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Circulation, ISSN 0009-7322, 06/2019, Volume 139, Issue 24, pp. 2765 - 2777
BACKGROUND:Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1)... 
acyl coenzyme A | coenzyme A ligases | heart failure | fatty acids | ceramides | Heart failure | Coenzyme A | Care and treatment | Lipid metabolism | Health aspects | Testing | Index Medicus | Abridged Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 08/2018, Volume 123, Issue Suppl_1
Journal Article
Magnetic Resonance in Medicine, ISSN 0740-3194, 12/2016, Volume 76, Issue 6, pp. 1879 - 1886
Journal Article
Circulation Research, ISSN 0009-7330, 02/2014, Volume 114, Issue 4, pp. 717 - 729
Metabolic signaling mechanisms are increasingly recognized to mediate the cellular response to alterations in workload demand, as a consequence of... 
heart failure | mobilization | cytosol | mitochondria | diabetes mellitus | metabolism | metabolic pathways
Journal Article
American Journal of Physiology: Heart and Circulatory Physiology, ISSN 0363-6135, 04/2017, Volume 312, Issue 4, pp. H681 - H681
Although alterations in fatty acid (FA) metabolism have been shown to have a negative impact on contractility of the hypertrophied heart, the targets of action... 
Journal Article
Circulation, ISSN 0009-7322, 11/2014, Volume 130, Issue 20, pp. 1790 - 1799
BACKGROUND—Intramyocardial triglyceride (TG) turnover is reduced in pressure-overloaded, failing hearts, limiting the availability of this rich source of... 
lipids | metabolism | fatty acids | genes | hypertrophy | PPAR-ALPHA | CARDIAC & CARDIOVASCULAR SYSTEMS | FLUX | FAILURE | INTACT HEART | SUBSTRATE | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | RAT-HEART | ENERGY-METABOLISM | CARNITINE PALMITOYLTRANSFERASE-I | Mitochondria, Heart - metabolism | Myocardial Contraction - drug effects | Male | Cardiomyopathy, Hypertrophic - complications | Gene Expression Profiling | Oleic Acid - pharmacology | Cell Nucleus - metabolism | Palmitates - administration & dosage | Dietary Fats - pharmacology | Palmitates - pharmacology | Myocardium - metabolism | Nuclear Magnetic Resonance, Biomolecular | Transcription, Genetic | Heart Failure - diet therapy | Oleic Acid - pharmacokinetics | Heart Failure - etiology | Disease Models, Animal | Oxidation-Reduction | Oleic Acid - administration & dosage | Cardiomyopathy, Hypertrophic - metabolism | Hypertrophy, Left Ventricular - metabolism | Rats | Ceramides - analysis | Heart Failure - metabolism | Rats, Sprague-Dawley | Lipolysis | Citric Acid Cycle | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Hypertrophy, Left Ventricular - complications | PPAR alpha - physiology | Myocytes, Cardiac - metabolism | Palmitates - pharmacokinetics | Dietary Fats - pharmacokinetics | Oxidation-reduction reaction | Nuclear magnetic resonance spectroscopy | Usage | Triglycerides | Health aspects | Analysis | Lipids | Fatty Acids | Metabolism | Genes | Hypertrophy
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A12756 - A12756
Reduced long chain fatty acid (LCFA) oxidation in pressure overloaded, hypertrophied hearts coincides with an isoform shift of carnitine palmitoyl transferase... 
Journal Article
Biochimica et biophysica acta, ISSN 0006-3002, 10/2016, Volume 1861, Issue 10, p. 1492
No longer regarded as physiologically inert the endogenous triacylglyceride (TAG) pool within the cardiomyocyte is now recognized to play a dynamic role in... 
Animals | Oxidation-Reduction | Signal Transduction | Humans | Heart Failure - metabolism | Mitochondria - metabolism | Fatty Acids - metabolism | Triglycerides - metabolism
Journal Article
American Journal of Physiology: Heart and Circulatory Physiology, ISSN 0363-6135, 06/2015, Volume 308, Issue 11, pp. H1414 - H1414
Sudden cardiac arrest (SCA) is a leading cause of death in the United States. Despite return of spontaneous circulation, patients die due to post-SCA syndrome... 
Journal Article
Magnetic resonance in medicine, ISSN 0740-3194, 12/2016, Volume 76, Issue 6, pp. 1879 - 1886
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A11238 - A11238
IntroductionMetabolic remodeling in heart failure (HF) produces dysfunctional lipid trafficking, resulting in reduced lipid availability for energy production... 
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 79, pp. 13 - 20
Abstract Diabetic hearts are subject to more extensive ischemia/reperfusion (ISC/REP) damage. This study examined the efficiency of citric acid cycle (CAC)... 
Cardiovascular | Reducing equivalents | db/db mouse malate–aspartate shuttle | Mitochondria | Uncoupling protein | Oxoglutarate–malate carrier | Db/db mouse malate-aspartate shuttle | Oxoglutarate-malate carrier | OXIDATION | INTACT HEARTS | CARDIAC & CARDIOVASCULAR SYSTEMS | DB/DB MICE | UNCOUPLING PROTEINS | FATTY-ACIDS | CELL BIOLOGY | RECOVERY | PERFUSED HEARTS | db/db mouse malate-aspartate shuttle | RAT-HEART | METABOLIC FLUX | MOUSE HEARTS | Myocardial Ischemia - metabolism | Male | Myocardial Reperfusion Injury - pathology | Mitochondrial Proteins - metabolism | Myocardium - metabolism | Carbon-13 Magnetic Resonance Spectroscopy | Malates - metabolism | Myocardial Ischemia - physiopathology | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | NAD - metabolism | Diabetes Mellitus, Experimental - physiopathology | Oxidation-Reduction | Mice, Inbred C57BL | Myocardium - pathology | Myocardial Reperfusion Injury - physiopathology | Citric Acid Cycle | Myocardial Reperfusion Injury - metabolism | Animals | Carrier Proteins - metabolism | Ion Channels - metabolism | Perfusion | Myocardial Ischemia - complications | Aspartic Acid - metabolism | Cytosol - metabolism | Uncoupling Protein 2 | Hemodynamics | PPAR alpha - metabolism | Uncoupling Protein 3 | Glucose metabolism | Aspartate | Mitochondrial DNA | Diabetes | Glucose | Dextrose | Citric acid | malate-aspartate shuttle | reducing equivalents | db mouse | oxoglutarate-malate carrier | mitochondria | uncoupling protein
Journal Article
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