The New England Journal of Medicine, ISSN 0028-4793, 12/2012, Volume 367, Issue 25, pp. 2396 - 2406
In two placebo-controlled trials, canakinumab, an anti-interleukin-1β monoclonal antibody, achieved a response, prevented flares, and allowed glucocorticoid...
RHEUMATOID-ARTHRITIS | CRITERIA | MEDICINE, GENERAL & INTERNAL | RECEPTOR ANTAGONIST ANAKINRA | EFFICACY | DOUBLE-BLIND | PRELIMINARY DEFINITION | FOLLOW-UP | CLASSIFICATION | SELECT CATEGORIES | CHILDREN | Glucocorticoids - therapeutic use | Double-Blind Method | Humans | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Male | Thrombocytopenia - chemically induced | Methotrexate - therapeutic use | Infection - chemically induced | Arthritis, Juvenile - drug therapy | Macrophage Activation Syndrome - etiology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Arthritis, Juvenile - complications | Female | Drug Therapy, Combination | Neutropenia - chemically induced | Child | Interleukin-1beta - antagonists & inhibitors | Drugs | Dose-response relationship (Biochemistry) | Product/Service Evaluations | Drug therapy | Juvenile arthritis | Pediatrics | Cytokines | Fever | Rheumatology | Index Medicus | Abridged Index Medicus
RHEUMATOID-ARTHRITIS | CRITERIA | MEDICINE, GENERAL & INTERNAL | RECEPTOR ANTAGONIST ANAKINRA | EFFICACY | DOUBLE-BLIND | PRELIMINARY DEFINITION | FOLLOW-UP | CLASSIFICATION | SELECT CATEGORIES | CHILDREN | Glucocorticoids - therapeutic use | Double-Blind Method | Humans | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Male | Thrombocytopenia - chemically induced | Methotrexate - therapeutic use | Infection - chemically induced | Arthritis, Juvenile - drug therapy | Macrophage Activation Syndrome - etiology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Arthritis, Juvenile - complications | Female | Drug Therapy, Combination | Neutropenia - chemically induced | Child | Interleukin-1beta - antagonists & inhibitors | Drugs | Dose-response relationship (Biochemistry) | Product/Service Evaluations | Drug therapy | Juvenile arthritis | Pediatrics | Cytokines | Fever | Rheumatology | Index Medicus | Abridged Index Medicus
Journal Article
Pediatric Rheumatology Online Journal, 05/2017, Volume 15, Issue S1, pp. 1 - 104
Journal Article
Pediatric Rheumatology Online Journal, 05/2017, Volume 15, Issue S1, pp. 203 - 259
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2016, Volume 75, Issue Suppl 2, pp. 265 - 266
BackgroundSJIA is a distinct and debilitating form of arthritis associated with elevated cytokine (interleukin [IL]-1 and IL-6) levels.1 Studies have shown...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2014, Volume 73, Issue Suppl 2, pp. 132 - 132
Background Canakinumab (CAN), a selective, fully-human anti-IL-1β monoclonal antibody is approved for SJIA in over 30 countries. Efficacy and safety of CAN...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue Suppl 2, pp. 608 - 608
BackgroundCanakinumab (CAN) leads to improvement for patients (pts) with systemic juvenile idiopathic arthritis (SJIA)1. However, little is known about...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2016, Volume 75, Issue Suppl 2, pp. 401 - 402
BackgroundThe main therapeutic goals that can determine success of biologic treatment in systemic juvenile idiopathic arthritis (SJIA) include achieving and...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 395
BackgroundStill's disease presents in paediatric and adult patients (pts) as a disease continuum with similar symptoms and pathophysiology.1,2ObjectivesTo...
Adolescence | Immunogenicity | Interleukin 1 | Monoclonal antibodies | Data processing | Juvenile rheumatoid arthritis | Arthritis | Adults | Teenagers | Children | Safety | Age
Adolescence | Immunogenicity | Interleukin 1 | Monoclonal antibodies | Data processing | Juvenile rheumatoid arthritis | Arthritis | Adults | Teenagers | Children | Safety | Age
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 01/2016, Volume 68, Issue 1, pp. 218 - 228
Objective In pivotal trials, canakinumab has been shown to be effective in the treatment of systemic juvenile idiopathic arthritis (JIA), but reported adverse...
PATHOGENESIS | OF-RHEUMATOLOGY RECOMMENDATIONS | DIAGNOSTIC-SIGNIFICANCE | INTERFERON-GAMMA | MEDICAL THERAPY | INTERLEUKIN-1 RECEPTOR ANTAGONIST | 2013 UPDATE | DOUBLE-BLIND | ANAKINRA | RHEUMATOLOGY | CHILDREN | Humans | Risk Factors | Antibodies, Monoclonal - adverse effects | Macrophage Activation Syndrome - chemically induced | Child, Preschool | Male | Arthritis, Juvenile - drug therapy | Young Adult | Infection - epidemiology | Adolescent | Macrophage Activation Syndrome - epidemiology | Female | Child | Antirheumatic Agents - therapeutic use | Databases, Factual | Confidence intervals
PATHOGENESIS | OF-RHEUMATOLOGY RECOMMENDATIONS | DIAGNOSTIC-SIGNIFICANCE | INTERFERON-GAMMA | MEDICAL THERAPY | INTERLEUKIN-1 RECEPTOR ANTAGONIST | 2013 UPDATE | DOUBLE-BLIND | ANAKINRA | RHEUMATOLOGY | CHILDREN | Humans | Risk Factors | Antibodies, Monoclonal - adverse effects | Macrophage Activation Syndrome - chemically induced | Child, Preschool | Male | Arthritis, Juvenile - drug therapy | Young Adult | Infection - epidemiology | Adolescent | Macrophage Activation Syndrome - epidemiology | Female | Child | Antirheumatic Agents - therapeutic use | Databases, Factual | Confidence intervals
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2014, Volume 73, Issue Suppl 2, pp. 130 - 130
Background Systemic juvenile idiopathic arthritis (SJIA) is characterized by recurrent flares of active disease comprising of fever, arthritis and markedly...
Journal Article
Pediatric Rheumatology, ISSN 1546-0096, 09/2014, Volume 12, Issue S1, pp. P66 - P66
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2013, Volume 72, Issue Suppl 3, pp. A325 - A326
Background Efficacy and safety of canakinumab (CAN), a selective, fully human, anti-interleukin-1β monoclonal antibody, in SJIA is supported by the results of...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2014, Volume 73, Issue Suppl 2, pp. 578 - 578
Background Canakinumab is a fully human, selective, anti-IL-1β monoclonal antibody approved for the treatment of patients with systemic juvenile idiopathic...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2013, Volume 71, Issue Suppl 3, pp. 705 - 705
Background IL-1β, a key inflammatory cytokine, appears to play a prominent role in systemic juvenile idiopathic arthritis (SJIA). Canakinumab (CAN), a fully...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2013, Volume 71, Issue Suppl 3, pp. 705 - 705
Background Systemic juvenile idiopathic arthritis (SJIA) is a rare autoinflammatory disease. Phase 3 data showed canakinumab (CAN), a fully human selective...
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2013, Volume 71, Issue Suppl 3, pp. 705 - 705
Background Systemic juvenile idiopathic arthritis (SJIA) is an IL1β-mediated autoinflammatory disease, characterized by spiking intermittent fever, rash, and...
Journal Article
Arthritis research & therapy, ISSN 1478-6354, 2011, Volume 13, Issue 6, pp. R202 - R202
Introduction: To assess the effect of canakinumab, a fully human anti-interleukin-1 beta antibody, on symptoms and health-related quality of life (HRQoL) in...
AUTOINFLAMMATORY DISEASES | RHEUMATOLOGY | ARTHRITIS | INTERLEUKIN-1-BETA | FATIGUE | SF-36 | Humans | Middle Aged | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Male | Young Adult | Cryopyrin-Associated Periodic Syndromes - blood | C-Reactive Protein - metabolism | Interleukin-6 - blood | Adult | Female | Surveys and Questionnaires | Cryopyrin-Associated Periodic Syndromes - pathology | Child | Interleukin-1beta - antagonists & inhibitors | Serum Amyloid A Protein - metabolism | Double-Blind Method | Drug Administration Schedule | Treatment Outcome | Cryopyrin-Associated Periodic Syndromes - drug therapy | Remission Induction | Adolescent | Quality of Life | Aged | Health Status
AUTOINFLAMMATORY DISEASES | RHEUMATOLOGY | ARTHRITIS | INTERLEUKIN-1-BETA | FATIGUE | SF-36 | Humans | Middle Aged | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Male | Young Adult | Cryopyrin-Associated Periodic Syndromes - blood | C-Reactive Protein - metabolism | Interleukin-6 - blood | Adult | Female | Surveys and Questionnaires | Cryopyrin-Associated Periodic Syndromes - pathology | Child | Interleukin-1beta - antagonists & inhibitors | Serum Amyloid A Protein - metabolism | Double-Blind Method | Drug Administration Schedule | Treatment Outcome | Cryopyrin-Associated Periodic Syndromes - drug therapy | Remission Induction | Adolescent | Quality of Life | Aged | Health Status
Journal Article