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1. Full Text The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus
by Leung, Po Sing
Nutrients, ISSN 2072-6643, 03/2016, Volume 8, Issue 3, pp. 147 - 147
HepG2 | Lipid metabolism | Glucose homeostasis | Calcitriol | Hypovitaminosis D | Insulin secretion | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Signal Transduction | Humans | Liver - metabolism | Risk Factors | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Liver - physiopathology | Vitamin D Deficiency - physiopathology | Diabetes Mellitus, Type 2 - epidemiology | Protective Factors | Animals | Diabetes Mellitus, Type 2 - physiopathology | Vitamin D Deficiency - epidemiology | Islets of Langerhans - metabolism | Islets of Langerhans - physiopathology | Vitamin D - metabolism | Vitamin D Deficiency - metabolism | Blood Glucose - metabolism | Index Medicus | glucose homeostasis | hypovitaminosis D | insulin secretion | calcitriol | lipid metabolism
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2. Full Text The Modulatory Action of Vitamin D on the Renin-Angiotensin System and the Determination of Hepatic Insulin Resistance
by Leung, Po Sing
Molecules (Basel, Switzerland), ISSN 1420-3049, 07/2019, Volume 24, Issue 13, p. 2479
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Liver - drug effects | Signal Transduction - drug effects | Humans | Insulin Resistance | Lipid Metabolism - drug effects | Glucose - metabolism | Vitamin D - pharmacology | Renin-Angiotensin System - drug effects | Diabetes Mellitus, Type 2 - metabolism | Diabetes Mellitus, Type 2 - pathology | Hep G2 Cells | Index Medicus | AT1 receptor calcitriol | HepG2 cells | type 2 diabetes | liver | pancreas | obesity
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3. Full Text The physiology of a local renin–angiotensin system in the pancreas
by Leung, Po Sing
The Journal of physiology, ISSN 0022-3751, 04/2007, Volume 580, Issue 1, pp. 31 - 37
Neurosciences | Physiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Animals | Islets of Langerhans - physiology | Pancreas - physiopathology | Humans | Islets of Langerhans - physiopathology | Pancreas - physiology | Renin-Angiotensin System - physiology | Pancreas, Exocrine - physiopathology | Pancreas, Exocrine - physiology | Physiological aspects | Pancreatic beta cells | Diabetes | Pancreatitis | Index Medicus | Topical Reviews
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4. The renin-angiotensin system
: current research progress in the pancreas, the RAS in the pancreas
by Leung, Po Sing
2010, Advances in experimental medicine and biology, ISBN 9789048190591, Volume 690., xvi, 207
Medicine | Pancreatic Diseases | Biology | Research | Renin-angiotensin system | Pancreas | Diseases
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5. Full Text Use of herbal medicines and natural products: An alternative approach to overcoming the apoptotic resistance of pancreatic cancer
by Li, Lin and Leung, Po Sing
The international journal of biochemistry & cell biology, ISSN 1357-2725, 08/2014, Volume 53, pp. 224 - 236
Bruceine D | Chinese medicine | Reactive oxygen species | Eriocalyxin B | Gemcitabine | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Pancreatic Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Quassins - administration & dosage | Reactive Oxygen Species - metabolism | Diterpenes - administration & dosage | Medicine, Chinese Traditional | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - pathology | Biological Products - administration & dosage | Herbal Medicine | Drug Resistance, Neoplasm - drug effects | Drugs | Usage | Medicine, Botanic | Pancreatic cancer | Adjuvant treatment | Heat shock proteins | Medicine, Herbal | Tumor proteins | Cancer | Apoptosis | Index Medicus
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6. Full Text Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions
by Zhang, Dan and Xie, Ting and Leung, Po Sing
Cellular physiology and biochemistry, ISSN 1015-8987, 11/2018, Volume 51, Issue 2, pp. 924 - 937
Original Paper | Ins-1E cells | Diabetes mellitus | Islets | Lipid metabolism | Nuclear factor-κB | Pancreas | Triglyceride | Insulin | Glucose Transporter Type 2 - genetics | AMP-Activated Protein Kinases - metabolism | Fibronectins - pharmacology | Palmitic Acid - pharmacology | Anti-Inflammatory Agents - pharmacology | Apoptosis - drug effects | Mice, Inbred C57BL | Rats | Glucose - pharmacology | Glucose Transporter Type 2 - metabolism | Triglycerides - metabolism | Fatty Acids, Nonesterified - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Insulin-Secreting Cells - cytology | Mice | Phosphorylation - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Acetyl-CoA Carboxylase - metabolism | Insulin Secretion - drug effects | Obesity | Oxidative stress | Phosphorylation | Pathogenesis | Homeostasis | Lipids | Inflammation | Glucose | Gene expression | Metabolism | Kinases | Fatty acids | Proteins | Hyperglycemia | Weight control | Penicillin | Insulin resistance | Ligands | Oxidation | Diabetes | Chemokines | Apoptosis | Index Medicus
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7. Full Text Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus
by So, Wing Yan and Leung, Po Sing
Medicinal research reviews, ISSN 0198-6325, 07/2016, Volume 36, Issue 4, pp. 672 - 704
peroxisome proliferator‐activated receptor gamma | glucose | FGF21 analogs | pancreas | lipid metabolism | peroxisome proliferator-activated receptor gamma | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Hypoglycemic Agents - therapeutic use | Humans | Fibroblast Growth Factors - biosynthesis | Fibroblast Growth Factors - pharmacology | Hypoglycemic Agents - chemistry | Diabetes Mellitus, Type 2 - metabolism | Molecular Targeted Therapy | Hypoglycemic Agents - pharmacology | Randomized Controlled Trials as Topic | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Animals | Diabetes Mellitus, Type 2 - drug therapy | Fibroblast Growth Factors - therapeutic use | Type 2 diabetes | Glucose metabolism | Physiological aspects | Development and progression | Fibroblast growth factors | Glucose | Health aspects | Cells | Dextrose | Fibroblasts | Diabetes | Growth factors | Metabolic disorders | Index Medicus
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8. FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential
by Leung, Po Sing
Future medicinal chemistry, ISSN 1756-8919, 04/2019, Volume 11, Issue 7, pp. 641 - 644
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Fatty Acids, Nonesterified - metabolism | Fibroblast Growth Factors - metabolism | Islets of Langerhans - drug effects | AMP-Activated Protein Kinases - metabolism | Animals | TOR Serine-Threonine Kinases - metabolism | Diet, High-Fat | Humans | Glucose - metabolism | Lipids | Diabetes Mellitus, Type 2 - drug therapy | Autophagy - drug effects
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9. Full Text Role of oxidative stress in pancreatic inflammation
by Leung, Po Sing and Chan, Yuk Cheung
Antioxidants & redox signaling, ISSN 1523-0864, 01/2009, Volume 11, Issue 1, pp. 135 - 165
Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Inflammation - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Signal Transduction | Reactive Nitrogen Species - metabolism | Antioxidants - metabolism | Humans | Pancreas - pathology | Pancreas - metabolism | Inflammation - metabolism | Animals | Models, Biological | Pancreatitis - metabolism | Pancreatitis, Chronic - metabolism | Oxidative stress | Care and treatment | Pancreatitis | Physiological aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Index Medicus
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