANCE | NEUROHORMONE GPCRS | WEST-NILE | Insecticides - pharmacology | Gene Expression Regulation | Insecticide Resistance - genetics | Receptors, G-Protein-Coupled - biosynthesis | Signal Transduction - genetics | Gene Knockdown Techniques | Culex - genetics | Animals | Signal Transduction - drug effects | Culex - drug effects | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Receptors, G-Protein-Coupled - genetics | Genome, Insect | Polymerase chain reaction | Signal transduction | Mosquitoes | G protein-coupled receptors | Permethrin | RNA-mediated interference | Genomes | Transduction | Gene expression
Journal Article
Circulation Research, ISSN 0009-7330, 02/2012, Volume 110, Issue 3, pp. 471 - 480
Journal Article