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by Warren, Helen R and Evangelou, Evangelos and Cabrera, Claudia P and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surenan, Praveen and Liu, Chunyu and Cook, James P and Kraja, Aldi T and nos, Fotios and Loh, Marie and Verweij, Niek and Marten, Jonathan and Karaman, Ibrahim and Lepe, Marcelo P. Segura and O'Reilly, Paul F and Knight, Joanne and Snieder, Harold and Kato, Norihiro and He, Jiang and Tai, E. Shyong and Said, M. Abdullah and Porteous, David and Alver, Maris and Poulter, Neil and Farrall, Martin and Gansevoort, Ron T and Padmanabhan, Sandosh and Magi, Reedik and Stanton, Alice and Connell, John and Bakker, Stephan J. L and Metspalu, Anes and Shields, Denis C and Thom, Simon and Brown, Morris and Sever, Peter and Esko, Tonu and Hayward, Caroline and van der Harst, Pim and Saleheen, Danish and Chowdhury, Rajiv and Chambers, John C and Chasman, Daniel I and Chakravarti, Aravinda and Newton-Cheh, Christopher and Lindgren, Cecilia M and Levy, Daniel and Kooner, Jaspal S and Keavney, Bernard and Tomaszewski, Maciej and Samani, Nilesh J and Howson, Joanna M. M and Tobin, Martin D and Munroe, Patricia B and Ehret, Georg B and Wain, Louise V and Barnes, Michael R and Tzoulaki, Joanna and Caulfield, Mark J and Elliott, Paul and Vaez, Ahmad and Jansen, Rick and Joehanes, Roby and van der Most, Peter J and Erzurumluoglu, A. Mesut and O'Reilly, Paul and Rose, Lynda M and Verwoert, Germaine C and Hottenga, Jouke-Jan and Strawbridge, Rona J and Arking, Dan E and Hwang, Shih-Jen and Guo, Xiuqing and Kutalik, Zoltan and Trompet, Stella and Shrine, Nick and Teumer, Alexander and Ried, Janina S and Bis, Joshua C and Smith, Albert V and Amin, Najaf and Nolte, Ilja M and Lyytikainen, Leo-Pekka and Mahajan, Anubha and Wareham, Nicholas J and Hofer, Edith and Joshi, Peter K and Kristiansson, Kati and Traglia, Michela and Havulinna, Aki S and Goel, Anuj and Nalls, Mike A and Sober, Siim and Vuckovic, gana and Luan, Jian'an and del Greco, Fabiola M and Ayers, Kristin L and ... and CHARGE BP Exome Consortium and UK Biobank CardioMetab Consortium and GoT2D Genes Consortium and Understanding Soc Sci Grp and Lifelines Cohort Study and Int Consortium Blood Pressure ICBP and BIOS Consortium and ExomeBP Consortium and CHD Exome Consortium and T2D-GENES Consortium and iGEN-BP Consortium and International Consortium of Blood Pressure (ICBP) 1000G Analyses and Understanding Society Scientific group and CHD Exome+ Consortium and Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium and International Genomics of Blood Pressure (iGEN-BP) Consortium and UK Biobank CardioMetabolic Consortium BP working group and GoT2DGenes Consortium and The CHD Exome+ Consortium and The International Consortium of Blood Pressure (ICBP) 1000G Analyses and The International Genomics of Blood Pressure (iGEN-BP) Consortium and The UK Biobank CardioMetabolic Consortium BP working group and The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium and The GoT2DGenes Consortium and The ExomeBP Consortium and The T2D-GENES Consortium and Stockholms universitet and Numerisk analys och datalogi (NADA) and Naturvetenskapliga fakulteten
Nature genetics, ISSN 1061-4036, 2017, Volume 49, Issue 3, pp. 403 - 415
Journal Article
by Marouli, Eirini and Graff, Mariaelisa and Medina-Gomez, Carolina and Lo, Ken Sin and Wood, Anew R and Kjaer, Troels R and Fine, Rebecca S and Lu, Yingchang and Schurmann, Claudia and Highland, Heather M and Rüeger, Sina and Thorleifsson, Gudmar and Justice, Anne E and Lamparter, David and Stirrups, Kathleen E and Turcot, Valérie and Young, Kristin L and Winkler, Thomas W and Esko, Tõnu and Karaderi, Tugce and Locke, Adam E and Masca, Nicholas G. D and Ng, Maggie C. Y and Mudgal, Poorva and Rivas, Manuel A and Vedantam, Sailaja and Mahajan, Anubha and Guo, Xiuqing and Abecasis, Goncalo and Aben, Katja K and Adair, Linda S and Alam, Dewan S and Albrecht, Eva and Allin, Kristine H and Allison, Matthew and Amouyel, Philippe and Appel, Emil V and Arveiler, Dominique and Asselbergs, Folkert W and Auer, Paul L and Balkau, Beverley and Banas, Bernhard and Bang, Lia E and Benn, Marianne and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bonnycastle, Lori L and Bork-Jensen, Jette and Bots, Michiel L and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Breen, Gerome and Brilliant, Murray H and Broer, Linda and Burt, Amber A and Butterworth, Adam S and Carey, David J and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-Der Ida and Chowdhury, Rajiv and Christensen, Cramer and Chu, Auey Y and Cocca, Massimiliano and Collins, Francis S and Cook, James P and Corley, Janie and Galbany, Jordi Corominas and Cox, Amanda J and Cuellar-Partida, Gabriel and Danesh, John and Davies, Gail and de Bakker, Paul I. W and de Borst, Gert J and de Denus, Simon and de Groot, Mark C. H and de Mutsert, Renée and Deary, Ian J and Dedoussis, George and Demerath, Ellen W and den Hollander, Anneke I and Dennis, Joe G and Di Angelantonio, Emanuele and nos, Fotios and Du, Mengmeng and Dunning, Alison M and Easton, Douglas F and Ebeling, Tapani and Edwards, Todd L and Ellinor, Patrick T and Elliott, Paul and Evangelou, Evangelos and Farmaki, Aliki-Eleni and Faul, Jessica D and ... and EPIC-CVD Consortium and GoT2D Genes Consortium and MAGIC Investigators and Global Lipids Genetics Consortium and EPIC-InterAct Consortium and ReproGen Consortium and ExomeBP Consortium and CHD Exome Consortium and T2D-Genes Consortium and The EPIC-InterAct Consortium and CHD Exome+ Consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Allmänmedicin and Umeå universitet and Medicin
Nature, ISSN 0028-0836, 2017, Volume 542, Issue 7640, pp. 186 - 190
Journal Article
by Turcot, Valérie and Lu, Yingchang and Highland, Heather M and Schurmann, Claudia and Justice, Anne E and Fine, Rebecca S and Bradfield, Jonathan P and Esko, Tõnu and Giri, Ayush and Graff, Mariaelisa and Guo, Xiuqing and Henicks, Auey E and Karaderi, Tugce and Lempradl, Adelheid and Locke, Adam E and Mahajan, Anubha and Marouli, Eirini and Sivapalaratnam, Suthesh and Young, Kristin L and Alfred, Tamuno and Feitosa, Mary F and Masca, Nicholas G. D and Manning, Alisa K and Medina-Gomez, Carolina and Mudgal, Poorva and Ng, Maggie C. Y and Reiner, Alex P and Vedantam, Sailaja and Willems, Sara M and Winkler, Thomas W and Abecasis, Gonçalo and Aben, Katja K and Alam, Dewan S and Alharthi, Sameer E and Allison, Matthew and Amouyel, Philippe and Asselbergs, Folkert W and Auer, Paul L and Balkau, Beverley and Bang, Lia E and Barroso, Inês and Bastarache, Lisa and Benn, Marianne and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boehnke, Michael and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bork-Jensen, Jette and Bots, Michiel L and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Breen, Gerome and Brilliant, Murray H and Broer, Linda and Brumat, Marco and Burt, Amber A and Butterworth, Adam S and Campbell, Peter T and Cappellani, Stefania and Carey, David J and Catamo, Eulalia and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-der I and Chowdhury, Rajiv and Christensen, Cramer and Chu, Auey Y and Cocca, Massimiliano and Collins, Francis S and Cook, James P and Corley, Janie and Corominas Galbany, Jordi and Cox, Amanda J and Crosslin, David S and Cuellar-Partida, Gabriel and D'Eustacchio, Angela and Danesh, John and Davies, Gail and Bakker, Paul I. W and Groot, Mark C. H and Mutsert, Renée and Deary, Ian J and Dedoussis, George and Demerath, Ellen W and Heijer, Martin and Hollander, Anneke I and Ruijter, Hester M and Dennis, Joe G and Denny, Josh C and Angelantonio, Emanuele and nos, Fotios and Du, Mengmeng and Dubé, Marie-Pierre and Dunning, Alison M and Easton, Douglas F and ... and Chd Exome Consortium and EPIC InterAct Consortium and Global Lipids Genetic Consortium and GoT2D Genes Consortium and MAGIC Investigators and Understanding Soc Sci Grp and ReproGen Consortium and Interval Study and Epic-Cvd Consortium and ExomeBP Consortium and T2D-Genes Consortium and INTERVAL Study and EPIC-CVD Consortium and EPIC InterAct Consortium and CHD Exome+ Consortium and Understanding Society Scientific Group and The MAGIC Investigators and Medicinska fakulteten and Avdelningen för medicin and Umeå universitet and Medicin and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Allmänmedicin
Nature genetics, ISSN 1061-4036, 2018, Volume 50, Issue 1, pp. 26 - +
Journal Article
by Gunter Schumann and Chunyu Liu and Paul O’Reilly and He Gao and Parkyong Song and Bing Xu and Barbara Ruggeri and Najaf Amin and Tianye Jia and Sarah Preis and Marcelo Segura Lepe and Shizuo Akira and Caterina Barbieri and Sebastian Baumeister and Stephane Cauchi and Toni-Kim Clarke and Stefan Enroth and Kristar Fische and Jenni Hällfors and Sarah E. Harris and Saskia Hieber and Edith Hofer and Jouke-Jan Hottenga and Åsa Johansson and Peter K. Joshi and Niina Kaartinen and Jaana Laitinen and Rozenn Lemaitre and Anu Loukola and Jian’an Luan and Leo-Pekka Lyytikäinen and Massimo Mangino and Ani Manichaikul and Hamdi Mbarek and Yuri Milaneschi and Alireza Moayyeri and Kenneth Mukamal and Christopher Nelson and Jennifer Nettleton and Eemil Partinen and Rajesh Rawal and Antonietta Robino and Lynda Rose and Cinzia Sala and Takashi Satoh and Reinhold Schmidt and Katharina Schraut and Robert Scott and Albert Vernon Smith and John M. Starr and Alexander Teumer and Stella Trompet and André G. Uitterlinden and Cristina Venturini and Anne-Claire Vergnaud and Niek Verweij and Veronique Vitart and Dragana Vuckovic and Juho Wedenoja and Loic Yengo and Bing Yu and Weihua Zhang and Jing Hua Zhao and Dorret I. Boomsma and John Chambers and Daniel I. Chasman and Toniolo Daniela and Eco de Geus and Ian Deary and Johan G. Eriksson and Tõnu Esko and Volker Eulenburg and Oscar H. Franco and Philippe Froguel and Christian Gieger and Hans J. Grabe and Vilmundur Gudnason and Ulf Gyllensten and Tamara B. Harris and Anna-Liisa Hartikainen and Andrew C. Heath and Lynne Hocking and Albert Hofman and Cornelia Huth and Marjo-Riitta Jarvelin and J. Wouter Jukema and Jaakko Kaprio and Jaspal S. Kooner and Zoltan Kutalik and Jari Lahti and Claudia Langenberg and Terho Lehtimäki and Yongmei Liu and Pamela A. F. Madden and Nicholas Martin and Alanna Morrison and Brenda Penninx and Nicola Pirastu and Bruce Psaty and Olli Raitakari and ... and Science for Life Laboratory, SciLifeLab and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik och genomik and Farmaceutiska fakulteten and Institutionen för farmaceutisk biovetenskap and Uppsala universitet
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 50, pp. 14372 - 14377
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified... 
ACTIVATION | mouse model | SWEET | alcohol consumption | DEPENDENCE | HEART | DISEASE | LIVER | MICE | human | beta-Klotho | CONSUMPTION | FGF21 | GENOME-WIDE ASSOCIATION | Alcohol consumption | Human | β-Klotho | Mouse model | MULTIDISCIPLINARY SCIENCES | Biological Sciences | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
BMC BIOINFORMATICS, ISSN 1471-2105, 11/2019, Volume 20, Issue 1, pp. 543 - 11
Background Transcriptomic data is often used to build statistical models which are predictive of a given phenotype, such as disease status. Genes work together... 
Pathways | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | CLASSIFICATION | Robustness | Predictive modelling | CANCER | Computational Biology - methods | Gene Expression | Phenotype | Signal Transduction | Humans | Transcriptome | Gene Expression Profiling | Models, Statistical | Databases, Factual
Journal Article
by Justice, Anne E and Karaderi, Tugce and Highland, Heather M and Young, Kristin L and Graff, Mariaelisa and Lu, Yingchang and Turcot, Valérie and Auer, Paul L and Fine, Rebecca S and Guo, Xiuqing and Schurmann, Claudia and Lempradl, Adelheid and Marouli, Eirini and Mahajan, Anubha and Winkler, Thomas W and Locke, Adam E and Medina-Gomez, Carolina and Esko, T. nu and Vedantam, Sailaja and Giri, Ayush and Lo, Ken Sin and Alfred, Tamuno and Mudgal, Poorva and Ng, Maggie C. Y and Heard-Costa, Nancy L and Feitosa, Mary F and Manning, Alisa K and Willems, Sara M and Sivapalaratnam, Suthesh and Abecasis, Goncalo and Alam, Dewan S and Allison, Matthew and Amouyel, Philippe and Arzumanyan, Zorayr and Balkau, Beverley and Bastarache, Lisa and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boehnke, Michael and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bork-Jensen, Jette and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Broer, Linda and Burt, Amber A and Hovingh, G. Kees and Aienne Cupples, L and North, Kari E and Lindgren, Cecilia M and Cohorts For Heart Aging Res Genomi and EPIC-CVD Consortium and InterAct and Global Lipids Genetic Consortium and GoT2D Genes Consortium and MAGIC Investigators and ReproGen Consortium and T2G Genes Consortium and ExomeBP Consortium and CHD Exome Consortium and CHD Exome+ Consortium and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and T2D-Genes Consortium and The MAGIC Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Avdelningen för medicin and Umeå universitet
Nature genetics, ISSN 1061-4036, 03/2019, Volume 51, Issue 3, pp. 452 - 469
Journal Article
by van Leeuwen, Elisabeth M and Sabo, Aniko and Bis, Joshua C and Huffman, Jennifer E and Manichaikul, Ani and Smith, Albert V and Feitosa, Mary F and Demissie, Serkalem and Joshi, Peter K and Duan, Qing and Marten, Jonathan and van Klinken, Jan B and Surakka, Ida and Nolte, Ilja M and Zhang, Weihua and Mbarek, Hamdi and Li-Gao, Ruifang and Trompet, Stella and Verweij, Niek and Evangelou, Evangelos and Lyytikäinen, Leo-Pekka and Tayo, Bamidele O and Deelen, Joris and van der Most, Peter J and van der Laan, Sander W and Arking, Dan E and Morrison, Alanna and Dehghan, Abbas and Franco, Oscar H and Hofman, Albert and Rivadeneira, Fernando and Sijbrands, Eric J and Uitterlinden, Andre G and Mychaleckyj, Josyf C and Campbell, Archie and Hocking, Lynne J and Padmanabhan, Sandosh and Brody, Jennifer A and Rice, Kenneth M and White, Charles C and Harris, Tamara and Isaacs, Aaron and Campbell, Harry and Lange, Leslie A and Rudan, Igor and Kolcic, Ivana and Navarro, Pau and Zemunik, Tatijana and Salomaa, Veikko and Kooner, Angad S and Kooner, Jaspal S and Lehne, Benjamin and Scott, William R and Tan, Sian-Tsung and de Geus, Eco J and Milaneschi, Yuri and Penninx, Brenda W J H and Willemsen, Gonneke and de Mutsert, Renée and Ford, Ian and Gansevoort, Ron T and Segura-Lepe, Marcelo P and Raitakari, Olli T and Viikari, Jorma S and Nikus, Kjell and Forrester, Terrence and McKenzie, Colin A and de Craen, Anton J M and de Ruijter, Hester M and Pasterkamp, Gerard and Snieder, Harold and Oldehinkel, Albertine J and Slagboom, P Eline and Cooper, Richard S and Kähönen, Mika and Lehtimäki, Terho and Elliott, Paul and van der Harst, Pim and Jukema, J Wouter and Mook-Kanamori, Dennis O and Boomsma, Dorret I and Chambers, John C and Swertz, Morris and Ripatti, Samuli and Willems van Dijk, Ko and Vitart, Veronique and Polasek, Ozren and Hayward, Caroline and Wilson, James G and Wilson, James F and Gudnason, Vilmundur and Rich, Stephen S and Psaty, Bruce M and Borecki, Ingrid B and Boerwinkle, Eric and Rotter, Jerome I and Cupples, L Adrienne and van Duijn, Cornelia M and CHARGE Lipids Working Grp and CHARGE Lipids Working Group and LifeLines Cohort Study
Journal of Medical Genetics, ISSN 0022-2593, 07/2016, Volume 53, Issue 7, pp. 441 - 449
Journal Article
Bioinformatics, ISSN 1367-4803, 05/2015, Volume 31, Issue 9, pp. 1505 - 1507
MOTIVATION: The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade,... 
TOXICOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Index Medicus | Toxicity | Risk assessment | Infrastructure | Archiving | Safety | Assessments | Online | Bioinformatics | Applications Notes
Journal Article