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1. Full Text Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
by Schlaepfer, Thomas E and Cohen, Michael X and Frick, Caroline and Kosel, Markus and Brodesser, Daniela and Axmacher, Nikolai and Joe, Alexius Young and Kreft, Martina and Lenartz, Doris and Sturm, Volker
Neuropsychopharmacology, ISSN 0893-133X, 01/2008, Volume 33, Issue 2, pp. 368 - 377
Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent... 
Nucleus accumbens | Cg25 | Anhedonia | Brain stimulation | Deep brain stimulation | Major depression | HUMAN VENTRAL STRIATUM | ANTERIOR CINGULATE CORTEX | DOPAMINE RELEASE | PSYCHIATRY | OBSESSIVE-COMPULSIVE-DISORDER | FOLLOW-UP | nucleus accumbens | NEUROSCIENCES | deep brain stimulation | NUCLEUS-ACCUMBENS | brain stimulation | VAGUS NERVE-STIMULATION | THERAPY | TRANSCRANIAL MAGNETIC STIMULATION | anhedonia | PHARMACOLOGY & PHARMACY | GLOBUS PALLIDUS | major depression | Double-Blind Method | Time Factors | Depressive Disorder - physiopathology | Humans | Depressive Disorder - therapy | Deep Brain Stimulation - ethics | Positron-Emission Tomography | Depressive Disorder - psychology | Reward | Philosophy | Depressive Disorder - diagnostic imaging
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2. Full Text Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?
by Kuhn, Jens and Lenartz, Doris and Huff, Wolfgang and Lee, SunHee and Koulousakis, Athanasios and Klosterkoetter, Joachim and Sturm, Volker
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 10/2007, Volume 78, Issue 10, pp. 1152 - 1153
Chronic consumption of alcohol represents one of the greatest health and socioeconomic problems worldwide. We report on a 54-year-old patient with a severe... 
DRUG | SURGERY | PSYCHIATRY | ETHANOL | IDENTIFICATION | ADDICTION | CLINICAL NEUROLOGY | Amphetamines | Anxieties | Rodents | Alcohol use
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3. Full Text Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response
by Alonso, Pino and Cuaas, Daniel and Gabriëls, Loes and Denys, Damiaan and Goodman, Wayne and Greenberg, Ben D and Jimenez-Ponce, Fiacro and Kuhn, Jens and Lenartz, Doris and Mallet, Luc and Nuttin, Bart and Real, Eva and Segalas, Cinto and Schuurman, Rick and du Montcel, Sophie Tezenas and Menchon, Jose M
PLoS ONE, ISSN 1932-6203, 2015, Volume 10, Issue 7, p. e0133591
Deep brain stimulation (DBS) has been proposed as an alternative to ablative neurosurgery for severe treatment-resistant Obsessive-Compulsive Disorder (OCD),... 
SUBTHALAMIC NUCLEUS STIMULATION | INFERIOR THALAMIC PEDUNCLE | ELECTRICAL-STIMULATION | MULTIDISCIPLINARY SCIENCES | DISEASE | TERM-FOLLOW-UP | ACCUMBENS | PATIENT | MAJOR DEPRESSION | ANTERIOR CAPSULAR STIMULATION | CAUDATE-NUCLEUS | Severity of Illness Index | Prognosis | Humans | Middle Aged | Obsessive-Compulsive Disorder - therapy | Risk Factors | Male | Treatment Outcome | Deep Brain Stimulation - adverse effects | Deep Brain Stimulation - methods | Obsessive-Compulsive Disorder - diagnosis | Patient Acceptance of Health Care | Quality of Life | Adult | Female | Patient outcomes | Analysis | Obsessive-compulsive disorder | Obsessive compulsive disorder | Brain | Biomedical research | Medical imaging | Deep brain stimulation | Psychotherapy | Stimulation | Neurosurgery | Patients | Nuclei | Quality of life | Nucleus accumbens | Studies | Brain research | Hospitals | Neuroses | Surgery | Neostriatum | Thalamus | Subthalamic nucleus | Psychiatry | Target detection | Estimulació elèctrica | Brain stimulation | Electric stimulation | Estimulació del cervell | Qualitat de vida | Life Sciences | Human health and pathology
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4. Full Text Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: Outcomes after one year
by Huff, Wolfgang and Lenartz, Doris and Schormann, Michael and Lee, Sun-Hee and Kuhn, Jens and Koulousakis, Anastosious and Mai, Juergen and Daumann, Joerg and Maarouf, Mohammad and Klosterkötter, Joachim and Sturm, Volker
Clinical Neurology and Neurosurgery, ISSN 0303-8467, 2009, Volume 112, Issue 2, pp. 137 - 143
Abstract Objective To investigate the effects of unilateral deep brain stimulation (DBS) in the right nucleus accumbens in patients with obsessive-compulsive... 
Neurology | Neurosurgery | Nucleus accumbens | Deep brain stimulation | Obsessive-compulsive disorder | ISSUES | SURGERY | DEPRESSION | CAPSULAR STIMULATION | MOOD | BASAL GANGLIA | RELIABILITY | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | Nucleus Accumbens - physiopathology | Obsessive-Compulsive Disorder - physiopathology | Double-Blind Method | Humans | Middle Aged | Obsessive-Compulsive Disorder - therapy | Male | Treatment Outcome | Cognition | Brain Mapping - methods | Functional Laterality | Deep Brain Stimulation - methods | Obsessive-Compulsive Disorder - surgery | Patient Selection | Cross-Over Studies | Obsessive-Compulsive Disorder - psychology | Time Factors | Quality of Life | Adult | Female | Interviews as Topic | Psychotherapy | Care and treatment | Patient outcomes | Studies | Clinical trials | Neuroses | Antidepressants | Parkinsons disease
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5. Full Text Deep Brain Stimulation in the Nucleus Accumbens for Intractable Tourette's Syndrome: Follow-Up Report of 36 Months
by Neuner, Irene and Podoll, Klaus and Lenartz, Doris and Sturm, Volker and Schneider, Frank
Biological Psychiatry, ISSN 0006-3223, 2009, Volume 65, Issue 4, pp. e5 - e6
Psychiatry | Tourette Syndrome - therapy | Follow-Up Studies | Humans | Middle Aged | Obsessive-Compulsive Disorder - therapy | Male | Electrodes, Implanted | Tourette Syndrome - complications | Nucleus Accumbens - physiology | Self Mutilation - psychology | Self Mutilation - etiology | Neurosurgical Procedures | Obsessive-Compulsive Disorder - complications | Obsessive-Compulsive Disorder - psychology | Deep Brain Stimulation | Tourette Syndrome - psychology
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6. Full Text Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review
by Kohl, Sina and Schönherr, Deva M and Luigjes, Judy and Denys, D and Mueller, Ulf J and Lenartz, Doris and Visser-Vandewalle, Veerle and Kuhn, Jens
BMC Psychiatry, ISSN 1471-244X, 2014, Volume 14, Issue 1, pp. 214 - 214
BACKGROUND: Obsessive-compulsive disorder is one of the most disabling of all psychiatric illnesses. Despite available pharmacological and psychotherapeutic... 
Obsessive compulsive disorder | Treatment-refractory | Deep brain stimulation | Psychiatric surgery | SUBTHALAMIC NUCLEUS STIMULATION | PSYCHIATRY | REGION | ELECTRICAL-STIMULATION | DISEASE | ACCUMBENS | PATIENT | OUTCOMES | INTERNAL CAPSULE | Humans | Obsessive-Compulsive Disorder - therapy | Deep Brain Stimulation | Internal Capsule - physiopathology | Medicine, Experimental | Medical research | Care and treatment | Obsessive-compulsive disorder | Brain research | Studies | Neuroses | Response rates | Clinical trials | Behavior
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7. Full Text Intracranial EEG Correlates of Expectancy and Memory Formation in the Human Hippocampus and Nucleus Accumbens
by Axmacher, Nikolai and Cohen, Michael X and Fell, Juergen and Haupt, Sven and Dümpelmann, Matthias and Elger, Christian E and Schlaepfer, Thomas E and Lenartz, Doris and Sturm, Volker and Ranganath, Charan
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 4, pp. 541 - 549
The human brain is adept at anticipating upcoming events, but in a rapidly changing world, it is essential to detect and encode events that violate these... 
SYSNEURO | HUMDISEASE | RARE TARGET | TEMPORAL-LOBE EPILEPSY | DECISION-MAKING | VISUAL-STIMULI | DOPAMINE | THETA-RHYTHM | DEEP BRAIN-STIMULATION | INTRACEREBRAL POTENTIALS | CHOLINERGIC INDUCTION | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | Cues | Humans | Middle Aged | Evoked Potentials - physiology | Male | Electroencephalography | Epilepsy - physiopathology | Reaction Time - physiology | Nucleus Accumbens - physiology | Pattern Recognition, Visual - physiology | Retention (Psychology) - physiology | Nerve Net - physiology | Recognition (Psychology) - physiology | Neuropsychological Tests | Analysis of Variance | Time Factors | Depressive Disorder - physiopathology | Brain Mapping | Signal Processing, Computer-Assisted | Adult | Female | Hippocampus - physiology | Photic Stimulation | Memory - physiology | Psychotherapy | Brain | Neurosciences | Neurons | Epilepsy | Depression, Mental | Studies | Electrodes | Animal behavior | Rodents | Amphetamines | Patients
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8. Full Text Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations
by Reuss, David E and Piro, Rosario M and Jones, David T. W and Simon, Matthias and Ketter, Ralf and Kool, Marcel and Becker, Albert and Sahm, Felix and Pusch, Stefan and Meyer, Jochen and Hagenlocher, Christian and Schweizer, Leonille and Capper, David and Kickingereder, Phillipp and Mucha, Jana and Koelsche, Christian and Jäger, Natalie and Santarius, Thomas and Tarpey, Patrick S and Stephens, Philip J and Andrew Futreal, P and Wellenreuther, Ruth and Kraus, Jürgen and Lenartz, Doris and Herold-Mende, Christel and Hartmann, Christian and Mawrin, Christian and Giese, Nathalia and Eils, Roland and Collins, V Peter and König, Rainer and Wiestler, Otmar D and Pfister, Stefan M and von Deimling, Andreas
Acta Neuropathologica, ISSN 0001-6322, 3/2013, Volume 125, Issue 3, pp. 351 - 358
Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of... 
Pathology | TRAF7 | Neurosciences | Medicine & Public Health | Secretory | NF2 | KLF4 | Meningioma | Krüppel-like factor 4 | VARIANTS | ALPHA | PATHOLOGY | CANCER | NEUROSCIENCES | Kruppel-like factor 4 | DISCOVERY | CLINICAL NEUROLOGY | GENE | ALIGNMENT | ESTROGEN | DIFFERENTIATION | EXPRESSION | Meningioma - pathology | Lysine - genetics | Meningeal Neoplasms - genetics | DNA Mutational Analysis | Genomics | Humans | Glutamine - genetics | Polymorphism, Single Nucleotide - genetics | Meningioma - genetics | Mutation - genetics | Kruppel-Like Transcription Factors - genetics | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Genetic aspects | Gliomas | Analysis | DNA | Glutamine | meningioma | Brain | Cytokeratin | Edema | Peripheral nerves | Neurofibromin 2 | Adenoma | Glioma | KLF4 protein | Sheaths | Lysine | Pituitary | Mutation | Codons | Differentiation | Pancreas | Tumors
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9. Full Text Deep brain stimulation of medial dorsal and ventral anterior nucleus of the thalamus in OCD: A retrospective case series
by Maarouf, Mohammad and Neudorfer, Clemens and El Majdoub, Faycal and Lenartz, Doris and Kuhn, Jens and Sturm, Volker
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0160750
Background The current notion that cortico-striato-thalamo-cortical circuits are involved in the pathophysiology of obsessive-compulsive disorder (OCD) has... 
FRONTAL-LOBE | TREATMENT-RESISTANT DEPRESSION | CAPSULAR STIMULATION | OBSESSIVE-COMPULSIVE-DISORDER | RHESUS-MONKEY | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | TERM-FOLLOW-UP | MEDIODORSAL NUCLEUS | MAJOR DEPRESSION | STEREOTACTIC LIMBIC LEUKOTOMY | Mediodorsal Thalamic Nucleus | Humans | Middle Aged | Obsessive-Compulsive Disorder - therapy | Male | Obsessive-Compulsive Disorder - complications | Obsessive-Compulsive Disorder - psychology | Deep Brain Stimulation | Anxiety - complications | Adult | Depression - complications | Female | Retrospective Studies | Quality of Health Care | Ventral Thalamic Nuclei | Care and treatment | Obsessive-compulsive disorder | Research | Brain stimulation | Health aspects | Obsessive compulsive disorder | Neuroses | Surgery | Behavior modification | Mental depression | Neurosurgery | Drug therapy | Patients | Psychiatry | Quality of life
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10. Full Text Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
by Bewernick, Bettina H and Hurlemann, René and Matusch, Andreas and Kayser, Sarah and Grubert, Christiane and Hadrysiewicz, Barbara and Axmacher, Nikolai and Lemke, Matthias and Cooper-Mahkorn, Deirdre and Cohen, Michael X and Brockmann, Holger and Lenartz, Doris and Sturm, Volker and Schlaepfer, Thomas E
Biological Psychiatry, ISSN 0006-3223, 2010, Volume 67, Issue 2, pp. 110 - 116
Background While most patients with depression respond to combinations of pharmacotherapy, psychotherapy, and electroconvulsive therapy (ECT), there are... 
Psychiatry | neuromodulation | nucleus accumbens | functional neuroimaging | Deep brain stimulation | major depression | treatment resistance | CINGULATE | PSYCHIATRY | DISORDERS | NEUROSCIENCES | CIRCUITS | MOOD | SOCIAL DEFEAT | SCALE | Nucleus Accumbens - diagnostic imaging | Amygdala - diagnostic imaging | Depression - physiopathology | Depression - pathology | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Gyrus Cinguli - diagnostic imaging | Male | Treatment Outcome | Positron-Emission Tomography - methods | Nucleus Accumbens - physiology | Deep Brain Stimulation - methods | Neuropsychological Tests | Psychiatric Status Rating Scales | Brain Mapping | Adult | Female | Fluorodeoxyglucose F18 | Aged | Depression - diagnostic imaging | Depression - therapy | Prefrontal Cortex - diagnostic imaging | Psychotherapy | Depression, Mental
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11. Full Text Neuroelectric Signatures of Reward Learning and Decision-Making in the Human Nucleus Accumbens
by Cohen, Michael X and Axmacher, Nikolai and Lenartz, Doris and Elger, Christian E and Sturm, Volker and Schlaepfer, Thomas E
Neuropsychopharmacology, ISSN 0893-133X, 06/2009, Volume 34, Issue 7, pp. 1649 - 1658
Learning that certain actions lead to risky rewards is critical for biological, social, and economic survival, but the precise neural mechanisms of such... 
Nucleus accumbens | Intracranial EEG | Reward | Motivation | Risk-taking | Prediction error | reward | PREDICTION ERRORS | NEURONAL-ACTIVITY | risk-taking | PSYCHIATRY | motivation | MEDIAL FRONTAL-CORTEX | nucleus accumbens | MAJOR DEPRESSION | RAT PREFRONTAL CORTEX | NEUROSCIENCES | intracranial EEG | DOPAMINE NEURONS | IN-VIVO | DORSAL STRIATUM | PHARMACOLOGY & PHARMACY | prediction error | DEEP BRAIN-STIMULATION | VENTRAL STRIATUM | Cues | Nucleus Accumbens - physiopathology | Depressive Disorder, Major - pathology | Frontal Lobe - physiopathology | Humans | Middle Aged | Depressive Disorder, Major - therapy | Evoked Potentials - physiology | Male | Feedback - physiology | Statistics as Topic | Reaction Time - physiology | Electroencephalography - methods | Deep Brain Stimulation - methods | Neuropsychological Tests | Learning - physiology | Analysis of Variance | Time Factors | Brain Mapping | Adult | Female | Decision Making - physiology
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