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1. Full Text Detection of silent myocardial ischemia in asymptomatic patients with diabetes: Results of a randomized trial and meta-analysis assessing the effectiveness of systematic screening
by Lièvre, Michel M and Moulin, Philippe and Thivolet, Charles and Rodier, Michel and Rigalleau, Vincent and Penfornis, Alfred and Pradignac, Alain and Ovize, Michel and DYNAMIT Investigators and DYNAMIT investigators and the DYNAMIT investigators
Trials, ISSN 1745-6215, 01/2011, Volume 12, Issue 1, pp. 23 - 23
Background: Most guidelines recommend a systematic screening of asymptomatic high risk patients with diabetes for silent ischemia, but the clinical benefit of... 
MEDICINE, RESEARCH & EXPERIMENTAL | RISK-FACTORS | THERAPY | RECOMMENDATIONS | MELLITUS | PREVALENCE | INTERVENTION | CORONARY-ARTERY-DISEASE | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Diabetes Complications - diagnosis | Asymptomatic Diseases | Diabetes Complications - therapy | Mass Screening - methods | Cause of Death | Diabetes Mellitus, Type 2 - epidemiology | Heart Failure - therapy | Exercise Test | Time Factors | Diabetes Mellitus, Type 2 - therapy | Female | Myocardial Ischemia - mortality | Stroke - mortality | Myocardial Ischemia - diagnosis | Stroke - therapy | Heart Failure - mortality | Emergency Service, Hospital | France - epidemiology | Risk Assessment | Risk Factors | Dipyridamole | Proportional Hazards Models | Hospitalization | Chi-Square Distribution | Ambulatory Care | Diabetes Complications - mortality | Vasodilator Agents | Hospitals | Diabetes Mellitus, Type 2 - mortality | Myocardial Ischemia - therapy | Survival Analysis | Aged | Silent myocardial ischemia | Diagnosis | Research | Diabetes | Medical screening | Risk factors | Index Medicus
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2. Full Text Late Outcomes of Transcatheter Aortic Valve Replacement in High-Risk Patients: The FRANCE-2 Registry
by Gilard, Martine and Eltchaninoff, Hélène and Donzeau-Gouge, Patrick and Chevreul, Karine and Fajadet, Jean and Leprince, Pascal and Leguerrier, Alain and Lievre, Michel and Prat, Alain and Teiger, Emmanuel and Lefevre, Thierry and Tchetche, Didier and Carrié, Didier and Himbert, Dominique and Albat, Bernard and Cribier, Alain and Sudre, Arnaud and Blanchard, Didier and Rioufol, Gilles and Collet, Frederic and Houel, Remi and Dos Santos, Pierre and Meneveau, Nicolas and Ghostine, Said and Manigold, Thibaut and Guyon, Philippe and Grisoli, Dominique and Le Breton, Herve and Delpine, Stephane and Didier, Romain and Favereau, Xavier and Souteyrand, Geraud and Ohlmann, Patrick and Doisy, Vincent and Grollier, Gilles and Gommeaux, Antoine and Claudel, Jean-Philippe and Bourlon, Francois and Bertrand, Bernard and Laskar, Marc and Iung, Bernard and Gilard, Martine and Laskar, Marc and Eltchaninoff, Hélène and Fajadet, Jean and Iung, Bernard and Teiger, Emmanuel and Donzeau-Gouge, Patrick and Leprince, Pascal and Leguerrier, Alain and Prat, Alain and Chevreul, Karine and Lievre, Michel and Bertrand, Michel and Cassagne, Jean and Boschat, Jacques and Lusson, Jean Rene and Mathieu, Pierre and Logeais, Yves and Bessou, Jean-Paul and Lefevre, Thierry and Chevalier, Bernard and Farge, Arnaud and Garot, Philippe and Hovasse, Thomas and Morice, Marie Claude and Romano, Mauro and Gouge, Patrick Donzeau and Tchetche, Didier and Vahdat, Olivier and Farah, Bruno and Fajadet, Jean and Carrie, Didier and Dumonteil, Nicolas and Fournial, Gérard and Marcheix, Bertrand and Himbert, Dominique and Nataf, Patrick and Vahanian, Alec and Albat, Bernard and Leclercq, Florence and Piot, Christophe and Schmutz, Laurent and Aubas, Pierre and du Cailar, A and Dubar, A and Durrleman, N and Fargosz, F and Levy, Gilles and Maupas, Eric and Rivalland, François and Robert, G and Eltchaninoff, Hélène and Bessou, Jean-Paul and Cribier, Alain and Tron, Christophe and Sudre, Arnaud and Juthier, Francis and Modine, Thomas and Van Belle, Eric and ... and FRANCE 2 Investigators
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2016, Volume 68, Issue 15, pp. 1637 - 1647
Background Transcatheter aortic valve replacement (TAVR) has revolutionized management of high-risk patients with severe aortic stenosis. However, survival and... 
aortic stenosis | risk score | predictive analysis | MORTALITY | SURVIVAL | LATE CLINICAL-OUTCOMES | IMPACT | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | PREDICTORS | LONG-TERM OUTCOMES | COREVALVE | PERMANENT PACEMAKER IMPLANTATION | 2-YEAR OUTCOMES | Transcatheter Aortic Valve Replacement | Prospective Studies | Risk Assessment | Time Factors | Humans | Aged, 80 and over | Female | Male | Registries | Treatment Outcome | Aortic Valve Stenosis - surgery | France | Heart valve diseases | Valves | Patient outcomes | Prostheses | Survival analysis | Heart attacks | Patients | Mortality | Index Medicus | Abridged Index Medicus | Life Sciences
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3. Full Text Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial
by Vilgrain, Valérie and Pereira, Helena and Assenat, Eric and Guiu, Boris and Ilonca, Alina Diana and Ilonca, Alina D and Pageaux, Georges-Philippe and Sibert, Annie and Bouattour, Mohamed and Lebtahi, Rachida and Allaham, Wassim and Barraud, Hélène and Laurent, Valérie and Mathias, Elodie and Bronowicki, Jean-Pierre and Tasu, Jean-Pierre and Perdrisot, Rémy and Silvain, Christine and Gerolami, René and Mundler, Olivier and Seitz, Jean-Francois and Vidal, Vincent and Aubé, Christophe and Oberti, Frédéric and Couturier, Olivier and Brenot-Rossi, Isabelle and Raoul, Jean-Luc and Sarran, Anthony and Costentin, Charlotte and Itti, Emmanuel and Luciani, Alain and Adam, René and Lewin, Maïté and Samuel, Didier and Ronot, Maxime and Dinut, Aurelia and Castera, Laurent and Chatellier, Gilles and Delhom - Christol, Elisabeth and Lonjon, Julie and Abdel-Rehim, Mohamed and Dieudonné, Arnaud and Bazin, Christophe and Chagneau-Derrode, Carine and Borentain, Patrick and Bouvier, Antoine and Vervueren, Laurent and Chalaye, Julia and Kobeiter, Hicham and Edeline, Julien and Garin, Etienne and Rolland, Yan and Archambeaud, Isabelle and Eugene, Thomas and Frampas, Eric and Cassinotto, Christophe and Guyot, Martine and Hiriart, Jean-Baptiste and Lapuyade, Bruno and Vergniol, Julien and Bachellier, Philippe and Detour, Julien and Duclos, Bernard and Greget, Michel and Habersetzer, Francois and Imperiale, Alessio and Merle, Philippe and Rode, Agnès and Morvan, Julie and Nguyen-Khac, Eric and Yzet, Thierry and Baudin, Guillaume and Chevallier, Patrick and Mahamat, Abakar and Piche, Thierry and Razzouk, Micheline and Hillon, Patrick and Loffroy, Romaric and Toubeau, Michel and Vincent, Julie and Barabino, Gabriele and Bouarioua, Nadia and Cuilleron, Muriel and Ecochard, Marie and Prevot-Bitot, Nathalie and Leroy, Vincent and Roux, Julie and Sengel, Christian and Bourcier, Valérie and Ganne-Carrie, Nathalie and Seror, Olivier and Costo, Sylvie and Dao, Thông and Pelage, Jean-Pierre and Dumortier, Jérôme and Giammarile, Francesco and Valette, Pierre-Jean and Ghazzar, Nadia and Pellerin, Olivier and Taieb, Julien and ... and SARAH Trial Grp and SARAH Trial Group
The Lancet Oncology, ISSN 1470-2045, 12/2017, Volume 18, Issue 12, pp. 1624 - 1636
Sorafenib is the recommended treatment for patients with advanced hepatocellular carcinoma. We aimed to compare the efficacy and safety of sorafenib to that of... 
SURVIVAL | THERAPY | ONCOLOGY | COMPETING RISK | TRANSARTERIAL CHEMOEMBOLIZATION | RADIOEMBOLIZATION | QUALITY-OF-LIFE | Niacinamide - analogs & derivatives | Carcinoma, Hepatocellular - mortality | Follow-Up Studies | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Liver Neoplasms - mortality | Dose-Response Relationship, Drug | Microspheres | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents - adverse effects | Neoplasm Invasiveness - pathology | Phenylurea Compounds - adverse effects | Adult | Female | Liver Neoplasms - pathology | Yttrium Radioisotopes - therapeutic use | Radiotherapy Dosage | Drug Administration Schedule | Administration, Oral | Brachytherapy - methods | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Niacinamide - adverse effects | Carcinoma, Hepatocellular - radiotherapy | Treatment Outcome | Niacinamide - administration & dosage | Disease-Free Survival | Phenylurea Compounds - administration & dosage | Liver Neoplasms - radiotherapy | Sorafenib | Carcinoma, Hepatocellular - pathology | Survival Analysis | Aged | Neoplasm Staging | Rare earth metals | Antimitotic agents | Product development | Hepatoma | Comparative analysis | Radiotherapy | Antineoplastic agents | Index Medicus | Life Sciences | Liver Neoplasms/drug therapy | Phenylurea Compounds/administration & dosage | Yttrium Radioisotopes/therapeutic use | Niacinamide/analogs & derivatives | Carcinoma, Hepatocellular/radiotherapy | Carcinoma, Hepatocellular/drug therapy | Cancer
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4. Full Text Predictive factors of early mortality after transcatheter aortic valve implantation: individual risk assessment using a simple score
by Iung, Bernard and Laouénan, Cédric and Himbert, Dominique and Eltchaninoff, Hélène and Chevreul, Karine and Donzeau-Gouge, Patrick and Fajadet, Jean and Leprince, Pascal and Leguerrier, Alain and Lièvre, Michel and Prat, Alain and Teiger, Emmanuel and Laskar, Marc and Vahanian, Alec and Gilard, Martine and FRANCE 2 Investigators and for the FRANCE 2 Investigators
Heart, ISSN 1355-6037, 07/2014, Volume 100, Issue 13, pp. 1016 - 1023
Objective Decision making for intervention in symptomatic aortic stenosis should balance the risks of surgery and of transcatheter aortic valve implantation... 
REPLACEMENT | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | CARDIAC-SURGERY | DISEASE | EUROPEAN REGISTRY | OUTCOME SOURCE REGISTRY | CLINICAL-OUTCOMES | Multivariate Analysis | Predictive Value of Tests | Heart Valve Prosthesis Implantation - instrumentation | Age Factors | Humans | Male | Cardiac Catheterization - mortality | Prosthesis Design | Aortic Valve Stenosis - mortality | Patient Selection | Time Factors | Cardiac Catheterization - methods | Aged, 80 and over | Female | Registries | France | Odds Ratio | Reproducibility of Results | Hospital Mortality | Risk Assessment | Comorbidity | Heart Valve Prosthesis | Risk Factors | Decision Support Techniques | Cardiac Catheterization - adverse effects | Heart Valve Prosthesis Implantation - methods | Heart Valve Prosthesis Implantation - mortality | Logistic Models | Treatment Outcome | Aortic Valve Stenosis - diagnosis | Aortic Valve Stenosis - therapy | Cardiac Catheterization - instrumentation | Heart Valve Prosthesis Implantation - adverse effects | Aged | Complications and side effects | Care and treatment | Aortic valve stenosis | Mortality | Risk assessment | Heart valve replacement | Risk factors | Heart attacks | Angina pectoris | Decision making | Index Medicus | Abridged Index Medicus
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5. Full Text Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis
by Mas, Jean-Louis and Chatellier, Gilles and Beyssen, Bernard and Branchereau, Alain and Moulin, Thierry and Becquemin, Jean-Pierre and Larrue, Vincent and Lièvre, Michel and Leys, Didier and Bonneville, Jean-François and Watelet, Jacques and Pruvo, Jean-Pierre and Albucher, Jean-François and Viguier, Alain and Piquet, Philippe and Garnier, Pierre and Viader, Fausto and Touzé, Emmanuel and Giroud, Maurice and Hosseini, Hassan and Pillet, Jean-Christophe and Favrole, Pascal and Neau, Jean-Philippe and Ducrocq, Xavier and EVAS-35 Investigators and EVA-3S Investigators
The New England Journal of Medicine, ISSN 0028-4793, 10/2006, Volume 355, Issue 16, pp. 1660 - 1671
In this randomized trial of patients with symptomatic carotid stenosis of 60% or more, patients who underwent endarterectomy had lower rates of death or stroke... 
SURGERY | STROKE | RISKS | MEDICINE, GENERAL & INTERNAL | BENEFIT | ANGIOPLASTY | CLINICAL-TRIAL | EVA-3S TRIAL | RANDOMIZED-TRIAL | ARTERY STENOSIS | CEREBRAL PROTECTION | Myocardial Infarction - epidemiology | Follow-Up Studies | Angioplasty | Humans | Carotid Stenosis - therapy | Male | Risk | Treatment Outcome | Incidence | Endarterectomy, Carotid - adverse effects | Carotid Stenosis - mortality | Female | Stroke - epidemiology | Aged | Stroke - mortality | Stents - adverse effects | Carotid Stenosis - surgery | Stenosis | Care and treatment | Comparative analysis | Endarterectomy | Health aspects | Stent (Surgery) | Cardiovascular disease | Stroke | Medical imaging | Index Medicus | Abridged Index Medicus | Neurons and Cognition | Life Sciences | Endarterectomy, Carotid | Myocardial Infarction | Carotid Stenosis | Stents
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6. Full Text Assessment of Patients’ and Physicians’ Compliance to an ACE Inhibitor Treatment Based on Urinary N-Acetyl Ser-Asp-Lys-Pro Determination in the Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) Study
by Michel Azizi and Joël Ménard and Séverine Peyrard and Michel Lièvre and Michel Marre and Gilles Chatellier
Diabetes Care, ISSN 0149-5992, 06/2006, Volume 29, Issue 6, pp. 1331 - 1336
Assessment of Patients’ and Physicians’ Compliance to an ACE Inhibitor Treatment Based on Urinary N -Acetyl Ser-Asp-Lys-Pro Determination in the... 
MEDICATION | CHRONIC HEART-FAILURE | CONVERTING ENZYME-INHIBITION | ENDOCRINOLOGY & METABOLISM | RANDOMIZED CONTROLLED-TRIAL | OUTCOMES | MELLITUS | PROLINE | PLASMA-LEVEL | ADHERENCE | THERAPEUTIC TRIALS | Albuminuria - psychology | Diabetes Mellitus, Type 2 - psychology | Biomarkers - urine | Double-Blind Method | Physicians | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - urine | Diabetic Angiopathies - drug therapy | Oligopeptides - urine | Proteinuria - psychology | Guideline Adherence | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Hypertension - psychology | Proteinuria - urine | Placebos | Female | Aged | Diabetic Angiopathies - psychology | Patient Compliance | Albuminuria - urine | Diabetic Angiopathies - urine | Hypertension - urine | Diabetes | Diagnosis | Drug therapy | Cardiovascular diseases | Studies | Drugs | Samples | Health behavior | Clinical trials | Cardiovascular disease | Statistical methods | Clinical medicine | ACE inhibitors | Patients | Index Medicus | Life Sciences | Other
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7. Full Text Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study)
by Marre, Michel and Lievre, Michel and Chatellier, Gilles and Mann, Johannes F E and Passa, Philippe and Ménard, Joël and DIABHYCAR Study Investigators
BMJ, ISSN 0959-8138, 02/2004, Volume 328, Issue 7438, pp. 495 - 499
Abstract Objective To investigate whether a low dose of the angiotensin converting enzyme (ACE) inhibitor ramipril lowers cardiovascular and renal events in... 
Myocardial infarction | Excretion | Albumins | Angiotensin converting enzyme inhibitors | Diabetic nephropathies | Placebos | Type 2 diabetes mellitus | Dosage | Primary care | Type 1 diabetes mellitus | Proteinuria | MEDICINE, GENERAL & INTERNAL | CONVERTING ENZYME-INHIBITION | EVENTS | MICROALBUMINURIA | PROTEINURIA | RISK | MELLITUS | BLOOD-PRESSURE REDUCTION | HYPERTENSION | NEPHROPATHY | ENALAPRIL | Albuminuria - etiology | Double-Blind Method | Humans | Middle Aged | Risk Factors | Male | Treatment Outcome | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Ramipril - administration & dosage | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Female | Aged | Blood Pressure - drug effects | Diabetic Angiopathies - prevention & control | Ramipril - adverse effects | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Drug therapy | Clinical outcomes | Diabetes | Index Medicus | Abridged Index Medicus | Primary Care
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8. Full Text KRAS Mutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab
by Astrid Lièvre and Jean-Baptiste Bachet and Valérie Boige and Anne Cayre and Delphine Le Corre and Emmanuel Buc and Marc Ychou and Olivier Bouché and Bruno Landi and Christophe Louvet and Thierry André and Fréderic Bibeau and Marie-Danièle Diebold and Philippe Rougier and Michel Ducreux and Gorana Tomasic and Jean-François Emile and Frédérique Penault-Llorca and Pierre Laurent-Puig
Journal of Clinical Oncology, ISSN 0732-183X, 01/2008, Volume 26, Issue 3, pp. 374 - 379
Purpose Cetuximab is efficient in advanced colorectal cancer (CRC). We previously showed that KRAS mutations were associated with resistance to cetuximab in 30... 
TRIAL | GROWTH-FACTOR RECEPTOR | 1ST-LINE TREATMENT | LEUCOVORIN | KIRSTEN RAS MUTATIONS | THERAPY | ONCOLOGY | PHASE-II | IRINOTECAN | OXALIPLATIN | FLUOROURACIL | Colorectal Neoplasms - mortality | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Prognosis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Proto-Oncogene Proteins - genetics | Survival Rate | Antineoplastic Agents - therapeutic use | Mutation - genetics | Adenocarcinoma - drug therapy | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Colorectal Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - genetics | Retrospective Studies | Cetuximab | Adenocarcinoma - mortality | Index Medicus
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9. Full Text Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance
by Grimaldi-Bensouda, Lamiae and Rossignol, Michel and Koné-Paut, Isabelle and Krivitzky, Alain and Lebrun-Frenay, Christine and Clet, Johanna and Brassat, David and Papeix, Caroline and Nicolino, Marc and Benhamou, Pierre-Yves and Fain, Olivier and Costedoat-Chalumeau, Nathalie and Courcoux, Marie-France and Viallard, Jean-François and Godeau, Bertrand and Papo, Thomas and Vermersch, Patrick and Bourgault-Villada, Isabelle and Breart, Gerard and Abenhaim, Lucien and PGRx-AD Study Grp and PGRx-AD Study Group
Journal of Autoimmunity, ISSN 0896-8411, 2017, Volume 79, pp. 84 - 90
Abstract Background Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization. Objectives To assess... 
Allergy and Immunology | Pharmacoepidemiology | HPV vaccine | Autoimmune disease | METAANALYSIS | SAFETY | GUILLAIN-BARRE-SYNDROME | GUIDELINES | VACCINATION | SCLEROSIS | ADOLESCENT GIRLS | IMMUNOLOGY | IMMUNIZATION | DATABASE | DIAGNOSTIC-CRITERIA | Autoimmune Diseases - epidemiology | Papillomavirus Infections - complications | Follow-Up Studies | Humans | Male | Risk | Autoimmune Diseases - etiology | Young Adult | Papillomavirus Infections - prevention & control | Adolescent | Papillomavirus Vaccines - adverse effects | Adult | Female | Papillomavirus Vaccines - immunology | Odds Ratio | Child | Population Surveillance | Vaccines | Autoimmune diseases | Papillomavirus infections | Risk factors | Index Medicus | Life Sciences | Immunology
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10. Full Text Aspirin in the secondary prevention of cardiovascular disease: An update of the APTC meta-analysis
by Lièvre, Michel and Cucherat, Michel
Fundamental and Clinical Pharmacology, ISSN 0767-3981, 06/2010, Volume 24, Issue 3, pp. 385 - 391
We updated the 2002 Antiplatelet Trialists' Collaboration meta-analysis of antiplatelet therapy to assess the effects of aspirin alone in the secondary... 
Secondary prevention | Cardiovascular disease | Aspirin | Meta-analysis | cardiovascular disease | secondary prevention | EVENTS | meta-analysis | ARTERIAL-DISEASE | ASA | STROKE | DIPYRIDAMOLE | THERAPY | LOW-DOSE ASPIRIN | RESTENOSIS | aspirin | PHARMACOLOGY & PHARMACY | OCCLUSION | Cardiovascular Diseases - metabolism | Randomized Controlled Trials as Topic - methods | Cardiovascular Diseases - prevention & control | Humans | Risk Factors | Cardiovascular Diseases - epidemiology | Aspirin - therapeutic use | Platelet Aggregation Inhibitors - therapeutic use | Secondary Prevention - methods | Prevention | Cardiovascular diseases | Analysis | Heart attack | Index Medicus
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