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Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. e14715 - e14715
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A17153 - A17153
Maintaining endothelial cells (EC) as a monolayer in the vessel wall, depends on a profile of gene expression and on the metabolic state, features influenced... 
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A17231 - A17231
BackgroundPulmonary arterial hypertension (PAH) is characterized by endothelial (EC) apoptosis related to loss of distal (D) pulmonary arteries (PA) and... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3600 - 3613
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE | BONE MORPHOGENETIC PROTEIN | ARTERIAL-HYPERTENSION | HEART-FAILURE | IN-VIVO | APELIN | SMOOTH-MUSCLE-CELLS | TGF-BETA RECEPTOR | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Microvessels - pathology | Male | Cell Hypoxia | Tacrolimus - pharmacology | Hypertension, Pulmonary - drug therapy | Endothelial Cells - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Bone Morphogenetic Protein 4 - physiology | Endothelium, Vascular - physiopathology | Rats | Hypertension, Pulmonary - metabolism | Inhibitor of Differentiation Protein 1 - metabolism | Neointima - metabolism | Rats, Sprague-Dawley | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | High-Throughput Screening Assays | Neointima - drug therapy | Neointima - pathology | Tacrolimus Binding Protein 1A - metabolism | Cell Line, Tumor | Inhibitor of Differentiation Protein 1 - genetics | Endothelium, Vascular - pathology | Mice | Hypertension, Pulmonary - pathology | Smad Proteins - metabolism | Pulmonary Artery - pathology | Apoptosis | Endothelial Cells - drug effects | Hypertension | Cell receptors | Physiological aspects | Cellular signal transduction | Research | Properties | Endothelium | Proteins | Medical research | Scholarships & fellowships | Research & development--R&D | Pulmonary arteries | Rodents | Hypoxia | Ligands | Mutation | Drug dosages
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 2940 - 2940
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2015, Volume 21, Issue 4, pp. 596 - 608
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2012, Volume 3, p. 6
PAX genes have been shown to be critically required for the development of specific tissues and organs during embryogenesis. In addition, PAX genes are... 
Proliferation | Differentiation | PAX | Stem cell | Cell cycle | Cancer | differentiation | Cell Cycle | stem cell | proliferation
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2015, Volume 191, Issue 11, pp. 1273 - 1286
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2015, Volume 192, Issue 3, pp. 356 - 366
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 04/2017, Volume 195, Issue 7, p. 930
Journal Article
Cell Reports, ISSN 2211-1247, 01/2019, Volume 26, Issue 5, pp. 1333 - 1343.e7
Using proteomic approaches, we uncovered a DNA damage response (DDR) function for peroxisome proliferator activated receptor γ (PPARγ) through its interaction... 
endothelial cells | DNA damage | pulmonary hypertension | MRN | vascular biology | ATM | PPARγ | TO-MESENCHYMAL TRANSITION | ACTIVATION | GENE | REPRESSION | LIGANDS | PHOSPHORYLATION | PATHWAY | DEPENDENT NUCLEAR-DYNAMICS | DAMAGE | CELL BIOLOGY
Journal Article
Circulation, ISSN 0009-7322, 11/2017, Volume 136, Issue 20, pp. 1920 - 1935
BACKGROUND:Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic, or... 
Pulmonary arterial hypertension (PAH) | SAM domain and HD domain-containing protein 1 (SAMHD1) | Human endogenous retrovirus K (HERV-K) | Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) | Tertiary lymphoid tissue | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | VIRUS | LYMPHOID NEOGENESIS | deoxyuridine triphosphate nucleotidohydrolase (dUTPase) | PROTEIN-RECEPTOR 2 | tertiary lymphoid tissue | HUMAN-HERPESVIRUS-8 | GENE | RESTRICTION FACTOR | human endogenous retrovirus K (HERV-K) | PERIPHERAL VASCULAR DISEASE | DIFFERENTIATION | EXPRESSION | pulmonary arterial hypertension (PAH) | DUTPASE | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Coculture Techniques | Humans | Middle Aged | Viral Proteins - immunology | Infant | Male | Young Adult | Inflammation - metabolism | SAM Domain and HD Domain-Containing Protein 1 - immunology | SAM Domain and HD Domain-Containing Protein 1 - biosynthesis | Leukocytes, Mononuclear - immunology | Up-Regulation - physiology | Inflammation Mediators - metabolism | Adult | Female | Child | Viral Proteins - biosynthesis | Antigen-Antibody Complex - biosynthesis | Inflammation Mediators - immunology | Cells, Cultured | Rats | Hypertension, Pulmonary - immunology | Hypertension, Pulmonary - metabolism | Inflammation - immunology | Rats, Sprague-Dawley | Leukocytes, Mononuclear - pathology | Animals | Adolescent | Antigen-Antibody Complex - immunology | Hypertension, Pulmonary - pathology
Journal Article
Cell metabolism, ISSN 1550-4131, 4/2015, Volume 21, Issue 4, pp. 596 - 608
Mitochondrial dysfunction, inflammation and mutant bone morphogenetic protein receptor (BMPR)2 are associated with pulmonary arterial hypertension (PAH), an... 
Journal Article
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