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animals (58) 58
endocrinology & metabolism (50) 50
rats (47) 47
female (38) 38
male (38) 38
rats, wistar (36) 36
index medicus (35) 35
neurosciences (22) 22
puberty (18) 18
gonadotropins (16) 16
humans (15) 15
luteinizing hormone - blood (15) 15
luteinizing-hormone (13) 13
hypothalamus - metabolism (12) 12
luteinizing hormone - secretion (12) 12
expression (11) 11
leptin (11) 11
luteinizing hormone (11) 11
mice (11) 11
physiology (11) 11
abridged index medicus (10) 10
arcuate nucleus (10) 10
follicle stimulating hormone - blood (10) 10
gene-expression (10) 10
kisspeptins (10) 10
neurons (10) 10
female rats (9) 9
ghrelin (9) 9
gonadotropin-releasing hormone - metabolism (9) 9
gonadotropin-releasing-hormone (9) 9
kisspeptin (9) 9
messenger-rna (9) 9
physiological aspects (9) 9
rat (9) 9
reproduction (9) 9
testosterone (9) 9
energy-balance (8) 8
growth hormone (8) 8
kiss-1 peptide (8) 8
luteinizing hormone - metabolism (8) 8
prolactin (8) 8
receptors, g-protein-coupled - genetics (8) 8
receptors, kisspeptin-1 (8) 8
research (8) 8
secretion (8) 8
sexual maturation - physiology (8) 8
animals, newborn (7) 7
follicle stimulating hormone - secretion (7) 7
gonadotropin-secretion (7) 7
gpr54 (7) 7
growth hormone - secretion (7) 7
growth-hormone (7) 7
hypothalamus (7) 7
original paper (7) 7
pituitary gland - metabolism (7) 7
analysis (6) 6
brain (6) 6
further section (6) 6
gene expression (6) 6
genetic aspects (6) 6
gonadotropin-releasing hormone (6) 6
gonadotropins - metabolism (6) 6
injections, intraventricular (6) 6
kisspeptins - metabolism (6) 6
lh-secretion (6) 6
monkey macaca-mulatta (6) 6
n-methylaspartate - pharmacology (6) 6
natural ligand (6) 6
neurokinin b (6) 6
neurons - metabolism (6) 6
nitric oxide (6) 6
orchiectomy (6) 6
ovariectomy (6) 6
peptide fragments - pharmacology (6) 6
peptides (6) 6
release (6) 6
adult (5) 5
age factors (5) 5
amino acid sequence (5) 5
body-weight (5) 5
energy balance (5) 5
excitatory amino acids (5) 5
gonadotropins - secretion (5) 5
growth hormone-releasing hormone (5) 5
hypothalamic kiss-1 system (5) 5
involvement (5) 5
kiss1 (5) 5
leptin - pharmacology (5) 5
mice, knockout (5) 5
pituitary (5) 5
pituitary gland - drug effects (5) 5
prepubertal rats (5) 5
progesterone (5) 5
prolactin - metabolism (5) 5
protein-coupled receptor (5) 5
receptors, g-protein-coupled - metabolism (5) 5
reproductive axis (5) 5
rna, messenger - metabolism (5) 5
aging - physiology (4) 4
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - pharmacology (4) 4
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1. Full Text Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
by Leonor Pinilla and Enrique Aguilar and Carlos Dieguez and Robert P. Millar and Manuel Tena-Sempere
Physiological Reviews, ISSN 0031-9333, 07/2012, Volume 92, Issue 3, pp. 1235 - 1316
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks have evolved to mediate the diverse internal and external... 
FEMALE RHESUS-MONKEYS | ANTEROVENTRAL PERIVENTRICULAR NUCLEUS | PHYSIOLOGY | MONKEY MACACA-MULATTA | HAMSTERS PHODOPUS-SUNGORUS | MESSENGER-RNA EXPRESSION | GONADOTROPIN-RELEASING-HORMONE | FOLLICLE-STIMULATING-HORMONE | ANTERIOR-PITUITARY-CELLS | METASTASIS-SUPPRESSOR GENE | PROTEIN-COUPLED-RECEPTOR | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Puberty - metabolism | Humans | Male | Receptors, Neuropeptide - metabolism | Sex Differentiation | Kisspeptins - metabolism | Neurokinin B - metabolism | Feedback, Physiological | Reproduction | Animals | Hypothalamus - metabolism | Gonadotropins - metabolism | Gonadotropin-Releasing Hormone - metabolism | Neural Pathways - metabolism | Female | Dynorphins - metabolism | Vertebrates | Physiological aspects | Gonadotropin | Research | Health aspects | Neurosecretion
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2. Full Text Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat
by Víctor M. Navarro and Juan M. Castellano and Sarah M. McConkey and Rafael Pineda and Francisco Ruiz-Pino and Leonor Pinilla and Donald K. Clifton and Manuel Tena-Sempere and Robert A. Steiner
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 01/2011, Volume 300, Issue 1, pp. 202 - 210
Neurokinin B (NKB) and its cognate receptor neurokinin 3 (NK3R) play a critical role in reproduction. NKB and NK3R are coexpressed with dynorphin (Dyn) and... 
Estradiol | Hypothalamus | PHYSIOLOGY | GONADOTROPIN-SECRETION | ARCUATE NUCLEUS | MORPHOLOGIC EVIDENCE | MESSENGER-RNA | LUTEINIZING-HORMONE SECRETION | DYNORPHIN-A | ENDOCRINOLOGY & METABOLISM | MEDIAN-EMINENCE | GENE-EXPRESSION | NEURONS | HYPOGONADOTROPIC HYPOGONADISM | hypothalamus | estradiol | Rats, Wistar | Arcuate Nucleus of Hypothalamus - cytology | Peptide Fragments - pharmacology | Substance P - pharmacology | Neurokinin B - agonists | Neurokinin B - genetics | RNA, Messenger - metabolism | Kisspeptins | Arcuate Nucleus of Hypothalamus - drug effects | Receptors, Neurokinin-3 - metabolism | Female | Neurons - metabolism | Prosencephalon - metabolism | Neurons - drug effects | Substance P - analogs & derivatives | Receptors, Neurokinin-3 - genetics | Gonadotropin-Releasing Hormone - secretion | Estradiol - metabolism | Luteinizing Hormone - blood | Arcuate Nucleus of Hypothalamus - metabolism | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Receptors, Neurokinin-3 - agonists | Rats | Organ Specificity | Neurokinin B - metabolism | Proteins - genetics | Feedback, Physiological | Animals | Proteins - metabolism | Signal Transduction - drug effects | Prosencephalon - cytology | Proto-Oncogene Proteins c-fos - genetics | Estrous Cycle - metabolism | Physiological aspects | Neurohormones | Genetic aspects | Research | Gonadotropin releasing hormone
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3. Full Text Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
by Juan M. Castellano and Victor M. Navarro and Rafael Fernández-Fernández and Juan Roa and Eva Vigo and Rafael Pineda and Carlos Dieguez and Enrique Aguilar and Leonor Pinilla and Manuel Tena-Sempere
Diabetes, ISSN 0012-1797, 09/2006, Volume 55, Issue 9, pp. 2602 - 2610
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats Juan M.... 
LH, luteinizing hormone | GnRH, gonadotropin-releasing hormone | GPR54, G protein-coupled receptor 54 | STZ, streptozotocin | INSULIN | GALANIN-LIKE PEPTIDE | MESSENGER-RNA | PROTEIN-COUPLED RECEPTOR | FEMALE RATS | GPR54 | ENDOCRINOLOGY & METABOLISM | PITUITARY-GONADAL AXIS | REPRODUCTIVE AXIS | NATURAL LIGAND | HORMONE-RELEASING ACTIVITY | Insulin - pharmacology | Testosterone - secretion | Rats, Wistar | Gene Expression Regulation - physiology | Rats | Male | Luteinizing Hormone - metabolism | Kisspeptins | Orchiectomy | Proteins - genetics | Animals | Hypothalamus - metabolism | Proteins - secretion | Leptin - pharmacology | Hypothalamus - drug effects | Diabetes Mellitus, Experimental - metabolism | Oligopeptides - pharmacology | Gonadotropin | Research | Diabetes | Gene expression | Health aspects
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4. Full Text New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
by Roa, Juan and Aguilar, Enrique and Dieguez, Carlos and Pinilla, Leonor and Tena-Sempere, Manuel
Frontiers in Neuroendocrinology, ISSN 0091-3022, 2007, Volume 29, Issue 1, pp. 48 - 69
Abstract Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor GPR54 as causative factor for absence of puberty and... 
Endocrinology & Metabolism | Kisspeptin | Puberty | Energy balance | Gonadotropin-releasing hormone (GnRH) | GPR54 | Leptin | KiSS-1 | Gonadotropins | Ovulation | Hypogonadism | HYPOTHALAMIC KISS-1 SYSTEM | MONKEY MACACA-MULATTA | kisspeptin | GONADOTROPIN-RELEASING-HORMONE | ESTROGEN-POSITIVE FEEDBACK | RIBONUCLEIC-ACID EXPRESSION | gonadotropins | gonadotropin-releasing hormone (GnRH) | energy balance | leptin | NEUROSCIENCES | LUTEINIZING-HORMONE | hypogonadism | ISOLATED HYPOGONADOTROPIC HYPOGONADISM | PROTEIN-COUPLED RECEPTOR | ENDOCRINOLOGY & METABOLISM | PITUITARY-GONADAL AXIS | puberty | METASTASIS-SUPPRESSOR GENE | ovulation | Ovulation - genetics | Gonads - physiology | Humans | Reproduction - genetics | Reproduction - physiology | Puberty - physiology | Kisspeptins | Puberty - genetics | Tumor Suppressor Proteins - physiology | Metabolic Networks and Pathways - genetics | Animals | Models, Biological | Tumor Suppressor Proteins - genetics | Metabolic Networks and Pathways - physiology | Receptors, G-Protein-Coupled - genetics | Hypothalamo-Hypophyseal System - physiology | Receptors, Kisspeptin-1 | Ovulation - physiology | Receptors, G-Protein-Coupled - physiology
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5. Full Text Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
by Felip, Alicia and Zanuy, Silvia and Pineda, Rafael and Pinilla, Leonor and Carrillo, Manuel and Tena-Sempere, Manuel and Gómez, Ana
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2009, Volume 312, Issue 1, pp. 61 - 71
Kisspeptins, the products of gene, have recently emerged as fundamental regulators of reproductive function in different mammalian and, presumably,... 
KiSS-1 | KiSS-2 | Gonadotropins | Dicentrarchus labrax | Vertebrate evolution | Rattus norvegicus | BASS DICENTRARCHUS-LABRAX | MONKEY MACACA-MULATTA | RIBONUCLEIC-ACID EXPRESSION | NATURAL LIGAND | LUTEINIZING-HORMONE | CELL BIOLOGY | MESSENGER-RNA | PROTEIN-COUPLED RECEPTOR-54 | ENDOCRINOLOGY & METABOLISM | PITUITARY-GONADAL AXIS | FOLLICLE-STIMULATING-HORMONE | Kiss-1 | REPRODUCTIVE AXIS | Rats, Wistar | Vertebrates - genetics | Synteny | Molecular Sequence Data | Male | Phylogeny | Kisspeptins | Oryzias - metabolism | Fish Proteins - genetics | Time Factors | Base Sequence | Cloning, Molecular | Aging | Female | Oryzias - genetics | Seasons | Gonadotropins, Pituitary - blood | Amino Acid Sequence | Fish Proteins - chemistry | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Fish Proteins - metabolism | Rats | Reproduction - genetics | Organ Specificity | Sequence Analysis, DNA | Zebrafish - genetics | Proteins - genetics | Sequence Alignment | Animals | Proteins - metabolism | Analysis of Variance | Bass - genetics | Zebrafish - metabolism | Bass - metabolism | Proteins - chemistry | Zebrafish Proteins - genetics | Vertebrates - metabolism | Animal genetics | Peptides | Fishes
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6. Full Text Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity
by León, Silvia and Barroso, Alexia and Vázquez, María J and García-Galiano, David and Manfredi-Lozano, María and Ruiz-Pino, Francisco and Heras, Violeta and Romero-Ruiz, Antonio and Roa, Juan and Schutz, Günther and Kirilov, Milen and Gaytan, Francisco and Pinilla, Leonor and Tena-Sempere, Manuel
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, p. 19206
Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are... 
RESPONSES | RAT | PHYSIOLOGICAL ROLES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NEUROPEPTIDE | SECRETION | PEPTIDE TLQP-21 | EXPRESSION | NEUROKININ B | MODULATION | Testis - metabolism | Receptors, G-Protein-Coupled - metabolism | Male | Mice, Knockout | Feedback, Physiological | Phenotype | Reproduction | Animals | Gonadotropins - metabolism | Gonadotropin-Releasing Hormone - metabolism | Fertility - drug effects | Female | Kisspeptins - pharmacology | Mice | Neurons - metabolism | Ovary - ultrastructure | Receptors, G-Protein-Coupled - genetics | Neurons - drug effects | Receptors, Kisspeptin-1 | Ovary - metabolism | Puberty | Tachykinin receptors | Neurons | Glutamic acid receptors (ionotropic) | Secretion | N-Methyl-D-aspartic acid receptors | Pituitary (anterior) | Gonadotropins | Testosterone | Feedback | Fertility | Luteinizing hormone | Gonadotropin-releasing hormone | Kiss1 protein | Tachykinin
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7. Full Text Intergenerational Influence of paternal obesity on metabolic and reproductive health parameters of the offspring: Male-preferential impact and involvement of kiss1-mediated pathways
by Sanchez-Garrido, Miguel Angel and Ruiz-Pino, Francisco and Velasco, Inmaculada and Barroso, Alexia and Fernandois, Daniela and Heras, Violeta and Manfredi-Lozano, Maria and Vazquez, Maria Jesus and Castellano, Juan Manuel and Roa, Juan and Pinilla, Leonor and Tena-Sempere, Manuel
Endocrinology, ISSN 0013-7227, 02/2018, Volume 159, Issue 2, pp. 1005 - 1018
Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders,... 
FEMALE RAT | HIGH-FAT DIET | GONADOTROPIN-RELEASING-HORMONE | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MICE | MECHANISMS | NATURAL LIGAND | KISS-1 PEPTIDE | FERTILITY | Reproductive health | Epidemics | Spermatozoa | Weaning | Body weight | Menopause | Hypothalamus | Impact tests | Males | High fat diet | Reproduction | Rodents | Gender aspects | Luteinizing hormone | Obesity | Reproductive systems | Sex differences | Pituitary (anterior) | Gonadotropins | Gender differences | Heredity | Metabolism | Gene expression | Glucose tolerance | Testosterone | Progeny | Intolerance | Offspring | Leptin | Disturbances | Kiss1 protein | Females | Metabolic disorders
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8. Full Text Metabolic control of puberty onset: New players, new mechanisms
by Roa, Juan and García-Galiano, David and Castellano, Juan M and Gaytan, Francisco and Pinilla, Leonor and Tena-Sempere, Manuel
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2010, Volume 324, Issue 1, pp. 87 - 94
Puberty, as the end-point of a complex series of maturational events affecting the components of the hypothalamic-pituitary-gonadal (HPG) axis, is gated by the... 
Puberty | Energy balance | Kiss1 | Ghrelin | Leptin | GPR54 | Crtc1 | mTOR | Kisspeptins | MTOR | HYPOTHALAMIC KISS-1 SYSTEM | GONADOTROPIN-RELEASING-HORMONE | CELL BIOLOGY | ENERGY-BALANCE | NEUROENDOCRINE REGULATION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | REPRODUCTIVE AXIS | LEPTIN RECEPTOR | SECRETION | EXPRESSION | Ghrelin - metabolism | Tumor Suppressor Proteins - metabolism | Animals | Signal Transduction | Puberty - metabolism | Humans | Leptin - metabolism | Sexual Maturation - physiology | Obesity - metabolism
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9. Full Text Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
by Martínez de Morentin, Pablo B and González-García, Ismael and Martins, Luís and Lage, Ricardo and Fernández-Mallo, Diana and Martínez-Sánchez, Noelia and Ruíz-Pino, Francisco and Liu, Ji and Morgan, Donald A and Pinilla, Leonor and Gallego, Rosalía and Saha, Asish K and Kalsbeek, Andries and Fliers, Eric and Bisschop, Peter H and Diéguez, Carlos and Nogueiras, Rubén and Rahmouni, Kamal and Tena-Sempere, Manuel and López, Miguel
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 41 - 53
Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol... 
ENERGY-BALANCE | NERVOUS-SYSTEM | METABOLIC SYNDROME | ACTIVATED PROTEIN-KINASE | NONSHIVERING THERMOGENESIS | ER-BETA | ESTROGEN-RECEPTOR-ALPHA | DEFICIENT ARKO MICE | ENDOCRINOLOGY & METABOLISM | BODY-TEMPERATURE | MELANIN-CONCENTRATING HORMONE | CELL BIOLOGY | AMP-Activated Protein Kinases - metabolism | Rats, Wistar | AMP-Activated Protein Kinases - antagonists & inhibitors | Rats | Rats, Sprague-Dawley | Sympathetic Nervous System - metabolism | AMP-Activated Protein Kinases - chemistry | Animals | Hypothalamus - metabolism | Hypothalamus - enzymology | Estrogen Receptor alpha - metabolism | Female | Adipose Tissue, Brown - metabolism | Ovary - injuries | Hypothalamus - drug effects | Thermogenesis - drug effects | Energy Metabolism - drug effects | Estradiol - pharmacology | Adipose tissues | Chronic diseases | Phenols | Brain | Estradiol | Cells | Neurosciences
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10. Full Text Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
by Manfredi-Lozano, Maria and Roa, Juan and Ruiz-Pino, Francisco and Piet, Richard and Garcia-Galiano, David and Pineda, Rafael and Zamora, Aurora and Leon, Silvia and Sanchez-Garrido, Miguel A and Romero-Ruiz, Antonio and Dieguez, Carlos and Vazquez, Maria Jesus and Herbison, Allan E and Pinilla, Leonor and Tena-Sempere, Manuel
Molecular Metabolism, ISSN 2212-8778, 2016, Volume 5, Issue 10, pp. 844 - 857
Abstract Objective Puberty is a key developmental phenomenon highly sensitive to metabolic modulation. Worrying trends of changes in the timing of puberty have... 
Endocrinology & Metabolism | Kisspeptin | Puberty | DREADDs | α-MSH | Metabolism | Leptin | FEMALE PUBERTY | GNRH NEURONS | KISS1 NEURONS | ARCUATE NUCLEUS | NEUROPEPTIDE-Y | HORMONE | ENDOCRINOLOGY & METABOLISM | alpha-MSH | POSTNATAL-DEVELOPMENT | MICE | NEUROKININ B | REPRODUCTION
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11. Full Text Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System
by Castellano, Juan M and Bentsen, Agnete H and Sánchez-Garrido, Miguel A and Ruiz-Pino, Francisco and Romero, Magdalena and Garcia-Galiano, David and Aguilar, Enrique and Pinilla, Leonor and Diéguez, Carlos and Mikkelsen, Jens D and Tena-Sempere, Manuel
Endocrinology, ISSN 0013-7227, 09/2011, Volume 152, Issue 9, pp. 3396 - 3408
Kiss1 neurons have recently emerged as a putative conduit for the metabolic gating of reproduction, with leptin being a regulator of hypothalamic Kiss1... 
REPRODUCTIVE FUNCTION | MESSENGER-RNA EXPRESSION | FEMALE RATS | SEXUAL-DIFFERENTIATION | PREDICTIVE ADAPTIVE RESPONSES |