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Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7643, pp. 45 - 47
Ageing is associated with an increased risk of cardiovascular disease caused by the rupture of inflamed cholesterol plaques in arteries. It emerges that this... 
TET2 | ATHEROSCLEROSIS | STEM-CELL PROLIFERATION | MICE | CLONAL HEMATOPOIESIS | MULTIDISCIPLINARY SCIENCES | Cardiovascular Diseases | Humans | Neoplasms | Physiological aspects | Cardiovascular diseases | Cancer
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2019, Volume 74, Issue 4, pp. 567 - 577
A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic... 
leukemia | cancer | cardio-oncology | cardiovascular risk | leukocyte
Journal Article
Leukemia, ISSN 0887-6924, 02/2019, Volume 33, Issue 2, pp. 390 - 402
Journal Article
Clinical Lymphoma Myeloma and Leukemia, ISSN 2152-2650, 09/2017, Volume 17, pp. S133 - S133
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2016, Volume 30, Issue 5, pp. 659 - 660
In this issue of , Ceribelli et al. use functional genomic and chemical screening to reveal the existence of a TCF4/BRD4-dependent oncogenic regulatory network... 
TUMOR | CELLS | FACTOR E2-2 | ONCOLOGY | CELL BIOLOGY | Hematologic Neoplasms - drug therapy | Dendritic Cells | Myeloproliferative Disorders | Humans | Skin Neoplasms | Genetic aspects | Genetic transcription | Dendritic cells | Tumors
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 05/2019, Volume 25, Issue 10, pp. 2956 - 2962
In 2013, two seminal studies identified gain-of-function mutations in the Calreticulin (CALR) gene in a subset of JAK2/MPL-negative myeloproliferative neoplasm... 
MOLECULAR-MECHANISM | JAK INHIBITOR | CELL-SURFACE CALRETICULIN | ACTIVATING MUTATION | POLYCYTHEMIA-VERA | RECEPTOR-RELATED PROTEIN | ONCOLOGY | MUTANT CALRETICULIN | ESSENTIAL THROMBOCYTHEMIA | CALR EXON-9 MUTATIONS | THROMBOPOIETIN RECEPTOR
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3831 - 3831
Abstract Hematopoietic stem cells (HSCs) are undifferentiated, self-renewing, pluripotent cells that have the capacity to differentiate into all mature... 
Journal Article
STEM CELLS, ISSN 1066-5099, 09/2018, Volume 36, Issue 9, pp. 1287 - 1294
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 9/2018, Volume 36, Issue 9, pp. 1287 - 1294
The recent characterization of clonal hematopoiesis in a large segment of the aging population has raised tremendous interest and concern alike. Mutations have... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 995 - 995
Abstract Introduction: Acute myeloid leukemia (AML) evolution is a multistep process in which cells evolve from hematopoietic stem and progenitor cells (HSPCs)... 
Journal Article
Journal Article
JAMA, ISSN 0098-7484, 08/2015, Volume 314, Issue 8, pp. 778 - 780
Acute myeloid leukemia (AML) represents a heterogeneous disease, both with respect to molecular pathogenesis and clinical outcome. Although dose-intensive... 
SURVIVAL | AML | MEDICINE, GENERAL & INTERNAL | PROGNOSTIC IMPACT | COMPLETE REMISSION | CLONAL HEMATOPOIESIS | MUTATIONS | INDEX | Humans | Leukemia, Myeloid, Acute - drug therapy | Female | Induction Chemotherapy | Male | Mutation | Leukemia, Myeloid, Acute - genetics | Regression (Disease) | Analysis | Leukemia | Medical prognosis | Medical treatment
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1471 - 1471
Abstract Acute Myeloid Leukemia (AML) is a biologically diverse disease with subtypes that can be identified through integrated cytogenetic, mutational, and... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 706 - 706
Abstract Myeloproliferative disorder (MPD) patients are at high risk of atherothrombotic events including myocardial infarction and stroke. The somatic... 
Journal Article
Seminars in Hematology, ISSN 0037-1963, 04/2019, Volume 56, Issue 2, pp. 84 - 89
Acute myeloid leukemia (AML) was one of the first cancers to be sequenced at the level of the whole genome. Molecular profiling of AML through targeted... 
AML | Epigenetics | Genetics | Targeted therapy | Acute myeloid leukemia | Clonal hematopoiesis | ADULT PATIENTS | GEMTUZUMAB OZOGAMICIN | IDH2 MUTATIONS | INDUCTION CHEMOTHERAPY | OPEN-LABEL | ACUTE MYELOID-LEUKEMIA | KINASE INHIBITOR | DNMT3A MUTATIONS | TET2 FUNCTION | HEMATOLOGY
Journal Article
Circulation Research, ISSN 0009-7330, 11/2018, Volume 123, Issue 11, pp. e35 - e47
RATIONALE:The mechanisms driving atherothrombotic risk in individuals with JAK2 (Jak2) positive clonal hematopoiesis or myeloproliferative neoplasms are poorly... 
atherosclerosis | macrophages | erythrocytes | inflammasomes | inflammation | Atherosclerosis | Neutrophils | Erythrocytes | Genetic aspects | Research | Gene expression | Macrophages
Journal Article
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