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Journal of the Royal Statistical Society: Series C (Applied Statistics), ISSN 0035-9254, 02/2019, Volume 68, Issue 2, pp. 427 - 444
Summary Clinical trials in vulnerable populations are extremely difficult to conduct. A sequential phase I–II trial aimed at finding the appropriate dose of... 
Newborns | Toxicity constraints | Time to event | Efficacy | Phase I–II | Phase I-II | DATA AUGMENTATION | INFANTS | CONTINUAL REASSESSMENT METHOD | STATISTICS & PROBABILITY | TOXICITY | I CLINICAL-TRIALS | ONSET | Medical research | Computer simulation | Newborn babies | Toxicity | Physicians | Clinical trials | Statistical inference | Bayesian analysis | Drug dosages | Seizures
Journal Article
Orphanet Journal of Rare Diseases, ISSN 1750-1172, 10/2018, Volume 13, Issue 1, pp. 186 - 9
Journal Article
Journal Article
Journal Article
Cpt Pharmacometrics and Systems Pharmacology, ISSN 2163-8306, 2017, Volume 6, Issue 7, pp. 416 - 417
During the last 10 years the European Medicines Agency (EMA) organized a number of workshops on modeling and simulation, working towards greater integration of... 
Models, Theoretical | Drug Discovery | Computer Simulation | Drug Industry | Europe | Simulation | Decision making | Communication
Journal Article
Orphanet journal of rare diseases, ISSN 1750-1172, 06/2016, Volume 11, Issue 1, p. 78
Most statistical design and analysis methods for clinical trials have been developed and evaluated where at least several hundreds of patients could be... 
Population Groups | Data Interpretation, Statistical | Clinical Trials as Topic | Rare Diseases | Humans
Journal Article
Journal Article
American Journal of PharmacoGenomics, ISSN 1175-2203, 01/2005, Volume 5, Issue 1, pp. 21 - 33
Hepatic metastases occur in about half of patients with colorectal cancer. Since hepatic metastases are often not accessible for surgery, chemotherapy of... 
Journal Article
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